The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol.
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to AR protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BAX protein]; [Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BAX protein]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BAX protein]
MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BCL2 protein] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BCL2 mRNA; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BCL2 protein
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BIRC5 protein 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BIRC5 protein]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BIRC5 protein]]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BIRC5 protein]; Fulvestrant promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of BIRC5 protein]]
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in increased cleavage of CASP9 protein
ESR1 protein affects the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 protein] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 mRNA; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCND1 protein
[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Fulvestrant] inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CCNE1 protein]
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA
[fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with Chlorpyrifos] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR1 protein; ESR1 protein affects the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of CCND1 mRNA]; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to and results in increased activity of ESR1 protein; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR1 protein] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of ESR1 mRNA
[fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein; [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased activity of ESR2 protein; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased activity of ESR2 protein N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of ESR2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; bicalutamide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; Cycloheximide inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]; MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of BCL2 protein]; MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased activity of NR1I2 protein
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PCNA protein]; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PCNA protein]]; Fulvestrant inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PCNA protein]; Fulvestrant promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PCNA protein]]
MIR21 mRNA mutant form inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 mRNA; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PDCD4 protein
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PDGFA mRNA [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased expression of PDGFA mRNA
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PGR mRNA N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PGR mRNA N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to PGR protein
[N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide promotes the reaction [Estradiol results in decreased expression of RARB mRNA] N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of RARB mRNA
N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of RB1 mRNA [systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] affects the expression of RB1 mRNA