2-nitrophenols - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2-nitrophenols	go back to main search page
Accession:	CHEBI:86421	browse the term
Definition:	A mononitrophenol that is 2-nitrophenol and its derivatives resulting from substitution of one or more of the hydrogens attached to the benzene ring by a non-nitro group.

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Rat (383 ) Mouse (379 ) Human (384 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (383)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carboxylesterase 1D

affects metabolic processing

ISO

CES1 protein affects the metabolism of 2-nitrophenol

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects chemical synthesis
increases oxidation

ISO
EXP

CYP1A1 protein affects the chemical synthesis of 2-nitrophenol
CYP1A1 protein results in increased oxidation of 2-nitrophenol

PMID:11409192 PMID:17159769

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects chemical synthesis

ISO
EXP

CYP2B6 protein affects the chemical synthesis of 2-nitrophenol

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

increases oxidation

EXP

CYP2C11 protein results in increased oxidation of 2-nitrophenol

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases oxidation
affects chemical synthesis

ISO
EXP

CYP2E1 protein results in increased oxidation of 2-nitrophenol
CYP2E1 protein affects the chemical synthesis of 2-nitrophenol

PMID:11409192 PMID:17159769 PMID:20027144

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

3-nitrotyrosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

ISO

[Asbestos, Crocidolite co-treated with IL1B protein] results in increased abundance of 3-nitrotyrosine; [Asbestos, Serpentine co-treated with IL1B protein] results in increased abundance of 3-nitrotyrosine

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

iodotyrosine deiodinase

multiple interactions

ISO

3-nitrotyrosine inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

4-Amino-2-nitrophenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 1 family, member A1

increases expression

EXP

4-amino-2-nitrophenol results in increased expression of ALDH1A1 protein

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

CD44 molecule

increases expression

EXP

4-amino-2-nitrophenol results in increased expression of CD44 protein

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

keratin 14

decreases expression

EXP

4-amino-2-nitrophenol results in decreased expression of KRT14 protein

NCBI chr10:85,638,182...85,642,450

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 3, pristanoyl

affects binding

EXP

entacapone binds to ACOX3 protein

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:79,302,042...79,400,881

G

acyl-CoA synthetase long-chain family member 1

affects binding

EXP

entacapone binds to ACSL1 protein

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

ADP-ribosylhydrolase like 1

affects binding

EXP

entacapone binds to ADPRHL1 protein

NCBI chr16:76,283,186...76,315,075

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

EXP

entacapone binds to AUH protein

NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,481,416...12,602,587

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

entacapone inhibits the reaction [[cadmium sulfate results in increased abundance of Cadmium] which results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

[entacapone co-treated with [cadmium sulfate results in increased abundance of Cadmium]] results in increased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

entacapone inhibits the reaction [[cadmium sulfate results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

clathrin heavy chain

affects binding

EXP

entacapone binds to CLTC protein

NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691

G

catechol-O-methyltransferase

decreases activity
affects binding
multiple interactions

ISO
EXP

entacapone results in decreased activity of COMT protein
entacapone binds to COMT protein
[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]

PMID:12898346 PMID:15566291 PMID:19783845 PMID:20334432 PMID:23206800 More...

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

enoyl-CoA hydratase, short chain 1

affects binding

EXP

entacapone binds to ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

epiregulin

increases expression

ISO

entacapone results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

entacapone inhibits the reaction [cadmium sulfate results in decreased expression of GCLC protein]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

ISO

entacapone results in decreased expression of GPAM protein

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

hemoglobin subunit beta

affects binding

EXP

entacapone binds to HBB protein

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

heme oxygenase 1

multiple interactions

ISO

entacapone promotes the reaction [cadmium sulfate results in increased expression of HMOX1 protein]
entacapone inhibits the reaction [[cadmium sulfate results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein]

PMID:39725363 PMID:39798863

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

EXP

entacapone binds to HSD17B13 protein

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:6,056,774...6,072,823

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

EXP

entacapone binds to HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

interleukin 1 alpha

increases expression

ISO

entacapone results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

ISO

entacapone results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

entacapone results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

entacapone inhibits the reaction [cadmium sulfate results in increased expression of NFE2L2 protein]
entacapone inhibits the reaction [[cadmium sulfate results in increased abundance of Cadmium] which results in increased expression of NFE2L2 protein]

PMID:39725363 PMID:39798863

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

pyruvate carboxylase

affects binding

EXP

entacapone binds to PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

phosphotyrosine interaction domain containing 1

decreases expression

ISO

entacapone results in decreased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

entacapone results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 7 member 11

decreases expression

ISO

entacapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

decreases expression

ISO

entacapone results in decreased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

synuclein alpha

multiple interactions

ISO

entacapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

superoxide dismutase 1

multiple interactions

ISO

entacapone inhibits the reaction [cadmium sulfate results in decreased expression of SOD1 protein]
entacapone inhibits the reaction [[cadmium sulfate results in increased abundance of Cadmium] which results in decreased expression of SOD1 protein]

PMID:39725363 PMID:39798863

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sulfotransferase family 2A member 1

affects binding

EXP

entacapone binds to SULT2A1 protein

NCBI chr 1:84,582,011...84,639,001

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6

affects binding

EXP

entacapone binds to SULT2A6 protein

NCBI chr 1:74,911,097...74,962,239
Ensembl chr 1:84,046,685...84,097,808

G

TNF alpha induced protein 6

decreases expression

ISO

entacapone results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of entacapone

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

ISO

UGT1A3 protein results in increased glucuronidation of entacapone

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation
decreases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of entacapone
UGT1A9 protein mutant form results in decreased glucuronidation of entacapone

PMID:15044611 PMID:15802387 PMID:16344532

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiopoietin 1

decreases expression

ISO

Roxarsone results in decreased expression of ANGPT1 mRNA

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

chondromodulin

decreases expression

ISO

Roxarsone results in decreased expression of CNMD mRNA

NCBI chr15:55,041,548...55,066,297
Ensembl chr15:61,450,450...61,475,350

G

C-X-C motif chemokine ligand 9

decreases expression

ISO

Roxarsone results in decreased expression of CXCL9 mRNA

NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases secretion

ISO

Roxarsone results in increased secretion of ENPP2 protein

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

FH2 domain containing 1

decreases expression

ISO

Roxarsone results in decreased expression of INF1 mRNA

NCBI chr 2:169,790,917...169,829,580
Ensembl chr 2:172,089,010...172,125,956

G

hepatocyte growth factor

increases expression

ISO

Roxarsone results in increased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

leptin

decreases expression

ISO

Roxarsone results in decreased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

matrix metallopeptidase 9

increases expression

ISO

Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mechanistic target of rapamycin kinase

increases expression
multiple interactions

EXP

Roxarsone results in increased expression of MTOR mRNA
Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

nitric oxide synthase 3

multiple interactions

ISO

Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

platelet and endothelial cell adhesion molecule 1

increases expression
multiple interactions

ISO

Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein]

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

plasminogen

decreases expression

ISO

Roxarsone results in decreased expression of PLG mRNA

NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320

G

ribosomal protein S6 kinase B1

multiple interactions
increases expression

EXP

Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]
Roxarsone results in increased expression of RPS6KB1 mRNA

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

vascular endothelial growth factor A

multiple interactions

EXP

Roxarsone results in increased expression of and results in increased secretion of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arylacetamide deacetylase

decreases expression

EXP

tolcapone results in decreased expression of AADAC mRNA

NCBI chr 2:146,293,449...146,351,061
Ensembl chr 2:146,313,279...146,324,525

G

alanyl-tRNA synthetase 1

increases expression

EXP

Tolcapone results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

tolcapone results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily D member 2

affects binding

EXP

tolcapone binds to ABCD2 protein

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202

G

abhydrolase domain containing 10, depalmitoylase

affects binding

EXP

tolcapone binds to ABHD10 protein

NCBI chr11:68,543,860...68,556,059
Ensembl chr11:68,543,606...68,557,640

G

acetyl-CoA acetyltransferase 2

increases expression

EXP

tolcapone results in increased expression of ACAT2 mRNA

NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095

G

acyl-CoA oxidase 3, pristanoyl

affects binding

EXP

tolcapone binds to ACOX3 protein

NCBI chr14:75,133,986...75,176,767
Ensembl chr14:79,302,042...79,400,881

G

acyl-CoA synthetase long-chain family member 1

affects binding
decreases expression

EXP
ISO

tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein

PMID:19783845 PMID:29688484

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

acyl-CoA synthetase long-chain family member 5

decreases expression

ISO

tolcapone results in decreased expression of ACSL5 protein

NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:264,294,864...264,341,943

G

acyl-CoA synthetase short-chain family member 2

increases expression

EXP

tolcapone results in increased expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830

