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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propranolol
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Accession:CHEBI:8499 term browser browse the term
Definition:A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.
Synonyms:exact_synonym: 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
 related_synonym: 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol;   1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol;   Formula=C16H21NO2;   InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3;   InChIKey=AQHHHDLHHXJYJD-UHFFFAOYSA-N;   Propanalol;   Propanolol;   SMILES=CC(C)NCC(O)COc1cccc2ccccc12;   beta-Propranolol;   propranololo;   propranololum
 xref: CAS:525-66-6;   DrugBank:DB00571;   Drug_Central:2303;   HMDB:HMDB0001849;   KEGG:C07407;   KEGG:D08443;   LINCS:LSM-4329
 xref_mesh: MESH:D011433
 xref: PMID:18259090;   PMID:24495884;   PMID:24504055;   Reaxys:987417;   Wikipedia:Propranolol



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propranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Propranolol results in increased expression of NPPA protein CTD PMID:2566282 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]
Propranolol results in decreased activity of REN protein
CTD PMID:2566282 PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Propranolol results in decreased expression of VIP protein CTD PMID:2566282 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1271
    role 1271
      biological role 1271
        xenobiotic 829
          propranolol 4
            (R)-(+)-propranolol + 0
            propranolol hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 1271
    subatomic particle 1271
      composite particle 1271
        hadron 1271
          baryon 1271
            nucleon 1271
              atomic nucleus 1271
                atom 1271
                  main group element atom 1264
                    main group molecular entity 1264
                      s-block molecular entity 1214
                        hydrogen molecular entity 1214
                          hydrides 372
                            organic hydride 76
                              organic fundamental parent 76
                                hydrocarbon 54
                                  cyclic hydrocarbon 26
                                    arene 25
                                      polycyclic arene 8
                                        ortho-fused polycyclic arene 8
                                          ortho-fused bicyclic arene 4
                                            naphthalene 4
                                              naphthol 4
                                                1-naphthol 4
                                                  propranolol 4
                                                    (R)-(+)-propranolol + 0
                                                    propranolol hydrochloride 0
paths to the root