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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butopamine
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Accession:CHEBI:82648 term browser browse the term
Definition:A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have R configuration. It is the most active of the four diastereoisomers that make up the animal feed additive ractopamine.
Synonyms:exact_synonym: 4-[(1R)-1-hydroxy-2-{[(2R)-4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl]phenol
 related_synonym: (R)-p-hydroxy-alpha-((((R)-3-(p-hydroxyphenyl)-1-methylpropyl)amino)methyl)benzyl alcohol;   (R,R)-ractopamine;   Formula=C18H23NO3;   InChI=1S/C18H23NO3/c1-13(2-3-14-4-8-16(20)9-5-14)19-12-18(22)15-6-10-17(21)11-7-15/h4-11,13,18-22H,2-3,12H2,1H3/t13-,18+/m1/s1;   InChIKey=YJQZYXCXBBCEAQ-ACJLOTCBSA-N;   LY 131126;   SMILES=C[C@H](CCc1ccc(O)cc1)NC[C@H](O)c1ccc(O)cc1;   butopamina;   butopaminum
 xref: CAS:66734-12-1;   KEGG:D03195;   PMID:12597381;   PMID:6854129;   PMID:7408391;   Patent:EP7205;   Reaxys:8395950
 cyclic_relationship: is_enantiomer_of CHEBI:82649



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ractopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 increases activity ISO ractopamine results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:57,912,760...57,914,802 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ractopamine binds to and results in increased activity of ESR1 protein CTD PMID:24928891 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ractopamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        agrochemical 16889
          animal growth promotant 255
            butopamine 3
              ractopamine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17892
                                    ammonia 17891
                                      organic amino compound 17891
                                        secondary amino compound 6968
                                          4-(1-hydroxy-2-\{[4-(4-hydroxyphenyl)butan-2-yl]amino\}ethyl)phenol 3
                                            butopamine 3
                                              ractopamine 3
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