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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:liquiritin
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Accession:CHEBI:80845 term browser browse the term
Definition:A flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage.
Synonyms:exact_synonym: 4-[(2S)-7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl]phenyl beta-D-glucopyranoside
 related_synonym: 4',7-dihydroxyflavanone 4'-(beta-D-glucopyranoside);   4'-O-beta-D-glucopyranosyl-7-hydroxyflavan-4-one;   7-hydroxyflavanone 4'-O-beta-D-glucoside;   7-hydroxyflavanone 4'-O-glucoside;   Formula=C21H22O9;   InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1;   InChIKey=DEMKZLAVQYISIA-ZRWXNEIDSA-N;   SMILES=OC[C@H]1O[C@@H](Oc2ccc(cc2)[C@@H]2CC(=O)c3ccc(O)cc3O2)[C@H](O)[C@@H](O)[C@@H]1O;   likviritin;   liquiritigenin 4'-O-beta-D-glucopyranoside;   liquiritigenin-4'-beta-D-glucoside;   liquiritoside
 xref: AGR:IND606831444;   CAS:551-15-5;   HMDB:HMDB0029520;   KEGG:C16989;   KNApSAcK:C00008193;   LIPID_MAPS_instance:LMPK12140021
 xref_mesh: MESH:C512196
 xref: MetaCyc:CPD-21623;   PMID:13829014;   PMID:25744461;   PMID:25746576;   PMID:25993793;   PMID:27892811;   PMID:29455337;   PMID:29545865;   PMID:30785275;   PMID:31083444;   PMID:31773731;   PMID:31956937;   PMID:32281178;   PMID:32322472;   PMID:32388008;   PMID:32390832;   Reaxys:61653;   Wikipedia:Liquiritin


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liquiritin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA CTD PMID:36008890 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in decreased expression of ABCC2 mRNA CTD PMID:36008890 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 mRNA CTD PMID:36008890 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA CTD PMID:36008890 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]		 CTD PMID:31589899 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein CTD PMID:21800547 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 EXP liquiritin results in increased expression of GCLC protein
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]		 CTD PMID:29908794 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
liquiritin results in increased expression of GCLM protein		 CTD PMID:29908794 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]		 CTD PMID:31589899 PMID:36008890 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] CTD PMID:29908794 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 mRNA; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 protein]		 CTD PMID:29908794 PMID:36008890 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]		 CTD PMID:31589899 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein] CTD PMID:36008890 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]		 CTD PMID:31589899 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein] CTD PMID:36008890 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] CTD PMID:29908794 PMID:31589899 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] CTD PMID:31589899 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance
multiple interactions		 ISO
EXP		 NFE2L2 gene mutant form results in decreased susceptibility to liquiritin
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
liquiritin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NFE2L2 protein]		 CTD PMID:29908794 PMID:36008890 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]		 CTD PMID:31589899 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 mRNA		 CTD PMID:29908794 PMID:36008890 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein] CTD PMID:36008890 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]		 CTD PMID:31589899 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein] CTD PMID:36008890 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:36008890 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein] CTD PMID:29908794 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] CTD PMID:31589899 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein] CTD PMID:36008890 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein] CTD PMID:29908794 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions EXP liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein] CTD PMID:29908794 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
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  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          liquiritin 29
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  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      monosaccharide 4877
                                        aldose 3232
                                          aldohexose 2884
                                            glucose 2837
                                              D-glucose 2835
                                                D-glucopyranose 1813
                                                  beta-D-glucose 1663
                                                    beta-D-glucoside 1471
                                                      liquiritin 29
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