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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prednisolone
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Accession:CHEBI:8378 term browser browse the term
Definition:A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
 related_synonym: (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;   1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol;   3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene;   Delta(1)-dehydrocortisol;   Delta(1)-dehydrohydrocortisone;   Delta(1)-hydrocortisone;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   hydroretrocortine;   metacortandralone;   prednisolona;   prednisolonum
 xref: CAS:50-24-8;   DrugBank:DB00860;   Drug_Central:2245;   HMDB:HMDB0014998;   KEGG:C07369;   KEGG:D00472
 xref_mesh: MESH:D011239
 xref: PMID:11294518;   PMID:23625982;   PMID:24392764;   Reaxys:1354103;   VSDB:1848;   Wikipedia:Prednisolone



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prednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Prednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Prednisolone results in increased expression of ACSL1 mRNA CTD PMID:17379860 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Prednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Prednisolone results in increased activity of AHR protein CTD PMID:30203046 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of AKR1B7 mRNA] CTD PMID:21149847 NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:64,020,686...64,064,909
JBrowse link
G Alb albumin increases expression
decreases secretion
multiple interactions
ISO
EXP
Prednisolone results in increased expression of ALB protein
Prednisolone results in decreased secretion of ALB protein
montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein]
CTD PMID:3404815 PMID:30276927 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Prednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Prednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Prednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO Prednisolone binds to and results in decreased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein mutant form
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Prednisolone results in increased expression of AR mRNA; Prednisolone results in increased expression of AR protein
CTD PMID:11956172 PMID:19490052 PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 decreases expression ISO Prednisolone results in decreased expression of ARHGAP45 mRNA CTD PMID:21621594 NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:10,325,539...10,341,890
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Prednisolone results in increased expression of ARRDC3 mRNA CTD PMID:24356939 NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Prednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Prednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 increases expression ISO Prednisolone results in increased expression of BMAL1 mRNA CTD PMID:16269518 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Prednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Prednisolone results in increased expression of CASP3 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]
CTD PMID:30276927 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Prednisolone results in decreased activity of CAT protein
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein]
CTD PMID:28921394 PMID:30276927 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 decreases expression ISO Prednisolone results in decreased expression of CBLL1 mRNA CTD PMID:21621594 NCBI chr 6:53,798,712...53,812,890
Ensembl chr 6:53,798,712...53,813,880
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA] CTD PMID:23133493 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of CCL2 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL2 mRNA]
Prednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
CTD PMID:20116850 PMID:23133493 PMID:36416909 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Prednisolone results in decreased expression of CCL20 mRNA; Prednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Prednisolone results in increased expression of CCL3 protein
Prednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]
CTD PMID:20116850 PMID:36416909 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Prednisolone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Prednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Prednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Prednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Prednisolone results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA] CTD PMID:23133493 NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:132,463,788...132,511,593
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO [Melphalan co-treated with Prednisolone] results in decreased expression of CD34 protein CTD PMID:10618687 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315
JBrowse link
G Cd84 CD84 molecule increases expression ISO Prednisolone results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:86,859,979...86,899,984
Ensembl chr13:86,859,990...86,894,318
JBrowse link
G Clgn calmegin decreases expression ISO Prednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Prednisolone results in increased expression of COL1A1 mRNA CTD PMID:19192274 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of CRH protein
sairei-to inhibits the reaction [Prednisolone results in decreased expression of CRH protein]
CTD PMID:9625448 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO Prednisolone results in increased expression of CRIM1 mRNA CTD PMID:24356939 NCBI chr 6:22,447,983...22,622,459
Ensembl chr 6:22,449,948...22,622,416
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Prednisolone results in decreased expression of CRY1 mRNA CTD PMID:16269518 NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Prednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Prednisolone results in decreased expression of CXCR2 protein CTD PMID:15804745 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Prednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of CYP2C19 mRNA] CTD PMID:21149847 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Prednisolone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:90,437,741...90,453,073
