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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allocholic acid
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Accession:CHEBI:81308 term browser browse the term
Definition:An allo-bile acid that is 5alpha-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Synonyms:exact_synonym: 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-oic acid
 related_synonym: (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid;   3alpha,7alpha,12alpha-Trihydroxy-5alpha-cholanoic acid;   5alpha-cholic acid;   Formula=C24H40O5;   InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14-,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1;   InChIKey=BHQCQFFYRZLCQQ-PGHAKIONSA-N;   SMILES=C1[C@@]2([C@]3(C[C@@H]([C@]4([C@]([C@@]3([C@@H](C[C@]2(C[C@@H](C1)O)[H])O)[H])(CC[C@]4([H])[C@@H](CCC(O)=O)C)[H])C)O)[H])C
 xref: CAS:2464-18-8;   HMDB:HMDB0000505;   KEGG:C17737;   LIPID_MAPS_instance:LMST04010092
 xref_mesh: MESH:C002001
 xref: MetaCyc:CPD-16581;   PMID:11041240;   PMID:12460600;   PMID:1255017;   PMID:12810826;   PMID:14012853;   PMID:14285492;   PMID:14689221;   PMID:15666352;   PMID:15672658;   PMID:16132221;   PMID:19464381;   PMID:23646473;   PMID:24940599;   PMID:28538412;   PMID:4644219;   PMID:4673765;   PMID:5073332;   PMID:5541504;   PMID:5542000;   PMID:5634890;   PMID:5797529;   PMID:5965294;   Reaxys:3222495
 cyclic_relationship: is_conjugate_acid_of CHEBI:137661



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allocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA] CTD PMID:37968239 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO allocholic acid affects the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA] CTD PMID:37968239 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO allocholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA] CTD PMID:37968239 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 mRNA] CTD PMID:37968239 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [allocholic acid co-treated with 1-Naphthylisothiocyanate] results in decreased expression of CYP8B1 protein; allocholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP8B1 mRNA] CTD PMID:37968239 NCBI chr 8:130,455,622...130,457,592 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NR1I2 mRNA] CTD PMID:37968239 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC10A2 mRNA] CTD PMID:37968239 NCBI chr16:91,088,089...91,111,025 JBrowse link
G Slc51a solute carrier family 51 member A multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51A mRNA] CTD PMID:37968239 NCBI chr11:68,299,086...68,313,485 JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO allocholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:37968239 NCBI chr 8:65,931,891...65,939,953 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          metabolite 19563
            marine metabolite 6753
              allocholic acid 9
                allocholoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic polycyclic compound 17315
                                  steroid 14736
                                    steroid fundamental parent 14531
                                      cholane 1034
                                        cholanoid 1034
                                          cholanic acids 1019
                                            5alpha-cholanic acids 9
                                              allo-bile acid 9
                                                allocholic acid 9
                                                  allocholoyl-CoA 0
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