|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCA1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCA1 protein] |
CTD |
PMID:34485530 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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|
G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
multiple interactions |
ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of ABCG1 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of ABCG1 protein] |
CTD |
PMID:34485530 |
|
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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|
G |
Acp5 |
acid phosphatase 5, tartrate resistant |
decreases expression |
ISO |
morroniside results in decreased expression of ACP5 mRNA |
CTD |
PMID:34638983 |
|
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP ISO |
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] |
CTD |
PMID:35279615 PMID:35679793 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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|
G |
Adora2a |
adenosine A2a receptor |
increases expression |
ISO |
morroniside results in increased expression of ADORA2A mRNA |
CTD |
PMID:35848187 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:32954801 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions increases expression |
EXP ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of ALPL mRNA] morroniside results in increased expression of ALPL mRNA |
CTD |
PMID:32643284 PMID:34638983 PMID:35848187 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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|
G |
Ang |
angiogenin |
increases expression |
EXP |
morroniside results in increased expression of ANG protein |
CTD |
PMID:24979385 |
|
NCBI chr15:24,312,711...24,323,361
|
|
G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of APOE protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of APOE protein] |
CTD |
PMID:34485530 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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|
G |
Arg1 |
arginase 1 |
increases expression |
ISO |
morroniside results in increased expression of ARG1 mRNA |
CTD |
PMID:34867417 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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|
G |
Asip |
agouti signaling protein |
multiple interactions |
ISO |
morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein]; morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein] |
CTD |
PMID:37769864 |
|
NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
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|
G |
Atg13 |
autophagy related 13 |
multiple interactions increases expression |
ISO |
MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein] |
CTD |
PMID:35957534 |
|
NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions affects expression |
EXP ISO |
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of BAX protein]; morroniside inhibits the reaction [Glucose results in increased expression of BAX protein] morroniside affects the expression of BAX protein |
CTD |
PMID:21963495 PMID:28106847 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
[morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; morroniside inhibits the reaction [Glucose results in decreased expression of BCL2 protein] morroniside results in increased expression of BCL2 mRNA |
CTD |
PMID:20966881 PMID:28106847 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO EXP |
MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein] morroniside inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein] |
CTD |
PMID:32954801 PMID:35957534 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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|
G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions |
EXP |
morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of BGLAP protein] |
CTD |
PMID:32643284 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
|
|
G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions increases expression |
EXP ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of BMP2 mRNA] morroniside results in increased expression of BMP2 mRNA |
CTD |
PMID:32643284 PMID:35848187 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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|
G |
Casp1 |
caspase 1 |
affects expression multiple interactions |
ISO |
morroniside affects the expression of CASP1 morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1] |
CTD |
PMID:33022338 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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|
G |
Casp3 |
caspase 3 |
decreases expression multiple interactions |
ISO EXP |
morroniside results in decreased expression of CASP3 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; [morroniside co-treated with Diosgenin] inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]] |
CTD |
PMID:20966881 PMID:28106847 PMID:32954801 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
morroniside results in decreased expression of CASP9 mRNA |
CTD |
PMID:20966881 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cat |
catalase |
multiple interactions |
EXP |
morroniside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] |
CTD |
PMID:32954801 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
affects expression |
ISO |
morroniside affects the expression of CCL2 protein |
CTD |
PMID:21963495 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
morroniside results in increased expression of CCND1 mRNA |
CTD |
PMID:35848187 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
morroniside results in increased expression of CDKN1A mRNA |
CTD |
PMID:35848187 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:35679793 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] |
CTD |
PMID:35679793 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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|
G |
Ctnnb1 |
catenin beta 1 |
increases expression |
EXP |
morroniside results in increased expression of CTNNB1 protein |
CTD |
PMID:24876057 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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|
G |
Ctsk |
cathepsin K |
decreases expression |
ISO |
morroniside results in decreased expression of CTSK mRNA |
CTD |
PMID:34638983 |
|
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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|
G |
Cyba |
cytochrome b-245 alpha chain |
affects expression |
ISO |
morroniside affects the expression of CYBA protein |
CTD |
PMID:21963495 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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|
G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
morroniside inhibits the reaction [A mutant form results in increased expression of FAS protein] morroniside inhibits the reaction [Palmitic Acid results in increased expression of FAS protein] |
CTD |
PMID:37769864 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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|
G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
EXP |
morroniside results in increased expression of FGF2 protein |
CTD |
PMID:24979385 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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|
G |
Gata3 |
GATA binding protein 3 |
