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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prilocaine
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Accession:CHEBI:8404 term browser browse the term
Definition:An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Synonyms:exact_synonym: N-(2-methylphenyl)-N(2)-propylalaninamide
 related_synonym: 2-(Propylamino)-o-propionotoluidide;   2-Methyl-alpha-propylaminopropionanilide;   Formula=C13H20N2O;   InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);   InChIKey=MVFGUOIZUNYYSO-UHFFFAOYSA-N;   N-(2-Methylphenyl)-2-(propylamino)propanamide;   Propitocaine;   SMILES=CCCNC(C)C(=O)Nc1ccccc1C;   alpha-n-Propylamino-2-methylpropionanilide;   o-Methyl-2-propylaminopropionanilide;   o-Methyl-alpha-propylaminopropionanilide;   prilocaina;   prilocaine base;   prilocainum
 alt_id: CHEBI:308749
 xref: Beilstein:2108498;   CAS:721-50-6;   DrugBank:DB00750;   Drug_Central:2265;   KEGG:C07531;   KEGG:D00553;   LINCS:LSM-5078
 xref_mesh: MESH:D011318
 xref: PMID:26049614;   PMID:26199764;   PMID:26356490;   PMID:9989796;   Patent:GB839943;   Patent:US3160662;   Wikipedia:Prilocaine


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prilocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Prilocaine results in increased phosphorylation of AKT1 protein CTD PMID:37561044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Il6 interleukin 6 increases expression ISO Prilocaine results in increased expression of IL6 protein CTD PMID:37561044 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Prilocaine results in increased expression of NOS2 protein CTD PMID:37561044 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Prilocaine results in increased expression of and results in increased phosphorylation of RELA protein CTD PMID:37561044 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            anaesthetic 11836
              local anaesthetic 7696
                prilocaine 4
                  prilocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              amino acid amide 1463
                                                prilocaine 4
                                                  prilocaine hydrochloride 0
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