CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phenytoin
Accession: CHEBI:8107
browse the term
Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5.
Synonyms: related_synonym: 5,5-Diphenyl-imidazolidine-2,4-dione; 5,5-diphenylimidazolidine-2,4-dione; 5,5-diphenyltetrahydro-1H-2,4-imidazoledione; DILANTIN; Formula=C15H12N2O2; InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19); InChIKey=CXOFVDLJLONNDW-UHFFFAOYSA-N; PHENTYTOIN; SMILES=O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1; fenitoina; phenytoine; phenytoinum
alt_id: CHEBI:100921
xref: CAS:57-41-0; DrugBank:DB00252; Drug_Central:2152; HMDB:HMDB0014397; KEGG:C07443; KEGG:D00512; LINCS:LSM-5663
xref_mesh: MESH:D010672
xref: PMID:10698828; PMID:12952753; PMID:15246836; PMID:15744730; PMID:16303054; PMID:7105825; PMID:7602118; PMID:9186244; Patent:WO2012174723; Reaxys:384532; Wikipedia:Phenytoin
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Aaas
aladin WD repeat nucleoporin
decreases expression
EXP
Phenytoin results in decreased expression of AAAS mRNA
CTD
PMID:20345932
NCBI chr 7:133,464,315...133,483,961
Ensembl chr 7:133,464,315...133,483,961
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Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
Phenytoin results in decreased expression of ABCA1 mRNA
CTD
PMID:15136057
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
affects response to substance affects abundance increases metabolic processing decreases activity increases transport increases expression multiple interactions
ISO EXP
ABCB1 protein affects the susceptibility to Phenytoin ABCB1 protein affects the abundance of Phenytoin ABCB1 protein results in increased metabolism of Phenytoin Phenytoin results in decreased activity of ABCB1 protein ABCB1A protein results in increased transport of Phenytoin Phenytoin results in increased expression of ABCB1 protein Amino Acids, Peptides, and Proteins inhibits the reaction [Phenytoin results in increased expression of ABCB1 protein]; Phenytoin results in increased expression of and results in increased activity of ABCB1A protein
CTD
PMID:8001500 PMID:10580886 PMID:14749549 PMID:15569486 PMID:16220110 PMID:17045309 PMID:17376120 PMID:17529887 PMID:18408562 PMID:18440557 PMID:18473823 More...
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
affects abundance
ISO
ABCB1B protein affects the abundance of Phenytoin
CTD
PMID:12122045
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions increases expression
EXP
KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC1 protein]
CTD
PMID:18473823
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
affects transport affects response to substance increases expression multiple interactions
EXP ISO
ABCC2 protein affects the transport of Phenytoin ABCC2 protein affects the susceptibility to Phenytoin Phenytoin results in increased expression of ABCC2 protein KN 62 inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Phenytoin results in increased expression of ABCC2 protein]
CTD
PMID:12663688 PMID:14636316 PMID:17376120 PMID:18473823
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Phenytoin results in increased expression of ABCC3 mRNA
CTD
PMID:17381134
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcg1
ATP binding cassette subfamily G member 1
decreases expression
ISO
Phenytoin results in decreased expression of ABCG1 mRNA
CTD
PMID:15136057
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abhd5
abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
increases expression
EXP
Phenytoin results in increased expression of ABHD5 mRNA
CTD
PMID:20345932
NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447
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Ablim1
actin-binding LIM protein 1
decreases expression
ISO
Phenytoin results in decreased expression of ABLIM1 mRNA
CTD
PMID:15136057
NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969
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Ace2
angiotensin converting enzyme 2
decreases expression
ISO
Phenytoin results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Ache
acetylcholinesterase
increases activity
ISO
Phenytoin results in increased activity of ACHE protein
CTD
PMID:16946593
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Adam8
ADAM metallopeptidase domain 8
decreases expression
ISO
Phenytoin results in decreased expression of ADAM8 mRNA
CTD
PMID:14741686
NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
increases expression
EXP
Phenytoin results in increased expression of ADAMTS9 mRNA
CTD
PMID:20345932
NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
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Adgrb3
adhesion G protein-coupled receptor B3
increases expression
EXP
Phenytoin results in increased expression of ADGRB3 mRNA
CTD
PMID:20345932
NCBI chr 9:27,421,168...28,148,979
Ensembl chr 9:27,421,168...28,148,855
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Adrb3
adrenoceptor beta 3
decreases expression
EXP
Phenytoin results in decreased expression of ADRB3 mRNA
CTD
PMID:20345932
NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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Afp
alpha-fetoprotein
decreases expression
ISO
Phenytoin results in decreased expression of AFP mRNA
CTD
PMID:14741686 PMID:26272751
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
decreases expression
EXP
Phenytoin results in decreased expression of AGAP3 mRNA
CTD
PMID:20345932
NCBI chr 4:10,674,746...10,724,848
Ensembl chr 4:10,674,064...10,725,244
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Ahr
aryl hydrocarbon receptor
multiple interactions increases expression
ISO EXP
CYP3A11 protein affects the reaction [Phenytoin results in increased expression of AHR mRNA] Phenytoin results in increased expression of AHR protein Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
CTD
PMID:17505019
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akap10
A-kinase anchoring protein 10
increases expression
EXP
Phenytoin results in increased expression of AKAP10 mRNA
CTD
PMID:20345932
NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769
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Akr7a3
aldo-keto reductase family 7 member A3
decreases expression increases expression
EXP
Phenytoin results in decreased expression of AKR7A3 mRNA Phenytoin results in increased expression of AKR7A3 mRNA
CTD
PMID:17381134
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
Phenytoin results in increased expression of ALDH1A1 mRNA
CTD
PMID:17381134
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases expression
ISO
Phenytoin results in decreased expression of ALDH1A2 mRNA
CTD
PMID:31711903
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Amn1
antagonist of mitotic exit network 1 homolog
increases expression
EXP
Phenytoin results in increased expression of AMN1 mRNA
CTD
PMID:20345932
NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016
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Anxa4
annexin A4
increases expression
ISO
Phenytoin results in increased expression of ANXA4 mRNA
CTD
PMID:14741686
NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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Anxa5
annexin A5
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA
CTD
PMID:21224054
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Apoa1
apolipoprotein A1
increases expression
ISO
Phenytoin results in increased expression of APOA1 mRNA
CTD
PMID:15136057
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apoa4
apolipoprotein A4
increases expression
ISO
Phenytoin results in increased expression of APOA4 mRNA
CTD
PMID:15136057
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoe
apolipoprotein E
increases expression
ISO
Phenytoin results in increased expression of APOE mRNA
CTD
PMID:15136057
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Ar
androgen receptor
multiple interactions increases activity increases expression
ISO EXP
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein Phenytoin results in increased activity of AR protein Phenytoin results in increased expression of AR mRNA; Phenytoin results in increased expression of AR protein Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
CTD
PMID:19226368 PMID:19490052
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arfip1
ARF interacting protein 1
increases expression
EXP
Phenytoin results in increased expression of ARFIP1 mRNA
CTD
PMID:20345932
NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
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Arhgap39
Rho GTPase activating protein 39
increases expression
EXP
Phenytoin results in increased expression of ARHGAP39 mRNA
CTD
PMID:20345932
NCBI chr 7:108,446,280...108,538,875
Ensembl chr 7:108,446,282...108,538,831
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Armc8
armadillo repeat containing 8
increases expression
EXP
Phenytoin results in increased expression of ARMC8 mRNA
CTD
PMID:20345932
NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520
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Atm
ATM serine/threonine kinase
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein
CTD
PMID:21224054
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atpaf1
ATP synthase mitochondrial F1 complex assembly factor 1
decreases expression
EXP
Phenytoin results in decreased expression of ATPAF1 mRNA
CTD
PMID:20345932
NCBI chr 5:129,265,789...129,292,463
Ensembl chr 5:129,266,404...129,293,556
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B4galt7
beta-1,4-galactosyltransferase 7
decreases expression
EXP
Phenytoin results in decreased expression of B4GALT7 mRNA
CTD
PMID:20345932
NCBI chr17:9,018,514...9,027,591
Ensembl chr17:9,018,935...9,027,573
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA
CTD
PMID:21224054
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
Phenytoin results in increased expression of and affects the localization of BCL2 protein Phenytoin results in decreased expression of BCL2 mRNA
CTD
PMID:9118846 PMID:10695937
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA
CTD
PMID:21224054
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bmp1
bone morphogenetic protein 1
decreases expression
ISO
Phenytoin results in decreased expression of BMP1 mRNA
CTD
PMID:14741686
NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
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Bmp4
bone morphogenetic protein 4
increases expression
ISO
Phenytoin results in increased expression of BMP4 mRNA
CTD
PMID:16141649
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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C2
complement C2
decreases expression
EXP
Phenytoin results in decreased expression of C2 mRNA
CTD
PMID:20345932
NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
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Cacybp
calcyclin binding protein
increases expression
EXP
Phenytoin results in increased expression of CACYBP mRNA
CTD
PMID:20345932
NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
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Calca
calcitonin-related polypeptide alpha
decreases expression
EXP
Phenytoin results in decreased expression of CALCA protein
CTD
PMID:2470235
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calm2
calmodulin 2
decreases expression
ISO
Phenytoin results in decreased expression of CALM2 mRNA
CTD
PMID:14741686
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Capn5
calpain 5
decreases expression
