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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Morroniside
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Accession:CHEBI:80852 term browser browse the term
Definition:A glycoside that has formula C17H26O11.
Synonyms:related_synonym: Formula=C17H26O11;   InChI=1S/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1;   InChIKey=YTZSBJLNMIQROD-SFBCHFHNSA-N;   SMILES=COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]2[C@H](C)O[C@@H](O)C[C@H]12
 xref: CAS:25406-64-8;   KEGG:C17000
 xref_mesh: MESH:C488401



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Morroniside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 protein] CTD PMID:34485530 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 protein] CTD PMID:34485530 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases expression ISO morroniside results in decreased expression of ACP5 mRNA CTD PMID:34638983 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]
CTD PMID:35279615 PMID:35679793 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO morroniside results in increased expression of ADORA2A mRNA CTD PMID:35848187 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein] CTD PMID:32954801 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
EXP
ISO
morroniside inhibits the reaction [Glucose results in decreased expression of ALPL mRNA]
morroniside results in increased expression of ALPL mRNA
CTD PMID:32643284 PMID:34638983 PMID:35848187 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Ang angiogenin increases expression EXP morroniside results in increased expression of ANG protein CTD PMID:24979385 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Apoe apolipoprotein E multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of APOE protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE protein] CTD PMID:34485530 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Arg1 arginase 1 increases expression ISO morroniside results in increased expression of ARG1 mRNA CTD PMID:34867417 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asip agouti signaling protein multiple interactions ISO morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein] CTD PMID:37769864 NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
JBrowse link
G Atg13 autophagy related 13 multiple interactions
increases expression
ISO MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein] CTD PMID:35957534 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
EXP
ISO
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein]
morroniside affects the expression of BAX protein
CTD PMID:21963495 PMID:28106847 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; morroniside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
morroniside results in increased expression of BCL2 mRNA
CTD PMID:20966881 PMID:28106847 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO
EXP
MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]
morroniside inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]
CTD PMID:32954801 PMID:35957534 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein] CTD PMID:32643284 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
EXP
ISO
morroniside inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA]
morroniside results in increased expression of BMP2 mRNA
CTD PMID:32643284 PMID:35848187 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp1 caspase 1 affects expression
multiple interactions
ISO morroniside affects the expression of CASP1
morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]
CTD PMID:33022338 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
ISO
EXP
morroniside results in decreased expression of CASP3 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]
CTD PMID:20966881 PMID:28106847 PMID:32954801 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 decreases expression ISO morroniside results in decreased expression of CASP9 mRNA CTD PMID:20966881 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP morroniside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] CTD PMID:32954801 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 affects expression ISO morroniside affects the expression of CCL2 protein CTD PMID:21963495 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO morroniside results in increased expression of CCND1 mRNA CTD PMID:35848187 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO morroniside results in increased expression of CDKN1A mRNA CTD PMID:35848187 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:35679793 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] CTD PMID:35679793 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP morroniside results in increased expression of CTNNB1 protein CTD PMID:24876057 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsk cathepsin K decreases expression ISO morroniside results in decreased expression of CTSK mRNA CTD PMID:34638983 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyba cytochrome b-245 alpha chain affects expression ISO morroniside affects the expression of CYBA protein CTD PMID:21963495 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of FAS protein]
CTD PMID:37769864 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP morroniside results in increased expression of FGF2 protein CTD PMID:24979385 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
affects binding
EXP
ISO
morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]
morroniside binds to GATA3 protein
CTD PMID:35679793 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Glo1 glyoxalase 1 multiple interactions EXP morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 protein] CTD PMID:32643284 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Glp1r glucagon-like peptide 1 receptor affects response to substance ISO GLP1R affects the susceptibility to morroniside CTD PMID:28098360 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
affects expression
ISO morroniside promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; morroniside results in increased expression of and results in increased phosphorylation of HMOX1 protein
morroniside affects the expression of HMOX1 protein
CTD PMID:21963495 PMID:34029560 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 affects expression ISO morroniside affects the expression of ICAM1 protein CTD PMID:21963495 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
SB 203580 inhibits the reaction [morroniside results in increased expression of IL10 mRNA]
morroniside results in increased expression of IL10 mRNA; morroniside results in increased expression of IL10 protein
CTD PMID:32595037 PMID:34867417 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]]
morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:32643284 PMID:33022338 PMID:33804203 PMID:35279615 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases expression ISO morroniside results in increased expression of IL4 mRNA CTD PMID:34867417 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]] CTD PMID:32643284 PMID:35279615 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP morroniside results in increased expression of and results in increased phosphorylation of KDR protein CTD PMID:31991140 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lipa lipase A, lysosomal acid type multiple interactions EXP LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein] CTD PMID:35679793 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Ly96 lymphocyte antigen 96 affects binding ISO morroniside binds to [TLR4 protein binds to LY96 protein] CTD PMID:34029560 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP morroniside results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:31991140 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP morroniside results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:31991140 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein] CTD PMID:26836014 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
affects expression
ISO morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]
morroniside affects the expression of MMP13
