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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol
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Accession:CHEBI:83851 term browser browse the term
Definition:A member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O-1 by a biphenyl-4-yl group.
Synonyms:related_synonym: 1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 xref: PPDB:84
 chemrof_formula: C20H23N3O2
 chemrof_smiles: CC(C)(C)C(O)C(Oc1ccc(-c2ccccc2)cc1)n1cncn1
 chemrof_inchi: InChI=1S/C20H23N3O2/c1-20(2,3)18(24)19(23-14-21-13-22-23)25-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,18-19,24H,1-3H3
 chemrof_inchikey: VGPIBGGRCVEHQZ-UHFFFAOYSA-N



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bitertanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases activity
ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein; bitertanol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
bitertanol results in decreased activity of AHR protein
CTD PMID:25684042 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Ar androgen receptor multiple interactions ISO [bitertanol co-treated with propiconazole co-treated with cypermethrin] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein; bitertanol inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bitertanol inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [bitertanol results in increased activity of AR protein] CTD PMID:15064155 PMID:23871939 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP bitertanol results in increased expression of CYP1A1 mRNA; bitertanol results in increased expression of CYP1A1 protein CTD PMID:16971034 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP bitertanol results in increased expression of CYP2B1 protein CTD PMID:16971034 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP bitertanol results in increased expression of CYP2B2 protein CTD PMID:16971034 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP bitertanol results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16971034 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity ISO bitertanol results in decreased activity of CYP51A1 protein CTD PMID:16989930 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [bitertanol results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO bitertanol binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO bitertanol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Ttr transthyretin multiple interactions ISO bitertanol inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:39365753 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      molecular entity 20871
        polyatomic entity 20745
          molecule 20540
            cyclic compound 20415
              ring assembly 7366
                biphenyls 6393
                  1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol 12
                    (1R,2R)-bitertanol + 12
                    (1R,2S)-bitertanol + 12
                    (1S,2R)-bitertanol + 12
                    (1S,2S)-bitertanol + 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  heteroarene 17357
                                    monocyclic heteroarene 15176
                                      azole 14629
                                        triazoles 8554
                                          1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol 12
                                            (1R,2R)-bitertanol + 12
                                            (1R,2S)-bitertanol + 12
                                            (1S,2R)-bitertanol + 12
                                            (1S,2S)-bitertanol + 12
paths to the root