G

actin alpha 2, smooth muscle

affects binding

EXP

tolcapone binds to ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

ADP-ribosylhydrolase like 1

affects binding

EXP

tolcapone binds to ADPRHL1 protein

NCBI chr16:76,283,186...76,315,075

G

aspartylglucosaminidase

decreases expression

EXP

tolcapone results in decreased expression of AGA mRNA

NCBI chr16:38,504,661...38,516,607
Ensembl chr16:45,223,339...45,249,551

G

allograft inflammatory factor 1

decreases expression

EXP

tolcapone results in decreased expression of AIF1 mRNA

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

adenylate kinase 2

affects binding

EXP

tolcapone binds to AK2 protein

NCBI chr 5:146,609,469...146,649,008
Ensembl chr 5:146,630,445...146,650,610

G

aldo-keto reductase family 1, member C1

affects binding

EXP

Tolcapone binds to AKR1C1 protein

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C3

decreases expression

EXP

tolcapone results in decreased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

aldo-keto reductase family 1, member D1

affects binding

EXP

tolcapone binds to AKR1D1 protein

NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540

G

aldehyde dehydrogenase 18 family, member A1

affects binding

EXP

tolcapone binds to ALDH18A1 protein

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383

G

aldehyde dehydrogenase 1 family, member B1

affects binding

EXP

tolcapone binds to ALDH1B1 protein

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365

G

aldehyde dehydrogenase 1 family, member L1

increases expression

EXP

tolcapone results in increased expression of ALDH1L1 mRNA

NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:124,617,217...124,664,704

G

aldehyde dehydrogenase 3 family, member A2

affects binding

EXP

tolcapone binds to ALDH3A2 protein

NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648

G

ALG13, UDP-N-acetylglucosaminyltransferase subunit

decreases expression

EXP

Tolcapone results in decreased expression of ALG13 mRNA

NCBI chr X:112,703,015...112,764,924
Ensembl chr X:112,702,796...112,739,356

G

autocrine motility factor receptor

increases expression

EXP

tolcapone results in increased expression of AMFR mRNA

NCBI chr19:11,002,451...11,038,182
Ensembl chr19:11,002,101...11,038,364

G

adipocyte plasma membrane associated protein

affects binding

EXP

tolcapone binds to APMAP protein

NCBI chr 3:159,869,451...159,897,727
Ensembl chr 3:159,869,451...159,897,726

G

apolipoprotein A1

affects binding

EXP

tolcapone binds to APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein B

decreases expression
decreases secretion

ISO

tolcapone results in decreased expression of APOB mRNA
tolcapone results in decreased secretion of APOB protein alternative form

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

apolipoprotein C2

decreases expression

EXP

tolcapone results in decreased expression of APOC2 mRNA

NCBI chr 1:88,457,397...88,462,365
Ensembl chr 1:88,457,396...88,463,438

G

apolipoprotein E

affects binding

EXP

tolcapone binds to APOE protein

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

apolipoprotein O-like

decreases expression

EXP

tolcapone results in decreased expression of APOOL mRNA

NCBI chr X:77,377,723...77,443,672
Ensembl chr X:81,570,053...81,640,036

G

ARF GTPase 4

affects binding

EXP

tolcapone binds to ARF4 protein

NCBI chr16:1,903,238...1,920,012
Ensembl chr16:1,903,371...1,920,011

G

ARF like GTPase 1

affects binding

EXP

tolcapone binds to ARL1 protein

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:25,006,981...25,019,319

G

ATPase family, AAA domain containing 1

affects binding

EXP

tolcapone binds to ATAD1 protein

NCBI chr 1:239,957,329...240,023,792
Ensembl chr 1:239,957,882...240,009,822

G

ATPase family, AAA domain containing 3A

affects binding

EXP

tolcapone binds to ATAD3A protein

NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:171,632,547...171,652,725

G

activating transcription factor 5

increases expression

EXP

tolcapone results in increased expression of ATF5 mRNA

NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:104,432,094...104,436,183

G

ATPase Na+/K+ transporting subunit beta 3

affects binding

EXP

tolcapone binds to ATP1B3 protein

NCBI chr 8:105,789,824...105,821,151
Ensembl chr 8:65,253,361...65,254,304
Ensembl chr 8:65,253,361...65,254,304

G

ATP synthase F1 subunit beta

affects binding

EXP

tolcapone binds to ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:1,099,860...1,106,462

G

ATP synthase F1 subunit gamma

affects binding

EXP

Tolcapone binds to ATP5F1C protein

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:73,333,588...73,383,073

G

ATP synthase F1 subunit epsilon

decreases expression

EXP

tolcapone results in decreased expression of ATP5F1E mRNA

NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:183,677,273...183,680,214

G

ATP synthase membrane subunit e

decreases expression
affects binding

EXP

tolcapone results in decreased expression of ATP5ME mRNA
tolcapone binds to ATP5ME protein

PMID:19783845 PMID:24136188

NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,464,800...1,465,988

G

ATP synthase membrane subunit f

affects binding

EXP

tolcapone binds to ATP5MF protein

NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709

G

ATP synthase membrane subunit G

decreases expression
affects binding

EXP

tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein

PMID:19783845 PMID:24136188

NCBI chr 8:54,122,457...54,130,407
Ensembl chr 8:54,122,457...54,132,831

G

ATP synthase membrane subunit K

decreases expression

EXP

Tolcapone results in decreased expression of ATP5MK mRNA

NCBI chr 1:255,915,255...255,922,185
Ensembl chr 1:255,915,259...255,922,106
Ensembl chr10:255,915,259...255,922,106

G

ATP synthase peripheral stalk subunit F6

decreases expression

EXP

tolcapone results in decreased expression of ATP5PF mRNA

NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466

G

ATP synthase peripheral stalk subunit OSCP

affects binding

EXP

tolcapone binds to ATP5PO protein

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520

G

AU RNA binding methylglutaconyl-CoA hydratase

affects binding

EXP

tolcapone binds to AUH protein

NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,481,416...12,602,587

G

gamma-butyrobetaine hydroxylase 1

decreases expression

EXP

tolcapone results in decreased expression of BBOX1 mRNA

NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064

G

basal cell adhesion molecule (Lutheran blood group)

affects binding

EXP

tolcapone binds to BCAM protein

NCBI chr 1:88,542,971...88,557,358
Ensembl chr 1:88,542,972...88,557,888

G

B-cell receptor-associated protein 29

decreases expression

EXP

tolcapone results in decreased expression of BCAP29 mRNA

NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:53,910,216...53,949,963

G

BCAS2, pre-mRNA processing factor

decreases expression

EXP

tolcapone results in decreased expression of BCAS2 mRNA

NCBI chr 2:193,381,000...193,388,881
Ensembl chr 2:193,380,982...193,388,878

G

bridge-like lipid transfer protein family member 1

increases expression

EXP

Tolcapone results in increased expression of BLTP1 mRNA

NCBI chr 2:121,636,181...121,852,802
Ensembl chr 2:121,636,323...121,852,802

G

BMP-binding endothelial regulator

affects binding

EXP

tolcapone binds to BMPER protein

NCBI chr 8:30,008,049...30,253,201
Ensembl chr 8:30,008,148...30,434,359

G

BMS1 ribosome biogenesis factor

affects binding

EXP

tolcapone binds to BMS1 protein

NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:153,230,471...153,267,429

G

bisphosphoglycerate mutase

decreases expression

EXP

tolcapone results in decreased expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627

G

basic transcription factor 3-like 4

decreases expression

EXP

tolcapone results in decreased expression of BTF3L4 mRNA

NCBI chr 5:128,796,594...128,816,219
Ensembl chr 5:128,796,594...128,816,602

G

C1D nuclear receptor corepressor

decreases expression

EXP

tolcapone results in decreased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:95,861,978...95,874,796

