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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7-oxolithocholic acid
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Accession:CHEBI:82679 term browser browse the term
Definition:A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.
Synonyms:exact_synonym: (3alpha,5beta)-3-hydroxy-7-oxocholan-24-oic acid
 related_synonym: 3-alpha-Hydroxy-7-oxo-5-beta-cholan-24-oic acid;   3alpha-Hydroxy-7-oxo-5beta-cholanic acid;   3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid;   7-Ketolithocholic acid;   7-oxo-3alpha-hydroxycholan-24-oic acid;   Formula=C24H38O4;   InChI=1S/C24H38O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-19,22,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,22+,23+,24-/m1/s1;   InChIKey=DXOCDBGWDZAYRQ-AURDAFMXSA-N;   Nutriacholic acid;   SMILES=C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@@H](O)C[C@H]1CC3=O
 xref: CAS:4651-67-6;   HMDB:HMDB0000467;   LIPID_MAPS_instance:LMST04010150
 xref_mesh: MESH:C023020
 xref: PMID:13525374;   PMID:21453287;   PMID:23933573;   PMID:2401860;   PMID:2811609;   PMID:2912152;   PMID:3480039;   PMID:3943698;   PMID:3943699;   PMID:4016150;   PMID:4063074;   PMID:4090568;   PMID:520764;   PMID:6631218;   PMID:7084613;   PMID:7380227;   PMID:7435569;   Reaxys:3222783
 cyclic_relationship: is_conjugate_acid_of CHEBI:78605


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7-oxolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases reduction
multiple interactions		 ISO HSD11B1 protein results in increased reduction of 7-ketolithocholic acid
[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid		 CTD PMID:21453287 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            protective agent 18263
              geroprotector 17404
                lithocholic acid 267
                  7-oxolithocholic acid 1
                    7-oxotaurolithocholic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic polycyclic compound 17311
                                  steroid 14705
                                    steroid fundamental parent 14516
                                      cholane 1004
                                        cholanoid 1010
                                          cholanic acids 994
                                            cholanic acid 988
                                              5beta-cholanic acid 988
                                                hydroxy-5beta-cholanic acid 994
                                                  bile acid 988
                                                    lithocholic acid 267
                                                      7-oxolithocholic acid 1
                                                        7-oxotaurolithocholic acid 0
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