multiple interactions affects binding |
EXP ISO |
morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA] morroniside binds to GATA3 protein |
CTD |
PMID:35679793 |
|
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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|
G |
Glo1 |
glyoxalase 1 |
multiple interactions |
EXP |
morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of GLO1 protein] |
CTD |
PMID:32643284 |
|
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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|
G |
Glp1r |
glucagon-like peptide 1 receptor |
affects response to substance |
ISO |
GLP1R affects the susceptibility to morroniside |
CTD |
PMID:28098360 |
|
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions affects expression |
ISO |
morroniside promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; morroniside results in increased expression of and results in increased phosphorylation of HMOX1 protein morroniside affects the expression of HMOX1 protein |
CTD |
PMID:21963495 PMID:34029560 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
affects expression |
ISO |
morroniside affects the expression of ICAM1 protein |
CTD |
PMID:21963495 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
ISO EXP |
SB 203580 inhibits the reaction [morroniside results in increased expression of IL10 mRNA] morroniside results in increased expression of IL10 mRNA; morroniside results in increased expression of IL10 protein |
CTD |
PMID:32595037 PMID:34867417 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL1B protein]] morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; morroniside inhibits the reaction [IL1B protein results in increased expression of CASP1]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] |
CTD |
PMID:32643284 PMID:33022338 PMID:33804203 PMID:35279615 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il4 |
interleukin 4 |
increases expression |
ISO |
morroniside results in increased expression of IL4 mRNA |
CTD |
PMID:34867417 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of IL6 protein]] |
CTD |
PMID:32643284 PMID:35279615 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Kdr |
kinase insert domain receptor |
multiple interactions |
EXP |
morroniside results in increased expression of and results in increased phosphorylation of KDR protein |
CTD |
PMID:31991140 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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|
G |
Lipa |
lipase A, lysosomal acid type |
multiple interactions |
EXP |
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein] |
CTD |
PMID:35679793 |
|
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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|
G |
Ly96 |
lymphocyte antigen 96 |
affects binding |
ISO |
morroniside binds to [TLR4 protein binds to LY96 protein] |
CTD |
PMID:34029560 |
|
NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
morroniside results in increased expression of and results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:31991140 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
morroniside results in increased expression of and results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:31991140 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of MAPT protein] |
CTD |
PMID:26836014 |
|
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions affects expression |
ISO |
morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP13] morroniside affects the expression of MMP13 |
CTD |
PMID:33022338 PMID:33804203 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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|
G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
ISO |
morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:33804203 |
|
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
morroniside results in decreased expression of MMP9 mRNA |
CTD |
PMID:34638983 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Mrc1 |
mannose receptor, C type 1 |
increases expression |
ISO |
morroniside results in increased expression of MRC1 mRNA |
CTD |
PMID:34867417 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions increases activity |
ISO EXP |
MTOR inhibits the reaction [morroniside results in increased expression of ATG13 protein]; MTOR inhibits the reaction [morroniside results in increased expression of BECN1 protein] morroniside inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein] morroniside results in increased activity of MTOR protein |
CTD |
PMID:32954801 PMID:35957534 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] |
CTD |
PMID:34029560 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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|
G |
Neurog2 |
neurogenin 2 |
increases expression |
EXP |
morroniside results in increased expression of NEUROG2 protein |
CTD |
PMID:24876057 |
|
NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
|
|
G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
decreases expression |
ISO |
morroniside results in decreased expression of NFATC1 mRNA |
CTD |
PMID:34638983 |
|
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects expression |
ISO |
morroniside promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein]; morroniside results in increased expression of and results in increased phosphorylation of NFE2L2 protein morroniside affects the expression of NFE2L2 protein |
CTD |
PMID:21963495 PMID:34029560 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions affects expression |
ISO |
morroniside inhibits the reaction [IL1B protein results in increased expression of NLRP3] morroniside affects the expression of NLRP3 |
CTD |
PMID:33022338 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions affects expression decreases expression |
ISO |
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] morroniside affects the expression of NOS2 protein morroniside results in decreased expression of NOS2 protein |
CTD |
PMID:20487222 PMID:21963495 PMID:34029560 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nox4 |
NADPH oxidase 4 |
affects expression |
ISO |
morroniside affects the expression of NOX4 protein |
CTD |
PMID:21963495 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
multiple interactions |
ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of NR1H2 protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein] |
CTD |
PMID:34485530 |
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NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
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G |
Nrp1 |
neuropilin 1 |
increases expression |
EXP |
morroniside results in increased expression of NRP1 protein |
CTD |
PMID:24979385 |
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NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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G |
Pax6 |
paired box 6 |
increases expression |
EXP |
morroniside results in increased expression of PAX6 protein |
CTD |
PMID:24876057 |
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NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
ISO |
morroniside results in increased expression of PCNA mRNA |
CTD |
PMID:35848187 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pomc |
proopiomelanocortin |
increases expression |
EXP |
