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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol
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Accession:CHEBI:855 term browser browse the term
Definition:A member of the class of triazoles that is 1-phenyl-1H-1,2,4-triazole substituted by 2-hydroxyphenyl groups at positions 3 and 5.
Synonyms:related_synonym: 2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)bis-phenol;   3,5-bis(2-hydroxyphenyl)-1-phenyl-1H-1,2,4-triazole;   Formula=C20H15N3O2;   InChI=1S/C20H15N3O2/c24-17-12-6-4-10-15(17)19-21-20(16-11-5-7-13-18(16)25)23(22-19)14-8-2-1-3-9-14/h1-13,24-25H;   InChIKey=ZSVXKCSZMLMPBW-UHFFFAOYSA-N;   SMILES=Oc1ccccc1-c1nc(-c2ccccc2O)n(n1)-c1ccccc1;   decarboxydeferasirox
 xref: KEGG:C11569;   Reaxys:4541552


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deferasirox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
increases activity		 ISO deferasirox results in increased expression of CASP3 protein
deferasirox results in increased activity of CASP3 protein		 CTD PMID:21439361 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein] CTD PMID:17631934 NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO deferasirox results in decreased activity of CDK2 protein CTD PMID:17631934 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 multiple interactions ISO deferasirox inhibits the reaction [CDK9 protein binds to CCNT1 protein] CTD PMID:17631934 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Clu clusterin increases expression EXP deferasirox results in increased expression of CLU protein CTD PMID:21439361 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO
EXP		 deferasirox results in increased expression of HAVCR1 protein CTD PMID:21439361 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO
EXP		 deferasirox results in increased expression of LCN2 protein CTD PMID:21439361 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Polr2a RNA polymerase II subunit A decreases phosphorylation ISO deferasirox results in decreased phosphorylation of POLR2A protein CTD PMID:17631934 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      molecular entity 19878
        polyatomic entity 19830
          heteroatomic molecular entity 19787
            hydroxides 19347
              organic hydroxy compound 18957
                phenols 18655
                  2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol 8
                    deferasirox 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  heteroarene 17155
                                    monocyclic heteroarene 14983
                                      azole 14506
                                        triazoles 8421
                                          1-phenyl-1H-1,2,4-triazole 15
                                            2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol 8
                                              deferasirox 8
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