N-(saturated fatty acyl)ethanolamine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	N-(saturated fatty acyl)ethanolamine	go back to main search page
Accession:	CHEBI:85283	browse the term
Definition:	Any N-acylethanolamine in which the acyl group is derived from a saturated fatty acid.
Synonyms:	related_synonym:	N-(2-hydroxyethyl) saturated fatty amide; N-(2-hydroxyethyl) saturated fatty amides; N-saturated fatty acyl-ethanolamines
	chemrof_smiles:	*C(=O)NCCO
	chemrof_formula:	C3H6NO2R
	cyclic_relationship:	has_functional_parent CHEBI:26607

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Rat (16 ) Mouse (15 ) Human (16 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (16)

palmitoyl ethanolamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases export

ISO

ABCB1 protein results in increased export of palmidrol

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

apolipoprotein B

affects folding

ISO

palmidrol affects the folding of APOB protein

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

aquaporin 3 (Gill blood group)

multiple interactions

ISO

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685

G

aquaporin 4

affects expression

ISO

palmidrol affects the expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098

G

claudin 3

multiple interactions
decreases expression

ISO

[TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA
palmidrol results in decreased expression of CLDN3 mRNA

NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841

G

claudin 5

decreases expression

ISO

palmidrol results in decreased expression of CLDN5 mRNA

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

cannabinoid receptor 1

multiple interactions

EXP

[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

cannabinoid receptor 2

affects binding
multiple interactions

ISO
EXP

palmidrol binds to CNR2 protein
[SR 144528 binds to and results in decreased activity of CNR2 protein] which results in decreased susceptibility to palmidrol analog

PMID:10617657 PMID:10688601 PMID:17558434

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

glutathione S-transferase alpha 1

multiple interactions

EXP

palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein]

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

interferon gamma

multiple interactions

ISO

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions

ISO

[hempseed oil co-treated with palmidrol] results in decreased expression of IL10 mRNA

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 6

multiple interactions

ISO

[hempseed oil co-treated with palmidrol] results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

lipocalin 2

multiple interactions

EXP

palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein]

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

peroxisome proliferator activated receptor alpha

multiple interactions
affects localization

EXP

[MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; [palmidrol co-treated with glyceryl 2-arachidonate] affects the localization of PPARA protein; [palmidrol co-treated with glyceryl 2-arachidonate] affects the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of PPARA protein]
palmidrol affects the localization of PPARA protein

PMID:17558434 PMID:31787870

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

tumor necrosis factor

multiple interactions

ISO

[palmidrol co-treated with TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA; [TNF protein co-treated with IFNG protein co-treated with palmidrol] results in decreased expression of CLDN3 mRNA; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]; palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of AQP3 mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

ISO

palmidrol inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of TRPV1 mRNA]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
atom	20872
nonmetal atom	20781
nitrogen atom	19576
nitrogen molecular entity	19576
organonitrogen compound	19311
carboxamide	17697
secondary carboxamide	1391
N-(saturated fatty acyl)ethanolamine	16
Lignoceroyl-EA	0
Margaroyl-EA	0
N-(butanoyl)ethanolamine	0
N-(decanoyl)ethanolamine	0
N-(docosanoyl)ethanolamine	0
N-(dodecanoyl)ethanolamine	0
N-(hexanoyl)ethanolamine	0
N-(icosanoyl)ethanolamine	0
N-(octanoyl)ethanolamine	0
N-(tetradecanoyl)ethanolamine	0
N-acylethanolamine 18:0 +	0
Pentadecanoyl-EA	0
palmitoyl ethanolamide	16
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
heteroorganic entity	20201
organochalcogen compound	19822
organooxygen compound	19713
carboxamide	17697
monocarboxylic acid amide	14860
fatty amide	856
N-(fatty acyl)-ethanolamine	52
N-(saturated fatty acyl)ethanolamine	16
Lignoceroyl-EA	0
Margaroyl-EA	0
N-(butanoyl)ethanolamine	0
N-(decanoyl)ethanolamine	0
N-(docosanoyl)ethanolamine	0
N-(dodecanoyl)ethanolamine	0
N-(hexanoyl)ethanolamine	0
N-(icosanoyl)ethanolamine	0
N-(octanoyl)ethanolamine	0
N-(tetradecanoyl)ethanolamine	0
N-acylethanolamine 18:0 +	0
Pentadecanoyl-EA	0
palmitoyl ethanolamide	16

paths to the root