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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:picrotoxinin
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Accession:CHEBI:8206 term browser browse the term
Definition:A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.
Synonyms:exact_synonym: (1R,3R,5S,8S,9R,12S,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2-yl)-4,7,10-trioxapentacyclo[6.4.1.1(9,12).0(3,5).0(5,13)]tetradecane-6,11-dione
 related_synonym: Formula=C15H16O6;   InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8-,9-,10-,13-,14-,15+/m1/s1;   InChIKey=PIMZUZSSNYHVCU-YKWPQBAZSA-N;   SMILES=[C@]123[C@]4([C@@]([C@@H]5[C@H](C(C)=C)[C@H]([C@]4(OC1=O)[H])OC5=O)(O)C[C@]2(O3)[H])C;   picrotoxinine
 xref: CAS:17617-45-7;   KEGG:C09529;   KNApSAcK:C00003350;   LIPID_MAPS_instance:LMPR0103540001
 xref_mesh: MESH:C022961
 xref: PDBeChem:RI5;   PMID:12770091;   PMID:17405877;   PMID:17675213;   PMID:17714449;   PMID:18031737;   PMID:21505038;   PMID:25238029;   PMID:27423910;   PMID:7916140;   Reaxys:42745


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picrotoxinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 decreases expression ISO picrotoxinin results in decreased expression of ESR1 protein CTD PMID:21278053 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP picrotoxinin results in increased expression of FOS mRNA; picrotoxinin results in increased expression of FOS protein CTD PMID:7534335 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]] CTD PMID:29038840 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases response to substance
multiple interactions		 EXP
ISO		 GABRB2 protein results in increased susceptibility to picrotoxinin
picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]		 CTD PMID:29038840 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
increases response to substance		 ISO picrotoxinin binds to GABRB3 protein
picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]
GABRB3 protein results in increased susceptibility to picrotoxinin		 CTD PMID:16537435 PMID:29038840 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]]; picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]] CTD PMID:29038840 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 multiple interactions EXP picrotoxinin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABRR3 protein] CTD PMID:10635063 NCBI chr11:40,902,812...40,955,263
Ensembl chr11:40,902,812...40,955,263 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO picrotoxinin results in increased phosphorylation of MAPK1 protein CTD PMID:21278053 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO picrotoxinin results in increased phosphorylation of MAPK3 protein CTD PMID:21278053 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
picrotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 increases expression
decreases expression		 EXP Picrotoxin results in increased expression of ABCC8 mRNA; Picrotoxin results in increased expression of ABCC8 protein
Picrotoxin results in decreased expression of ABCC8 mRNA		 CTD PMID:18021373 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Picrotoxin results in decreased expression of ACSL5 mRNA CTD PMID:15170462 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 decreases expression EXP Picrotoxin results in decreased expression of ACSL6 mRNA CTD PMID:15170462 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adcy4 adenylate cyclase 4 increases expression EXP Picrotoxin results in increased expression of ADCY4 mRNA CTD PMID:15170462 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases expression EXP Picrotoxin results in increased expression of ADRA1B mRNA CTD PMID:15170462 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP Picrotoxin results in increased expression of ADRA2A mRNA CTD PMID:15170462 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Picrotoxin results in increased expression of ADRB2 mRNA CTD PMID:15170462 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Picrotoxin results in increased expression of AGTR1A mRNA CTD PMID:15170462 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Picrotoxin results in decreased expression of AGTR2 mRNA CTD PMID:15170462 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Alad aminolevulinate dehydratase decreases activity
multiple interactions		 ISO Picrotoxin results in decreased activity of ALAD protein
carvacryl acetate inhibits the reaction [Picrotoxin results in decreased activity of ALAD protein]		 CTD PMID:25490531 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B increases expression EXP Picrotoxin results in increased expression of ALDOB mRNA CTD PMID:15170462 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression EXP Picrotoxin results in increased expression of ALOX12 mRNA CTD PMID:15170462 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Picrotoxin results in increased expression of ALOX5AP mRNA CTD PMID:15170462 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta decreases expression EXP Picrotoxin results in decreased expression of ATP5F1D mRNA CTD PMID:15170462 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP decreases expression EXP Picrotoxin results in decreased expression of ATP5PO mRNA CTD PMID:15170462 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Picrotoxin results in decreased expression of BCL2L1 mRNA CTD PMID:15170462 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases methylation		 ISO
EXP		 Picrotoxin results in increased expression of BDNF mRNA
Picrotoxin results in increased expression of BDNF protein
Picrotoxin results in decreased methylation of BDNF promoter		 CTD PMID:11279263 PMID:18184782 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Calb1 calbindin 1 decreases expression EXP Picrotoxin results in decreased expression of CALB1 protein CTD PMID:15382257 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Calb2 calbindin 2 decreases expression EXP Picrotoxin results in decreased expression of CALB2 protein CTD PMID:15382257 NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438 		JBrowse link
G Casp2 caspase 2 increases expression EXP Picrotoxin results in increased expression of CASP2 mRNA CTD PMID:15170462 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Cckar cholecystokinin A receptor increases expression EXP Picrotoxin results in increased expression of CCKAR mRNA CTD PMID:15170462 NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747 		JBrowse link
