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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:8-(4-chlorophenylthio)-cAMP
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Accession:CHEBI:84612 term browser browse the term
Definition:A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.
Synonyms:exact_synonym: (4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-2,7-dihydroxytetrahydro-2H,4H-2lambda(5)-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
 related_synonym: 8-((4-Chlorophenyl)thio)cyclic-3',5'-amp;   8-(4-chlorophenylthio)-3',5'-cyclic AMP;   8-(4-chlorophenylthio)-cyclic AMP;   8-(4-chlorophenylthio)adenosine cyclic 3',5'-phosphate;   8-CPT-cAMP;   8-Parachlorophenylthio camp;   Formula=C16H15ClN5O6PS;   InChI=1S/C16H15ClN5O6PS/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20)/t9-,11-,12-,15-/m1/s1;   InChIKey=AAZMHPMNAVEBRE-SDBHATRESA-N;   SMILES=Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12
 xref: CAS:41941-66-6
 xref_mesh: MESH:C015929
 xref: PMID:23382200;   PMID:24586238;   PMID:24605759;   Reaxys:598763


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8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 498
    role 498
      biological role 498
        pharmacological role 164
          agonist 92
            protein kinase agonist 46
              8-(4-chlorophenylthio)-cAMP 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 498
    subatomic particle 498
      composite particle 498
        hadron 498
          baryon 498
            nucleon 498
              atomic nucleus 498
                atom 498
                  main group element atom 491
                    p-block element atom 491
                      chalcogen 447
                        oxygen atom 445
                          oxygen molecular entity 445
                            hydroxides 420
                              oxoacid 375
                                pnictogen oxoacid 14
                                  phosphorus oxoacid 9
                                    phosphoric acids 9
                                      phosphoric acid 9
                                        phosphoric acid derivative 8
                                          phosphate 8
                                            organic phosphate 8
                                              carbohydrate phosphate 3
                                                phospho sugar 3
                                                  aldose phosphate 3
                                                    aldopentose phosphate 3
                                                      ribose phosphate 3
                                                        ribonucleotide 3
                                                          purine ribonucleotide 2
                                                            adenyl ribonucleotide 2
                                                              3',5'-cyclic AMP 2
                                                                8-(4-chlorophenylthio)-cAMP 1
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