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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:primidone
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Accession:CHEBI:8412 term browser browse the term
Definition:A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Synonyms:exact_synonym: 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-deoxyphenobarbital;   5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16);   InChIKey=DQMZLTXERSFNPB-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)NCNC1=O)c1ccccc1;   primidona;   primidonum
 xref: CAS:125-33-7;   DrugBank:DB00794;   Drug_Central:2267;   HMDB:HMDB0014932;   KEGG:C07371;   KEGG:D00474;   LINCS:LSM-2700
 xref_mesh: MESH:D011324
 xref: PMID:10716065;   PMID:17253477;   PMID:24712318;   PMID:24812533;   Reaxys:218034;   Wikipedia:Primidone


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primidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Primidone results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Primidone results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Primidone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il24 interleukin 24 increases expression ISO Primidone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Primidone results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Primidone results in increased expression of S100A8 mRNA CTD PMID:28138970 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Primidone results in increased expression of S100A9 mRNA CTD PMID:28138970 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Primidone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        xenobiotic 18722
          primidone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteromonocyclic compound 17791
                                    diazines 13215
                                      pyrimidines 13085
                                        pyrimidone 10512
                                          primidone 8
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