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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pindolol
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Accession:CHEBI:8214 term browser browse the term
Definition:A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Synonyms:exact_synonym: 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
 related_synonym: 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol;   1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol;   1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol;   4-(2-hydroxy-3-isopropylaminopropoxy)-indole;   Betapindol;   Blockin L;   Blocklin-L;   Calvisken;   Cardilate;   Carvisken;   Decreten;   Durapindol;   Formula=C14H20N2O2;   Glauco-Visken;   InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3;   InChIKey=JZQKKSLKJUAGIC-UHFFFAOYSA-N;   Pectobloc;   Pinbetol;   Prinodolol;   Pynastin;   SMILES=CC(C)NCC(O)COc1cccc2[nH]ccc12;   Visken;   pindololum
 xref: CAS:13523-86-9;   DrugBank:DB00960;   Drug_Central:2176;   HMDB:HMDB0015095;   KEGG:C07445;   KEGG:D00513;   LINCS:LSM-1953
 xref_mesh: MESH:D010869
 xref: PMID:11022403;   PMID:11050366;   PMID:11185947;   PMID:11379796;   PMID:23020995;   Patent:NL6601040;   Reaxys:1536506;   Wikipedia:Pindolol


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pindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 increases expression
multiple interactions
increases activity
affects binding		 ISO
EXP		 Pindolol results in increased expression of ADRB1 protein
Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
[Pindolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; CGP 20712A affects the reaction [Pindolol results in increased activity of ADRB1 protein]; Pindolol binds to and results in decreased activity of ADRB1 protein; Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Pindolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Pindolol binds to ADRB1 protein		 CTD PMID:2175014 PMID:2462161 PMID:2888869 PMID:12761341 PMID:14730417 More... NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression
multiple interactions
affects binding		 ISO
EXP		 Pindolol results in decreased expression of ADRB2 protein
[Pindolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Pindolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Pindolol binds to and results in decreased activity of ADRB2 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]		 CTD PMID:2175014 PMID:2462161 PMID:14730417 PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO		 Pindolol binds to and results in increased activity of ADRB3 protein
[Pindolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Pindolol binds to and results in increased activity of ADRB3 protein; Pindolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]		 CTD PMID:1682311 PMID:7815362 PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein] CTD PMID:7104148 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP Pindolol binds to and affects the activity of HTR1A protein; Pindolol binds to and results in decreased activity of HTR1A protein CTD PMID:2207497 PMID:9809859 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP Pindolol binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Pindolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Prl prolactin multiple interactions ISO
EXP		 Pindolol inhibits the reaction [Buspirone results in increased secretion of PRL protein] CTD PMID:18194152 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ren renin multiple interactions
decreases activity
decreases expression		 ISO Pindolol inhibits the reaction [REN protein results in increased cleavage of AGT protein]
Pindolol results in decreased activity of REN protein
Pindolol results in decreased expression of REN protein		 CTD PMID:791319 PMID:973972 PMID:7104148 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            cardiovascular drug 8648
              vasodilator agent 6037
                pindolol 10
                  (R)-(+)-pindolol 0
                  (S)-(-)-pindolol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  azane 17886
                                    ammonia 17885
                                      organic amino compound 17885
                                        secondary amino compound 6962
                                          secondary amine 1850
                                            pindolol 10
                                              (R)-(+)-pindolol 0
                                              (S)-(-)-pindolol 0
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