G

C1GALT1-specific chaperone 1

decreases expression

EXP

tolcapone results in decreased expression of C1GALT1C1 mRNA

NCBI chr X:122,243,736...122,248,217
Ensembl chr X:122,234,454...122,248,422

G

complement C4B

increases expression

EXP

tolcapone results in increased expression of C4B mRNA

NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289

G

complement C5

increases expression

EXP

tolcapone results in increased expression of C5 mRNA

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

complement C8 alpha chain

increases expression

EXP

tolcapone results in increased expression of C8A mRNA

NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:124,812,131...124,866,710

G

similar to human chromosome 11 open reading frame 71

decreases expression

EXP

Tolcapone results in decreased expression of C8H11ORF71 mRNA

NCBI chr 8:48,838,556...48,838,970
Ensembl chr 8:57,734,900...57,738,597

G

similar to human chromosome 15 open reading frame 61

decreases expression

EXP

Tolcapone results in decreased expression of C8H15ORF61 mRNA

NCBI chr 8:63,868,125...63,872,863
Ensembl chr 8:72,757,256...72,768,748

G

carbonyl reductase 4

decreases expression

EXP

tolcapone results in decreased expression of CBR4 mRNA

NCBI chr16:28,629,928...28,684,230
Ensembl chr16:33,617,399...33,656,832

G

cyclin L2

increases expression

EXP

tolcapone results in increased expression of CCNL2 mRNA

NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:171,699,689...171,711,231

G

chaperonin containing TCP1 subunit 7

affects binding

EXP

tolcapone binds to CCT7 protein

NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:119,546,730...119,563,973

G

CD36 molecule

increases expression

ISO

tolcapone results in increased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

complement factor B

increases expression

EXP

tolcapone results in increased expression of CFB mRNA

NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740

G

coiled-coil-helix-coiled-coil-helix domain containing 1

decreases expression

EXP

tolcapone results in decreased expression of CHCHD1 mRNA

NCBI chr15:3,641,973...3,643,155
Ensembl chr15:3,641,981...3,643,155

G

coiled-coil-helix-coiled-coil-helix domain containing 7

decreases expression

EXP

tolcapone results in decreased expression of CHCHD7 mRNA

NCBI chr 5:16,957,127...16,961,682
Ensembl chr 5:21,754,719...21,759,274

G

chromatin accessibility complex subunit 1

decreases expression

EXP

tolcapone results in decreased expression of CHRAC1 mRNA

NCBI chr 7:106,901,841...106,905,441

G

churchill domain containing 1

decreases expression

EXP

tolcapone results in decreased expression of CHURC1 mRNA

NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:101,203,841...101,237,748

G

cytosolic iron-sulfur assembly component 2A

decreases expression

EXP

tolcapone results in decreased expression of CIAO2A mRNA

NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:75,565,567...75,577,541

G

cell death-inducing DFFA-like effector a

increases expression

ISO

tolcapone results in increased expression of CIDEA mRNA

NCBI chr18:63,164,817...63,190,384
Ensembl chr18:63,164,099...63,190,382

G

CDGSH iron sulfur domain 1

affects binding

EXP

tolcapone binds to CISD1 protein

NCBI chr20:17,254,462...17,267,843
Ensembl chr20:17,254,187...17,271,042

G

C-type lectin domain family 4, member A3

decreases expression

EXP

Tolcapone results in decreased expression of CLEC4A3 mRNA

NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:157,885,895...157,896,727

G

clathrin heavy chain

affects binding

EXP

tolcapone binds to CLTC protein

NCBI chr10:72,014,984...72,073,308
Ensembl chr10:72,014,986...72,070,691

G

cornichon family member 4

decreases expression

EXP

tolcapone results in decreased expression of CNIH4 mRNA

NCBI chr13:95,442,054...95,458,163
Ensembl chr13:95,442,054...95,459,590

G

COMM domain containing 6

decreases expression

EXP

tolcapone results in decreased expression of COMMD6 mRNA

NCBI chr15:78,467,333...78,474,382
Ensembl chr15:84,882,548...84,889,194

G

catechol-O-methyltransferase

decreases activity
multiple interactions
increases methylation
affects binding

ISO
EXP

tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein

PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 More...

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

COPI coat complex subunit gamma 1

affects binding

EXP

tolcapone binds to COPG1 protein

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

COPI coat complex subunit gamma 2

decreases expression

EXP

tolcapone results in decreased expression of COPG2 mRNA

NCBI chr 4:60,333,455...60,468,953
Ensembl chr 4:60,333,455...60,469,145

G

coenzyme Q10A

decreases expression

EXP

tolcapone results in decreased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:1,376,591...1,382,722

G

coenzyme Q3 methyltransferase

decreases expression

EXP

tolcapone results in decreased expression of COQ3 mRNA

NCBI chr 5:40,226,313...40,257,383
Ensembl chr 5:40,226,368...40,257,617

G

cytochrome c oxidase subunit 6C

affects binding
decreases expression

EXP

tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA

PMID:19783845 PMID:24136188

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166

G

cytochrome c oxidase subunit 7A2

decreases expression

EXP

tolcapone results in decreased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:55,514,261...55,514,512
Ensembl chr 8:55,514,261...55,514,512

G

cytochrome c oxidase subunit 7B

decreases expression

EXP

tolcapone results in decreased expression of COX7B mRNA

NCBI chr X:75,149,036...75,155,285
Ensembl chr X:75,148,996...75,155,284

G

ceruloplasmin

increases expression

EXP

tolcapone results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

cAMP responsive element modulator

decreases expression

EXP

tolcapone results in decreased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

cysteine-rich protein 2

increases expression

EXP

tolcapone results in increased expression of CRIP2 mRNA

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:138,041,906...138,047,120

G

chromosome segregation 1 like

affects binding

EXP

tolcapone binds to CSE1L protein

NCBI chr 3:176,060,183...176,097,909
Ensembl chr 3:176,060,215...176,108,734

G

cystatin B

decreases expression

EXP

tolcapone results in decreased expression of CSTB mRNA

NCBI chr20:10,245,157...10,247,199
Ensembl chr20:10,245,158...10,247,199

G

cytochrome c-1

affects binding

EXP

tolcapone binds to CYC1 protein

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:109,947,766...109,950,657

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

EXP
ISO

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Tolcapone results in decreased activity of CYP1A1 protein

PMID:18493746 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression

EXP
ISO

tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA

PMID:18493746 PMID:24136188

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Tolcapone results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance

ISO

CYP3A4 protein results in increased susceptibility to Tolcapone

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 51

increases expression

EXP

tolcapone results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

death-associated protein

increases expression

EXP

tolcapone results in increased expression of DAP mRNA

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

dCMP deaminase

affects binding

EXP

tolcapone binds to DCTD protein

NCBI chr16:44,066,952...44,098,654
Ensembl chr16:50,787,875...50,831,186

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

affects binding

EXP

tolcapone binds to DDOST protein

NCBI chr 5:155,805,612...155,812,728
Ensembl chr 5:155,805,454...155,813,121

G

DEAD-box helicase 18

affects binding

EXP

tolcapone binds to DDX18 protein

NCBI chr13:32,729,697...32,743,161
Ensembl chr13:35,282,467...35,295,972

G

24-dehydrocholesterol reductase

affects binding
increases expression

EXP

tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA

PMID:19783845 PMID:24136188

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

7-dehydrocholesterol reductase

affects binding

EXP

tolcapone binds to DHCR7 protein

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

distal membrane arm assembly component 1

decreases expression

EXP

tolcapone results in decreased expression of DMAC1 mRNA

NCBI chr 5:94,288,900...94,290,053
Ensembl chr 5:94,280,654...94,290,119

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

EXP

tolcapone results in decreased expression of DNAJC15 mRNA

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:59,594,314...59,658,987

G

dedicator of cytokinesis 11

decreases expression

EXP

tolcapone results in decreased expression of DOCK11 mRNA

NCBI chr X:119,997,523...120,180,643
Ensembl chr X:119,997,552...120,180,634

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

decreases expression

EXP

tolcapone results in decreased expression of DPM3 mRNA

NCBI chr 2:174,676,532...174,677,047
Ensembl chr15:52,612,418...52,612,696

G

dpy-30 histone methyltransferase complex regulatory subunit

decreases expression

EXP

tolcapone results in decreased expression of DPY30 mRNA

NCBI chr 6:26,872,812...26,893,580
Ensembl chr 6:26,872,732...26,894,930

G

deoxythymidylate kinase

decreases expression

EXP

tolcapone results in decreased expression of DTYMK mRNA

NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:101,762,899...101,774,504

G

dynein light chain LC8-type 1

decreases expression

EXP

tolcapone results in decreased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dynein light chain Tctex-type 3

decreases expression

EXP

tolcapone results in decreased expression of DYNLT3 mRNA

NCBI chr X:16,000,425...16,009,632
Ensembl chr X:16,000,395...16,009,627

G

EBP, cholestenol delta-isomerase

increases expression

EXP

tolcapone results in increased expression of EBP mRNA

NCBI chr X:16,971,372...16,977,782
Ensembl chr X:16,971,405...16,977,781

G

enoyl-CoA hydratase, short chain 1

affects binding

EXP

tolcapone binds to ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

elongin C

decreases expression

EXP

tolcapone results in decreased expression of ELOC mRNA

NCBI chr 5:7,444,769...7,461,187
Ensembl chr 5:7,445,018...7,464,128
Ensembl chr20:7,445,018...7,464,128

