CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (5alpha)-cholestan-3beta-ol
Accession: CHEBI:86570
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Definition: A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.
Synonyms: related_synonym: (3beta,5alpha)-cholestan-3-ol; 5alpha-cholestanol; Formula=C27H48O; InChI=1S/C27H48O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-25,28H,6-17H2,1-5H3/t19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1; InChIKey=QYIXCDOBOSTCEI-QCYZZNICSA-N; SMILES=CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C; cholestanol; dihydrocholesterol; zymostanol
xref: CAS:80-97-7
xref_mesh: MESH:D004083
xref: Reaxys:2418594
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases secretion
ISO
CYP27A1 protein results in increased secretion of Cholestanol
CTD
PMID:12117727
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
G
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
increases hydroxylation
ISO
CYP46A1 protein results in increased hydroxylation of Cholestanol
CTD
PMID:14640697
NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760
G
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
multiple interactions
ISO
[Cholestanol co-treated with NAD] binds to HSD17B10 protein
CTD
PMID:25526675
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
G
Sult2a1
sulfotransferase family 2A member 1
increases sulfation
ISO
SULT2A1 protein results in increased sulfation of Cholestanol
CTD
PMID:21839837
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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