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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phentermine
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Accession:CHEBI:8080 term browser browse the term
Definition:A primary amine that has formula C10H15N.
Synonyms:exact_synonym: 2-methyl-1-phenylpropan-2-amine
 related_synonym: Formula=C10H15N;   InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3;   InChIKey=DHHVAGZRUROJKS-UHFFFAOYSA-N;   SMILES=CC(C)(N)Cc1ccccc1;   alpha,alpha-Dimethylphenethylamine;   fentermina;   phenterminum
 xref: Beilstein:0970319;   CAS:122-09-8;   DrugBank:DB00191;   Drug_Central:2140;   KEGG:C07438;   KEGG:D05458;   LINCS:LSM-4174
 xref_mesh: MESH:D010645
 xref: Patent:US2408345;   Patent:US2590079;   Wikipedia:Phentermine
 cyclic_relationship: is_conjugate_base_of CHEBI:50508


show annotations for term's descendants           Sort by:
phentermine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased phosphorylation of AKT1 protein] CTD PMID:26887589 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Phentermine results in decreased expression of CCL2 mRNA CTD PMID:36687627 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ffar4 free fatty acid receptor 4 increases expression ISO Phentermine results in increased expression of FFAR4 mRNA CTD PMID:36687627 NCBI chr 1:235,873,576...235,891,597
Ensembl chr 1:235,873,576...235,891,597 		JBrowse link
G Il13 interleukin 13 increases expression ISO Phentermine results in increased expression of IL13 mRNA CTD PMID:36687627 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Phentermine results in decreased expression of IL6 mRNA CTD PMID:36687627 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased expression of SLC6A3 protein] CTD PMID:26887589 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            central nervous system drug 16773
              phentermine 6
                phentermine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        primary amino compound 9347
                                          primary amine 6362
                                            phentermine 6
                                              phentermine hydrochloride 0
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