G

epiregulin

decreases expression

ISO

Tolcapone results in decreased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

coagulation factor V

increases expression

EXP

tolcapone results in increased expression of F5 mRNA

NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247

G

family with sequence similarity 162, member A

affects binding

EXP

tolcapone binds to FAM162A protein

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

fibrillarin-like 1

affects binding

EXP

tolcapone binds to FBLL1 protein

NCBI chr10:20,762,716...20,764,359
Ensembl chr10:20,761,581...20,764,670

G

Fcf1 rRNA-processing protein

decreases expression

EXP

tolcapone results in decreased expression of FCF1 mRNA

NCBI chr 6:104,617,780...104,629,643
Ensembl chr 6:110,348,845...110,372,221

G

fibrinogen alpha chain

affects binding

EXP

tolcapone binds to FGA protein

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

formation of mitochondrial complex V assembly factor 1

decreases expression

EXP

tolcapone results in decreased expression of FMC1 mRNA

NCBI chr 4:68,241,009...68,249,045
Ensembl chr 4:68,241,009...68,268,534

G

glutaryl-CoA dehydrogenase

affects binding

EXP

tolcapone binds to GCDH protein

NCBI chr19:40,168,038...40,174,536
Ensembl chr19:40,168,141...40,175,686

G

golgi glycoprotein 1

affects binding

EXP

tolcapone binds to GLG1 protein

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:56,006,459...56,133,528

G

glia maturation factor, gamma

decreases expression

EXP

tolcapone results in decreased expression of GMFG mRNA

NCBI chr 1:92,856,154...92,866,722
Ensembl chr 1:92,854,995...92,866,723

G

G protein subunit gamma 10

decreases expression

EXP

tolcapone results in decreased expression of GNG10 mRNA

NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:78,651,167...78,658,059

G

G protein subunit gamma 5

decreases expression

EXP

tolcapone results in decreased expression of GNG5 mRNA

NCBI chr 2:238,054,954...238,063,451
Ensembl chr11:58,096,362...58,096,565
Ensembl chr 2:58,096,362...58,096,565

G

glypican 3

affects binding

EXP

tolcapone binds to GPC3 protein

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

general transcription factor IIH subunit 5

decreases expression

EXP

tolcapone results in decreased expression of GTF2H5 mRNA

NCBI chr 1:49,061,904...49,068,612
Ensembl chr 1:49,061,959...49,070,039

G

H2A.Z variant histone 2

affects binding

EXP

Tolcapone binds to H2AZ2 protein

NCBI chr14:85,507,228...85,526,166
Ensembl chr14:85,507,228...85,526,207
Ensembl chr16:85,507,228...85,526,207

G

hemoglobin subunit beta

affects binding

EXP

tolcapone binds to HBB protein

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:167,630,245...167,663,873

G

HIG1 hypoxia inducible domain family, member 1A

decreases expression

EXP

tolcapone results in decreased expression of HIGD1A mRNA

NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888

G

histidine triad nucleotide binding protein 3

decreases expression

EXP

tolcapone results in decreased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:28,854,844...28,867,125

G

histone cluster 1 H4 family member B

decreases expression

EXP

Tolcapone results in decreased expression of HIST1H4B mRNA

NCBI chr17:47,176,246...47,180,690
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr 4:41,797,152...41,806,539

G

heterogeneous nuclear ribonucleoprotein H1

affects binding

EXP

tolcapone binds to HNRNPH1 protein

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906

G

hydroxysteroid (17-beta) dehydrogenase 11

affects binding

EXP

tolcapone binds to HSD17B11 protein

NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,997,906...6,047,811

G

hydroxysteroid (17-beta) dehydrogenase 12

affects binding

EXP

tolcapone binds to HSD17B12 protein

NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938

G

hydroxysteroid (17-beta) dehydrogenase 13

affects binding

EXP

tolcapone binds to HSD17B13 protein

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:6,056,774...6,072,823

G

hydroxysteroid (17-beta) dehydrogenase 4

affects binding

EXP

tolcapone binds to HSD17B4 protein

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

hydroxysteroid dehydrogenase like 2

increases expression

EXP

tolcapone results in increased expression of HSDL2 mRNA

NCBI chr 5:79,238,881...79,274,051
Ensembl chr 5:79,212,525...79,274,798

G

intraflagellar transport associated protein

decreases expression

EXP

Tolcapone results in decreased expression of IFTAP mRNA

NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:108,267,132...108,361,573

G

insulin-like growth factor binding protein 1

increases expression

EXP

tolcapone results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

interleukin 24

decreases expression

ISO

Tolcapone results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

importin 7

affects binding

EXP

tolcapone binds to IPO7 protein

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:173,497,503...173,536,778

G

isochorismatase domain containing 2b

decreases expression

EXP

Tolcapone results in decreased expression of ISOC2B mRNA

NCBI chr 1:78,001,735...78,022,565
Ensembl chr 1:78,001,735...78,022,564

G

integral membrane protein 2A

affects binding

EXP

tolcapone binds to ITM2A protein

NCBI chr X:76,559,183...76,565,144
Ensembl chr X:76,559,181...76,565,437

G

jagunal homolog 1

affects binding

EXP

tolcapone binds to JAGN1 protein

NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:148,147,229...148,151,915

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

tolcapone results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

alpha-ketoglutarate dehydrogenase subunit 4

decreases expression

EXP

Tolcapone results in decreased expression of KGD4 mRNA

NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:33,604,613...33,615,095

G

kininogen 1

increases expression

EXP

Tolcapone results in increased expression of KNG1 mRNA

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148

G

L antigen family, member 3

decreases expression

EXP

tolcapone results in decreased expression of LAGE3 mRNA

NCBI chr X:157,289,497...157,290,920

G

lipopolysaccharide binding protein

increases expression

EXP

tolcapone results in increased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

leucine rich repeat containing 59

affects binding

EXP

tolcapone binds to LRRC59 protein

NCBI chr10:80,069,162...80,083,820
Ensembl chr10:80,069,120...80,084,079

G

LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

EXP

tolcapone results in decreased expression of LSM3 mRNA

NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:125,578,185...125,584,429

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

EXP

tolcapone results in decreased expression of LSM5 mRNA

NCBI chr 4:87,281,260...87,284,476
Ensembl chr 4:87,281,260...87,284,476
Ensembl chr 6:87,281,260...87,284,476

G

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

EXP

tolcapone results in decreased expression of LSM7 mRNA

NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:9,507,367...9,514,115

G

mago homolog, exon junction complex subunit

decreases expression

EXP

tolcapone results in decreased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:127,868,055...127,875,384

G

MBL associated serine protease 1

increases expression

EXP

tolcapone results in increased expression of MASP1 mRNA

NCBI chr11:90,839,081...90,909,922
Ensembl chr11:90,839,061...90,917,470

G

matrin 3

decreases expression

EXP

tolcapone results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,432,179...27,470,421

G

methylmalonyl CoA epimerase

decreases expression

EXP

tolcapone results in decreased expression of MCEE mRNA

NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:127,376,298...127,400,367

G

MCTS1, re-initiation and release factor

decreases expression

EXP

tolcapone results in decreased expression of MCTS1 mRNA

NCBI chr X:122,215,602...122,228,101
Ensembl chr X:122,216,439...122,229,631

G

mediator complex subunit 21

decreases expression

EXP

tolcapone results in decreased expression of MED21 mRNA

NCBI chr 4:181,291,191...181,314,504
Ensembl chr 4:181,291,271...181,298,234

G

mediator complex subunit 28

decreases expression

EXP

tolcapone results in decreased expression of MED28 mRNA

NCBI chr14:65,594,785...65,603,583
Ensembl chr14:69,807,319...69,816,115

G

mediator complex subunit 31

decreases expression

EXP

tolcapone results in decreased expression of MED31 mRNA

NCBI chr10:56,836,944...56,840,326
Ensembl chr10:57,335,507...57,338,889

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Tolcapone results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methyltransferase 5, N6-adenosine