G Cckbr cholecystokinin B receptor increases expression EXP Picrotoxin results in increased expression of CCKBR mRNA CTD PMID:15170462 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Picrotoxin results in decreased expression of CCND2 mRNA CTD PMID:15170462 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 increases expression EXP Picrotoxin results in increased expression of CCND3 mRNA CTD PMID:15170462 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression EXP Picrotoxin results in increased expression of CCR2 mRNA CTD PMID:15170462 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression EXP Picrotoxin results in increased expression of CHRM1 mRNA CTD PMID:15170462 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases expression EXP Picrotoxin results in increased expression of CHRM2 mRNA CTD PMID:15170462 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression EXP Picrotoxin results in increased expression of CHRM3 mRNA CTD PMID:15170462 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Picrotoxin results in increased expression of CPT1A mRNA CTD PMID:15170462 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP Picrotoxin results in increased expression of CPT1B mRNA CTD PMID:15170462 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Picrotoxin results in increased expression of CXCR4 mRNA CTD PMID:15170462 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression EXP Picrotoxin results in decreased expression of DECR1 mRNA CTD PMID:15170462 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Picrotoxin results in decreased expression of DHCR7 mRNA CTD PMID:15170462 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Picrotoxin results in increased expression of DRD4 mRNA CTD PMID:15170462 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn3 endothelin 3 multiple interactions EXP Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Picrotoxin results in decreased expression of EDNRB mRNA CTD PMID:15170462 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Picrotoxin results in increased expression of FOS; Picrotoxin results in increased expression of FOS mRNA CTD PMID:1380685 PMID:9500968 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP Picrotoxin results in increased expression of FOSL1 mRNA CTD PMID:15170462 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Picrotoxin results in increased expression of FSHR mRNA CTD PMID:15170462 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Fzd2 frizzled class receptor 2 increases expression EXP Picrotoxin results in increased expression of FZD2 mRNA CTD PMID:15170462 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions EXP 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Picrotoxin affects the localization of GABBR2 protein]; Picrotoxin results in decreased expression of and affects the localization of GABBR2 protein CTD PMID:24482233 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO
EXP		 delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:9316872 PMID:14637376 PMID:17054655 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 PMID:14637376 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Picrotoxin inhibits the reaction [Chloralose results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO
EXP		 Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:14637376 PMID:17054655 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO
EXP		 delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Picrotoxin inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Picrotoxin results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]		 CTD PMID:9316872 PMID:14637376 PMID:17054655 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Picrotoxin results in increased expression of GAD1 mRNA CTD PMID:15170462 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance
increases expression		 ISO
EXP		 GAD2 gene mutant form results in increased susceptibility to Picrotoxin
Picrotoxin results in increased expression of GAD2 mRNA; Picrotoxin results in increased expression of GAD2 protein		 CTD PMID:8954991 PMID:15170462 PMID:15382257 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Picrotoxin binds to and results in decreased activity of GLRA1 protein CTD PMID:15081878 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Picrotoxin results in decreased expression of GNAI1 mRNA CTD PMID:15170462 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Picrotoxin results in decreased expression of GNAI2 mRNA CTD PMID:15170462 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gng8 G protein subunit gamma 8 increases expression EXP Picrotoxin results in increased expression of GNG8 mRNA CTD PMID:15170462 NCBI chr 1:77,564,512...77,568,371
Ensembl chr 1:77,564,515...77,568,371 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression EXP Picrotoxin results in increased expression of GNRHR mRNA CTD PMID:15170462 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP Picrotoxin results in decreased expression of GPD1 mRNA CTD PMID:15170462 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP Picrotoxin results in decreased expression of HADHB mRNA CTD PMID:15170462 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B increases expression EXP Picrotoxin results in increased expression of HTR5B mRNA CTD PMID:15170462 NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 increases expression EXP Picrotoxin results in increased expression of HTR6 mRNA CTD PMID:15170462 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Picrotoxin results in decreased expression of IDI1 mRNA CTD PMID:15170462 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression
increases expression		 EXP Picrotoxin results in decreased expression of KCNJ11 mRNA; Picrotoxin results in decreased expression of KCNJ11 protein