ISO
Phenytoin results in decreased expression of CAPN5 mRNA
CTD
PMID:14741686
NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923
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Car6
carbonic anhydrase 6
increases expression
EXP
Phenytoin results in increased expression of CAR6 mRNA
CTD
PMID:20345932
NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
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Caskin1
CASK interacting protein 1
affects expression
EXP
Phenytoin affects the expression of CASKIN1 mRNA
CTD
PMID:20345932
NCBI chr10:13,512,684...13,533,380
Ensembl chr10:13,513,465...13,533,377
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Cat
catalase
decreases response to substance
ISO
CAT protein results in decreased susceptibility to Phenytoin
CTD
PMID:21252394
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbll1
Cbl proto-oncogene like 1
increases expression
EXP
Phenytoin results in increased expression of CBLL1 mRNA
CTD
PMID:20345932
NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Phenytoin results in increased expression of CCL2 protein
CTD
PMID:14578793
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccnc
cyclin C
increases expression
EXP
Phenytoin results in increased expression of CCNC mRNA
CTD
PMID:20345932
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
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Ccnd1
cyclin D1
multiple interactions decreases expression
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA Phenytoin results in decreased expression of CCND1 mRNA; Phenytoin results in decreased expression of CCND1 protein MIR4680 affects the reaction [Phenytoin results in decreased expression of CCND1 protein]
CTD
PMID:14741686 PMID:21224054 PMID:38191190
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
decreases expression multiple interactions
ISO
Phenytoin results in decreased expression of CCNE1 protein MIR4680 affects the reaction [Phenytoin results in decreased expression of CCNE1 protein]
CTD
PMID:38191190
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccng1
cyclin G1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA
CTD
PMID:21224054
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cd47
Cd47 molecule
decreases expression
EXP
Phenytoin results in decreased expression of CD47 mRNA
CTD
PMID:17381134
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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Cdh2
cadherin 2
decreases expression
ISO
Phenytoin results in decreased expression of CDH2 mRNA
CTD
PMID:9118846
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
Phenytoin results in decreased expression of CDK1 mRNA
CTD
PMID:26272751
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression multiple interactions
ISO
Phenytoin results in decreased expression of CDKN1A mRNA [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
CTD
PMID:14741686 PMID:21224054
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdx2
caudal type homeo box 2
increases expression
EXP
Phenytoin results in increased expression of CDX2 mRNA
CTD
PMID:20345932
NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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Cela2a
chymotrypsin like elastase 2A
decreases expression
ISO
Phenytoin results in decreased expression of CELA2A mRNA
CTD
PMID:14741686
NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
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Cep57
centrosomal protein 57
increases expression
EXP
Phenytoin results in increased expression of CEP57 mRNA
CTD
PMID:20345932
NCBI chr 8:10,669,588...10,689,257
Ensembl chr 8:10,669,590...10,689,249
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Cer1
cerberus 1, DAN family BMP antagonist
decreases expression
ISO
Phenytoin results in decreased expression of CER1 mRNA
CTD
PMID:26272751
NCBI chr 5:97,306,427...97,309,783
Ensembl chr 5:97,306,431...97,309,783
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Chek2
checkpoint kinase 2
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA
CTD
PMID:21224054
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Ckm
creatine kinase, M-type
increases expression
ISO
Phenytoin results in increased expression of CKM protein
CTD
PMID:6682525
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Clcn6
chloride voltage-gated channel 6
decreases expression
EXP
Phenytoin results in decreased expression of CLCN6 mRNA
CTD
PMID:20345932
NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
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Cmpk1
cytidine/uridine monophosphate kinase 1
increases expression
EXP
Phenytoin results in increased expression of CMPK1 mRNA
CTD
PMID:20345932
NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830
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Cnot7
CCR4-NOT transcription complex, subunit 7
increases expression
EXP
Phenytoin results in increased expression of CNOT7 mRNA
CTD
PMID:20345932
NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
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Col11a1
collagen type XI alpha 1 chain
increases expression
ISO
Phenytoin results in increased expression of COL11A1 mRNA
CTD
PMID:14741686
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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Col18a1
collagen type XVIII alpha 1 chain
decreases expression
ISO
Phenytoin results in decreased expression of COL18A1 mRNA
CTD
PMID:14741686
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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Col1a1
collagen type I alpha 1 chain
multiple interactions decreases expression increases expression
ISO
Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA] Phenytoin results in decreased expression of COL1A1 mRNA Phenytoin results in increased expression of COL1A1 mRNA
CTD
PMID:8971655 PMID:14741686
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
increases expression affects expression
ISO
Phenytoin results in increased expression of COL1A2 mRNA Phenytoin affects the expression of COL1A2 mRNA
CTD
PMID:14741686 PMID:24704097
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Col6a1
collagen type VI alpha 1 chain
decreases expression increases expression
ISO
Phenytoin results in decreased expression of COL6A1 mRNA Phenytoin results in increased expression of COL6A1 mRNA
CTD
PMID:8224229 PMID:14741686
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
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Col6a2
collagen type VI alpha 2 chain
increases expression
ISO
Phenytoin results in increased expression of COL6A2 mRNA
CTD
PMID:8224229
NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
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Col6a3
collagen type VI alpha 3 chain
increases expression
ISO
Phenytoin results in increased expression of COL6A3 mRNA
CTD
PMID:8224229
NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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Cp
ceruloplasmin
decreases expression
EXP
Phenytoin results in decreased expression of CP mRNA
CTD
PMID:17381134
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cpsf6
cleavage and polyadenylation specific factor 6
increases expression
EXP
Phenytoin results in increased expression of CPSF6 mRNA
CTD
PMID:20345932
NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
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Crh
corticotropin releasing hormone
affects expression
EXP
Phenytoin affects the expression of CRH mRNA
CTD
PMID:20345932
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crppa
CDP-L-ribitol pyrophosphorylase A
increases expression
EXP
Phenytoin results in increased expression of CRPPA mRNA
CTD
PMID:20345932
NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028
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Ctsb
cathepsin B
increases expression decreases activity
ISO
Phenytoin results in increased expression of CTSB mRNA Phenytoin results in decreased activity of CTSB protein
CTD
PMID:10914799 PMID:14741686
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsl
cathepsin L
increases expression decreases activity
ISO
Phenytoin results in increased expression of CTSL mRNA Phenytoin results in decreased activity of CTSL protein
CTD
PMID:10914799
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cul4a
cullin 4A
increases expression
EXP
Phenytoin results in increased expression of CUL4A mRNA
CTD
PMID:20345932
NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
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Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
EXP
Phenytoin results in increased expression of CX3CL1 mRNA
CTD
PMID:20345932
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA
CTD
PMID:21224054
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]
CTD
PMID:23986454
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
Phenytoin results in decreased activity of CYP19A1 protein
CTD
PMID:17959350
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP ISO
Phenytoin results in increased expression of CYP1A1 mRNA
CTD
PMID:9860486 PMID:17381134
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CTD
PMID:23397584
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA
CTD
PMID:21224054
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases expression increases expression
EXP
Phenytoin results in decreased expression of CYP2B1 mRNA Phenytoin results in increased expression of CYP2B1 mRNA
CTD
PMID:9819145 PMID:10945841
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Phenytoin results in increased expression of CYP2B2 mRNA
CTD
PMID:10945841
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions increases activity increases expression decreases expression
ISO
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein; pimagedine inhibits the reaction [Phenytoin results in increased expression of CYP2B6 mRNA] Phenytoin results in increased activity of CYP2B6 protein Phenytoin results in increased expression of CYP2B6 mRNA; Phenytoin results in increased expression of CYP2B6 protein [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA Phenytoin results in decreased expression of CYP2B10 protein
CTD
PMID:12571232 PMID:12695351 PMID:14977870 PMID:15123723 PMID:17041008 PMID:17954527 PMID:18206661 PMID:18332078 PMID:19226368 PMID:21224054 PMID:21924250 PMID:23850985 PMID:28289823 More...
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions decreases hydroxylation increases metabolic processing increases hydroxylation decreases metabolic processing affects metabolic processing affects expression increases expression
ISO EXP
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CYP2C19 gene polymorphism results in decreased hydroxylation of Phenytoin CYP2C19 protein results in increased metabolism of Phenytoin CYP2C19 protein results in increased hydroxylation of Phenytoin CYP2C19 gene polymorphism results in decreased metabolism of Phenytoin CYP2C19 protein affects the metabolism of Phenytoin Phenytoin affects the expression of CYP2C29 mRNA Phenytoin results in increased expression of CYP2C protein; Phenytoin results in increased expression of CYP2C29 mRNA; Phenytoin results in increased expression of CYP2C29 protein [Phenytoin results in decreased activity of CYP2C29 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]
CTD
PMID:9146858 PMID:9333104 PMID:9579299 PMID:9860067 PMID:12051692 PMID:15155833 PMID:15569425 PMID:15855726 PMID:16220110 PMID:16789993 PMID:18511451 PMID:19136022 PMID:19903449 PMID:21766881 PMID:23397584 More...