decreases expression

EXP

tolcapone results in decreased expression of METTL5 mRNA

NCBI chr 3:75,033,605...75,046,359
Ensembl chr 3:75,026,861...75,045,831

G

major facilitator superfamily domain containing 5

decreases expression

EXP

tolcapone results in decreased expression of MFSD5 mRNA

NCBI chr 7:133,409,096...133,411,377
Ensembl chr 7:135,269,076...135,290,342

G

microsomal glutathione S-transferase 1

affects binding

EXP

tolcapone binds to MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

MIA SH3 domain ER export factor 3

decreases expression

EXP

tolcapone results in decreased expression of MIA3 mRNA

NCBI chr13:94,970,421...95,012,071
Ensembl chr13:97,494,275...97,543,587

G

MKKS centrosomal shuttling protein

decreases expression

EXP

tolcapone results in decreased expression of MKKS mRNA

NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:144,654,566...144,672,831

G

makorin ring finger protein 1

decreases expression

EXP

tolcapone results in decreased expression of MKRN1 mRNA

NCBI chr 4:69,142,710...69,170,211
Ensembl chr 4:69,142,723...69,164,020

G

metabolism of cobalamin associated D

decreases expression

EXP

tolcapone results in decreased expression of MMADHC mRNA

NCBI chr 3:34,708,649...34,726,554
Ensembl chr 3:55,117,833...55,135,851

G

mitochondrial ribosomal protein L1

decreases expression

EXP

tolcapone results in decreased expression of MRPL1 mRNA

NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,604,499...13,663,602

G

mitochondrial ribosomal protein L13

decreases expression

EXP

tolcapone results in decreased expression of MRPL13 mRNA

NCBI chr 7:88,841,265...88,862,821
Ensembl chr 7:88,841,266...88,862,848

G

mitochondrial ribosomal protein L14

decreases expression

EXP

tolcapone results in decreased expression of MRPL14 mRNA

NCBI chr 9:22,800,286...22,812,711
Ensembl chr 9:22,795,744...22,812,855

G

mitochondrial ribosomal protein L18

decreases expression

EXP

tolcapone results in decreased expression of MRPL18 mRNA

NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:50,384,367...50,389,763

G

mitochondrial ribosomal protein L20

decreases expression

EXP

tolcapone results in decreased expression of MRPL20 mRNA

NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728

G

mitochondrial ribosomal protein L22

decreases expression

EXP

tolcapone results in decreased expression of MRPL22 mRNA

NCBI chr10:42,843,165...42,856,243
Ensembl chr10:42,843,222...42,856,227

G

mitochondrial ribosomal protein L23

decreases expression

EXP

tolcapone results in decreased expression of MRPL23 mRNA

NCBI chr 1:207,116,930...207,124,702
Ensembl chr 1:207,116,462...207,124,699

G

mitochondrial ribosomal protein L30

decreases expression

EXP

tolcapone results in decreased expression of MRPL30 mRNA

NCBI chr 9:47,621,226...47,631,986
Ensembl chr 9:47,621,227...47,633,484

G

mitochondrial ribosomal protein L32

decreases expression

EXP

tolcapone results in decreased expression of MRPL32 mRNA

NCBI chr17:55,260,651...55,263,517
Ensembl chr17:55,260,270...55,263,517

G

mitochondrial ribosomal protein L36

decreases expression

EXP

tolcapone results in decreased expression of MRPL36 mRNA

NCBI chr 1:31,794,025...31,797,446
Ensembl chr 1:31,790,887...31,797,808

G

mitochondrial ribosomal protein L40

decreases expression

EXP

tolcapone results in decreased expression of MRPL40 mRNA

NCBI chr11:95,637,751...95,643,587
Ensembl chr11:95,637,712...95,643,586

G

mitochondrial ribosomal protein L53

decreases expression

EXP

tolcapone results in decreased expression of MRPL53 mRNA

NCBI chr 4:117,173,043...117,173,933

G

mitochondrial ribosomal protein S14

decreases expression

EXP

tolcapone results in decreased expression of MRPS14 mRNA

NCBI chr13:74,962,597...74,968,344
Ensembl chr13:74,962,515...74,970,975

G

mitochondrial ribosomal protein S18C

decreases expression

EXP

tolcapone results in decreased expression of MRPS18C mRNA

NCBI chr14:9,116,688...9,122,943

G

mitochondrial ribosomal protein S24

decreases expression

EXP

tolcapone results in decreased expression of MRPS24 mRNA

NCBI chr14:80,584,671...80,588,801

G

mitochondrial ribosomal protein S33

decreases expression

EXP

tolcapone results in decreased expression of MRPS33 mRNA

NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:69,563,503...69,572,177

G

membrane-spanning 4-domains, subfamily A, member 6B

decreases expression

EXP

Tolcapone results in decreased expression of MS4A6B mRNA

NCBI chr 1:208,281,016...208,301,771
Ensembl chr 1:217,705,961...217,727,450

G

methylthioadenosine phosphorylase

affects binding

EXP

tolcapone binds to MTAP protein

NCBI chr 5:103,874,460...103,920,684
Ensembl chr 5:108,988,830...109,055,214

G

microsomal triglyceride transfer protein

increases expression

ISO

tolcapone results in increased expression of MTTP protein

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

mevalonate kinase

increases expression

EXP

tolcapone results in increased expression of MVK mRNA

NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503

G

N(alpha)-acetyltransferase 20, NatB catalytic subunit

decreases expression

EXP

tolcapone results in decreased expression of NAA20 mRNA

NCBI chr 3:153,775,351...153,790,129
Ensembl chr 3:153,775,338...153,790,916

G

N-acetyltransferase 10

affects binding

EXP

tolcapone binds to NAT10 protein

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:110,566,582...110,604,836

G

NADH:ubiquinone oxidoreductase subunit A1

decreases expression

EXP

tolcapone results in decreased expression of NDUFA1 mRNA

NCBI chr X:121,289,904...121,293,555
Ensembl chr X:121,289,925...121,293,555

G

NADH:ubiquinone oxidoreductase subunit A2

decreases expression

EXP

tolcapone results in decreased expression of NDUFA2 mRNA

NCBI chr18:28,629,795...28,631,884
Ensembl chr18:28,629,795...28,631,884

G

NADH:ubiquinone oxidoreductase subunit A6

decreases expression

EXP

tolcapone results in decreased expression of NDUFA6 mRNA

NCBI chr 7:115,746,460...115,750,317
Ensembl chr 7:115,746,460...115,750,317

G

NADH:ubiquinone oxidoreductase subunit A7

decreases expression

EXP

tolcapone results in decreased expression of NDUFA7 mRNA

NCBI chr 7:15,311,446...15,324,226
Ensembl chr 7:15,311,286...15,334,138

G

NADH:ubiquinone oxidoreductase subunit A9

affects binding

EXP

tolcapone binds to NDUFA9 protein

NCBI chr 4:161,345,398...161,374,188
Ensembl chr 4:161,345,400...161,375,025

G

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

EXP

tolcapone results in decreased expression of NDUFB6 mRNA

NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:60,196,585...60,206,055

G

NADH:ubiquinone oxidoreductase subunit C2

decreases expression

EXP

tolcapone results in decreased expression of NDUFC2 mRNA

NCBI chr 1:161,122,370...161,129,413
Ensembl chr 1:161,123,150...161,129,419

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression

EXP

tolcapone results in decreased expression of NDUFS4 mRNA

NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:47,684,406...47,794,931

G

NADH:ubiquinone oxidoreductase subunit S5

decreases expression

EXP

tolcapone results in decreased expression of NDUFS5 mRNA

NCBI chr 5:135,974,029...135,979,705
Ensembl chr 2:184,849,197...185,028,909
Ensembl chr 5:184,849,197...185,028,909
Ensembl chr14:184,849,197...185,028,909

G

NFE2 like bZIP transcription factor 2

decreases expression

ISO

tolcapone results in decreased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nipsnap homolog 1

affects binding

EXP

tolcapone binds to NIPSNAP1 protein

NCBI chr14:79,734,234...79,758,101
Ensembl chr14:83,957,702...83,981,576

G

nipsnap homolog 2

affects binding

EXP

tolcapone binds to NIPSNAP2 protein

NCBI chr12:26,906,068...26,944,201
Ensembl chr12:32,547,819...32,580,303

G

NME/NM23 nucleoside diphosphate kinase 3

decreases expression

EXP

tolcapone results in decreased expression of NME3 mRNA

NCBI chr10:14,421,922...14,422,878
Ensembl chr10:14,421,702...14,422,907

G

NOP56 ribonucleoprotein

affects binding

EXP

tolcapone binds to NOP56 protein

NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:137,929,646...137,934,959

G

nephrocystin 1

decreases expression

EXP

tolcapone results in decreased expression of NPHP1 mRNA

NCBI chr 3:135,413,927...135,469,505
Ensembl chr 3:135,413,927...135,469,505

G

NPL4 homolog, ubiquitin recognition factor

increases expression

EXP

tolcapone results in increased expression of NPLOC4 mRNA

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

EXP

tolcapone results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear protein 2, transcriptional regulator

decreases expression

EXP

tolcapone results in decreased expression of NUPR2 mRNA

NCBI chr12:26,800,123...26,803,228
Ensembl chr12:32,433,966...32,439,487

G

prolyl 4-hydroxylase subunit alpha 1

affects binding

EXP

tolcapone binds to P4HA1 protein

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,845,141...27,895,404

G

pyruvate carboxylase

affects binding

EXP

tolcapone binds to PC protein

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940

G

proliferating cell nuclear antigen

decreases expression

EXP

tolcapone results in decreased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphate cytidylyltransferase 1A, choline

affects binding

EXP

tolcapone binds to PCYT1A protein

NCBI chr11:81,818,914...81,862,623
Ensembl chr11:81,819,285...81,862,395

G

PDZ domain containing 11

decreases expression

EXP

tolcapone results in decreased expression of PDZD11 mRNA

NCBI chr X:69,758,765...69,761,811
Ensembl chr X:69,759,029...69,761,797

G

prefoldin subunit 1

decreases expression

EXP

tolcapone results in decreased expression of PFDN1 mRNA

NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,287,913...28,341,123

G

prefoldin subunit 5

decreases expression

EXP

tolcapone results in decreased expression of PFDN5 mRNA

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:135,330,172...135,335,099

G

phosphoglucomutase 1

increases expression

EXP

tolcapone results in increased expression of PGM1 mRNA

NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:119,710,737...119,770,159

G

progesterone receptor

multiple interactions

ISO

tolcapone binds to and results in decreased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphatidylinositol glycan anchor biosynthesis, class P