Ensembl chr 1:90,438,224...90,453,073
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Prednisolone results in increased expression of CYP3A4 mRNA CTD PMID:12673034 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression ISO Prednisolone results in decreased expression of DBP mRNA CTD PMID:16269518 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Prednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Prednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Prednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO Prednisolone results in increased expression of FMO2 mRNA CTD PMID:21621594 NCBI chr13:77,755,131...77,777,597
Ensembl chr13:77,757,629...77,777,534
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Prednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 PMID:21621594 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Prednisolone results in decreased expression of GDF5 mRNA CTD PMID:18830904 NCBI chr 3:164,914,401...164,918,593
Ensembl chr 3:164,914,401...164,918,593
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO Prednisolone results in increased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:70,541,862...70,549,843
JBrowse link
G Gm2a ganglioside GM2 activator increases expression ISO Prednisolone results in increased expression of GM2A mRNA CTD PMID:17379860 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,719,938...39,732,451
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Prednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:31,689,485...31,836,199
Ensembl chr  X:31,690,359...31,733,272
JBrowse link
G Gsdme gasdermin E decreases expression ISO Prednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Prednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Prednisolone results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Prednisolone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Prednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Prednisolone CTD PMID:16549198 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Prednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Prednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Prednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Prednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Prednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Prednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of IFNG protein
Prednisolone results in decreased expression of IFNG mRNA
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]
Prednisolone inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]
CTD PMID:11043609 PMID:15821026 PMID:23133493 PMID:34590760 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance
increases expression
ISO Prednisolone results in decreased susceptibility to IGF1 protein
Prednisolone results in increased expression of IGF1 protein
CTD PMID:16079165 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
JBrowse link
G Ighe immunoglobulin heavy constant epsilon decreases expression ISO Prednisolone results in decreased expression of IGHE protein CTD PMID:15821026
G Il10 interleukin 10 decreases expression
decreases secretion
decreases expression
ISO Prednisolone results in decreased expression of IL10 protein
Prednisolone results in decreased secretion of IL10 protein
prednisolone decreases expression of IL10 protein in LPS-stimulated human PBMC
CTD
RGD
PMID:15821026 PMID:28003376 PMID:10493164 RGD:40903016 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il12b interleukin 12B decreases secretion
multiple interactions
ISO Prednisolone results in decreased secretion of IL12B protein
Prednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]
CTD PMID:28003376 PMID:36416909 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein] CTD PMID:23133493 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA] CTD PMID:23133493 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases secretion
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Prednisolone results in decreased expression of IL1B mRNA
Prednisolone results in decreased secretion of IL1B protein
Prednisolone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
prednisolone decreases expression of IL1b mRNA and protein in LPS-stimulated human PBMC
CTD
RGD
PMID:9259316 PMID:16442096 PMID:17379860 PMID:22119283 PMID:10493164 RGD:40903016 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Prednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il2 interleukin 2 decreases expression ISO Prednisolone results in decreased expression of IL2 protein CTD PMID:15821026 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Prednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]
Prednisolone results in decreased expression of IL4 protein
Prednisolone inhibits the reaction [Amiodarone results in increased expression of IL4 protein]
CTD PMID:15821026 PMID:16442096 PMID:23133493 PMID:34590760 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of IL5 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA]
CTD PMID:15821026 PMID:23133493 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Amiodarone results in increased secretion of IL6 protein]
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]
Prednisolone results in decreased expression of IL6 mRNA
Prednisolone results in decreased expression of IL6 mRNA; Prednisolone results in decreased expression of IL6 protein
prednisolone decreases expression of IL6 mRNA and protein in LPS-stimulated human PBMC
Prednisolone inhibits the reaction [Amiodarone results in increased expression of IL6 protein]
CTD
RGD
PMID:11043609 PMID:11288978 PMID:16442096 PMID:19192274 PMID:34590760 More... RGD:40903016 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Prednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Prednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Prednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein] CTD PMID:34590760 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Prednisolone results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050
JBrowse link
G Kmt2a lysine methyltransferase 2A decreases response to substance ISO KMT2A gene mutant form results in decreased susceptibility to Prednisolone CTD PMID:14712291 NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317
JBrowse link
