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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pendimethalin
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Accession:CHEBI:83569 term browser browse the term
Definition:A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.
Synonyms:exact_synonym: 3,4-dimethyl-2,6-dinitro-N-(pentan-3-yl)aniline
 related_synonym: 3,4-Dimethyl-2,6-dinitro-N-(1-ethylpropyl)aniline;   Formula=C13H19N3O4;   InChI=1S/C13H19N3O4/c1-5-10(6-2)14-12-11(15(17)18)7-8(3)9(4)13(12)16(19)20/h7,10,14H,5-6H2,1-4H3;   InChIKey=CHIFOSRWCNZCFN-UHFFFAOYSA-N;   N-(1-Ethylpropyl)-2,6-dinitro-3,4-xylidine;   N-(1-Ethylpropyl)-3,4-dimethyl-2,6-dinitroaniline;   N-(1-Ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzenamine;   N-(3-Pentyl)-3,4-dimethyl-2,6-dinitroaniline;   Penoxalin;   Penoxaline;   Penoxyn;   Phenoxalin;   SMILES=CCC(CC)Nc1c(cc(C)c(C)c1[N+]([O-])=O)[N+]([O-])=O;   pendimethaline
 alt_id: CHEBI:7958
 xref: CAS:40487-42-1;   KEGG:C11019
 xref_mesh: MESH:C030856
 xref: PMID:22983723;   PMID:23646829;   PMID:24007481;   PMID:24183287;   PMID:24240661;   PMID:24293324;   PMID:24587520;   PMID:24688423;   PMID:25145238;   PMID:25398239;   PPDB:511;   Pesticides:pendimethalin;   Reaxys:2157711;   Wikipedia:Pendimethalin


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pendimethalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO pendimethalin binds to ALB protein CTD PMID:27636401 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression		 ISO
EXP		 Dihydrotestosterone inhibits the reaction [pendimethalin results in increased activity of AR protein]; pendimethalin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
pendimethalin results in decreased expression of AR mRNA		 CTD PMID:15064155 PMID:19897005 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP pendimethalin results in increased expression of BAX mRNA; pendimethalin results in increased expression of BAX protein CTD PMID:30459330 PMID:34738321 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP pendimethalin results in decreased expression of BCL2 mRNA CTD PMID:30459330 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression EXP pendimethalin results in increased expression of CASP3 mRNA CTD PMID:30459330 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
decreases expression		 EXP pendimethalin results in decreased activity of CAT protein
pendimethalin results in decreased expression of CAT protein		 CTD PMID:30459330 PMID:34738321 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to pendimethalin CTD PMID:15853388 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions		 ISO pendimethalin results in increased activity of ESR1 protein
pendimethalin binds to and results in increased activity of ESR1 protein		 CTD PMID:15064155 PMID:20143881 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity
increases expression		 ISO
EXP		 pendimethalin results in increased activity of ESR2 protein
pendimethalin results in increased expression of ESR2 mRNA		 CTD PMID:15064155 PMID:19897005 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fasn fatty acid synthase increases expression EXP pendimethalin results in increased expression of FASN protein CTD PMID:34738321 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP pendimethalin results in increased activity of GPT protein CTD PMID:34738321 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Ifng interferon gamma increases expression EXP pendimethalin results in increased expression of IFNG mRNA CTD PMID:30459330 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP pendimethalin results in decreased expression of IGF1 mRNA CTD PMID:19897005 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pendimethalin binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO pendimethalin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pendimethalin binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO pendimethalin binds to THRB protein CTD PMID:28973306 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP pendimethalin results in increased expression of TNF mRNA; pendimethalin results in increased expression of TNF protein CTD PMID:30459330 PMID:34738321 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        agrochemical 16894
          pendimethalin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        aromatic amine 15504
                                          anilines 14403
                                            substituted aniline 14042
                                              pendimethalin 18
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