decreases expression

EXP

tolcapone results in decreased expression of PIGP mRNA

NCBI chr11:47,152,601...47,158,766
Ensembl chr11:47,148,465...47,160,082

G

phosphatidylinositol glycan anchor biosynthesis, class S

affects binding

EXP

tolcapone binds to PIGS protein

NCBI chr10:63,222,611...63,237,190
Ensembl chr10:63,720,661...63,735,253

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 4

decreases expression

EXP

tolcapone results in decreased expression of PIN4 mRNA

NCBI chr X:67,232,066...67,238,709
Ensembl chr X:71,272,043...71,289,187

G

perilipin 2

affects binding

EXP

tolcapone binds to PLIN2 protein

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

perilipin 3

affects binding

EXP

tolcapone binds to PLIN3 protein

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,198,336...1,210,231

G

patatin-like phospholipase domain containing 2

increases expression

EXP

tolcapone results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

RNA polymerase I subunit H

decreases expression

EXP

Tolcapone results in decreased expression of POLR1H mRNA

NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,595,945...1,604,088

G

RNA polymerase II subunit G

decreases expression

EXP

tolcapone results in decreased expression of POLR2G mRNA

NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:215,118,262...215,121,805

G

pre-mRNA processing factor 8

affects binding

EXP

tolcapone binds to PRPF8 protein

NCBI chr10:60,829,778...60,852,887
Ensembl chr10:60,829,778...60,852,887

G

peroxiredoxin like 2A

affects binding

EXP

tolcapone binds to PRXL2A protein

NCBI chr16:16,900,697...16,920,521
Ensembl chr16:16,900,699...16,920,561

G

proteasome 26S subunit, ATPase 5

affects binding

EXP

tolcapone binds to PSMC5 protein

NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921

G

proteasome activator subunit 2

affects binding

EXP

tolcapone binds to PSME2 protein

NCBI chr15:33,048,452...33,053,055
Ensembl chr15:33,048,457...33,053,102

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

Tolcapone results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

peptidyl-tRNA hydrolase 2

affects binding

EXP

tolcapone binds to PTRH2 protein

NCBI chr10:72,002,450...72,012,606
Ensembl chr10:71,985,245...72,045,352

G

RNA guanine-7 methyltransferase activating subunit

decreases expression

EXP

tolcapone results in decreased expression of RAMAC mRNA

NCBI chr 1:145,117,752...145,123,640
Ensembl chr 1:145,117,736...145,124,256

G

RAN, member RAS oncogene family

affects binding

EXP

tolcapone binds to RAN protein

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:33,311,158...33,314,317

G

RAP1A, member of RAS oncogene family

decreases expression

EXP

tolcapone results in decreased expression of RAP1A mRNA

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808

G

ribosomal biogenesis factor

decreases expression

EXP

Tolcapone results in decreased expression of RBIS mRNA

NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:88,702,536...88,719,527

G

RNA binding motif protein 8A

decreases expression

EXP

tolcapone results in decreased expression of RBM8A mRNA

NCBI chr 2:186,854,018...186,856,802
Ensembl chr 2:186,854,036...186,856,802

G

retinol binding protein 1

decreases expression

EXP

tolcapone results in decreased expression of RBP1 mRNA

NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:107,887,417...107,983,847

G

receptor accessory protein 6

affects binding

EXP

tolcapone binds to REEP6 protein

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740

G

similar to RIKEN cDNA 1110059G10

decreases expression

EXP

tolcapone results in decreased expression of RGD1311745 mRNA

NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:131,475,906...131,482,865

G

ring finger protein 7

decreases expression

EXP

tolcapone results in decreased expression of RNF7 mRNA

NCBI chr 8:105,918,395...105,927,643
Ensembl chr 8:105,918,395...105,927,405

G

renalase, FAD-dependent amine oxidase

decreases expression

EXP

tolcapone results in decreased expression of RNLS mRNA

NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:240,450,702...240,723,043

G

reactive oxygen species modulator 1

decreases expression

EXP

tolcapone results in decreased expression of ROMO1 mRNA

NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:165,120,035...165,121,394

G

replication protein A3

decreases expression

EXP

tolcapone results in decreased expression of RPA3 mRNA

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:37,270,966...37,274,183

G

ribosomal protein L10A

affects binding

EXP

tolcapone binds to RPL10A protein

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,390,179...6,393,091

G

ribosomal protein L15

affects binding

EXP

tolcapone binds to RPL15 protein

NCBI chr15:9,934,663...9,937,946
Ensembl chr15:9,934,679...9,938,308

G

ribosomal protein L18A

affects binding

EXP

tolcapone binds to RPL18A protein

NCBI chr16:18,576,467...18,578,653
Ensembl chr 1:70,166,729...70,167,654
Ensembl chr16:70,166,729...70,167,654

G

ribosomal protein L22

affects binding

EXP

tolcapone binds to RPL22 protein

NCBI chr 5:168,114,432...168,126,114
Ensembl chr 5:168,111,074...168,126,114
Ensembl chr 4:168,111,074...168,126,114
Ensembl chr 7:168,111,074...168,126,114

G

ribosomal protein L22 like 1

decreases expression

EXP

tolcapone results in decreased expression of RPL22L1 mRNA

NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:113,683,196...113,685,132

G

ribosomal protein L23

affects binding

EXP

tolcapone binds to RPL23 protein

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:83,262,592...83,272,214

G

ribosomal protein L35A

decreases expression

EXP

tolcapone results in decreased expression of RPL35A mRNA

NCBI chr11:67,726,031...67,729,953
Ensembl chr 5:163,826,849...163,827,306
Ensembl chr11:163,826,849...163,827,306

G

ribosomal protein L36A

decreases expression

EXP

tolcapone results in decreased expression of RPL36A mRNA

NCBI chr X:102,058,573...102,062,162
Ensembl chr20:22,034,086...22,034,406

G

ribosomal protein L41

decreases expression

EXP

tolcapone results in decreased expression of RPL41 mRNA

NCBI chr 7:977,885...978,965

G

ribosomal protein L7A

affects binding

EXP

tolcapone binds to RPL7A protein

NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:30,637,059...30,639,791
Ensembl chr18:30,637,059...30,639,791

G

ribosomal protein L7-like 1

affects binding

EXP

tolcapone binds to RPL7L1 protein

NCBI chr 9:14,198,101...14,206,119
Ensembl chr 9:21,695,707...21,703,735

G

ribosomal protein L9

decreases expression

EXP

tolcapone results in decreased expression of RPL9 mRNA

NCBI chr14:43,247,536...43,250,784
Ensembl chr14:43,247,588...43,250,782
Ensembl chr 1:43,247,588...43,250,782

G

ribonuclease P/MRP subunit p21

decreases expression

EXP

tolcapone results in decreased expression of RPP21 mRNA

NCBI chr20:1,986,225...2,025,308
Ensembl chr20:2,023,186...2,025,308

G

ribosomal protein S11

affects binding

EXP

tolcapone binds to RPS11 protein

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:104,742,155...104,744,337

G

ribosomal protein S14

affects binding

EXP

tolcapone binds to RPS14 protein

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:56,498,245...56,503,091

G

ribosomal protein S15a

decreases expression

EXP

tolcapone results in decreased expression of RPS15A mRNA

NCBI chr 1:181,854,396...181,861,330
Ensembl chr 1:181,854,396...181,861,201

G

ribosomal protein S20

affects binding

EXP

tolcapone binds to RPS20 protein

NCBI chr 5:21,616,687...21,618,068
Ensembl chr 3:42,839,965...43,095,621
Ensembl chr 9:42,839,965...43,095,621
Ensembl chr 5:42,839,965...43,095,621

G

ribosomal protein S21, pseudogene 1

decreases expression

EXP

tolcapone results in decreased expression of RPS21 mRNA

NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:158,670,116...158,670,490

G

ribosomal protein S24

decreases expression

EXP

tolcapone results in decreased expression of RPS24 mRNA

NCBI chr16:95,429...101,146
Ensembl chr16:96,484...101,144

G

ribosomal protein s25

decreases expression

EXP

tolcapone results in decreased expression of RPS25 mRNA

NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:53,629,861...53,632,808
Ensembl chr 8:53,629,861...53,632,808

G

ribosomal protein S27

decreases expression

EXP

tolcapone results in decreased expression of RPS27 mRNA

NCBI chr 2:177,963,499...177,964,708
Ensembl chr 2:177,963,496...177,964,607
Ensembl chr12:177,963,496...177,964,607

G

ribosomal protein S27a

affects binding

EXP

tolcapone binds to RPS27A protein

NCBI chr14:107,486,664...107,488,941
Ensembl chr 5:138,465,088...138,466,080
Ensembl chr14:138,465,088...138,466,080
Ensembl chr 5:138,465,088...138,466,080