G Krt8 keratin 8 increases expression ISO Prednisolone results in increased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Prednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081
JBrowse link
G Lcn2 lipocalin 2 decreases secretion ISO Prednisolone results in decreased secretion of LCN2 protein CTD PMID:28003376 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
JBrowse link
G Ltf lactotransferrin decreases expression ISO Prednisolone results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Prednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443
JBrowse link
G Ly96 lymphocyte antigen 96 decreases expression ISO Prednisolone results in decreased expression of LY96 mRNA CTD PMID:17379860 NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein] CTD PMID:34590760 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein] CTD PMID:34590760 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Prednisolone inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein] CTD PMID:34590760 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Prednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Prednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Prednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Prednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA] CTD PMID:28921394 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein] CTD PMID:22119283 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:16442096 PMID:22119283 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Muc16 mucin 16, cell surface associated decreases expression ISO Prednisolone results in decreased expression of MUC16 protein CTD PMID:12169874 NCBI chr 8:24,440,840...24,644,494 JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Prednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Prednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:65,242,169...65,244,296
Ensembl chr 7:65,242,135...65,244,277
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Prednisolone results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nid2 nidogen 2 increases expression ISO Prednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,506,756...4,562,949
JBrowse link
G Nmb neuromedin B decreases expression ISO Prednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Prednisolone results in increased expression of NOS2 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]
CTD PMID:30276927 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Prednisolone results in decreased expression of NR1D1 mRNA CTD PMID:16269518 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance
multiple interactions
affects binding
increases activity
ISO NR3C1 protein alternative form affects the susceptibility to Prednisolone
NR3C1 protein alternative form inhibits the reaction [Prednisolone results in increased activity of NR3C1 protein alternative form]; Prednisolone binds to and results in increased activity of NR3C1 protein
Prednisolone binds to NR3C1 protein
CTD PMID:11956172 PMID:14694204 PMID:15362971 PMID:15704223 PMID:15705660 More... NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Prednisolone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Prednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Prednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Prednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Prednisolone results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:85,402,151...85,439,342
Ensembl chr13:85,402,169...85,439,342
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisolone results in increased expression of PCK1 mRNA CTD PMID:20065017 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Prednisolone results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Prednisolone results in increased expression of PDLIM1 mRNA CTD PMID:17379860 NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Prednisolone results in increased expression of PER1 mRNA; Prednisolone results in increased expression of PER1 protein CTD PMID:16269518 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211
JBrowse link
G Per2 period circadian regulator 2 decreases expression ISO Prednisolone results in decreased expression of PER2 mRNA CTD PMID:16269518 NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Prednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Prednisolone results in decreased expression of PILRA mRNA CTD PMID:19192274 NCBI chr12:23,452,626...23,464,772 JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:75,825,626...75,863,296
Ensembl chr11:75,825,585...75,878,165
JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Prednisolone results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:64,361,520...64,733,171
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Prednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of POMC protein; Prednisolone results in decreased expression of POMC protein modified form
sairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]
CTD PMID:9625448 PMID:14694204 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Prednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324
JBrowse link
G Prlr prolactin receptor multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of PRLR mRNA] CTD PMID:21149847 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Prednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rdh16 retinol dehydrogenase 16 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of RDH2 mRNA] CTD PMID:21149847 NCBI chr 7:65,499,763...65,510,304 JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions
decreases expression
EXP
ISO
Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]
Prednisolone results in decreased expression of RGS4 mRNA
CTD PMID:19192274 PMID:21149847 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO Prednisolone results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Prednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Prednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Prednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320
JBrowse link
G Scg2 secretogranin II multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of SCG2 mRNA] CTD PMID:21149847 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA] CTD PMID:21149847 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Prednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
decreases expression
