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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,3,3',4,4',5-Hexachlorobiphenyl
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Accession:CHEBI:81522 term browser browse the term
Definition:A hexachlorobiphenyl that has formula C12H4Cl6.
Synonyms:related_synonym: Formula=C12H4Cl6;   InChI=1S/C12H4Cl6/c13-7-2-1-5(3-8(7)14)6-4-9(15)11(17)12(18)10(6)16/h1-4H;   InChIKey=LCXMEXLGMKFLQO-UHFFFAOYSA-N;   PCB 156;   SMILES=Clc1ccc(cc1Cl)-c1cc(Cl)c(Cl)c(Cl)c1Cl
 xref: CAS:38380-08-4;   KEGG:C18120
 xref_mesh: MESH:C087667


show annotations for term's descendants           Sort by:
2,3,3',4,4',5-Hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
affects binding		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of AHR protein; 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4',5-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
2,3,3',4,4',5-hexachlorobiphenyl binds to AHR protein		 CTD PMID:10448124 PMID:11339718 PMID:12850102 PMID:15352264 PMID:20728228 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of AHRR mRNA CTD PMID:29738842 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of ALDH3A1 mRNA CTD PMID:29738842 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B1 mRNA CTD PMID:16396990 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP11B2 mRNA CTD PMID:16396990 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; [Tetrachlorodibenzodioxin co-treated with 2,3,3',4,4',5-hexachlorobiphenyl] results in increased expression of CYP1A1 protein
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A1 protein		 CTD PMID:10986007 PMID:11339718 PMID:15352264 PMID:16750337 PMID:18493746 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
decreases activity
increases expression
multiple interactions		 ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of CYP1A2 protein
2,3,3',4,4',5-hexachlorobiphenyl results in decreased activity of CYP1A2 protein
2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1A2 mRNA
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]		 CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:23674508 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO
EXP		 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:23674508 PMID:25654323 PMID:29738842 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of CYP3A11 mRNA CTD PMID:17324954 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to ESR1 protein CTD PMID:16293362 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK1 protein CTD PMID:16293362 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2,3,3',4,4',5-hexachlorobiphenyl binds to and results in increased activity of MAPK3 protein CTD PMID:16293362 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions		 ISO 2,3,3',4,4',5-hexachlorobiphenyl results in increased activity of NR1I3 protein
2,3,3',4,4',5-hexachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]		 CTD PMID:19746742 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP 2,3,3',4,4',5-hexachlorobiphenyl results in increased expression of TIPARP mRNA CTD PMID:29738842 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      chemical role 19498
        environmental contaminant 18883
          persistent organic pollutant 16792
            polychlorobiphenyl 6038
              hexachlorobiphenyl 2074
                2,3,3',4,4',5-Hexachlorobiphenyl 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            organic hydride 18704
                              organic fundamental parent 18704
                                hydrocarbon 18452
                                  halohydrocarbon 15873
                                    haloarene 6426
                                      chloroarene 6040
                                        chlorobiphenyl 6040
                                          polychlorobiphenyl 6038
                                            hexachlorobiphenyl 2074
                                              2,3,3',4,4',5-Hexachlorobiphenyl 15
paths to the root