CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (E)-dimethomorph
Accession: CHEBI:83426
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Definition: An enamide resulting from the formal condensation of (2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.
Synonyms: exact_synonym: (2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one
related_synonym: Formula=C21H22ClNO4; InChI=1S/C21H22ClNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+; InChIKey=QNBTYORWCCMPQP-NBVRZTHBSA-N; SMILES=COc1ccc(cc1OC)C(=C\\C(=O)N1CCOCC1)\\c1ccc(Cl)cc1
xref: CAS:113210-97-2; PMID:12033804; PMID:20623489; PMID:22902184; PMID:23496017; Reaxys:8794474
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity
ISO
dimethomorph results in decreased activity of ABCB1 protein
CTD
PMID:37985955
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Amh
anti-Mullerian hormone
decreases expression
EXP
dimethomorph results in decreased expression of AMH mRNA
CTD
PMID:36410587
NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Anxa10
annexin A10
increases expression
ISO
dimethomorph results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
G
Ar
androgen receptor
multiple interactions
ISO
dimethomorph inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; dimethomorph inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD
PMID:21310686 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arg1
arginase 1
decreases expression
ISO
dimethomorph results in decreased expression of ARG1 mRNA
CTD
PMID:32194361
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Bax
BCL2 associated X, apoptosis regulator
increases expression
EXP
dimethomorph results in increased expression of BAX mRNA
CTD
PMID:36410587
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Sulfur co-treated with quinoxyfen co-treated with dimethomorph] results in decreased expression of BCL2 mRNA
CTD
PMID:35564597
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bmp15
bone morphogenetic protein 15
increases expression
EXP
dimethomorph results in increased expression of BMP15 mRNA
CTD
PMID:36410587
NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases expression
ISO
dimethomorph results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
dimethomorph results in decreased expression of CYP7A1 mRNA; dimethomorph results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Ddx4
DEAD-box helicase 4
increases expression
EXP
dimethomorph results in increased expression of DDX4 mRNA
CTD
PMID:36410587
NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723
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Esr1
estrogen receptor 1
multiple interactions
ISO
dimethomorph binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO
dimethomorph results in decreased expression of G6PC1 mRNA
CTD
PMID:32194361
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression
EXP
dimethomorph results in decreased expression of HSD3B1 mRNA
CTD
PMID:36410587
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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Inha
inhibin subunit alpha
decreases expression
EXP
dimethomorph results in decreased expression of INHA mRNA
CTD
PMID:36410587
NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[Sulfur co-treated with quinoxyfen co-treated with dimethomorph] results in decreased expression of NFE2L2 mRNA
CTD
PMID:35564597
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
dimethomorph binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pcna
proliferating cell nuclear antigen
increases expression
EXP
dimethomorph results in increased expression of PCNA mRNA
CTD
PMID:36410587
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pde4a
phosphodiesterase 4A
decreases activity
ISO
dimethomorph results in decreased activity of PDE4A protein
CTD
PMID:21251949
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
dimethomorph binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Star
steroidogenic acute regulatory protein
decreases expression
EXP
dimethomorph results in decreased expression of STAR mRNA
CTD
PMID:36410587
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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