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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flutolanil
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Accession:CHEBI:81792 term browser browse the term
Definition:A member of the class of benzamides, obtained by formal condensation of the carboxy group of 2-(trifluoromethyl)benzoic acid with the amino group of 3-(ispropyloxy)aniline. A fungicide used to control a range of pathogens especially Rhizoctonia spp. on rice, turf and other crops.
Synonyms:exact_synonym: N-[3-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)benzamide
 related_synonym: 3'-isopropoxy-2-trifloromethylbenzoic acid anilide;   Formula=C17H16F3NO2;   InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22);   InChIKey=PTCGDEVVHUXTMP-UHFFFAOYSA-N;   Moncut;   N-(3-(1-Methylethoxy)phenyl)-2-(trifluoromethyl)benzamide;   N-(3-isopropoxyphenyl)-2-(trifluoromethyl)benzamide;   NNF-136;   SMILES=CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1;   alpha,alpha,alpha-Trifluoro-3'-isopropoxy-o-toluanilide;   o-trifluoromethyl-m'-isopropoxybenzoic anilide
 xref: CAS:66332-96-5;   KEGG:C18502
 xref_mesh: MESH:C475882
 xref: MetaCyc:CPD-15890;   PDBeChem:FTN;   PMID:21587472;   PPDB:352;   Pesticides:flutolanil;   Reaxys:2163858



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flutolanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO flutolanil results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
multiple interactions
ISO flutolanil results in decreased expression of ESR1 protein
flutolanil binds to and results in increased activity of ESR1 protein
CTD PMID:17904202 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO flutolanil binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Pgr progesterone receptor increases expression ISO flutolanil results in increased expression of PGR mRNA CTD PMID:17904202 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO flutolanil results in increased activity of PPARG protein CTD PMID:20143881 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO flutolanil results in increased expression of TFF1 mRNA CTD PMID:17904202 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      application 20634
        pesticide 18470
          antifungal agrochemical 12197
            flutolanil 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            heteroorganic entity 20226
                              organochalcogen compound 19910
                                organooxygen compound 19813
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      carboacyl group 18078
                                        univalent carboacyl group 18078
                                          carbamoyl group 17914
                                            carboxamide 17914
                                              monocarboxylic acid amide 15947
                                                arenecarboxamide 8282
                                                  benzamides 8279
                                                    flutolanil 6
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