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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-(3-(trifluoromethyl)phenyl)piperazine
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Accession:CHEBI:83536 term browser browse the term
Definition:A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.
Synonyms:related_synonym: 1-(m-trifluoromethylphenyl)piperazine;   3-trifluoromethylphenylpiperazine;   Formula=C11H13F3N2;   InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2;   InChIKey=KKIMDKMETPPURN-UHFFFAOYSA-N;   N-(alpha,alpha,alpha-trifluoro-3-tolyl)piperazine;   SMILES=C1=C(C(F)(F)F)C=CC=C1N2CCNCC2;   TFMPP
 xref: CAS:15532-75-9;   LINCS:LSM-24939
 xref_mesh: MESH:C018406
 xref: PMID:23890650;   PMID:24547667;   PMID:24810679;   PMID:24968061;   Reaxys:614217;   Wikipedia:Trifluoromethylphenylpiperazine


show annotations for term's descendants           Sort by:
1-(3-(trifluoromethyl)phenyl)piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNA CTD PMID:26821219 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of BHMT mRNA CTD PMID:26821219 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of CYP51 mRNA CTD PMID:26821219 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of CYP8B1 mRNA CTD PMID:26821219 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [Estradiol binds to ESR1 protein] CTD PMID:23026265 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fads1 fatty acid desaturase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FADS1 mRNA CTD PMID:26821219 NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fasn fatty acid synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FASN mRNA CTD PMID:26821219 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDFT1 mRNA CTD PMID:26821219 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDPS mRNA CTD PMID:26821219 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of GPNMB mRNA CTD PMID:26821219 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA CTD PMID:26821219 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCS1 mRNA CTD PMID:26821219 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of IDI1 mRNA CTD PMID:26821219 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of MSMO1 mRNA CTD PMID:26821219 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PCSK9 mRNA CTD PMID:26821219 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pgr progesterone receptor increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PGR mRNA CTD PMID:23026265 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Rragd Ras-related GTP binding D increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of RRAGD mRNA CTD PMID:26821219 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356 		JBrowse link
G Sqle squalene epoxidase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of SQLE mRNA CTD PMID:26821219 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Sult2a6 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of SULT2A6 mRNA CTD PMID:26821219 NCBI chr 1:74,911,097...74,962,239
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of TFF1 mRNA CTD PMID:23026265 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        xenobiotic 19523
          1-(3-(trifluoromethyl)phenyl)piperazine 23
            LY-165163 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            organic hydride 19080
                              organic fundamental parent 19080
                                hydrocarbon 18734
                                  halohydrocarbon 16111
                                    haloalkane 13049
                                      fluoroalkane 9305
                                        fluoromethanes 6825
                                          tetrafluoromethane 6825
                                            trifluoromethyl group 6825
                                              (trifluoromethyl)benzenes 6825
                                                1-(3-(trifluoromethyl)phenyl)piperazine 23
                                                  LY-165163 0
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