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c7
cytochrome P450, family 2, subfamily c, polypeptide 7
increases metabolic processing
EXP
CYP2C9 protein results in increased metabolism of Phenytoin
CTD
PMID:15569425
NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions
ISO
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin
CTD
PMID:23397584
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions increases expression decreases expression
ISO EXP
NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP2E1 mRNA] Phenytoin results in increased expression of CYP2E1 mRNA; Phenytoin results in increased expression of CYP2E1 protein Phenytoin results in decreased expression of CYP2E1 mRNA
CTD
PMID:17381134 PMID:18206661
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions increases activity
EXP ISO
Phenytoin results in increased expression of CYP3A2 mRNA; Phenytoin results in increased expression of CYP3A2 protein Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] Phenytoin results in increased expression of CYP3A4 mRNA; Phenytoin results in increased expression of CYP3A4 protein Phenytoin results in increased activity of CYP3A4 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NOC 18 inhibits the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; Phenytoin promotes the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
CTD
PMID:9512926 PMID:10219967 PMID:12065438 PMID:12505310 PMID:12673034 PMID:12695340 PMID:14977870 PMID:15466163 PMID:16207822 PMID:16837568 PMID:17505019 PMID:17954527 PMID:18206661 PMID:18332078 PMID:19226368 PMID:21402137 PMID:21742782 PMID:23397584 PMID:28289823 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
decreases expression increases expression
EXP
Phenytoin results in decreased expression of CYP3A23-3A1 mRNA Phenytoin results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:10945841 PMID:17381134
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
ISO
Phenytoin results in increased expression of CYP3A5 mRNA Phenytoin results in increased expression of CYP3A13 mRNA
CTD
PMID:12673034 PMID:19903449
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
decreases expression
EXP
Phenytoin results in decreased expression of CYP4A1 mRNA
CTD
PMID:17381134
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA
CTD
PMID:21224054
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp7b1
cytochrome P450 family 7 subfamily B member 1
increases expression
EXP
Phenytoin results in increased expression of CYP7B1 mRNA
CTD
PMID:20345932
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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Dap3
death associated protein 3
increases expression
ISO
Phenytoin results in increased expression of DAP3 mRNA
CTD
PMID:14741686
NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
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Dapk2
death-associated protein kinase 2
decreases expression
ISO
Phenytoin results in decreased expression of DAPK2 mRNA
CTD
PMID:14741686
NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA
CTD
PMID:21224054
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Dhx9
DExH-box helicase 9
increases expression
EXP
Phenytoin results in increased expression of DHX9 mRNA
CTD
PMID:20345932
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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Dmtn
dematin actin binding protein
decreases expression
EXP
Phenytoin results in decreased expression of DMTN mRNA
CTD
PMID:20345932
NCBI chr15:45,677,974...45,702,261
Ensembl chr15:45,677,977...45,705,601
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Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA
CTD
PMID:21224054
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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E2f1
E2F transcription factor 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA
CTD
PMID:21224054
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Ebpl
EBP like
increases expression
EXP
Phenytoin results in increased expression of EBPL mRNA
CTD
PMID:20345932
NCBI chr15:35,508,074...35,531,472
Ensembl chr15:35,508,074...35,531,472
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Egr1
early growth response 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA
CTD
PMID:21224054
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr3
early growth response 3
increases expression
EXP
Phenytoin results in increased expression of EGR3 mRNA
CTD
PMID:20345932
NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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Eif1a
eukaryotic translation initiation factor 1A
increases expression
EXP
Phenytoin results in increased expression of EIF1A mRNA
CTD
PMID:20345932
NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
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Emx2
empty spiracles homeobox 2
decreases expression
ISO
Phenytoin results in decreased expression of EMX2 mRNA
CTD
PMID:9118846
NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594
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Enpep
glutamyl aminopeptidase
decreases expression increases expression
EXP
Phenytoin results in decreased expression of ENPEP mRNA Phenytoin results in increased expression of ENPEP mRNA
CTD
PMID:17381134
NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
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Eomes
eomesodermin
increases expression
ISO
Phenytoin results in increased expression of EOMES mRNA
CTD
PMID:14741686
NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316
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Ephx1
epoxide hydrolase 1
affects response to substance increases expression
ISO EXP
EPHX1 gene polymorphism affects the susceptibility to Phenytoin Phenytoin results in increased expression of EPHX1 mRNA
CTD
PMID:17381134 PMID:19952982
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Ephx2
epoxide hydrolase 2
decreases expression
EXP
Phenytoin results in decreased expression of EPHX2 mRNA
CTD
PMID:17381134
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression multiple interactions
ISO
Phenytoin results in decreased expression of ERBB2 mRNA; Phenytoin results in decreased expression of ERBB2 protein MIR4680 affects the reaction [Phenytoin results in decreased expression of ERBB2 mRNA]; MIR4680 affects the reaction [Phenytoin results in decreased expression of ERBB2 protein]
CTD
PMID:38191190
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Esr1
estrogen receptor 1
increases expression
ISO
Phenytoin results in increased expression of ESR1 mRNA; Phenytoin results in increased expression of ESR1 protein
CTD
PMID:19490052
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Eya1
EYA transcriptional coactivator and phosphatase 1
decreases expression
ISO
Phenytoin results in decreased expression of EYA1 mRNA
CTD
PMID:31711903
NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
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F10
coagulation factor X
decreases expression
EXP
Phenytoin results in decreased expression of F10 mRNA
CTD
PMID:17381134
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
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F2
coagulation factor II, thrombin
multiple interactions
ISO
[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]
CTD
PMID:16376047
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Faslg
Fas ligand
multiple interactions decreases expression
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA Phenytoin results in decreased expression of FASL mRNA
CTD
PMID:21224054 PMID:23986454
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fbxl3
F-box and leucine-rich repeat protein 3
increases expression
EXP
Phenytoin results in increased expression of FBXL3 mRNA
CTD
PMID:20345932
NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867
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Fbxo30
F-box protein 30
increases expression
EXP
Phenytoin results in increased expression of FBXO30 mRNA
CTD
PMID:20345932
NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
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Fgf12
fibroblast growth factor 12
increases expression
EXP
Phenytoin results in increased expression of FGF12 mRNA
CTD
PMID:20345932
NCBI chr11:71,997,151...72,564,757
Ensembl chr11:71,997,099...72,562,607
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Fgf5
fibroblast growth factor 5
increases expression
ISO
Phenytoin results in increased expression of FGF5 mRNA
CTD
PMID:14741686
NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
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Fgf8
fibroblast growth factor 8
increases expression
ISO
Phenytoin results in increased expression of FGF8 mRNA
CTD
PMID:31711903
NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
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Fgf9
fibroblast growth factor 9
increases expression
ISO
Phenytoin results in increased expression of FGF9 mRNA
CTD
PMID:14741686
NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
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Fgfr2
fibroblast growth factor receptor 2
increases expression
ISO
Phenytoin results in increased expression of FGFR2 mRNA; Phenytoin results in increased expression of FGFR2 protein
CTD
PMID:11352631
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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Flrt2
fibronectin leucine rich transmembrane protein 2
increases expression
ISO
Phenytoin results in increased expression of FLRT2 mRNA
CTD
PMID:14741686
NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
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Fmo1
flavin containing dimethylaniline monoxygenase 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA
CTD
PMID:21224054
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Fmo4
flavin containing dimethylaniline monoxygenase 4
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA
CTD
PMID:21224054
NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874
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Fmod
fibromodulin
decreases expression
ISO
Phenytoin results in decreased expression of FMOD mRNA
CTD
PMID:14741686
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
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Fmr1
fragile X messenger ribonucleoprotein 1
increases expression
EXP
Phenytoin results in increased expression of FMR1 mRNA
CTD
PMID:20345932
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
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Fn1
fibronectin 1
increases expression
ISO
Phenytoin results in increased expression of FN1 mRNA
CTD
PMID:14741686
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fndc3a
fibronectin type III domain containing 3a
increases expression
EXP
Phenytoin results in increased expression of FNDC3A mRNA
CTD
PMID:20345932
NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
EXP
[Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA] Phenytoin results in decreased expression of FOS protein
CTD
PMID:7789465 PMID:8758711
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxc2
forkhead box C2
decreases expression
ISO
Phenytoin results in decreased expression of FOXC2 mRNA
CTD
PMID:31711903
NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
G
Foxp3
forkhead box P3
multiple interactions decreases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA Phenytoin results in decreased expression of FOXP3 mRNA
CTD
PMID:23986454
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
G
Frs3
fibroblast growth factor receptor substrate 3
decreases expression
ISO
Phenytoin results in decreased expression of FRS3 mRNA
CTD
PMID:14741686
NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
EXP
Phenytoin results in decreased expression of G6PC1 mRNA
CTD
PMID:17381134
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
G
G6pd
glucose-6-phosphate dehydrogenase
affects response to substance
ISO
G6PDX protein affects the susceptibility to Phenytoin
CTD
PMID:10627286
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA
CTD
PMID:21224054
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gata3
GATA binding protein 3
multiple interactions decreases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA Phenytoin results in decreased expression of GATA3 mRNA
CTD
PMID:23986454
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
EXP
Phenytoin results in increased expression of GCLM mRNA
CTD
PMID:20345932
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Glul
glutamate-ammonia ligase
decreases activity
ISO
Phenytoin results in decreased activity of GLUL protein
CTD
PMID:10323596
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gnl2
G protein nucleolar 2
increases expression
EXP
Phenytoin results in increased expression of GNL2 mRNA
CTD
PMID:20345932
NCBI chr 5:137,293,141...137,318,528
Ensembl chr 5:137,293,081...137,318,526
G
Gnpda2
glucosamine-6-phosphate deaminase 2
increases expression
EXP
Phenytoin results in increased expression of GNPDA2 mRNA
CTD
PMID:20345932
NCBI chr14:38,520,663...38,538,713
Ensembl chr14:38,520,705...38,538,713
G
Gpm6a
glycoprotein m6a
increases expression
EXP
Phenytoin results in increased expression of GPM6A mRNA
CTD
PMID:20345932
NCBI chr16:36,641,282...36,973,377
Ensembl chr16:36,641,284...36,973,475
G
Gpx2
glutathione peroxidase 2
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA
CTD
PMID:21224054
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
increases expression
EXP
Phenytoin results in increased expression of GRIN1 mRNA
CTD
PMID:20345932
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Gsta1
glutathione S-transferase alpha 1
increases expression
ISO
Phenytoin results in increased expression of GSTA1 mRNA
CTD
PMID:11134551
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gsta2
glutathione S-transferase alpha 2
increases expression decreases expression
EXP
Phenytoin results in increased expression of GSTA2 mRNA Phenytoin results in decreased expression of GSTA2 mRNA
CTD
PMID:17381134
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
G
Gstk1
glutathione S-transferase kappa 1
decreases expression
ISO
Phenytoin results in decreased expression of GSTK1 mRNA
CTD
PMID:14741686
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
G
Gstm1
glutathione S-transferase mu 1
increases expression multiple interactions
EXP ISO
Phenytoin results in increased expression of GSTM1 mRNA [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD
PMID:17381134 PMID:21224054
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
increases expression
EXP
Phenytoin results in increased expression of GSTM2 mRNA
CTD
PMID:17381134
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm5
glutathione S-transferase, mu 5
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA
CTD
PMID:21224054
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
Gsto1
glutathione S-transferase omega 1
decreases expression
ISO
Phenytoin results in decreased expression of GSTO1 mRNA
CTD
PMID:14741686
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
G
Gusb
glucuronidase, beta
multiple interactions decreases activity
ISO
Phenytoin inhibits the reaction [Misonidazole results in increased activity of GUSB protein] Phenytoin results in decreased activity of GUSB protein
CTD
PMID:6696821
NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
G
Hdac7
histone deacetylase 7
increases expression
ISO
Phenytoin results in increased expression of HDAC7 mRNA
CTD
PMID:26272751
NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
G
Helz
helicase with zinc finger
increases expression
EXP
Phenytoin results in increased expression of HELZ mRNA
CTD
PMID:20345932
NCBI chr10:92,479,403...92,645,234
Ensembl chr10:92,501,518...92,638,383
G
Hexim1
HEXIM P-TEFb complex subunit 1
increases expression
EXP
Phenytoin results in increased expression of HEXIM1 mRNA
CTD
PMID:20345932
NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189
G
Hmgb1
high mobility group box 1
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein
CTD
PMID:23986454
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA Phenytoin results in increased expression of HMOX1 mRNA
CTD
PMID:17381134 PMID:21224054
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
increases expression
EXP
Phenytoin results in increased expression of HNRNPA2B1 mRNA
CTD
PMID:20345932
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
G
Hook3
hook microtubule-tethering protein 3
increases expression
EXP
Phenytoin results in increased expression of HOOK3 mRNA
CTD
PMID:20345932
NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338
G
Hoxa2
homeobox A2
decreases expression
ISO
Phenytoin results in decreased expression of HOXA2 mRNA; Phenytoin results in decreased expression of HOXA2 protein
CTD
PMID:10789828
NCBI chr 4:81,262,668...81,266,970
Ensembl chr 4:81,262,768...81,265,044
G
Hoxb7
homeo box B7
increases expression
ISO
Phenytoin results in increased expression of HOXB7 mRNA
CTD
PMID:31711903
NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034
G
Hoxb9
homeo box B9
increases expression
ISO
Phenytoin results in increased expression of HOXB9 mRNA
CTD
PMID:31711903
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA
CTD
PMID:21224054
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA
CTD
PMID:21224054
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspb1
heat shock protein family B (small) member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA
CTD
PMID:21224054
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
G
Hspd1
heat shock protein family D (Hsp60) member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA
CTD
PMID:21224054
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Hspe1
heat shock protein family E (Hsp10) member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA
CTD
PMID:21224054
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
G
Ifng
interferon gamma
decreases expression
ISO
Phenytoin results in decreased expression of IFNG protein
CTD
PMID:10982153
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Ifngr1
interferon gamma receptor 1
increases expression
ISO
Phenytoin results in increased expression of IFNGR1 mRNA
CTD
PMID:14741686
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
G
Ifngr2
interferon gamma receptor 2
increases expression
ISO
Phenytoin results in increased expression of IFNGR2 mRNA
CTD
PMID:14741686
NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
G
Igf1
insulin-like growth factor 1
decreases expression
EXP
Phenytoin results in decreased expression of IGF1 mRNA
CTD
PMID:17381134
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf2
insulin-like growth factor 2
increases expression
ISO
Phenytoin results in increased expression of IGF2 mRNA
CTD
PMID:9988880
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Ihh
Indian hedgehog signaling molecule
increases expression
ISO
Phenytoin results in increased expression of IHH mRNA
CTD
PMID:16141649
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
G
Il17a
interleukin 17A
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein
CTD
PMID:23986454
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA
CTD
PMID:21224054
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
ISO
Phenytoin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA] [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein
CTD
PMID:8971655 PMID:21224054 PMID:23986454
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il23a
interleukin 23 subunit alpha
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA
CTD
PMID:23986454
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
G
Il6
interleukin 6
multiple interactions increases expression
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA Phenytoin results in increased expression of IL6 mRNA
CTD
PMID:21224054 PMID:23986454
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Il6r
interleukin 6 receptor
decreases expression
ISO
Phenytoin results in decreased expression of IL6RA mRNA
CTD
PMID:15136057
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
G
Inpp5f
inositol polyphosphate-5-phosphatase F
increases expression
EXP
Phenytoin results in increased expression of INPP5F mRNA
CTD
PMID:20345932
NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276
G
Insr
insulin receptor
increases expression
ISO
Phenytoin results in increased expression of INSR mRNA
CTD
PMID:14741686
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
G
Ipp
intracisternal A particle-promoted polypeptide
increases expression
EXP
Phenytoin results in increased expression of IPP mRNA
CTD
PMID:20345932
NCBI chr 5:129,962,528...130,001,237
Ensembl chr 5:129,962,643...130,001,242
G
Irf9
interferon regulatory factor 9
increases expression
EXP
Phenytoin results in increased expression of IRF9 mRNA
CTD
PMID:20345932
NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
G
Itga2
integrin subunit alpha 2
decreases expression
ISO
Phenytoin results in decreased expression of ITGA2 protein
CTD
PMID:15948689
NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
G
Itga8
integrin subunit alpha 8
increases expression
ISO
Phenytoin results in increased expression of ITGA8 mRNA
CTD
PMID:14741686
NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
G
Itgb1
integrin subunit beta 1
decreases expression
ISO
Phenytoin results in decreased expression of ITGB1 protein
CTD
PMID:15948689
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Itgb3bp
integrin subunit beta 3 binding protein
increases expression
EXP
Phenytoin results in increased expression of ITGB3BP mRNA
CTD
PMID:20345932
NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
G
Jade1
jade family PHD finger 1
multiple interactions decreases expression
ISO
MIR4680 affects the reaction [Phenytoin results in decreased expression of JADE1 mRNA]; MIR4680 affects the reaction [Phenytoin results in decreased expression of JADE1 protein] Phenytoin results in decreased expression of JADE1 mRNA; Phenytoin results in decreased expression of JADE1 protein
CTD
PMID:38191190
NCBI chr 2:124,543,233...124,596,361
Ensembl chr 2:124,543,286...124,596,354
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Phenytoin results in decreased expression of JUN mRNA
CTD
PMID:9118846
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
increases expression
EXP
Phenytoin results in increased expression of KCND2 mRNA
CTD
PMID:20345932
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Phenytoin results in decreased activity of KCNH2 protein
CTD
PMID:21158687
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kctd3
potassium channel tetramerization domain containing 3
increases expression
EXP
Phenytoin results in increased expression of KCTD3 mRNA
CTD
PMID:20345932
NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718
G
Kdr
kinase insert domain receptor
increases expression
ISO
Phenytoin results in increased expression of KDR mRNA
CTD
PMID:26272751
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases expression
EXP
Phenytoin results in increased expression of KHDRBS2 mRNA
CTD
PMID:20345932
NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530
G
Klf2
KLF transcription factor 2
increases expression
EXP
Phenytoin results in increased expression of KLF2 mRNA
CTD
PMID:20345932
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
G
Klhl2
kelch-like family member 2
increases expression
EXP
Phenytoin results in increased expression of KLHL2 mRNA
