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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prednisone
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Accession:CHEBI:8382 term browser browse the term
Definition:A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Synonyms:related_synonym: 1,2-Dehydrocortisone;   1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione;   17,21-Dihydroxypregna-1,4-diene-3,11,20-trione;   Dehydrocortisone;   Formula=C21H26O5;   InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1;   InChIKey=XOFYZVNMUHMLCC-ZPOLXVRWSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   prednison;   prednisona;   prednisonum
 xref: Beilstein:2065301;   CAS:53-03-2;   DrugBank:DB00635;   Drug_Central:2253;   KEGG:C07370
 xref_mesh: MESH:D011241
 xref: PMID:10438974;   PMID:15859934;   PMID:18971570;   PMID:23093541;   PMID:23395281;   Patent:US2579479;   Patent:US2837464;   Patent:US2897216;   Patent:US3134718;   Reaxys:2065301;   Wikipedia:Prednisone


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prednisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Prednisone results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases secretion
affects response to substance		 ISO Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]
ABCB1A protein affects the susceptibility to Prednisone		 CTD PMID:15502009 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prednisone CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases activity		 ISO Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]
Prednisone results in increased activity of ABCC3 protein		 CTD PMID:15979871 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO Prednisone results in decreased expression of AKT1 mRNA CTD PMID:38439560 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases expression ISO Prednisone results in decreased expression of ALB mRNA CTD PMID:38439560 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO Prednisone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Prednisone results in decreased expression of BAX mRNA CTD PMID:38439560 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Prednisone results in decreased expression of CASP9 mRNA CTD PMID:38439560 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Prednisone results in decreased expression of CCL11 protein CTD PMID:15523430 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CCL13 protein CTD PMID:15523430 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Prednisone results in increased expression of CDKN1A protein CTD PMID:15034294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Prednisone results in increased expression of CDKN1B protein CTD PMID:15034294 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Prednisone results in increased expression of CDKN2B protein CTD PMID:15034294 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
decreases expression		 ISO Prednisone affects the expression of CEBPA mRNA
Prednisone results in decreased expression of CEBPA protein		 CTD PMID:38439560 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Prednisone results in decreased expression of CPT1A mRNA CTD PMID:38439560 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CXCL12 mRNA CTD PMID:38439560 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Prednisone results in increased expression of CYP27A1 mRNA CTD PMID:38439560 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Prednisone results in decreased expression of DLK1 mRNA CTD PMID:38439560 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Gcg glucagon multiple interactions
decreases expression		 EXP [Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA
Prednisone results in decreased expression of GCG mRNA		 CTD PMID:12524409 PMID:14705828 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Prednisone results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Prednisone results in decreased expression of HNF4A mRNA; Prednisone results in decreased expression of HNF4A protein CTD PMID:38439560 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Prednisone results in decreased expression of IGF1 mRNA CTD PMID:38439560 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Prednisone results in decreased expression of IL5 protein CTD PMID:12722970 PMID:15523430 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Prednisone results in decreased expression of ITGB1 mRNA CTD PMID:38439560 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Prednisone results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt19 keratin 19 increases expression ISO Prednisone results in increased expression of KRT19 mRNA CTD PMID:38439560 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO Prednisone results in decreased expression of MAP2K1 mRNA CTD PMID:38439560 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO Prednisone results in decreased expression of MAP2K2 mRNA CTD PMID:38439560 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO Prednisone results in decreased expression of MAPK1 mRNA CTD PMID:38439560 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO Prednisone results in decreased expression of MAPK3 mRNA CTD PMID:38439560 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Prednisone results in decreased expression of MKI67 mRNA CTD PMID:38439560 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS2 mRNA] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Prednisone binds to and results in increased activity of NR3C1 protein CTD PMID:28973534 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisone results in increased expression of PCK1 mRNA CTD PMID:38439560 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Prednisone results in decreased expression of PCNA mRNA; Prednisone results in decreased expression of PCNA protein CTD PMID:38439560 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Prednisone results in increased expression of PLAT protein CTD PMID:10452346 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Prednisone results in decreased expression of PPARA mRNA CTD PMID:38439560 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Prednisone results in decreased expression of PROM mRNA CTD PMID:38439560 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C decreases expression ISO Prednisone results in decreased expression of PTPRC mRNA CTD PMID:38439560 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Prednisone results in decreased expression of PYGM protein CTD PMID:8815173 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Prednisone results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prednisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO Prednisone affects the expression of SOX9 mRNA CTD PMID:38439560 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307 PMID:19293598 NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Prednisone results in decreased expression of TGFB1 protein CTD PMID:12722970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Prednisone results in increased expression of TNF protein CTD PMID:19584951 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Vdr vitamin D receptor increases expression
affects response to substance		 ISO Prednisone results in increased expression of VDR protein
VDR gene polymorphism affects the susceptibility to Prednisone		 CTD PMID:7662588 PMID:15713801 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        anti-inflammatory agent 16700
          anti-inflammatory drug 14951
            prednisone 63
              20alpha-dihydroprednisone 0
              20beta-dihydroprednisone 0
              6alpha-hydroxyprednisone 0
              6beta-hydroxyprednisone 0
              Delta(6)-prednisone 0
              cortancyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbonyl compound 18937
                                    ketone 17268
                                      oxyketone 8910
                                        alpha-oxyketone 8918
                                          alpha-hydroxy ketone 8918
                                            primary alpha-hydroxy ketone 7792
                                              prednisone 63
                                                20alpha-dihydroprednisone 0
                                                20beta-dihydroprednisone 0
                                                6alpha-hydroxyprednisone 0
                                                6beta-hydroxyprednisone 0
                                                Delta(6)-prednisone 0
                                                cortancyl 0
paths to the root