The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein
[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; HRH1 protein promotes the reaction [Triprolidine results in decreased susceptibility to CXCL8 protein]; Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine binds to and results in increased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein] Triprolidine results in decreased activity of HRH1 protein Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]
Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]
[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein
Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]
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