CTD
PMID:20345932
NCBI chr16:24,860,744...24,973,348
Ensembl chr16:24,860,667...24,973,341
G
Klhl7
kelch-like family member 7
increases expression
EXP
Phenytoin results in increased expression of KLHL7 mRNA
CTD
PMID:20345932
NCBI chr 4:11,006,366...11,055,399
Ensembl chr 4:11,006,375...11,055,541
G
Krit1
KRIT1, ankyrin repeat containing
increases expression
EXP
Phenytoin results in increased expression of KRIT1 mRNA
CTD
PMID:20345932
NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359
G
Krt2
keratin 2
increases expression
ISO
Phenytoin results in increased expression of KRT2 mRNA
CTD
PMID:14741686
NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
G
Kyat1
kynurenine aminotransferase 1
increases activity
EXP
Phenytoin results in increased activity of KYAT1 protein
CTD
PMID:16765940
NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
G
Lama2
laminin subunit alpha 2
increases expression
EXP
Phenytoin results in increased expression of LAMA2 mRNA
CTD
PMID:20345932
NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
G
Lap3
leucine aminopeptidase 3
affects expression
EXP
Phenytoin affects the expression of LAP3 mRNA
CTD
PMID:20345932
NCBI chr14:65,608,375...65,627,359
Ensembl chr14:65,608,376...65,627,359
G
Lcat
lecithin cholesterol acyltransferase
increases expression
ISO
Phenytoin results in increased expression of LCAT mRNA
CTD
PMID:15136057
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Ldb2
LIM domain binding 2
increases expression
EXP
Phenytoin results in increased expression of LDB2 mRNA
CTD
PMID:20345932
NCBI chr14:66,277,044...66,598,071
Ensembl chr14:66,277,085...66,597,778
G
Lpin1
lipin 1
increases expression
ISO
Phenytoin results in increased expression of LPIN1 mRNA
CTD
PMID:14741686
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
G
Lrba
LPS responsive beige-like anchor protein
increases expression
EXP
Phenytoin results in increased expression of LRBA mRNA
CTD
PMID:20345932
NCBI chr 2:171,623,668...172,202,576
Ensembl chr 2:171,621,507...172,202,724
G
Lsm1
LSM1 homolog, mRNA degradation associated
decreases expression
EXP
Phenytoin results in decreased expression of LSM1 mRNA
CTD
PMID:20345932
NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852
G
Ltbp4
latent transforming growth factor beta binding protein 4
increases expression
EXP
Phenytoin results in increased expression of LTBP4 mRNA
CTD
PMID:20345932
NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178
G
Lypla1
lysophospholipase 1
increases expression
EXP
Phenytoin results in increased expression of LYPLA1 mRNA
CTD
PMID:20345932
NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746
G
Map1b
microtubule-associated protein 1B
increases expression
ISO
Phenytoin results in increased expression of MAP1B mRNA
CTD
PMID:14741686
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
G
Map3k4
mitogen activated protein kinase kinase kinase 4
increases expression
EXP
Phenytoin results in increased expression of MAP3K4 mRNA
CTD
PMID:20345932
NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Phenytoin results in decreased phosphorylation of MAPK1 protein
CTD
PMID:15948689
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Phenytoin results in decreased phosphorylation of MAPK3 protein
CTD
PMID:15948689
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapre3
microtubule-associated protein, RP/EB family, member 3
increases expression
EXP
Phenytoin results in increased expression of MAPRE3 mRNA
CTD
PMID:20345932
NCBI chr 6:25,513,800...25,558,876
Ensembl chr 6:25,513,800...25,558,881
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Mbl1
mannose binding lectin 1
decreases expression
EXP
Phenytoin results in decreased expression of MBL1 mRNA
CTD
PMID:17381134
NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
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Mdk
midkine
increases expression
ISO
Phenytoin results in increased expression of MDK mRNA
CTD
PMID:14741686
NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
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Mdm2
MDM2 proto-oncogene
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA
CTD
PMID:21224054
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Me1
malic enzyme 1
increases expression
EXP
Phenytoin results in increased expression of ME1 mRNA
CTD
PMID:17381134
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Meox1
mesenchyme homeobox 1
decreases expression
ISO
Phenytoin results in decreased expression of MEOX1 mRNA
CTD
PMID:31711903
NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
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Mesp1
mesoderm posterior bHLH transcription factor 1
increases expression
ISO
Phenytoin results in increased expression of MESP1 mRNA
CTD
PMID:26272751
NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
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Mex3d
mex-3 RNA binding family member D
increases expression
EXP
Phenytoin results in increased expression of MEX3D mRNA
CTD
PMID:20345932
NCBI chr 7:9,325,575...9,332,705
Ensembl chr 7:9,325,488...9,332,096
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Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
increases expression
EXP
Phenytoin results in increased expression of MGAT2 mRNA
CTD
PMID:20345932
NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases methylation
ISO
Phenytoin results in increased methylation of MGMT promoter
CTD
PMID:15949900
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mki67
marker of proliferation Ki-67
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein
CTD
PMID:21224054
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp1
matrix metallopeptidase 1
decreases expression increases expression
ISO
Phenytoin results in decreased expression of MMP1 mRNA Phenytoin results in increased expression of MMP1 mRNA
CTD
PMID:10914799 PMID:14741686 PMID:15948689
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
Phenytoin results in decreased expression of MMP2 mRNA
CTD
PMID:15948689
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp3
matrix metallopeptidase 3
decreases expression
ISO
Phenytoin results in decreased expression of MMP3 mRNA
CTD
PMID:15948689
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mrps18c
mitochondrial ribosomal protein S18C
increases expression
EXP
Phenytoin results in increased expression of MRPS18C mRNA
CTD
PMID:20345932
NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516
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Mtf2
metal response element binding transcription factor 2
increases expression
EXP
Phenytoin results in increased expression of MTF2 mRNA
CTD
PMID:20345932
NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524
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Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
increases expression
EXP
Phenytoin results in increased expression of MTHFD1L mRNA
CTD
PMID:20345932
NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
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Mtx2
metaxin 2
increases expression
EXP
Phenytoin results in increased expression of MTX2 mRNA
CTD
PMID:20345932
NCBI chr 3:59,730,206...59,792,202
Ensembl chr 3:59,730,197...59,792,201
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression decreases expression
ISO
Phenytoin results in increased expression of MYC protein Phenytoin results in decreased expression of MYC mRNA
CTD
PMID:10695937 PMID:26272751
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myo1e
myosin IE
increases expression
ISO
Phenytoin results in increased expression of MYO1E mRNA
CTD
PMID:26272751
NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
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Nap1l2
nucleosome assembly protein 1-like 2
affects expression
EXP
Phenytoin affects the expression of NAP1L2 mRNA
CTD
PMID:20345932
NCBI chr X:68,174,051...68,176,449
Ensembl chr X:68,173,987...68,176,666
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Ncan
neurocan
increases expression
ISO
Phenytoin results in increased expression of NCAN mRNA
CTD
PMID:14741686
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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Ncl
nucleolin
decreases expression
EXP
Phenytoin results in decreased expression of NCL mRNA
CTD
PMID:17381134
NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
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Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]
CTD
PMID:21924250
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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Nelfa
negative elongation factor complex member A
decreases expression
EXP
Phenytoin results in decreased expression of NELFA mRNA
CTD
PMID:20345932
NCBI chr14:76,808,920...76,832,998
Ensembl chr14:76,808,870...76,832,994
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Nes
nestin
decreases expression
ISO
Phenytoin results in decreased expression of NES mRNA
CTD
PMID:26272751
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Neurog2
neurogenin 2
increases expression
ISO
Phenytoin results in increased expression of NEUROG2 mRNA
CTD
PMID:31711903
NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases expression
ISO
Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of NFKB1 protein] Phenytoin results in increased expression of NFKB1 mRNA
CTD
PMID:10700573 PMID:14741686
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
decreases degradation
ISO
Phenytoin results in decreased degradation of NFKBIA protein
CTD
PMID:15948689
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngly1
N-glycanase 1
increases expression
EXP
Phenytoin results in increased expression of NGLY1 mRNA
CTD
PMID:20345932
NCBI chr15:9,153,738...9,210,228
Ensembl chr15:9,153,738...9,204,630
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA
CTD
PMID:23986454
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA
CTD
PMID:21224054
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Npas2
neuronal PAS domain protein 2
increases expression
EXP
Phenytoin results in increased expression of NPAS2 mRNA
CTD
PMID:20345932
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
Phenytoin results in increased expression of NQO1 mRNA
CTD
PMID:17381134
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity increases expression affects activity
ISO EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of and results in increased activity of CYP2B6 protein]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP2C9 mRNA]; NR1I2 protein affects the reaction [Phenytoin results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin binds to and results in increased activity of NR1I2 protein; Phenytoin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] Phenytoin results in increased activity of NR1I2 protein Phenytoin results in increased expression of NR1I2 protein Phenytoin affects the activity of NR1I2 protein
CTD
PMID:12065438 PMID:12695340 PMID:12695351 PMID:14600250 PMID:14977870 PMID:15039302 PMID:18473823 PMID:21402137 PMID:23611293 More...
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions increases localization increases activity increases expression
ISO EXP
[Phenytoin results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]; Phenytoin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein] Phenytoin results in increased localization of NR1I3 protein NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C29 mRNA]; NR1I3 protein affects the reaction [Phenytoin results in increased expression of CYP2C37 mRNA] Phenytoin results in increased expression of NR1I3 protein
CTD
PMID:15123723 PMID:15155833 PMID:15849716 PMID:16936065 PMID:17041008 PMID:18473823 PMID:21924250 More...
