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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pectolinarigenin
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Accession:CHEBI:81336 term browser browse the term
Definition:A dimethoxyflavone that is the 6,4'-dimethyl ether derivative of scutellarein.
Synonyms:exact_synonym: 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
 related_synonym: 4'-Methylcapillarisin;   5,7-Dihydroxy-4',6-dimethoxyflavone;   Formula=C17H14O6;   InChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)13-7-11(18)15-14(23-13)8-12(19)17(22-2)16(15)20/h3-8,19-20H,1-2H3;   InChIKey=GPQLHGCIAUEJQK-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1;   scutellarein-6,4'-dimethyl ether
 xref: CAS:520-12-7;   KEGG:C17784;   KNApSAcK:C00003838;   LIPID_MAPS_instance:LMPK12111164
 xref_mesh: MESH:C528671
 xref: PMID:23537094;   PMID:25456423;   PMID:25924515;   Reaxys:315341


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pectolinarigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions 		ISO pectolinarigenin results in increased phosphorylation of ATM protein
TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] 		CTD PMID:37393350 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		ISO TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein] CTD PMID:37393350 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions 		ISO pectolinarigenin results in increased expression of H2AX protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein] 		CTD PMID:37393350 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation 		ISO Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein] CTD PMID:37393350 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO pectolinarigenin results in decreased expression of MKI67 protein CTD PMID:37393350 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions 		ISO pectolinarigenin results in increased expression of SQSTM1 protein
Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] 		CTD PMID:37393350 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO pectolinarigenin binds to and results in increased expression of TOP2A protein; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] CTD PMID:37393350 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions 		ISO pectolinarigenin results in increased expression of TP53 protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein] 		CTD PMID:37393350 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO pectolinarigenin results in increased expression of TP53BP1 protein CTD PMID:37393350 NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects binding 		ISO UGT1A1 protein results in increased glucuronidation of pectolinarigenin
pectolinarigenin binds to UGT1A1 protein 		CTD PMID:37797876 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects binding
increases glucuronidation 		ISO pectolinarigenin binds to UGT1A3 protein
UGT1A3 protein results in increased glucuronidation of pectolinarigenin 		CTD PMID:37797876 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects binding
increases glucuronidation 		ISO pectolinarigenin binds to UGT1A9 protein
UGT1A9 protein results in increased glucuronidation of pectolinarigenin 		CTD PMID:37797876 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of pectolinarigenin CTD PMID:37797876 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            scutellarein 71
              pectolinarigenin 13
                pectolinarin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  oxacycle 18300
                                    benzopyran 12186
                                      1-benzopyran 11917
                                        flavonoid 7550
                                          anthoxanthin 4621
                                            flavones 4621
                                              hydroxyflavone 4598
                                                trihydroxyflavone 465
                                                  apigenin 311
                                                    scutellarein 71
                                                      pectolinarigenin 13
                                                        pectolinarin 0
paths to the root