CTD PMID:33022338 PMID:33804203 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:33804203 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO morroniside results in decreased expression of MMP9 mRNA CTD PMID:34638983 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression ISO morroniside results in increased expression of MRC1 mRNA CTD PMID:34867417 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO
EXP
MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein]; MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein]
morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein]
morroniside results in increased activity of MTOR protein
CTD PMID:32954801 PMID:35957534 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:34029560 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Neurog2 neurogenin 2 increases expression EXP morroniside results in increased expression of NEUROG2 protein CTD PMID:24876057 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 decreases expression ISO morroniside results in decreased expression of NFATC1 mRNA CTD PMID:34638983 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
affects expression
ISO morroniside promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein]; morroniside results in increased expression of and results in increased phosphorylation of NFE2L2 protein
morroniside affects the expression of NFE2L2 protein
CTD PMID:21963495 PMID:34029560 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
affects expression
ISO morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]
morroniside affects the expression of NLRP3
CTD PMID:33022338 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
decreases expression
ISO morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
morroniside affects the expression of NOS2 protein
morroniside results in decreased expression of NOS2 protein
CTD PMID:20487222 PMID:21963495 PMID:34029560 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox4 NADPH oxidase 4 affects expression ISO morroniside affects the expression of NOX4 protein CTD PMID:21963495 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein] CTD PMID:34485530 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nrp1 neuropilin 1 increases expression EXP morroniside results in increased expression of NRP1 protein CTD PMID:24979385 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Pax6 paired box 6 increases expression EXP morroniside results in increased expression of PAX6 protein CTD PMID:24876057 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO morroniside results in increased expression of PCNA mRNA CTD PMID:35848187 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pomc proopiomelanocortin increases expression EXP morroniside results in increased expression of POMC mRNA alternative form CTD PMID:32595037 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A protein] CTD PMID:34485530 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppme1 protein phosphatase methylesterase 1 multiple interactions ISO morroniside inhibits the reaction [Okadaic Acid results in increased expression of PPME1 protein] CTD PMID:26836014 NCBI chr 1:154,668,099...154,715,079
Ensembl chr 1:154,668,109...154,715,110
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] CTD PMID:26836014 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta multiple interactions ISO morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] CTD PMID:26836014 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP morroniside results in increased expression of and results in increased phosphorylation of PRKCD protein CTD PMID:31991140 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects expression
decreases expression
ISO morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
morroniside affects the expression of PTGS2 protein
morroniside results in decreased expression of PTGS2 protein
CTD PMID:20487222 PMID:21963495 PMID:33804203 PMID:34029560 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects expression
decreases expression
ISO
EXP
morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein]
morroniside inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]
morroniside affects the expression of RELA protein
morroniside results in decreased expression of RELA protein
CTD PMID:20487222 PMID:21963495 PMID:33804203 PMID:35279615 PMID:37769864 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
affects expression
increases expression
EXP
ISO
morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]
morroniside affects the expression of RUNX2 protein
morroniside results in increased expression of RUNX2 mRNA
CTD PMID:32643284 PMID:34638983 PMID:35848187 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of SCD protein]
CTD PMID:37769864 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO morroniside results in increased expression of SP7 mRNA CTD PMID:34638983 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression
multiple interactions
ISO
EXP
morroniside affects the expression of SPP1 protein
morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]
CTD PMID:32643284 PMID:35848187 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP morroniside inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein] CTD PMID:32954801 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP
ISO
morroniside results in increased expression of and results in increased phosphorylation of SRC protein
morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of and results in increased activity of SRC protein]
CTD PMID:26836014 PMID:31991140 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 affects expression
multiple interactions
ISO morroniside affects the expression of SREBF1 protein
morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]
morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]
CTD PMID:20487222 PMID:37769864 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 affects expression ISO morroniside affects the expression of SREBF2 protein CTD PMID:20487222 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein]
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein]
CTD PMID:35279615 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tcf7l2 transcription factor 7 like 2 increases expression EXP morroniside results in increased expression of TCF7L2 protein CTD PMID:24876057 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tek TEK receptor tyrosine kinase increases expression EXP morroniside results in increased expression of TEK protein CTD PMID:24979385 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA]
morroniside inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
CTD PMID:35279615 PMID:35679793 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
affects binding
ISO morroniside inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
morroniside binds to [TLR4 protein binds to LY96 protein]
CTD PMID:34029560 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]]
morroniside inhibits the reaction [Palmitic Acid results in increased expression of TNF protein]
morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:32643284 PMID:35279615 PMID:37769864 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO morroniside results in decreased expression of TNFSF11 mRNA CTD PMID:20966881 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP morroniside results in increased expression of VEGFA protein CTD PMID:24979385 PMID:31991140 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wnt3a Wnt family member 3A increases expression EXP morroniside results in increased expression of WNT3A protein CTD PMID:24876057 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          oxygen atom 19535
            oxygen molecular entity 19535
              organooxygen compound 19184
                carbohydrates and carbohydrate derivatives 15285
                  carbohydrate derivative 14300
                    glycosyl compound 13062
                      glycoside 11830
                        Morroniside 87
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      carbohydrate derivative 14300
                                        glycosyl compound 13062
                                          glycoside 11830
                                            Morroniside 87
paths to the root