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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prodigiosin
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Accession:CHEBI:82758 term browser browse the term
Definition:A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.
Synonyms:exact_synonym: 4-methoxy-5-[(Z)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
 related_synonym: 4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-2,2'-bipyrrole;   Formula=C20H25N3O;   InChI=1S/C20H25N3O/c1-4-5-6-8-15-11-16(22-14(15)2)12-19-20(24-3)13-18(23-19)17-9-7-10-21-17/h7,9-13,21,23H,4-6,8H2,1-3H3/b16-12-;   InChIKey=SZXDNGVQRDTJSD-VBKFSLOCSA-N;   SMILES=CCCCCC1=C\\C(=C\\c2[nH]c(cc2OC)-c2ccc[nH]2)N=C1C
 xref: CAS:82-89-3
 xref_mesh: MESH:D011353
 xref: MetaCyc:CPD-16992;   PMID:15853884;   PMID:24247721;   PMID:24372158;   PMID:24440841;   PMID:24587717;   PMID:24619531;   PMID:24781979;   PMID:24817724;   PMID:25063175;   PMID:25199250;   PMID:25201292;   Reaxys:4526727;   Wikipedia:Prodigiosin


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prodigiosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Prodigiosin results in increased expression of ABCC1 mRNA CTD PMID:15746575 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein] CTD PMID:36447373 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein] CTD PMID:36447373 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of BCL2 protein] CTD PMID:36447373 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein] CTD PMID:36447373 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
decreases response to substance		 ISO Prodigiosin results in decreased expression of BIRC5 mRNA; Prodigiosin results in decreased expression of BIRC5 protein
Prodigiosin inhibits the reaction [Paclitaxel results in increased expression of BIRC5 protein]
BIRC5 results in decreased susceptibility to Prodigiosin		 CTD PMID:19133282 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions		 ISO
EXP		 Prodigiosin results in increased cleavage of CASP3 protein
Prodigiosin results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [Prodigiosin results in increased activity of CASP3 protein]
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased activity of CASP3 protein]		 CTD PMID:15746575 PMID:31077745 PMID:36447373 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage
increases activity		 ISO Prodigiosin results in increased cleavage of CASP8 protein
Prodigiosin results in increased activity of CASP8 protein		 CTD PMID:15746575 PMID:31077745 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity		 ISO Prodigiosin results in increased cleavage of CASP9 protein
Prodigiosin results in increased activity of CASP9 protein		 CTD PMID:15746575 PMID:19133282 PMID:31077745 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein] CTD PMID:36447373 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein] CTD PMID:21925195 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased activity of GSR protein] CTD PMID:36447373 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of HMOX1 mRNA] CTD PMID:36447373 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] CTD PMID:36447373 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:31077745 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:31077745 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:31077745 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Prodigiosin results in decreased phosphorylation of MAPK8 protein CTD PMID:31077745 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation ISO Prodigiosin results in decreased phosphorylation of MAPK9 protein CTD PMID:31077745 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of NFE2L2 mRNA] CTD PMID:36447373 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased degradation of NFKBIA protein] CTD PMID:21925195 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein]
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of NOS2 mRNA]		 CTD PMID:21925195 PMID:36447373 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Prodigiosin results in increased cleavage of PARP1 protein CTD PMID:15746575 PMID:19133282 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of PTGS2 protein] CTD PMID:36447373 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression
decreases response to substance		 ISO pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]; SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]
Prodigiosin results in decreased expression of RAD51 mRNA; Prodigiosin results in decreased expression of RAD51 protein
RAD51 protein results in decreased susceptibility to Prodigiosin		 CTD PMID:22579953 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of RELA protein]
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of RELA protein]		 CTD PMID:21925195 PMID:36447373 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Prodigiosin results in increased expression of SQSTM1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of SQSTM1 protein]		 CTD PMID:31077745 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] CTD PMID:36447373 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          prodigiosin 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organonitrogen heterocyclic compound 18174
                                    polypyrrole 696
                                      tripyrrole 28
                                        prodigiosin 28
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