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr2f1
nuclear receptor subfamily 2, group F, member 1
increases expression
EXP
Phenytoin results in increased expression of NR2F1 mRNA
CTD
PMID:20345932
NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions increases expression
ISO EXP
Dexamethasone promotes the reaction [NR3C1 protein affects the reaction [NR1I2 protein promotes the reaction [Phenytoin results in increased expression of CYP2B6 mRNA]]]; NR3C1 protein promotes the reaction [Phenytoin results in increased expression of CYP3A4 mRNA] Phenytoin results in increased expression of NR3C1 mRNA
CTD
PMID:10219967 PMID:12695351 PMID:20345932
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrcam
neuronal cell adhesion molecule
decreases expression
ISO
Phenytoin results in decreased expression of NRCAM mRNA
CTD
PMID:26272751
NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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Nsmce3
NSE3 homolog, SMC5-SMC6 complex component
increases expression
EXP
Phenytoin results in increased expression of NSMCE3 mRNA
CTD
PMID:20345932
NCBI chr 1:118,401,302...118,402,629
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Nt5dc1
5'-nucleotidase domain containing 1
increases expression
EXP
Phenytoin results in increased expression of NT5DC1 mRNA
CTD
PMID:20345932
NCBI chr20:38,105,677...38,208,613
Ensembl chr20:38,105,678...38,208,591
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Ntf3
neurotrophin 3
decreases expression
ISO
Phenytoin results in decreased expression of NTF3 mRNA
CTD
PMID:7841657
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Nup153
nucleoporin 153
increases expression
EXP
Phenytoin results in increased expression of NUP153 mRNA
CTD
PMID:20345932
NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
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Olig3
oligodendrocyte transcription factor 3
increases expression
ISO
Phenytoin results in increased expression of OLIG3 mRNA
CTD
PMID:31711903
NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
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Oprm1
opioid receptor, mu 1
multiple interactions
ISO
[cyprodime binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Phenytoin
CTD
PMID:7870991
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Pafah1b1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
decreases expression
ISO
Phenytoin results in decreased expression of PAFAH1B1 mRNA
CTD
PMID:15136057
NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
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Pafah1b2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2
decreases expression
ISO
Phenytoin results in decreased expression of PAFAH1B2 mRNA
CTD
PMID:15136057
NCBI chr 8:46,260,069...46,312,073
Ensembl chr 8:46,261,064...46,279,833
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Pard6g
par-6 family cell polarity regulator gamma
increases expression
EXP
Phenytoin results in increased expression of PARD6G mRNA
CTD
PMID:20345932
NCBI chr18:73,497,992...73,565,048
Ensembl chr18:73,498,021...73,565,029
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Parg
poly (ADP-ribose) glycohydrolase
increases expression
EXP
Phenytoin results in increased expression of PARG mRNA
CTD
PMID:20345932
NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
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Pax3
paired box 3
decreases expression
ISO
Phenytoin results in decreased expression of PAX3 mRNA
CTD
PMID:9118846 PMID:31711903
NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
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Pax6
paired box 6
increases expression
ISO
Phenytoin results in increased expression of PAX6 mRNA
CTD
PMID:31711903
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pbx1
PBX homeobox 1
increases expression
EXP
Phenytoin results in increased expression of PBX1 mRNA
CTD
PMID:20345932
NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
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Pcyox1
prenylcysteine oxidase 1
increases expression
EXP
Phenytoin results in increased expression of PCYOX1 mRNA
CTD
PMID:20345932
NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
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Pdgfa
platelet derived growth factor subunit A
increases expression
ISO
Phenytoin results in increased expression of PDGFA mRNA
CTD
PMID:14741686
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Pdgfb
platelet derived growth factor subunit B
increases expression
EXP ISO
Phenytoin results in increased expression of PDGFB mRNA; Phenytoin results in increased expression of PDGFB protein
CTD
PMID:8463938 PMID:9029455 PMID:14741686
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pgrmc1
progesterone receptor membrane component 1
increases expression
EXP
Phenytoin results in increased expression of PGRMC1 mRNA
CTD
PMID:17381134
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
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Phf14
PHD finger protein 14
increases expression
EXP
Phenytoin results in increased expression of PHF14 mRNA
CTD
PMID:20345932
NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
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Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
increases expression
ISO
Phenytoin results in increased expression of PIP4K2A mRNA
CTD
PMID:14741686
NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029
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Plaur
plasminogen activator, urokinase receptor
decreases expression
ISO
Phenytoin results in decreased expression of PLAUR mRNA
CTD
PMID:14741686
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Plcl1
phospholipase C-like 1
increases expression
EXP
Phenytoin results in increased expression of PLCL1 mRNA
CTD
PMID:20345932
NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
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Plec
plectin
increases expression
EXP
Phenytoin results in increased expression of PLEC mRNA
CTD
PMID:20345932
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
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Pltp
phospholipid transfer protein
increases expression
ISO
Phenytoin results in increased expression of PLTP mRNA
CTD
PMID:15136057
NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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Plxnb2
plexin B2
decreases expression
ISO
Phenytoin results in decreased expression of PLXNB2 mRNA
CTD
PMID:14741686
NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
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Pnn
pinin, desmosome associated protein
increases expression
EXP
Phenytoin results in increased expression of PNN mRNA
CTD
PMID:20345932
NCBI chr 6:76,758,138...76,766,451
Ensembl chr 6:76,758,117...76,766,889
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Pon1
paraoxonase 1
decreases expression affects activity
ISO
Phenytoin results in decreased expression of PON1 mRNA Phenytoin affects the activity of PON1 protein
CTD
PMID:15136057 PMID:28032682
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Por
cytochrome p450 oxidoreductase
increases activity
ISO
Phenytoin results in increased activity of POR protein
CTD
PMID:12051692
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Pou3f1
POU class 3 homeobox 1
increases expression
ISO
Phenytoin results in increased expression of POU3F1 protein
CTD
PMID:12781989
NCBI chr 5:136,910,391...136,913,371
Ensembl chr 5:136,910,391...136,913,371
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Ppil4
peptidylprolyl isomerase like 4
increases expression
EXP
Phenytoin results in increased expression of PPIL4 mRNA
CTD
PMID:20345932
NCBI chr 1:2,273,582...2,305,639
Ensembl chr 1:2,273,609...2,305,632
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Prkdc
protein kinase, DNA-activated, catalytic subunit
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline]
CTD
PMID:21224054
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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Prl
prolactin
decreases expression
EXP
Phenytoin results in decreased expression of PRL mRNA; Phenytoin results in decreased expression of PRL protein
CTD
PMID:3734668
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prmt3
protein arginine methyltransferase 3
increases expression
EXP
Phenytoin results in increased expression of PRMT3 mRNA
CTD
PMID:20345932
NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
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Prss12
serine protease 12
increases expression
ISO
Phenytoin results in increased expression of PRSS12 mRNA
CTD
PMID:14741686
NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
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Psip1
PC4 and SRSF1 interacting protein 1
increases expression
EXP
Phenytoin results in increased expression of PSIP1 mRNA
CTD
PMID:20345932
NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
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Psmc6
proteasome 26S subunit, ATPase 6
increases expression
EXP
Phenytoin results in increased expression of PSMC6 mRNA
CTD
PMID:20345932
NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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Psmd12
proteasome 26S subunit, non-ATPase 12
increases expression
EXP
Phenytoin results in increased expression of PSMD12 mRNA
CTD
PMID:20345932
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
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Ptbp2
polypyrimidine tract binding protein 2
increases expression
EXP
Phenytoin results in increased expression of PTBP2 mRNA
CTD
PMID:20345932
NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506
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Ptch1
patched 1
increases expression
ISO
Phenytoin results in increased expression of PTCH1 mRNA
CTD
PMID:16141649
NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
EXP
Phenytoin results in increased expression of PTGS2 mRNA
CTD
PMID:20345932
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pth
parathyroid hormone
increases expression
ISO
Phenytoin results in increased expression of PTH protein
CTD
PMID:20683115
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Rad50
RAD50 double strand break repair protein
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA
CTD
PMID:21224054
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Rai1
retinoic acid induced 1
increases expression
EXP
Phenytoin results in increased expression of RAI1 mRNA
CTD
PMID:20345932
NCBI chr10:44,913,231...45,008,232
Ensembl chr10:44,947,909...45,008,232
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Ranbp6
RAN binding protein 6
increases expression
EXP
Phenytoin results in increased expression of RANBP6 mRNA
CTD
PMID:20345932
NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942
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Rapgef4
Rap guanine nucleotide exchange factor 4
increases expression
EXP
Phenytoin results in increased expression of RAPGEF4 mRNA
CTD
PMID:20345932
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
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Rara
retinoic acid receptor, alpha
increases expression decreases expression
ISO
Phenytoin results in increased expression of RARA mRNA Phenytoin results in decreased expression of RARA mRNA
CTD
PMID:9118846 PMID:9988880
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rarb
retinoic acid receptor, beta
increases expression
ISO
Phenytoin results in increased expression of RARB mRNA
CTD
PMID:9988880
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rarg
retinoic acid receptor, gamma
increases expression
ISO
Phenytoin results in increased expression of RARG mRNA
CTD
PMID:9988880
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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Rbm12
