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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:proguanil
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Accession:CHEBI:8455 term browser browse the term
Definition:A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Synonyms:exact_synonym: N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
 related_synonym: 1-(p-chlorophenyl)-5-isopropylbiguanide;   Chlorguanide;   Chloroguanide;   Formula=C11H16ClN5;   InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17);   InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N;   N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide;   SMILES=CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1;   proguanilum
 xref: CAS:500-92-5;   DrugBank:DB01131;   Drug_Central:2282;   HMDB:HMDB0015263;   KEGG:C07631;   KEGG:D08428;   LINCS:LSM-2618
 xref_mesh: MESH:D002727
 xref: PMID:10348748;   PMID:10848923;   PMID:15504827;   PMID:8866915;   Reaxys:2811599;   Wikipedia:Proguanil


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proguanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
decreases activity 		ISO CYP2C19 protein results in increased metabolism of Proguanil
Proguanil results in decreased activity of CYP2C19 protein 		CTD PMID:11124226 PMID:12464242 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Proguanil results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Proguanil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antimicrobial drug 11286
            antiprotozoal drug 7498
              proguanil 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                carbocyclic compound 18974
                                  benzenoid aromatic compound 18458
                                    benzenes 18333
                                      chlorobenzenes 15276
                                        monochlorobenzenes 12247
                                          proguanil 5
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