Picrotoxin results in increased expression of KCNJ11 mRNA; Picrotoxin results in increased expression of KCNJ11 protein		 CTD PMID:18021373 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases expression EXP Picrotoxin results in decreased expression of KRAS mRNA CTD PMID:15170462 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Ldhb lactate dehydrogenase B decreases expression EXP Picrotoxin results in decreased expression of LDHB mRNA CTD PMID:15170462 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Ldhc lactate dehydrogenase C increases expression EXP Picrotoxin results in increased expression of LDHC mRNA CTD PMID:15170462 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor increases expression EXP Picrotoxin results in increased expression of LHCGR mRNA CTD PMID:15170462 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Lpl lipoprotein lipase decreases expression EXP Picrotoxin results in decreased expression of LPL mRNA CTD PMID:15170462 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lta4h leukotriene A4 hydrolase increases expression EXP Picrotoxin results in increased expression of LTA4H mRNA CTD PMID:15170462 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein]
Picrotoxin results in increased phosphorylation of MAPK1 protein		 CTD PMID:35137321 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein]
Picrotoxin results in increased phosphorylation of MAPK3 protein		 CTD PMID:35137321 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mc4r melanocortin 4 receptor increases expression EXP Picrotoxin results in increased expression of MC4R mRNA CTD PMID:15170462 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mvk mevalonate kinase increases expression EXP Picrotoxin results in increased expression of MVK mRNA CTD PMID:15170462 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 decreases expression EXP Picrotoxin results in decreased expression of NDUFS6 mRNA CTD PMID:15170462 NCBI chr 1:29,968,833...29,977,423
Ensembl chr 1:29,968,842...29,977,467 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 increases expression EXP Picrotoxin results in increased expression of NPY1R mRNA CTD PMID:15170462 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprk1 opioid receptor, kappa 1 increases expression EXP Picrotoxin results in increased expression of OPRK1 mRNA CTD PMID:15170462 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases expression EXP Picrotoxin results in increased expression of OPRM1 mRNA CTD PMID:15170462 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pde4d phosphodiesterase 4D increases expression EXP Picrotoxin results in increased expression of PDE4D mRNA CTD PMID:15170462 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression EXP Picrotoxin results in decreased expression of PFKP mRNA CTD PMID:15170462 NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression EXP Picrotoxin results in decreased expression of PGAM1 mRNA CTD PMID:15170462 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression EXP Picrotoxin results in increased expression of PGAM2 mRNA CTD PMID:15170462 NCBI chr14:80,681,796...80,683,907
Ensembl chr14:80,681,776...80,683,940 		JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP Picrotoxin results in decreased expression of PRKCD mRNA CTD PMID:15170462 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon decreases expression EXP Picrotoxin results in decreased expression of PRKCE mRNA CTD PMID:15170462 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression EXP Picrotoxin results in decreased expression of PSMA3 mRNA CTD PMID:15170462 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965 		JBrowse link
G Psma4 proteasome 20S subunit alpha 4 decreases expression EXP Picrotoxin results in decreased expression of PSMA4 mRNA CTD PMID:15170462 NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 increases expression EXP Picrotoxin results in increased expression of PSMB8 mRNA CTD PMID:15170462 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283 		JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression EXP Picrotoxin results in decreased expression of PSMC3 mRNA CTD PMID:15170462 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358 		JBrowse link
G Pvalb parvalbumin decreases expression EXP Picrotoxin results in decreased expression of PVALB protein CTD PMID:15382257 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Ryr2 ryanodine receptor 2 increases expression EXP Picrotoxin results in increased expression of RYR2 mRNA CTD PMID:21113126 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Smad1 SMAD family member 1 decreases expression EXP Picrotoxin results in decreased expression of SMAD1 mRNA CTD PMID:15170462 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad3 SMAD family member 3 increases expression EXP Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP Picrotoxin results in decreased expression of SMAD7 mRNA CTD PMID:15170462 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sqle squalene epoxidase decreases expression EXP Picrotoxin results in decreased expression of SQLE mRNA CTD PMID:15170462 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Sstr2 somatostatin receptor 2 increases expression EXP Picrotoxin results in increased expression of SSTR2 mRNA CTD PMID:15170462 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression EXP Picrotoxin results in increased expression of TGFBR3 mRNA CTD PMID:15170462 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression EXP Picrotoxin results in decreased expression of TRHR mRNA CTD PMID:15170462 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309 		JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression EXP Picrotoxin results in increased expression of TSHR mRNA CTD PMID:15170462 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Picrotoxin results in increased expression of UCP2 mRNA CTD PMID:15170462 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 increases expression EXP Picrotoxin results in increased expression of UCP3 mRNA CTD PMID:15170462 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          antagonist 17233
            GABA antagonist 3874
              picrotoxinin 101
                picrotin + 97
                picrotoxin 97
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  terpene 14063
                                    terpenoid 13762
                                      sesquiterpenoid 3287
                                        picrotoxane sesquiterpenoid 101
                                          picrotoxinin 101
                                            picrotin + 97
                                            picrotoxin 97
paths to the root