morroniside results in increased expression of POMC mRNA alternative form |
CTD |
PMID:32595037 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Palmitic Acid results in decreased expression of PPARGC1A protein] |
CTD |
PMID:34485530 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppme1 |
protein phosphatase methylesterase 1 |
multiple interactions |
ISO |
morroniside inhibits the reaction [Okadaic Acid results in increased expression of PPME1 protein] |
CTD |
PMID:26836014 |
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NCBI chr 1:154,668,099...154,715,079
Ensembl chr 1:154,668,109...154,715,110
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions |
ISO |
morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] |
CTD |
PMID:26836014 |
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NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
multiple interactions |
ISO |
morroniside inhibits the reaction [Okadaic Acid results in decreased methylation of and results in increased phosphorylation of and results in decreased activity of [PPP2CA protein binds to PPP2CB protein]]; morroniside results in increased activity of [PPP2CA protein binds to PPP2CB protein] |
CTD |
PMID:26836014 |
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NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
morroniside results in increased expression of and results in increased phosphorylation of PRKCD protein |
CTD |
PMID:31991140 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions affects expression decreases expression |
ISO |
morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] morroniside affects the expression of PTGS2 protein morroniside results in decreased expression of PTGS2 protein |
CTD |
PMID:20487222 PMID:21963495 PMID:33804203 PMID:34029560 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects expression decreases expression |
ISO EXP |
morroniside inhibits the reaction [A mutant form results in increased phosphorylation of RELA protein]; morroniside inhibits the reaction [IL1B protein results in increased expression of RELA protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein] morroniside inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein] morroniside affects the expression of RELA protein morroniside results in decreased expression of RELA protein |
CTD |
PMID:20487222 PMID:21963495 PMID:33804203 PMID:35279615 PMID:37769864 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions affects expression increases expression |
EXP ISO |
morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of RUNX2 protein] morroniside affects the expression of RUNX2 protein morroniside results in increased expression of RUNX2 mRNA |
CTD |
PMID:32643284 PMID:34638983 PMID:35848187 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
morroniside inhibits the reaction [A mutant form results in increased expression of SCD1 protein] morroniside inhibits the reaction [Palmitic Acid results in increased expression of SCD protein] |
CTD |
PMID:37769864 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Sp7 |
Sp7 transcription factor |
increases expression |
ISO |
morroniside results in increased expression of SP7 mRNA |
CTD |
PMID:34638983 |
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NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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G |
Spp1 |
secreted phosphoprotein 1 |
affects expression multiple interactions |
ISO EXP |
morroniside affects the expression of SPP1 protein morroniside inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA] |
CTD |
PMID:32643284 PMID:35848187 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
morroniside inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein] |
CTD |
PMID:32954801 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
EXP ISO |
morroniside results in increased expression of and results in increased phosphorylation of SRC protein morroniside inhibits the reaction [Okadaic Acid results in increased phosphorylation of and results in increased activity of SRC protein] |
CTD |
PMID:26836014 PMID:31991140 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
affects expression multiple interactions |
ISO |
morroniside affects the expression of SREBF1 protein morroniside inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein] morroniside inhibits the reaction [A mutant form results in increased expression of SREBF1 protein] |
CTD |
PMID:20487222 PMID:37769864 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
affects expression |
ISO |
morroniside affects the expression of SREBF2 protein |
CTD |
PMID:20487222 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO EXP |
morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein] morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein] |
CTD |
PMID:35279615 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tcf7l2 |
transcription factor 7 like 2 |
increases expression |
EXP |
morroniside results in increased expression of TCF7L2 protein |
CTD |
PMID:24876057 |
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NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
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G |
Tek |
TEK receptor tyrosine kinase |
increases expression |
EXP |
morroniside results in increased expression of TEK protein |
CTD |
PMID:24979385 |
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NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; LIPA affects the reaction [morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA mRNA]; morroniside inhibits the reaction [TGFB1 protein results in decreased expression of LIPA protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; morroniside inhibits the reaction [TGFB1 protein results in increased expression of GATA3 mRNA] morroniside inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] |
CTD |
PMID:35279615 PMID:35679793 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions affects binding |
ISO |
morroniside inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] morroniside binds to [TLR4 protein binds to LY96 protein] |
CTD |
PMID:34029560 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; S-4-bromobenzylglutathione cyclopentyl diester inhibits the reaction [morroniside inhibits the reaction [Glucose results in increased secretion of TNF protein]] morroniside inhibits the reaction [Palmitic Acid results in increased expression of TNF protein] morroniside inhibits the reaction [A mutant form results in increased expression of TNF protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] |
CTD |
PMID:32643284 PMID:35279615 PMID:37769864 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf11 |
TNF superfamily member 11 |
decreases expression |
ISO |
morroniside results in decreased expression of TNFSF11 mRNA |
CTD |
PMID:20966881 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
EXP |
morroniside results in increased expression of VEGFA protein |
CTD |
PMID:24979385 PMID:31991140 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Wnt3a |
Wnt family member 3A |
increases expression |
EXP |
morroniside results in increased expression of WNT3A protein |
CTD |
PMID:24876057 |
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NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324
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