ISO Prednisolone results in increased expression of SLC7A11 mRNA
Prednisolone results in decreased expression of SLC7A11 mRNA
CTD PMID:19192274 PMID:24356939 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Slc7a8 solute carrier family 7 member 8 increases expression ISO Prednisolone results in increased expression of SLC7A8 mRNA CTD PMID:19192274 NCBI chr15:32,153,016...32,212,715
Ensembl chr15:32,153,018...32,212,715
JBrowse link
G Sms spermine synthase decreases expression ISO Prednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:41,331,693...41,387,713
Ensembl chr  X:41,331,799...41,387,712
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Prednisolone results in decreased expression of SOD2 mRNA CTD PMID:19192274 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Prednisolone results in decreased expression of SOX9 mRNA CTD PMID:17379860 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Prednisolone results in decreased expression of SRSF7 mRNA CTD PMID:21621594 NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:20,564,044...20,571,212
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Prednisolone results in increased expression of SRXN1 mRNA CTD PMID:24356939 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Prednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Sts steroid sulfatase increases expression ISO Prednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104
JBrowse link
G Sult2a2 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of SULT2A2 mRNA] CTD PMID:21149847 NCBI chr 1:85,037,518...85,104,532
Ensembl chr 1:84,962,100...85,104,511
JBrowse link
G Tafa5 TAFA chemokine like family member 5 increases expression ISO Prednisolone results in increased expression of TAFA5 mRNA CTD PMID:21621594 NCBI chr 7:120,493,447...120,714,720
Ensembl chr 7:120,493,060...120,714,718
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
increases expression
EXP
ISO
(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]; (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA] CTD PMID:9259316 PMID:14694204 PMID:15784656 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
JBrowse link
G Tex261 testis expressed 261 decreases expression ISO Prednisolone results in decreased expression of TEX261 mRNA CTD PMID:21621594 NCBI chr 4:117,813,050...117,818,408
Ensembl chr 4:117,811,176...117,819,180
JBrowse link
G Tf transferrin increases expression ISO Prednisolone results in increased expression of TF protein CTD PMID:3404815 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 decreases expression ISO Prednisolone results in decreased expression of TFPI2 mRNA CTD PMID:17379860 NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:32,936,854...32,941,426
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of TGFB1 protein
pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11728950 PMID:28921394 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Prednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:28921394 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Prednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
multiple interactions
decreases expression
ISO
EXP
Prednisolone results in increased expression of TNF mRNA
Prednisolone results in decreased expression of TNF mRNA
[pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Prednisolone inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]
prednisolone decreases expression of TNFa mRNA and protein in LPS-stimulated human PBMC
Prednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
CTD
RGD
PMID:11043609 PMID:19233868 PMID:20054000 PMID:22119283 PMID:28921394 More... RGD:40903016 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Prednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106
JBrowse link
G Trim63 tripartite motif containing 63 increases expression ISO Prednisolone results in increased expression of TRIM63 mRNA CTD PMID:20065017 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Prednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Prednisolone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Prednisolone results in increased expression of VLDLR mRNA CTD PMID:24356939 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154
JBrowse link
G Xist X inactive specific transcript decreases expression ISO Prednisolone results in decreased expression of XIST mRNA CTD PMID:17379860 NCBI chr  X:72,540,753...72,558,266 JBrowse link
6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein
CTD PMID:16932953 PMID:22079615 PMID:22464980 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]
CTD PMID:15187100 PMID:30878453 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases secretion
EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:130,270,554...130,282,218
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980
JBrowse link
G Ar androgen receptor multiple interactions ISO Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061 PMID:26093215 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases secretion
decreases expression
multiple interactions
EXP Methylprednisolone results in decreased secretion of BGLAP protein
Methylprednisolone results in decreased expression of BGLAP mRNA; Methylprednisolone results in decreased expression of BGLAP protein
[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of BGLAP protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of BGLAP mRNA]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of BGLAP protein]
CTD PMID:30291735 PMID:37659742 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G Capn2 calpain 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein
CTD PMID:1942778 PMID:30291735 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:172,910,681...172,922,062
JBrowse link
G Clgn calmegin decreases expression ISO Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:41,601,568...41,633,207
Ensembl chr19:41,601,568...41,633,325
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA
CTD PMID:19192274 PMID:26093215 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
increases activity
ISO Methylprednisolone results in decreased expression of CYP3A4 mRNA
Methylprednisolone results in increased activity of CYP3A4 protein
CTD PMID:15964336 PMID:16837568 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]
CTD PMID:21931329 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594
JBrowse link
