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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Thioperamide
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Accession:CHEBI:81391 term browser browse the term
Definition:A primary aliphatic amine that has formula C15H24N4S.
Synonyms:related_synonym: Formula=C15H24N4S;   InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20);   InChIKey=QKDDJDBFONZGBW-UHFFFAOYSA-N;   SMILES=S=C(NC1CCCCC1)N1CCC(CC1)c1c[nH]cn1
 xref: CAS:106243-16-7;   KEGG:C17933;   LINCS:LSM-3426
 xref_mesh: MESH:C052075


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Thioperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh2 histamine receptor H 2 multiple interactions EXP [[thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine; [thioperamide results in increased abundance of Histamine] which results in increased activity of HRH2 protein; [zolantidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to thioperamide CTD PMID:11640976 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hrh3 histamine receptor H3 multiple interactions
decreases activity		 ISO
EXP		 thioperamide binds to and results in decreased activity of HRH3 protein
thioperamide binds to and results in decreased activity of HRH3 protein; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]
thioperamide results in decreased activity of HRH3 protein
Thioperamide binds to Hrh3 protein; Thioperamide inhibits the reaction [N-methylhistamine binds to Hrh3 protein]		 CTD
RGD		 PMID:7957603 PMID:11527950 PMID:11640976 PMID:21276809 PMID:22995146 More... RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Hrh4 histamine receptor H4 decreases activity EXP thioperamide results in decreased activity of HRH4 protein CTD PMID:22995146 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345 		JBrowse link
G Il16 interleukin 16 multiple interactions ISO thioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP thioperamide inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP		 thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        NMR chemical shift reference compound 18091
          ammonia 17890
            organic amino compound 17890
              amine 8307
                primary amine 6369
                  primary aliphatic amine 192
                    Thioperamide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        primary amino compound 9354
                                          primary amine 6369
                                            primary aliphatic amine 192
                                              Thioperamide 6
paths to the root