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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flutriafol
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Accession:CHEBI:81923 term browser browse the term
Definition:A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops.
Synonyms:exact_synonym: rac-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol
 related_synonym: (+-)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol;   (RS)-2,4'-difluoro-alpha-(1H-1,2,4-triazol-1-ylmethyl)benzhydryl alcohol;   Formula=C16H13F2N3O;   PP 450;   R 152450;   alpha-(2-fluorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol;   rac flutriafol;   rac-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol
 xref: CAS:76674-21-0;   KEGG:C18734
 xref_mesh: MESH:C543009
 xref: PMID:18178235;   PMID:20533452;   PMID:21740052;   PMID:22885544;   PMID:22983725;   PMID:23208429;   PMID:24611465;   PMID:25300182;   PMID:25376483;   Patent:EP15756;   Pesticides:76674-21-0;   Pesticides:flutriafol;   Reaxys:7141682


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flutriafol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression EXP flutriafol results in increased expression of BAX protein CTD PMID:34200939 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP flutriafol results in decreased expression of BCL2 protein CTD PMID:34200939 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP flutriafol results in increased expression of and results in increased cleavage of CASP3 protein CTD PMID:34200939 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO
EXP 		Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP1A2 mRNA] CTD PMID:34200939 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression
multiple interactions 		ISO flutriafol results in increased expression of CYP2C19 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2C19 mRNA] 		CTD PMID:34200939 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions 		ISO flutriafol results in increased expression of CYP2E1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2E1 mRNA] 		CTD PMID:34200939 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions 		ISO
EXP 		flutriafol results in increased expression of CYP3A4 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP3A4 mRNA]
flutriafol results in increased expression of CYP3A2 mRNA 		CTD PMID:34200939 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP51A1 mRNA] CTD PMID:34200939 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTO2 mRNA] CTD PMID:34200939 NCBI chr 1:256,673,376...256,695,154
Ensembl chr 1:256,673,274...256,695,146 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions 		ISO flutriafol results in increased expression of GSTP1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTP1 mRNA] 		CTD PMID:34200939 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
increases localization
multiple interactions 		EXP
ISO 		flutriafol results in decreased expression of NFE2L2 protein
flutriafol results in increased localization of NFE2L2 protein
Acetylcysteine inhibits the reaction [flutriafol results in increased localization of NFE2L2 protein] 		CTD PMID:34200939 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions 		ISO flutriafol results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO1 mRNA] 		CTD PMID:34200939 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO2 mRNA] CTD PMID:34200939 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      chemical substance 14605
        mixture 13923
          racemate 12316
            flutriafol 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  heteroarene 17448
                                    monocyclic heteroarene 15186
                                      azole 14620
                                        triazoles 8516
                                          1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol 13
                                            (R)-flutriafol 13
                                              flutriafol 13
paths to the root