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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Isodrin
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Accession:CHEBI:82100 term browser browse the term
Definition:An organochlorine compound that has formula C12H8Cl6.
Synonyms:related_synonym: Formula=C12H8Cl6;   InChI=1S/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4-,5-,6-,7+,10+,11+/m1/s1;   InChIKey=QBYJBZPUGVGKQQ-KCHUEWMZSA-N;   SMILES=ClC1=C(Cl)[C@@]2(Cl)[C@@H]3[C@H]4C[C@@H](C=C4)[C@@H]3[C@@]1(Cl)C2(Cl)Cl
 xref: CAS:465-73-6;   KEGG:C18961



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endrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Endrin results in increased expression of ADIPOQ mRNA CTD PMID:34801515 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Ar androgen receptor multiple interactions ISO Endrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases activity
increases expression
decreases expression
ISO Endrin results in decreased activity of CEBPA protein
Endrin results in increased expression of CEBPA mRNA
Endrin results in decreased expression of CEBPA protein
CTD PMID:10385688 PMID:34801515 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Endrin results in increased expression of CEBPB mRNA CTD PMID:34801515 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions
increases expression
ISO MK 2206 inhibits the reaction [Endrin results in increased expression of CEBPD mRNA]; Sirolimus inhibits the reaction [Endrin results in increased expression of CEBPD mRNA] CTD PMID:34801515 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cycs cytochrome c, somatic increases reduction ISO Endrin results in increased reduction of CYCS protein CTD PMID:12049837 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Endrin results in increased expression of CYP26A1 mRNA
AGN 193109 inhibits the reaction [Endrin results in increased expression of CYP26A1 mRNA]
CTD PMID:15589975 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Endrin results in increased expression of CYP2B6 protein CTD PMID:15548381 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Endrin results in increased expression of CYP3A4 protein CTD PMID:15548381 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
ISO Endrin binds to and results in increased activity of ESR1 protein
Endrin results in increased activity of ESR1 protein
CTD PMID:15064155 PMID:16626760 PMID:26022396 PMID:26139245 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO Endrin binds to and results in decreased activity of ESR2 protein
Endrin results in increased activity of ESR2 protein
CTD PMID:16626760 PMID:26139245 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fasn fatty acid synthase increases expression ISO Endrin results in increased expression of FASN mRNA CTD PMID:34801515 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Endrin results in increased activity of GSR protein CTD PMID:2276583 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Endrin results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA CTD PMID:28263720 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lrrc2 leucine rich repeat containing 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA CTD PMID:28263720 NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA CTD PMID:28263720 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects activity ISO Endrin affects the activity of NFKB1 protein CTD PMID:10385688 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO Endrin binds to and results in increased activity of NR1I2 protein
Endrin results in increased activity of NR1I2 protein
CTD PMID:15548381 PMID:16054614 PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Endrin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO Endrin results in increased activity of NR3C1 protein CTD PMID:19927138 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA CTD PMID:28263720 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA CTD PMID:28263720 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Endrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA CTD PMID:28263720 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
increases expression
ISO Endrin results in decreased expression of PPARG protein
MK 2206 inhibits the reaction [Endrin results in increased expression of PPARG mRNA]; Sirolimus inhibits the reaction [Endrin results in increased expression of PPARG mRNA]
CTD PMID:10385688 PMID:34801515 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Endrin results in increased expression of RARB mRNA CTD PMID:15589975 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression
increases activity
ISO Endrin results in increased expression of RARG mRNA
Endrin results in increased activity of RARG protein
CTD PMID:15589975 PMID:30639747 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA CTD PMID:28263720 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO Endrin binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Endrin results in increased expression of SLC2A4 mRNA CTD PMID:34801515 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tp53 tumor protein p53 affects response to substance ISO TRP53 protein affects the susceptibility to Endrin CTD PMID:10802220 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP Endrin inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        main group molecular entity 19811
          p-block molecular entity 19811
            halogen molecular entity 18673
              chlorine molecular entity 18457
                organochlorine compound 18295
                  Isodrin 39
                    endrin 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organohalogen compound 18523
                                organochlorine compound 18295
                                  Isodrin 39
                                    endrin 39
paths to the root