G Dmd dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:51,070,273...53,437,835
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:106,811,769...106,890,961
Ensembl chr14:106,802,304...106,892,808
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G F8 coagulation factor VIII increases expression ISO Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FABP4 mRNA
bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of FABP4 mRNA]
CTD PMID:37659742 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:118,190,478...118,269,965
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein]
CTD PMID:21931329 NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491
JBrowse link
G Fcer2 Fc epsilon receptor II multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr12:6,540,697...6,552,364
Ensembl chr12:6,540,703...6,549,374
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FOXO1 protein
echinacoside inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]; Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]
CTD PMID:21931329 PMID:38336255 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Gip gastric inhibitory polypeptide increases secretion EXP Methylprednisolone results in increased secretion of GIP protein CTD PMID:6753106 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:31,689,485...31,836,199
Ensembl chr  X:31,690,359...31,733,272
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein
CTD PMID:1942778 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581
JBrowse link
G Gsdme gasdermin E decreases expression ISO Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,854,612...88,897,043
Ensembl chr 4:88,854,640...88,896,993
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
ISO [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein
CTD PMID:15329590 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:243,286,052...243,306,877
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:243,328,723...243,366,404
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:67,637,545...67,683,968
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521
JBrowse link
G Il10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein
CTD PMID:7988651 PMID:11997017 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636
JBrowse link
G Il5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein
CTD PMID:19192274 PMID:26093215 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins1 insulin 1 multiple interactions ISO cobaltiprotoporphyrin inhibits the reaction [Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; Methylprednisolone inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:15919478 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:53,563,073...53,630,760
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:118,056,935...118,069,090
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:108,815,970...108,820,444
Ensembl chr 7:108,816,887...108,820,443
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882
JBrowse link
G Mbp myelin basic protein decreases expression ISO Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
CTD PMID:26093215 PMID:28557239 PMID:30891624 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006
JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Methylprednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:65,242,169...65,244,296
Ensembl chr 7:65,242,135...65,244,277
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nid2 nidogen 2 increases expression ISO Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,506,756...4,562,949
JBrowse link
G Nmb neuromedin B decreases expression ISO Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:144,278,453...144,281,422
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:41,439,645...41,463,392
Ensembl chr12:41,439,643...41,464,420
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:75,825,626...75,863,296
Ensembl chr11:75,825,585...75,878,165
JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:125,155,945...125,235,667
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
EXP bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of PPARG mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in increased expression of PPARG protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in decreased expression of PPARG mRNA]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in decreased expression of PPARG protein]
Methylprednisolone results in increased expression of PPARG mRNA; Methylprednisolone results in increased expression of PPARG protein
CTD PMID:37659742 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:47,920,480...47,943,547
Ensembl chr13:47,922,590...47,932,324
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Ren renin increases activity
multiple interactions
EXP Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:235222 PMID:6277579 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884
JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO Methylprednisolone results in decreased expression of RIGI mRNA CTD PMID:19192274 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:60,117,398...60,165,995
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:146,690,577...146,714,394
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:48,774,985...48,788,320
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
decreases expression
EXP bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Methylprednisolone results in decreased expression of RUNX2 protein]; Methylprednisolone inhibits the reaction [bisphenol A diglycidyl ether results in increased expression of RUNX2 protein]
Methylprednisolone results in decreased expression of RUNX2 mRNA; Methylprednisolone results in decreased expression of RUNX2 protein
CTD PMID:37659742 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Sms spermine synthase decreases expression ISO Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:41,331,693...41,387,713
Ensembl chr  X:41,331,799...41,387,712
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
increases activity
EXP
ISO
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA
Methylprednisolone results in increased activity of SOD2 protein
CTD PMID:1942778 PMID:19192274 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Sts steroid sulfatase increases expression ISO Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:46,102,548...46,111,104