G

S100 calcium binding protein A10

decreases expression

EXP

tolcapone results in decreased expression of S100A10 mRNA

NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:181,904,261...181,913,103

G

sterol-C5-desaturase

increases expression

EXP

tolcapone results in increased expression of SC5D mRNA

NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277

G

stearoyl-CoA desaturase

affects binding
decreases expression

EXP

tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA

PMID:19783845 PMID:24136188

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

succinate dehydrogenase complex flavoprotein subunit A

affects binding

EXP

tolcapone binds to SDHA protein

NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121

G

succinate dehydrogenase complex iron sulfur subunit B

affects binding

EXP

tolcapone binds to SDHB protein

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667

G

SEC11 homolog C, signal peptidase complex subunit

affects binding

EXP

tolcapone binds to SEC11C protein

NCBI chr18:59,320,932...59,337,272
Ensembl chr18:61,590,885...61,607,348

G

SEC31 homolog A, COPII coat complex component

affects binding

EXP

tolcapone binds to SEC31A protein

NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,518,648...9,573,585

G

Serpine1 mRNA binding protein 1

affects binding

EXP

tolcapone binds to SERBP1 protein

NCBI chr 4:97,731,200...97,748,438
Ensembl chr 4:97,731,277...97,751,518

G

splicing factor 3B, subunit 6

affects binding

EXP

tolcapone binds to SF3B6 protein

NCBI chr 6:27,826,044...27,835,086
Ensembl chr 6:33,545,512...33,554,608

G

sideroflexin 1

affects binding

EXP

tolcapone binds to SFXN1 protein

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

SIK family kinase 3

increases expression

EXP

tolcapone results in increased expression of SIK3 mRNA

NCBI chr 8:55,208,969...55,419,138
Ensembl chr 8:55,208,815...55,419,138

G

solute carrier family 1 member 5

affects binding

EXP

tolcapone binds to SLC1A5 protein

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 25 member 1

affects binding

EXP

tolcapone binds to SLC25A1 protein

NCBI chr11:96,560,054...96,563,071
Ensembl chr11:96,560,041...96,565,052

G

solute carrier family 25 member 13

affects binding

EXP

tolcapone binds to SLC25A13 protein

NCBI chr 4:35,145,721...35,328,403
Ensembl chr 4:35,145,721...35,328,360

G

solute carrier family 25 member 4

affects binding

EXP

tolcapone binds to SLC25A4 protein

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700

G

solute carrier family 25 member 5

affects binding

EXP

tolcapone binds to SLC25A5 protein

NCBI chr X:120,897,616...120,900,683
Ensembl chr X:120,897,563...120,900,688

G

solute carrier family 25 member 5, pseudogene 11

affects binding

EXP

tolcapone binds to SLC25A6 protein

NCBI chr18:68,571,222...68,572,461
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 39 member 7

affects binding

EXP

tolcapone binds to SLC39A7 protein

NCBI chr20:4,824,967...4,828,431
Ensembl chr20:4,824,688...4,828,430

G

solute carrier family 7 member 11

decreases expression

ISO

Tolcapone results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

decreases expression

ISO

Tolcapone results in decreased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

small integral membrane protein 26

decreases expression

EXP

tolcapone results in decreased expression of SMIM26 mRNA

NCBI chr 3:131,990,147...131,991,779
Ensembl chr 3:152,443,579...152,445,447

G

SNAP-associated protein

decreases expression

EXP

tolcapone results in decreased expression of SNAPIN mRNA

NCBI chr 2:178,269,157...178,271,746
Ensembl chr 2:178,269,166...178,272,041

G

synuclein alpha

multiple interactions

ISO

tolcapone inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

small nuclear ribonucleoprotein U4/U6.U5 subunit 27

decreases expression

EXP

Tolcapone results in decreased expression of SNRNP27 mRNA

NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:120,679,255...120,690,656

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

EXP

tolcapone results in decreased expression of SNRPB2 mRNA

NCBI chr 3:150,852,814...150,862,364
Ensembl chr 3:150,852,790...150,863,428

G

small nuclear ribonucleoprotein D3 polypeptide

decreases expression

EXP

tolcapone results in decreased expression of SNRPD3 mRNA

NCBI chr20:13,129,555...13,145,100
Ensembl chr20:13,109,294...13,145,763

G

small nuclear ribonucleoprotein polypeptide E

decreases expression

EXP

tolcapone results in decreased expression of SNRPE mRNA

NCBI chr13:47,596,324...47,609,390
Ensembl chr 8:129,294,325...129,294,603
Ensembl chr13:129,294,325...129,294,603

G

small nuclear ribonucleoprotein polypeptide F

decreases expression

EXP

tolcapone results in decreased expression of SNRPF mRNA

NCBI chr 7:30,017,460...30,024,162
Ensembl chr 7:30,017,460...30,024,162

G

small nuclear ribonucleoprotein polypeptide G

decreases expression

EXP

tolcapone results in decreased expression of SNRPG mRNA

NCBI chr 4:120,369,676...120,377,263
Ensembl chr 4:120,369,685...120,377,261
Ensembl chr X:120,369,685...120,377,261

