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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sofosbuvir
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Accession:CHEBI:85083 term browser browse the term
Definition:A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
Synonyms:related_synonym: Formula=C22H29FN3O9P;   GI 7977;   GS-7977;   InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1;   InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N;   PSI-7977;   SMILES=CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1;   Sovaldi;   isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
 xref: CAS:1190307-88-0;   Drug_Central:4811;   KEGG:D10366;   PMID:25123381;   PMID:25159822;   PMID:25261839;   PMID:25304641;   PMID:25322962;   PMID:25583164;   PMID:25601269;   PMID:25614962;   PMID:25619265;   PMID:25621961;   PMID:25622055;   PMID:25641426;   PMID:25645644;   PMID:25659285;   PMID:25674516;   PMID:25676703;   PMID:25708155;   Reaxys:20867484;   Wikipedia:Sofosbuvir


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sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pro-agent 11549
          prodrug 11293
            sofosbuvir 2
              Epclusa 0
              Harvoni 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13926
                                      phosphoric acid 13926
                                        phosphoric acid derivative 13835
                                          phosphate 13834
                                            organic phosphate 13834
                                              carbohydrate phosphate 1965
                                                phospho sugar 1810
                                                  aldose phosphate 1807
                                                    aldopentose phosphate 1799
                                                      ribose phosphate 1794
                                                        ribonucleotide 1756
                                                          ribonucleoside 5'-phosphate 759
                                                            ribonucleoside 5'-monophosphate 476
                                                              pyrimidine ribonucleoside 5'-monophosphate 439
                                                                uridine 5'-monophosphate 3
                                                                  sofosbuvir 2
                                                                    Epclusa 0
                                                                    Harvoni 0
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