RNA binding motif protein 12
increases expression
EXP
Phenytoin results in increased expression of RBM12 mRNA
CTD
PMID:20345932
NCBI chr 3:144,609,661...144,629,911
Ensembl chr 3:144,611,623...144,629,915
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Rbm3
RNA binding motif protein 3
increases expression
EXP
Phenytoin results in increased expression of RBM3 mRNA
CTD
PMID:20345932
NCBI chr X:14,348,909...14,352,387
Ensembl chr X:14,348,910...14,353,580
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Rbm34
RNA binding motif protein 34
increases expression
EXP
Phenytoin results in increased expression of RBM34 mRNA
CTD
PMID:20345932
NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715
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Rbp2
retinol binding protein 2
increases expression
ISO
Phenytoin results in increased expression of RBP2 mRNA
CTD
PMID:9118846
NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
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Rdh14
retinol dehydrogenase 14
increases expression
EXP
Phenytoin results in increased expression of RDH14 mRNA
CTD
PMID:20345932
NCBI chr 6:33,156,569...33,161,712
Ensembl chr 6:33,156,569...33,161,712
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases activity
ISO
Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased localization of and results in increased activity of RELA protein] Phenytoin results in increased activity of RELA protein
CTD
PMID:10700573 PMID:15322231
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rhoa
ras homolog family member A
decreases expression
ISO
Phenytoin results in decreased expression of RHOA mRNA
CTD
PMID:15136057
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Riok2
RIO kinase 2
increases expression
EXP
Phenytoin results in increased expression of RIOK2 mRNA
CTD
PMID:20345932
NCBI chr 1:58,103,132...58,119,397
Ensembl chr 1:58,103,084...58,120,512
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Rnaseh1
ribonuclease H1
decreases expression
EXP
Phenytoin results in decreased expression of RNASEH1 mRNA
CTD
PMID:20345932
NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
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Rnd1
Rho family GTPase 1
increases expression
EXP
Phenytoin results in increased expression of RND1 mRNA
CTD
PMID:20345932
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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Rnf115
ring finger protein 115
increases expression
EXP
Phenytoin results in increased expression of RNF115 mRNA
CTD
PMID:20345932
NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823
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Rpe
ribulose-5-phosphate-3-epimerase
increases expression
EXP
Phenytoin results in increased expression of RPE mRNA
CTD
PMID:20345932
NCBI chr 9:68,191,027...68,211,295
Ensembl chr 9:68,191,292...68,211,591
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Rpl28
ribosomal protein L28
increases expression
ISO
Phenytoin results in increased expression of RPL28 mRNA
CTD
PMID:14741686
NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
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Rps6ka3
ribosomal protein S6 kinase A3
increases expression
EXP
Phenytoin results in increased expression of RPS6KA3 mRNA
CTD
PMID:20345932
NCBI chr X:35,517,306...35,623,296
Ensembl chr X:35,517,306...35,623,207
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Rpsa
ribosomal protein SA
increases expression
ISO
Phenytoin results in increased expression of RPSA mRNA
CTD
PMID:14741686
NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
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Rsrc1
arginine and serine rich coiled-coil 1
decreases expression
EXP
Phenytoin results in decreased expression of RSRC1 mRNA
CTD
PMID:20345932
NCBI chr 2:151,226,821...151,632,771
Ensembl chr 2:151,231,156...151,632,765
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Ryr2
ryanodine receptor 2
increases expression
EXP
Phenytoin results in increased expression of RYR2 mRNA
CTD
PMID:20345932
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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S100a10
S100 calcium binding protein A10
increases expression
ISO
Phenytoin results in increased expression of S100A10 mRNA
CTD
PMID:14741686
NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
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S100a4
S100 calcium-binding protein A4
increases expression
ISO
Phenytoin results in increased expression of S100A4 mRNA
CTD
PMID:14741686
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA
CTD
PMID:23986454
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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S100a9
S100 calcium binding protein A9
multiple interactions increases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA Phenytoin results in increased expression of S100A9 mRNA
CTD
PMID:23986454
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Sart3
spliceosome associated factor 3, U4/U6 recycling protein
increases expression
EXP
Phenytoin results in increased expression of SART3 mRNA
CTD
PMID:20345932
NCBI chr12:42,859,026...42,887,041
Ensembl chr12:42,859,305...42,887,038
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Sc5d
sterol-C5-desaturase
increases expression
ISO
Phenytoin results in increased expression of SC5D mRNA
CTD
PMID:14741686
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Scaf1
SR-related CTD-associated factor 1
increases expression
EXP
Phenytoin results in increased expression of SCAF1 mRNA
CTD
PMID:20345932
NCBI chr 1:95,485,448...95,499,389
Ensembl chr 1:95,485,448...95,496,029
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Scarb1
scavenger receptor class B, member 1
decreases expression
ISO
Phenytoin results in decreased expression of SCARB1 mRNA
CTD
PMID:15136057
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Scn1a
sodium voltage-gated channel alpha subunit 1
affects response to substance
ISO
SCN1A gene polymorphism affects the susceptibility to Phenytoin; SCN1A protein affects the susceptibility to Phenytoin
CTD
PMID:15805193 PMID:17001291
NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699
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Scn1b
sodium voltage-gated channel beta subunit 1
affects binding multiple interactions decreases response to substance
ISO
Phenytoin binds to [SCN1B protein binds to SCN3A protein] Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein] SCN1B protein mutant form results in decreased susceptibility to Phenytoin
CTD
PMID:15922564
NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
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Scn2a
sodium voltage-gated channel alpha subunit 2
decreases activity
ISO
Phenytoin results in decreased activity of SCN2A protein
CTD
PMID:11212204
NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
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Scn3a
sodium voltage-gated channel alpha subunit 3
multiple interactions affects binding
ISO
Phenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein] Phenytoin binds to [SCN1B protein binds to SCN3A protein]
CTD
PMID:15922564
NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
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Sdc4
syndecan 4
decreases expression
ISO
Phenytoin results in decreased expression of SDC4 mRNA
CTD
PMID:15136057
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
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Sele
selectin E
multiple interactions
ISO
[clobazam co-treated with Phenytoin] results in increased expression of SELE protein
CTD
PMID:16376047
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Senp7
SUMO specific peptidase 7
increases expression
EXP
Phenytoin results in increased expression of SENP7 mRNA
CTD
PMID:20345932
NCBI chr11:44,423,733...44,584,129
Ensembl chr11:44,423,735...44,564,711
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Serpinc1
serpin family C member 1
multiple interactions
ISO
[clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein]
CTD
PMID:16376047
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA
CTD
PMID:21224054
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sh3yl1
SH3 and SYLF domain containing 1
increases expression
EXP
Phenytoin results in increased expression of SH3YL1 mRNA
CTD
PMID:20345932
NCBI chr 6:47,522,098...47,565,858
Ensembl chr 6:47,522,091...47,565,858
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Shh
sonic hedgehog signaling molecule
increases expression
ISO
Phenytoin results in increased expression of SHH mRNA
CTD
PMID:26272751
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Siah1
siah E3 ubiquitin protein ligase 1
increases expression
EXP
Phenytoin results in increased expression of SIAH1A mRNA
CTD
PMID:20345932
NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808
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Sipa1l1
signal-induced proliferation-associated 1 like 1
increases expression
EXP
Phenytoin results in increased expression of SIPA1L1 mRNA
CTD
PMID:20345932
NCBI chr 6:101,839,351...102,118,408
Ensembl chr 6:101,839,404...102,116,950
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Slc22a7
solute carrier family 22 member 7
decreases expression
EXP
Phenytoin results in decreased expression of SLC22A7 mRNA
CTD
PMID:17381134
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc4a3
solute carrier family 4 member 3
increases expression
EXP
Phenytoin results in increased expression of SLC4A3 mRNA
CTD
PMID:20345932
NCBI chr 9:77,036,243...77,053,940
Ensembl chr 9:77,037,016...77,049,105
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Smarca1
SNF2 related chromatin remodeling ATPase 1
increases expression
EXP
Phenytoin results in increased expression of SMARCA1 mRNA
CTD
PMID:20345932
NCBI chr X:126,980,201...127,066,385
Ensembl chr X:126,994,947...127,066,347
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Smarca5
SNF2 related chromatin remodeling ATPase 5
increases expression
EXP
Phenytoin results in increased expression of SMARCA5 mRNA
CTD
PMID:20345932
NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594
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Smc2
structural maintenance of chromosomes 2
increases expression
EXP
Phenytoin results in increased expression of SMC2 mRNA
CTD
PMID:20345932
NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
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Smc3
structural maintenance of chromosomes 3
increases expression
ISO
Phenytoin results in increased expression of SMC3 mRNA
CTD
PMID:14741686
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Smc5
structural maintenance of chromosomes 5
increases expression
EXP
Phenytoin results in increased expression of SMC5 mRNA
CTD
PMID:20345932
NCBI chr 1:220,769,366...220,839,138
Ensembl chr 1:220,769,366...220,839,096
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Snx2
sorting nexin 2
increases expression
EXP
Phenytoin results in increased expression of SNX2 mRNA
CTD
PMID:20345932
NCBI chr18:46,602,223...46,643,870
Ensembl chr18:46,602,284...46,643,865
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Sp3
Sp3 transcription factor
increases expression
ISO
Phenytoin results in increased expression of SP3 mRNA
CTD
PMID:14741686
NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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St13
ST13, Hsp70 interacting protein
increases expression
EXP
Phenytoin results in increased expression of ST13 mRNA
CTD
PMID:17381134
NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
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Stat4
signal transducer and activator of transcription 4
decreases expression
ISO
Phenytoin results in decreased expression of STAT4 mRNA
CTD
PMID:14741686
NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
