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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acrivastine
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Accession:CHEBI:83168 term browser browse the term
Definition:A member of the class of pyridines that is (pyridin-2-yl)acrylic acid substituted at position 6 by a [(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl group. It is a non-sedating antihistamine used for treatment of hayfever, urticaria, and rhinitis.
Synonyms:exact_synonym: (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
 related_synonym: (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid;   BW 825C;   BW A825C;   Formula=C22H24N2O2;   InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+;   InChIKey=PWACSDKDOHSSQD-IUTFFREVSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1cccc(\\C=C\\C(O)=O)n1;   acrivastina;   acrivastinum
 xref: CAS:87848-99-5;   Drug_Central:82;   KEGG:D02760
 xref_mesh: MESH:C043648
 xref: PMID:1355745;   PMID:1715267;   PMID:18968530;   PMID:1970907;   PMID:22936420;   PMID:23047471;   PMID:24813276;   PMID:2569998;   PMID:2569999;   PMID:2570000;   PMID:2570001;   PMID:2570003;   PMID:2574054;   PMID:2859204;   PMID:2901993;   PMID:2906886;   PMID:6149965;   PMID:7860231;   PMID:8630717;   Reaxys:6739893;   Wikipedia:Acrivastine


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acrivastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO acrivastine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          antagonist 17233
            histamine antagonist 4893
              H1-receptor antagonist 4146
                acrivastine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        tertiary amino compound 10150
                                          N-alkylpyrrolidine 1236
                                            acrivastine 1
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