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
[Cyclophosphamide co-treated with Methylprednisolone] inhibits the reaction [Paraquat results in increased expression of TNF protein]
Methylprednisolone results in decreased expression of TNF protein
CTD PMID:8384958 PMID:26093215 PMID:28557239 PMID:33737140 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:136,298,082...136,311,106
JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein]
CTD PMID:21931329 NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731
JBrowse link
G Vwf von Willebrand factor decreases expression
increases expression
ISO Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein
CTD PMID:7491699 PMID:20405515 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757
JBrowse link
alclometasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO alclometasone dipropionate results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO alclometasone dipropionate results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Ifng interferon gamma decreases expression ISO alclometasone dipropionate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il2 interleukin 2 decreases expression ISO alclometasone dipropionate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il3 interleukin 3 decreases expression ISO alclometasone dipropionate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810
JBrowse link
G Il4 interleukin 4 decreases expression ISO alclometasone dipropionate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il5 interleukin 5 decreases expression ISO alclometasone dipropionate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alclometasone dipropionate results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
beclomethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO Beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]
Beclomethasone results in increased expression of ABCB1 mRNA; Beclomethasone results in increased expression of ABCB1 protein
CTD PMID:15370884 PMID:16442095 PMID:22464980 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Beclomethasone results in increased expression of ABCB4 mRNA CTD PMID:15370884 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Beclomethasone results in increased expression of ABCC1 mRNA CTD PMID:15370884 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Beclomethasone results in increased activity of ABCG2 protein
CTD PMID:15365089 PMID:16442095 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO Beclomethasone results in decreased activity of ACP5 protein CTD PMID:8429434 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Beclomethasone results in increased expression of ADRB2 mRNA CTD PMID:9032216 PMID:15679717 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression ISO Beclomethasone results in decreased expression of BDKRB1 mRNA CTD PMID:18039523 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Beclomethasone results in decreased expression of BGLAP protein CTD PMID:7746775 PMID:9232087 PMID:9544892 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318
JBrowse link
G Casp9 caspase 9 increases activity ISO Beclomethasone results in increased activity of CASP9 protein CTD PMID:11734450 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases expression ISO Beclomethasone results in increased expression of CAT protein CTD PMID:10445599 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein] CTD PMID:17988555 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Beclomethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Beclomethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Beclomethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Beclomethasone results in decreased expression of CCL5 mRNA; Beclomethasone results in decreased expression of CCL5 protein
CTD PMID:8534483 PMID:10903220 PMID:14643170 PMID:15679717 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
increases activity
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CSF2 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Beclomethasone results in decreased secretion of CSF2 protein
Beclomethasone results in increased activity of CSF2 protein
CTD PMID:7545059 PMID:10460758 PMID:10868704 PMID:11167953 PMID:11730731 More... NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Beclomethasone results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Beclomethasone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:90,437,741...90,453,073
Ensembl chr 1:90,438,224...90,453,073
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases expression
ISO 1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Mifepristone inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:12538830 PMID:23512537 PMID:24555085 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Beclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180
JBrowse link
G Fcer1g Fc epsilon receptor Ig decreases expression EXP Beclomethasone results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:86,181,908...86,186,766
Ensembl chr13:86,181,908...86,186,859
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases activity
ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Beclomethasone results in decreased expression of FOS protein CTD PMID:9797757 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases activity
increases expression
multiple interactions
ISO Beclomethasone results in increased activity of GGT5 protein
Beclomethasone results in increased expression of GGT5 mRNA
[Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
CTD PMID:11447392 NCBI chr20:13,042,694...13,070,960
Ensembl chr20:13,042,696...13,070,892
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Beclomethasone CTD PMID:16549198 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Beclomethasone results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il13 interleukin 13 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
Beclomethasone results in increased activity of IL13 protein
CTD PMID:17988555 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Beclomethasone results in decreased secretion of IL1B protein
Beclomethasone results in decreased expression of IL1B protein