G

superoxide dismutase 1

decreases expression

ISO

tolcapone results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

decreases expression

ISO

tolcapone results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

signal recognition particle 14

decreases expression

EXP

tolcapone results in decreased expression of SRP14 mRNA

NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:125,896,556...125,899,819

G

SRP receptor subunit beta

affects binding

EXP

tolcapone binds to SRPRB protein

NCBI chr 8:103,768,685...103,782,632

G

SS18 like 2

decreases expression

EXP

tolcapone results in decreased expression of SS18L2 mRNA

NCBI chr 8:121,375,263...121,377,877
Ensembl chr 8:130,252,782...130,257,367

G

signal sequence receptor subunit 1

affects binding

EXP

tolcapone binds to SSR1 protein

NCBI chr17:26,833,720...26,861,821
Ensembl chr17:27,039,269...27,067,348

G

SH3 and cysteine rich domain 3

decreases expression

EXP

tolcapone results in decreased expression of STAC3 mRNA

NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:65,228,352...65,235,878

G

signal transducer and activator of transcription 3

increases expression

EXP

tolcapone results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

sulfotransferase family 2A member 1

affects binding

EXP

tolcapone binds to SULT2A1 protein

NCBI chr 1:84,582,011...84,639,001

G

sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6

affects binding

EXP

Tolcapone binds to SULT2A6 protein

NCBI chr 1:74,911,097...74,962,239
Ensembl chr 1:84,046,685...84,097,808

G

TATA-box binding protein associated factor 9

decreases expression

EXP

tolcapone results in decreased expression of TAF9 mRNA

NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:33,531,368...33,536,078

G

tubulin folding cofactor A

decreases expression

EXP

tolcapone results in decreased expression of TBCA mRNA

NCBI chr 2:27,745,985...27,800,624
Ensembl chr 2:27,746,268...27,800,641

G

transcription elongation factor A like 8

decreases expression

EXP

tolcapone results in decreased expression of TCEAL8 mRNA

NCBI chr X:103,962,930...103,965,000
Ensembl chr X:103,961,187...103,965,394

G

transferrin receptor 2

increases expression

EXP

tolcapone results in increased expression of TFR2 mRNA

NCBI chr12:24,744,450...24,761,413
Ensembl chr12:24,744,450...24,761,413

G

translocase of inner mitochondrial membrane 10

decreases expression

EXP

tolcapone results in decreased expression of TIMM10 mRNA

NCBI chr 3:90,315,048...90,318,613
Ensembl chr 3:90,315,092...90,318,614

G

translocase of inner mitochondrial membrane 44

affects binding

EXP

tolcapone binds to TIMM44 protein

NCBI chr12:7,410,424...7,428,179
Ensembl chr12:7,410,424...7,427,125

G

translocase of inner mitochondrial membrane 8 homolog B

decreases expression

EXP

tolcapone results in decreased expression of TIMM8B mRNA

NCBI chr 8:59,850,737...59,852,117
Ensembl chr 8:59,850,728...59,852,962

G

thymidine kinase 2

affects binding

EXP

tolcapone binds to TK2 protein

NCBI chr19:713,043...737,345
Ensembl chr19:715,318...738,355

G

TM2 domain containing 1

decreases expression

EXP

tolcapone results in decreased expression of TM2D1 mRNA

NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:118,136,299...118,170,283

G

transmembrane p24 trafficking protein 10

affects binding

EXP

tolcapone binds to TMED10 protein

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:110,722,889...110,757,777

G

transmembrane p24 trafficking protein 4

affects binding

EXP

tolcapone binds to TMED4 protein

NCBI chr14:85,338,980...85,343,577
Ensembl chr14:85,338,980...85,343,577

G

transmembrane p24 trafficking protein 9

affects binding

EXP

tolcapone binds to TMED9 protein

NCBI chr17:9,034,797...9,039,311
Ensembl chr17:9,034,823...9,039,319

G

transmembrane protein 126A

decreases expression

EXP

tolcapone results in decreased expression of TMEM126A mRNA

NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:153,835,236...153,843,160

G

transmembrane protein 126B

decreases expression

EXP

tolcapone results in decreased expression of TMEM126B mRNA

NCBI chr 1:153,852,081...153,864,038
Ensembl chr 1:153,852,088...153,863,970

G

transmembrane protein 128

decreases expression

EXP

tolcapone results in decreased expression of TMEM128 mRNA

NCBI chr14:72,539,530...72,548,623
Ensembl chr14:76,752,603...76,772,217

G

transmembrane protein 203

decreases expression

EXP

tolcapone results in decreased expression of TMEM203 mRNA

NCBI chr 3:8,070,904...8,071,732
Ensembl chr 3:28,465,345...28,472,140

G

transmembrane protein 238

decreases expression

EXP

tolcapone results in decreased expression of TMEM238 mRNA

NCBI chr 1:69,057,083...69,062,477
Ensembl chr 1:78,085,670...78,093,983

G

transmembrane protein 256

decreases expression

EXP

tolcapone results in decreased expression of TMEM256 mRNA

NCBI chr10:55,056,959...55,058,869
Ensembl chr10:55,056,760...55,058,862

G

thymosin beta 4, X-linked

decreases expression

EXP

tolcapone results in decreased expression of TMSB4X mRNA

NCBI chr X:30,761,611...30,763,612
Ensembl chr X:30,761,612...30,763,613

G

TNF alpha induced protein 8

affects binding

EXP

tolcapone binds to TNFAIP8 protein

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:45,370,406...45,486,036

G

TNF receptor superfamily member 1A

increases expression

EXP

tolcapone results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

translocase of outer mitochondrial membrane 20

affects binding

EXP

tolcapone binds to TOMM20 protein

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510

G

translocase of outer mitochondrial membrane 40

affects binding

EXP

tolcapone binds to TOMM40 protein

NCBI chr 1:88,486,745...88,498,833
Ensembl chr 1:88,486,758...88,499,671

G

translocase of outer mitochondrial membrane 7

affects binding

EXP

tolcapone binds to TOMM7 protein

NCBI chr 4:12,197,503...12,204,344
Ensembl chr 4:12,197,491...12,204,343

G

tumor protein p53 inducible protein 3

decreases expression

EXP

Tolcapone results in decreased expression of TP53I3 mRNA

NCBI chr 6:27,818,327...27,825,753

G

trafficking protein particle complex subunit 2L

decreases expression

EXP

tolcapone results in decreased expression of TRAPPC2L mRNA

NCBI chr19:67,570,954...67,574,722

G

tetraspanin 6

decreases expression

EXP

tolcapone results in decreased expression of TSPAN6 mRNA

NCBI chr X:101,385,686...101,395,371
Ensembl chr X:101,385,694...101,392,627

G

tubulin, beta 6 class V

affects binding

EXP

tolcapone binds to TUBB6 protein

NCBI chr18:63,213,287...63,222,926
Ensembl chr18:63,213,279...63,224,303

G

thioredoxin domain containing 17

decreases expression

EXP

tolcapone results in decreased expression of TXNDC17 mRNA

NCBI chr10:57,331,312...57,334,284
Ensembl chr10:57,331,312...57,334,284

G

ubiquitin C-terminal hydrolase L3, pseudogene 1

decreases expression

EXP

tolcapone results in decreased expression of UCHL3-PS1 mRNA

NCBI chr 3:161,856,954...161,857,835

G

UDP glucuronosyltransferase family 1 member A9

decreases glucuronidation
increases glucuronidation

ISO

UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

ubiquinol cytochrome c reductase core protein 2

affects binding

EXP

tolcapone binds to UQCRC2 protein

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

affects binding

EXP

tolcapone binds to UQCRFS1 protein

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950

G

UV radiation resistance associated

increases expression

EXP

tolcapone results in increased expression of UVRAG mRNA

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:162,596,515...162,854,348

G

voltage-dependent anion channel 2

affects binding

EXP

tolcapone binds to VDAC2 protein

NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,512,216...2,532,229

G

voltage-dependent anion channel 3

affects binding

EXP

tolcapone binds to VDAC3 protein

NCBI chr16:76,137,489...76,153,933
Ensembl chr16:76,137,504...76,155,304

G

visinin-like 1

affects binding

EXP

tolcapone binds to VSNL1 protein

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556

G

WASH complex subunit 3

decreases expression

EXP

tolcapone results in decreased expression of WASHC3 mRNA

NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:24,508,544...24,618,473

G

wolframin ER transmembrane glycoprotein

affects binding

EXP

tolcapone binds to WFS1 protein

NCBI chr14:78,035,205...78,059,718
Ensembl chr14:78,034,864...78,060,459

G

tyrosyl-tRNA synthetase 1

increases expression

EXP

Tolcapone results in increased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377

G

YEATS domain containing 4

decreases expression

EXP

tolcapone results in decreased expression of YEATS4 mRNA

NCBI chr 7:54,744,220...54,751,361
Ensembl chr 7:54,744,221...54,751,361

G

zinc and ring finger 1

increases expression

EXP

tolcapone results in increased expression of ZNRF1 mRNA

NCBI chr19:39,496,414...39,581,600
Ensembl chr19:56,405,728...56,490,881

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
chemical entity	20860
group	20803
inorganic group	20299
nitro group	11225
nitro compound	11225
C-nitro compound	10948
nitrophenol	1682
mononitrophenol	1669
2-nitrophenols	383
(3-bromo-4-hydroxy-5-nitrophenyl)acetic acid +	0
(3-bromo-4-hydroxy-5-nitrophenyl)acetyl azide	0
(4-hydroxy-3-iodo-5-nitrophenyl)acetic acid +	0
(4-hydroxy-3-nitrophenyl)acetyl azide	0
1-((4-hydroxy-3-nitrophenyl)acetoxy)pyrrolidine-2,5-dione	0
1-((4-hydroxy-5-iodo-3-nitrophenyl)acetoxy)pyrrolidine-2,5-dione	0
2-nitrophenol +	5
3-O-ethylentacapone	0
3-O-methylentacapone	0
3-nitrotyramine	0
3-nitrotyrosine +	2
4-Amino-2-nitrophenol	3
4-hydroxy-3-nitrocyclohexa-2,5-dien-1-one	0
4-hydroxy-3-nitrophenylacetaldehyde	0
5-nitrovanillin +	0
6-(4-hydroxy-3-nitrobenzamido)hexanoic acid	0
6-(4-hydroxy-5-iodo-3-nitrobenzamido)hexanoic acid	0
6-[(3-bromo-4-hydroxy-5-nitrophenyl)acetamido]caproic acid +	0
6-[(4-hydroxy-3-nitrophenyl)acetamido]caproic acid +	0
N-[(4-hydroxy-3-iodo-5-nitrophenyl)acetyl]-betaAlaGlyGly	0
entacapone +	34
roxarsone	14
roxarsone (III)	0
tolcapone	349
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
main group element atom	20781
p-block element atom	20781
carbon group element atom	20715
carbon atom	20710
organic molecular entity	20710
organic molecule	20654
organic cyclic compound	20404
organic aromatic compound	20237
phenols	19435
nitrophenol	1682
mononitrophenol	1669
2-nitrophenols	383
(3-bromo-4-hydroxy-5-nitrophenyl)acetic acid +	0
(3-bromo-4-hydroxy-5-nitrophenyl)acetyl azide	0
(4-hydroxy-3-iodo-5-nitrophenyl)acetic acid +	0
(4-hydroxy-3-nitrophenyl)acetyl azide	0
1-((4-hydroxy-3-nitrophenyl)acetoxy)pyrrolidine-2,5-dione	0
1-((4-hydroxy-5-iodo-3-nitrophenyl)acetoxy)pyrrolidine-2,5-dione	0
2-nitrophenol +	5
3-O-ethylentacapone	0
3-O-methylentacapone	0
3-nitrotyramine	0
3-nitrotyrosine +	2
4-Amino-2-nitrophenol	3
4-hydroxy-3-nitrocyclohexa-2,5-dien-1-one	0
4-hydroxy-3-nitrophenylacetaldehyde	0
5-nitrovanillin +	0
6-(4-hydroxy-3-nitrobenzamido)hexanoic acid	0
6-(4-hydroxy-5-iodo-3-nitrobenzamido)hexanoic acid	0
6-[(3-bromo-4-hydroxy-5-nitrophenyl)acetamido]caproic acid +	0
6-[(4-hydroxy-3-nitrophenyl)acetamido]caproic acid +	0
N-[(4-hydroxy-3-iodo-5-nitrophenyl)acetyl]-betaAlaGlyGly	0
entacapone +	34
roxarsone	14
roxarsone (III)	0
tolcapone	349

paths to the root