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Sult1a1
sulfotransferase family 1A member 1
decreases expression
EXP
Phenytoin results in decreased expression of SULT1A1 mRNA
CTD
PMID:9566755 PMID:17381134
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Sult2a1
sulfotransferase family 2A member 1
decreases expression
EXP
Phenytoin results in decreased expression of SULT2A1 mRNA
CTD
PMID:9566755
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Syn1
synapsin I
multiple interactions decreases expression
ISO
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYN1 mRNA]
CTD
PMID:27413119
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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Syp
synaptophysin
multiple interactions decreases expression
ISO
Thyroxine inhibits the reaction [Phenytoin results in decreased expression of SYP mRNA]
CTD
PMID:27413119
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Sypl1
synaptophysin-like 1
increases expression
EXP
Phenytoin results in increased expression of SYPL1 mRNA
CTD
PMID:20345932
NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330
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Taf9b
TATA-box binding protein associated factor 9b
increases expression
EXP
Phenytoin results in increased expression of TAF9B mRNA
CTD
PMID:20345932
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
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Tbx21
T-box transcription factor 21
multiple interactions decreases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA Phenytoin results in decreased expression of TBX21 mRNA
CTD
PMID:23986454
NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
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Tceal1
transcription elongation factor A like 1
increases expression
EXP
Phenytoin results in increased expression of TCEAL1 mRNA
CTD
PMID:20345932
NCBI chr X:100,058,485...100,060,439
Ensembl chr X:100,058,132...100,060,551
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Tcf15
transcription factor 15
decreases expression
ISO
Phenytoin results in decreased expression of TCF15 mRNA
CTD
PMID:31711903
NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
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Terf1
telomeric repeat binding factor 1
increases expression
EXP
Phenytoin results in increased expression of TERF1 mRNA
CTD
PMID:20345932
NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
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Tgfa
transforming growth factor alpha
increases expression
ISO
Phenytoin results in increased expression of TGFA mRNA
CTD
PMID:9988880
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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Tgfb1
transforming growth factor, beta 1
increases expression decreases expression
ISO
Phenytoin results in increased expression of TGFB1 mRNA Phenytoin results in decreased expression of TGFB1 mRNA
CTD
PMID:7841657 PMID:9988880 PMID:16141649
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfb2
transforming growth factor, beta 2
decreases expression
ISO
Phenytoin results in decreased expression of TGFB2 mRNA
CTD
PMID:9118846
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tgfb3
transforming growth factor, beta 3
increases expression
ISO
Phenytoin results in increased expression of TGFB3 mRNA
CTD
PMID:14741686
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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Thoc6
THO complex subunit 6
decreases expression
EXP
Phenytoin results in decreased expression of THOC6 mRNA
CTD
PMID:20345932
NCBI chr10:12,700,051...12,705,411
Ensembl chr10:12,700,051...12,706,925
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
Phenytoin results in increased expression of TIMP1 mRNA; Phenytoin results in increased expression of TIMP1 protein
CTD
PMID:10914799 PMID:14741686 PMID:15948689
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tkt
transketolase
increases expression
EXP
Phenytoin results in increased expression of TKT mRNA
CTD
PMID:17381134
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Tlr2
toll-like receptor 2
multiple interactions increases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA Phenytoin results in increased expression of TLR2 mRNA
CTD
PMID:23986454
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
multiple interactions decreases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA Phenytoin results in decreased expression of TLR4 mRNA
CTD
PMID:23986454
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr9
toll-like receptor 9
multiple interactions decreases expression
ISO
[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA Phenytoin results in decreased expression of TLR9 mRNA
CTD
PMID:23986454
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnf
tumor necrosis factor
increases expression
ISO
Phenytoin results in increased expression of TNF mRNA
CTD
PMID:14741686
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA
CTD
PMID:21224054
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tp53
tumor protein p53
increases expression
ISO
Phenytoin results in increased expression of TP53 mRNA
CTD
PMID:11134551
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53bp2
tumor protein p53 binding protein, 2
increases expression
EXP
Phenytoin results in increased expression of TRP53BP2 mRNA
CTD
PMID:20345932
NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432
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Tradd
TNFRSF1A-associated via death domain
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA
CTD
PMID:21224054
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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Trmt10b
tRNA methyltransferase 10B
increases expression
EXP
Phenytoin results in increased expression of TRMT10B mRNA
CTD
PMID:20345932
NCBI chr 5:59,548,845...59,572,529
Ensembl chr 5:59,548,869...59,572,526
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Tut4
terminal uridylyl transferase 4
increases expression
EXP
Phenytoin results in increased expression of TUT4 mRNA
CTD
PMID:20345932
NCBI chr 5:123,201,723...123,306,582
Ensembl chr 5:123,203,003...123,306,465
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Txnrd1
thioredoxin reductase 1
increases expression
EXP
Phenytoin results in increased expression of TXNRD1 mRNA
CTD
PMID:17381134
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ube2d2
ubiquitin-conjugating enzyme E2D 2
increases expression
EXP
Phenytoin results in increased expression of UBE2D2 mRNA
CTD
PMID:20345932
NCBI chr18:27,364,325...27,406,322
Ensembl chr18:27,364,303...27,406,181
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Ubl5
ubiquitin-like 5
decreases expression
EXP
Phenytoin results in decreased expression of UBL5 mRNA
CTD
PMID:20345932
NCBI chr 8:19,181,504...19,185,224
Ensembl chr 8:19,181,615...19,185,217
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Ubr1
ubiquitin protein ligase E3 component n-recognin 1
increases expression
EXP
Phenytoin results in increased expression of UBR1 mRNA
CTD
PMID:20345932
NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204
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Ugdh
UDP-glucose 6-dehydrogenase
decreases expression
EXP
Phenytoin results in decreased expression of UGDH mRNA
CTD
PMID:17381134
NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
affects expression increases expression multiple interactions increases activity
ISO EXP
Phenytoin affects the expression of UGT1A1 mRNA Phenytoin results in increased expression of UGT1A1 mRNA; Phenytoin results in increased expression of UGT1A1 protein Phenytoin results in increased expression of and results in increased activity of UGT1A1 protein Phenytoin results in increased activity of UGT1A1 protein
CTD
PMID:10421657 PMID:15849716 PMID:17381134 PMID:27413119
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression
EXP
Phenytoin results in increased expression of UGT1A6 mRNA
CTD
PMID:17381134
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Phenytoin results in increased expression of UGT2B1 mRNA
CTD
PMID:17381134
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Uncx
UNC homeobox
decreases expression
ISO
Phenytoin results in decreased expression of UNCX mRNA
CTD
PMID:31711903
NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
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Ung
uracil-DNA glycosylase
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA
CTD
PMID:21224054
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Vars2
valyl-tRNA synthetase 2, mitochondrial
increases expression
EXP
Phenytoin results in increased expression of VARS2 mRNA
CTD
PMID:20345932
NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994
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Vcan
versican
increases expression
ISO
Phenytoin results in increased expression of VCAN mRNA
CTD
PMID:14741686
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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Vegfb
vascular endothelial growth factor B
decreases expression
ISO
Phenytoin results in decreased expression of VEGFB mRNA
CTD
PMID:14741686
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Vim
vimentin
increases expression
ISO
Phenytoin results in increased expression of VIM mRNA
CTD
PMID:14741686
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Wnt1
Wnt family member 1
decreases expression
ISO
Phenytoin results in decreased expression of WNT1 mRNA
CTD
PMID:7841657
NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
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Wnt3
Wnt family member 3
decreases expression
ISO
Phenytoin results in decreased expression of WNT3 mRNA
CTD
PMID:26272751
NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
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Wnt5a
Wnt family member 5A
increases expression
ISO
Phenytoin results in increased expression of WNT5A mRNA
CTD
PMID:31711903
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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Xrcc4
X-ray repair cross complementing 4
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA
CTD
PMID:21224054
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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Yme1l1
YME1-like 1 ATPase
increases expression
EXP
Phenytoin results in increased expression of YME1L1 mRNA
CTD
PMID:20345932
NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335
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Zap70
zeta chain of T cell receptor associated protein kinase 70
decreases expression
ISO
Phenytoin results in decreased expression of ZAP70 mRNA
CTD
PMID:15136057
NCBI chr 9:38,989,750...39,011,701
Ensembl chr 9:38,989,750...39,011,700
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Zfp131
zinc finger protein 131
increases expression
EXP
Phenytoin results in increased expression of ZFP131 mRNA
CTD
PMID:20345932
NCBI chr 2:51,722,774...51,753,662
Ensembl chr 2:51,725,541...51,753,639
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Zfp503
zinc finger protein 503
increases expression
EXP
Phenytoin results in increased expression of ZFP503 mRNA
CTD
PMID:20345932
NCBI chr15:2,313,060...2,316,848
Ensembl chr15:2,313,060...2,316,848
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Zfp638
zinc finger protein 638
increases expression
EXP
Phenytoin results in increased expression of ZFP638 mRNA
CTD
PMID:20345932
NCBI chr 4:116,355,934...116,475,051
Ensembl chr 4:116,402,428...116,479,845
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Zscan21
zinc finger and SCAN domain containing 21
increases expression
EXP
Phenytoin results in increased expression of ZSCAN21 mRNA
CTD
PMID:20345932
NCBI chr12:16,998,496...17,024,167
Ensembl chr12:16,998,538...17,013,506
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