CTD PMID:7545059 PMID:9176529 PMID:9371735 PMID:10460758 PMID:15337628 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Beclomethasone results in decreased expression of IL1RN protein CTD PMID:11015126 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Beclomethasone results in decreased expression of IL2RA protein CTD PMID:8111605 PMID:9314351 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein] CTD PMID:11167953 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]
Beclomethasone results in decreased expression of IL4 protein
CTD PMID:7988651 PMID:18076728 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL5 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL5 protein]
Beclomethasone results in decreased expression of IL5 protein
CTD PMID:7988651 PMID:10813552 PMID:11167953 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein] CTD PMID:17988555 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression ISO Beclomethasone results in increased expression of KLK3 mRNA CTD PMID:9815800 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586
JBrowse link
G Ltf lactotransferrin multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]
Beclomethasone results in decreased secretion of LTF protein
CTD PMID:11112886 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189
JBrowse link
G Mefv MEFV innate immunity regulator, pyrin increases response to substance ISO MEFV mutant form results in increased susceptibility to Beclomethasone CTD PMID:20828792 NCBI chr10:12,288,514...12,303,337
Ensembl chr10:12,293,782...12,303,333
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein] CTD PMID:10455257 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
Beclomethasone results in decreased expression of MMP9 protein
CTD PMID:10452757 PMID:10455257 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Beclomethasone results in decreased expression of NOS2 protein CTD PMID:12668791 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Beclomethasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects localization
increases expression
affects binding
multiple interactions
increases activity
ISO
EXP
Beclomethasone affects the localization of NR3C1 protein
Beclomethasone results in increased expression of NR3C1 mRNA
Beclomethasone binds to NR3C1 protein
[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein; [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein; Beclomethasone affects the localization of and results in increased activity of NR3C1 protein; Beclomethasone binds to and results in increased activity of NR3C1 protein
Beclomethasone results in increased activity of NR3C1 protein
CTD PMID:16814 PMID:2207292 PMID:15362971 PMID:15679717 PMID:15860753 More... NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Beclomethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:75,825,626...75,863,296
Ensembl chr11:75,825,585...75,878,165
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases activity
multiple interactions
ISO Beclomethasone results in decreased activity of PLA2G4A protein
Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]
CTD PMID:15337628 PMID:20573295 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:93,708,218...93,719,147
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Beclomethasone results in decreased expression of RNASE2 protein CTD PMID:12166584 NCBI chr15:26,923,125...26,923,934
Ensembl chr15:26,923,134...26,923,955
JBrowse link
G Rnase3 ribonuclease A family member 3 multiple interactions
decreases expression
ISO [Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]; Beclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]
Beclomethasone results in decreased expression of RNASE3 protein
CTD PMID:1443864 PMID:10513351 PMID:10573242 PMID:12166584 PMID:12587966 More... NCBI chr15:26,985,399...26,986,269
Ensembl chr15:26,985,271...26,986,400
JBrowse link
G Sele selectin E multiple interactions ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA] CTD PMID:9371735 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Beclomethasone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Beclomethasone results in increased expression of TIMP1 protein CTD PMID:10452757 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Beclomethasone results in decreased secretion of TNF protein
CTD PMID:8937731 PMID:9150321 PMID:9819297 PMID:10100995 PMID:10903220 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Beclomethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        xenobiotic 19528
          prednisolone 243
            16-hydroxyprednisolone + 0
            20alpha-dihydroprednisolone 0
            20beta-dihydroprednisolone 0
            6-methylprednisolone + 132
            6alpha-hydroxyprednisolone 0
            6beta-hydroxyprednisolone 0
            Delta(6)-prednisolone 0
            alclometasone 0
            alclometasone dipropionate 10
            beclomethasone + 59
            prednisolone phosphate 0
            prednisolone succinate 0
            prednisolone-16-carboxylic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbonyl compound 19440
                                    ketone 17484
                                      oxo steroid 10644
                                        3-oxo steroid 10023
                                          3-oxo-Delta(4) steroid 9260
                                            progesterone 2736
                                              Delta(1)-progesterone 254
                                                prednisolone 243
                                                  16-hydroxyprednisolone + 0
                                                  20alpha-dihydroprednisolone 0
                                                  20beta-dihydroprednisolone 0
                                                  6-methylprednisolone + 132
                                                  6alpha-hydroxyprednisolone 0
                                                  6beta-hydroxyprednisolone 0
                                                  Delta(6)-prednisolone 0
                                                  alclometasone 0
                                                  alclometasone dipropionate 10
                                                  beclomethasone + 59
                                                  prednisolone phosphate 0
                                                  prednisolone succinate 0
                                                  prednisolone-16-carboxylic acid + 0
paths to the root