Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:varenicline
go back to main search page
Accession:CHEBI:84500 term browser browse the term
Definition:An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Synonyms:exact_synonym: 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline
 related_synonym: 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine;   Formula=C13H13N3;   InChI=1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2/t8-,9+;   InChIKey=JQSHBVHOMNKWFT-DTORHVGOSA-N;   SMILES=C1[C@H]2CNC[C@@H]1c1cc3nccnc3cc21;   vareniclina;   vareniclinum
 xref: CAS:249296-44-4;   DrugBank:DB01273;   Drug_Central:2808;   HMDB:HMDB0015398;   KEGG:D08669;   LINCS:LSM-5358
 xref_mesh: MESH:D000068580
 xref: PDBeChem:QMR;   PMID:24406270;   PMID:24652107;   PMID:24763764;   PMID:24856597;   PMID:24906297;   PMID:24949564;   PMID:25062287;   PMID:25145377;   PMID:25331778;   PMID:25352081;   PMID:25410148;   PMID:25449275;   PMID:25462656;   PMID:25475645;   PMID:25485645;   PMID:25497715;   PMID:25572451;   PMID:25588294;   PMID:25616031;   Reaxys:10668886;   Wikipedia:Varenicline
 cyclic_relationship: is_conjugate_base_of CHEBI:84508


show annotations for term's descendants           Sort by:
varenicline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E affects response to substance ISO APOE protein affects the susceptibility to Varenicline CTD PMID:28202387 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 protein]
Varenicline results in increased expression of CD36 mRNA; Varenicline results in increased expression of CD36 protein		 CTD PMID:28202387 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions		 ISO Varenicline results in decreased expression of CDH5
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Varenicline results in decreased expression of CDH5]; methyllycaconitine inhibits the reaction [Varenicline results in decreased expression of CDH5]; pyrazolanthrone inhibits the reaction [Varenicline results in decreased expression of CDH5]; SB 203580 inhibits the reaction [Varenicline results in decreased expression of CDH5]		 CTD PMID:28842382 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:16766716 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP		 Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
varenicline binds to Chrna4 protein; varenicline inhibits [alpha-conotoxin MII binds to Chrna4 protein] in rat brain striatal sections		 CTD
RGD		 PMID:16766716 PMID:20100906 PMID:20207347 PMID:20331614 PMID:20373480 More... RGD:8549526 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit multiple interactions
affects binding		 EXP Varenicline binds to and results in increased activity of CHRNA6 protein
Varenicline binds to Chrna6 protein
Varenicline inhibits the reaction [alpha-Conotoxin MII binds to Chrna6]; Varenicline inhibits the reaction [epibatidine binds to Chrna6].		 CTD
RGD		 PMID:16766716 PMID:22550286 PMID:22550286 RGD:8549526, RGD:8549526 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA7 protein binds to CHRNA7 protein] CTD PMID:16766716 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP		 Varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]		 CTD PMID:16766716 PMID:20100906 PMID:20207347 PMID:20331614 PMID:20373480 More... NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:16766716 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Varenicline results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Varenicline results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases activity		 ISO Varenicline results in increased phosphorylation of MAPK1 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein]
Varenicline results in decreased activity of MAPK1 protein		 CTD PMID:28202387 PMID:28842382 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases activity		 ISO Varenicline results in increased phosphorylation of MAPK3 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein]
Varenicline results in decreased activity of MAPK3 protein		 CTD PMID:28202387 PMID:28842382 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression
multiple interactions		 ISO Varenicline results in increased expression of OLR1 mRNA; Varenicline results in increased expression of OLR1 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 protein]		 CTD PMID:28202387 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Varenicline results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions		 ISO Varenicline results in increased phosphorylation of RELA protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of RELA protein]		 CTD PMID:28202387 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects response to substance ISO SLC22A2 gene SNP affects the susceptibility to Varenicline CTD PMID:25143296 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        pharmacological role 19080
          neurotransmitter agent 16797
            serotonergic drug 4339
              serotonergic agonist 1021
                varenicline 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        secondary amino compound 6954
                                          varenicline 17
paths to the root