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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:endrin
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Accession:CHEBI:81526 term browser browse the term
Definition:An organochlorine compound resulting from the epoxidation of the double bond of isodrin. It is the endo, endo stereoisomer of dieldrin. It is an insecticide mainly used on field crops such as cotton and grains and has also been used as a rodenticide to control mice and voles. The product is banned in many countries since it is a persistent organic pollutant.
Synonyms:exact_synonym: rel-(1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene
 related_synonym: (1R,2S,3R,6S,7R,8S,9S,11R)-3,4,5,6,13,13-Hexachloro-10-oxapentacyclo[6.3.1.1(3,6).0(2,7).0(9,11)]tridec-4-ene;   (1R,4S,4aS,5S,6S,7R,8R,8aR)-1,2,3,4,10,10-hexachloro-1,4,4a,5,6,7,8,8a-octahydro-6,7-epoxy-1,4:5,8-dimethanonaphthalene;   (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphtho[2,3-b]oxirene;   (1aR,2R,2aR,3R,6S,6aS,7S,7aS)-rel-3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth[2,3-b]oxirene;   1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo,endo-1,4:5,8-dimethanonaphthalene;   1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-exo-1,4-exo-5,8-dimethanonaphthalene;   EN 57;   Endrex;   Endricol;   Formula=C12H8Cl6O;   Hexacrin;   Hexadrin;   InChI=1S/C12H8Cl6O/c13-8-9(14)11(16)5-3-1-2(6-7(3)19-6)4(5)10(8,15)12(11,17)18/h2-7H,1H2/t2-,3+,4-,5+,6-,7+,10-,11+;   InChIKey=DFBKLUNHFCTMDC-GKRDHZSOSA-N;   Mendrin;   Nendrin;   OMS 197;   Oktanex;   SMILES=[H][C@]12O[C@@]1([H])[C@@]1([H])C[C@]2([H])[C@]2([H])[C@@]1([H])[C@]1(Cl)C(Cl)=C(Cl)[C@@]2(Cl)C1(Cl)Cl;   Stardrin;   compound 269;   endrine;   experimental insecticide 269;   isodrin epoxide
 xref: AGR:IND606456156;   CAS:72-20-8;   Chemspider:21782117;   FooDB:FDB003234;   HMDB:HMDB0031211;   KEGG:C18124
 xref_mesh: MESH:D004732
 xref: PMID:10385688;   PMID:10523931;   PMID:1455427;   PMID:19268453;   PMID:2497330;   PMID:28918582;   PMID:29425943;   PMID:29784328;   PMID:3062692;   PMID:32897838;   PMID:3588147;   PMID:7397023;   PPDB:266;   Pesticides:endrin;   Reaxys:91397;   Wikipedia:Endrin


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endrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Endrin results in increased expression of ADIPOQ mRNA CTD PMID:34801515 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:28,632,197...29,349,721 		JBrowse link
G Ar androgen receptor multiple interactions ISO Endrin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:26022396 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr12:15,534,123...15,538,299
Ensembl chr12:15,534,123...15,538,515 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases activity
decreases expression
increases expression 		ISO Endrin results in decreased activity of CEBPA protein
Endrin results in decreased expression of CEBPA protein
Endrin results in increased expression of CEBPA mRNA 		CTD PMID:10385688 PMID:34801515 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Endrin results in increased expression of CEBPB mRNA CTD PMID:34801515 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions
increases expression 		ISO MK 2206 inhibits the reaction [Endrin results in increased expression of CEBPD mRNA]; Sirolimus inhibits the reaction [Endrin results in increased expression of CEBPD mRNA] CTD PMID:34801515 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824 		JBrowse link
G Cycs cytochrome c, somatic increases reduction ISO Endrin results in increased reduction of CYCS protein CTD PMID:12049837 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions 		ISO Endrin results in increased expression of CYP26A1 mRNA
AGN 193109 inhibits the reaction [Endrin results in increased expression of CYP26A1 mRNA] 		CTD PMID:15589975 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Endrin results in increased expression of CYP2B6 protein CTD PMID:15548381 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Endrin results in increased expression of CYP3A4 protein CTD PMID:15548381 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425 		JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 5:154,449,566...154,476,966
Ensembl chr 5:154,449,566...154,476,966 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity 		ISO Endrin binds to and results in increased activity of ESR1 protein
Endrin results in increased activity of ESR1 protein 		CTD PMID:15064155 PMID:16626760 PMID:26022396 PMID:26139245 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity 		ISO Endrin binds to and results in decreased activity of ESR2 protein
Endrin results in increased activity of ESR2 protein 		CTD PMID:16626760 PMID:26139245 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Endrin results in increased expression of FASN mRNA CTD PMID:34801515 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Endrin results in increased activity of GSR protein CTD PMID:2276583 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Endrin results in increased expression of HSP90AA1 mRNA alternative form CTD PMID:8792849 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA CTD PMID:28263720 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812 		JBrowse link
G Lrrc2 leucine rich repeat containing 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA CTD PMID:28263720 NCBI chr 8:119,814,514...119,847,587
Ensembl chr 8:119,814,509...119,847,583 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA CTD PMID:28263720 NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:136,383,560...136,500,192 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects activity ISO Endrin affects the activity of NFKB1 protein CTD PMID:10385688 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity 		ISO Endrin binds to and results in increased activity of NR1I2 protein
Endrin results in increased activity of NR1I2 protein 		CTD PMID:15548381 PMID:16054614 PMID:21115097 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Endrin results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO Endrin results in increased activity of NR3C1 protein CTD PMID:19927138 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA CTD PMID:28263720 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA CTD PMID:28263720 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA CTD PMID:28263720 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Endrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA CTD PMID:28263720 NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:150,675,377...150,715,566 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
increases expression
multiple interactions 		ISO Endrin results in decreased expression of PPARG protein
Endrin results in increased expression of PPARG mRNA
MK 2206 inhibits the reaction [Endrin results in increased expression of PPARG mRNA]; Sirolimus inhibits the reaction [Endrin results in increased expression of PPARG mRNA] 		CTD PMID:10385688 PMID:34801515 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Endrin results in increased expression of RARB mRNA CTD PMID:15589975 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rarg retinoic acid receptor, gamma increases expression
increases activity 		ISO Endrin results in increased expression of RARG mRNA
Endrin results in increased activity of RARG protein 		CTD PMID:15589975 PMID:30639747 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:135,246,427...135,268,889 		JBrowse link
G Ret ret proto-oncogene multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA CTD PMID:28263720 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO Endrin binds to RORA protein CTD PMID:32278787 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO Endrin results in increased expression of SLC2A4 mRNA CTD PMID:34801515 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Tp53 tumor protein p53 affects response to substance ISO TRP53 protein affects the susceptibility to Endrin CTD PMID:10802220 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP Endrin inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        xenobiotic 19525
          endrin 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20403
                                organic heterocyclic compound 19386
                                  organic heteromonocyclic compound 18197
                                    saturated organic heteromonocyclic parent 11495
                                      oxirane 11488
                                        epoxide 11487
                                          endrin 39
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