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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol
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Accession:CHEBI:855 term browser browse the term
Definition:A member of the class of triazoles that is 1-phenyl-1H-1,2,4-triazole substituted by 2-hydroxyphenyl groups at positions 3 and 5.
Synonyms:related_synonym: 2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)bis-phenol;   3,5-bis(2-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazole;   Formula=C20H15N3O2;   InChI=1S/C20H15N3O2/c24-17-12-6-4-10-15(17)19-21-20(16-11-5-7-13-18(16)25)23(22-19)14-8-2-1-3-9-14/h1-13,24-25H;   InChIKey=ZSVXKCSZMLMPBW-UHFFFAOYSA-N;   SMILES=Oc1ccccc1-c1nc(-c2ccccc2O)n(n1)-c1ccccc1;   decarboxydeferasirox
 xref: KEGG:C11569;   Reaxys:4541552


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deferasirox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
increases activity 		ISO deferasirox results in increased expression of CASP3 protein
deferasirox results in increased activity of CASP3 protein 		CTD PMID:21439361 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein] CTD PMID:17631934 NCBI chr 7:131,566,176...131,596,988
Ensembl chr 7:131,566,176...131,596,938 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO deferasirox results in decreased activity of CDK2 protein CTD PMID:17631934 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions ISO deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein] CTD PMID:17631934 NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:36,394,169...36,399,528 		JBrowse link
G Clu clusterin increases expression EXP deferasirox results in increased expression of CLU protein CTD PMID:21439361 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO
EXP 		deferasirox results in increased expression of HAVCR1 protein CTD PMID:21439361 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO
EXP 		deferasirox results in increased expression of LCN2 protein CTD PMID:21439361 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Polr2a RNA polymerase II subunit A decreases phosphorylation ISO deferasirox results in decreased phosphorylation of POLR2A protein CTD PMID:17631934 NCBI chr10:54,951,162...54,977,179
Ensembl chr10:54,951,162...54,977,179 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      molecular entity 20859
        polyatomic entity 20803
          heteroatomic molecular entity 20740
            hydroxides 20230
              organic hydroxy compound 19765
                phenols 19435
                  2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol 8
                    deferasirox 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  heteroarene 17448
                                    monocyclic heteroarene 15186
                                      azole 14620
                                        triazoles 8516
                                          1-phenyl-1H-1,2,4-triazole 15
                                            2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol 8
                                              deferasirox 8
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