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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:afzelin
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Accession:CHEBI:80790 term browser browse the term
Definition:A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside
 related_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-ol;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl alpha-L-rhamnoside;   Formula=C21H20O10;   InChI=1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1;   InChIKey=SOSLMHZOJATCCP-AEIZVZFYSA-N;   Kaempferin;   Kaempferol 3-O-alpha-L-rhamnopyranoside;   SMILES=C1=C(C=C(C2=C1OC(=C(C2=O)O[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)C4=CC=C(C=C4)O)O)O;   kaempferol 3-O-alpha-L-rhamnoside;   kaempferol-3-rhamnoside;   kaempherol 3-O-alpha-rhamnoside
 alt_id: CHEBI:145298
 xref: CAS:482-39-3;   KEGG:C16911;   KNApSAcK:C00005140;   LIPID_MAPS_instance:LMPK12111842
 xref_mesh: MESH:C477954
 xref: PDBeChem:AFE;   PMID:23626759;   PMID:24423008;   PMID:24642906;   PMID:27287415;   PMID:27861739;   PMID:27992083;   PMID:29497935;   PMID:29715535;   PMID:29967287;   PMID:30080245;   PMID:30450965;   PMID:30990334;   PMID:31017255;   PMID:31323310;   PMID:31384828;   PMID:31401185;   Reaxys:1359648;   Wikipedia:Afzelin
 cyclic_relationship: is_conjugate_acid_of CHEBI:144433


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afzelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mitf melanocyte inducing transcription factor increases expression ISO afzelin results in increased expression of MITF mRNA; afzelin results in increased expression of MITF protein CTD PMID:27287415 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790 		JBrowse link
G Tyr tyrosinase multiple interactions
increases expression 		ISO afzelin results in increased expression of and results in increased activity of TYR protein
afzelin results in increased expression of TYR mRNA 		CTD PMID:27287415 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO afzelin results in increased expression of TYRP1 mRNA; afzelin results in increased expression of TYRP1 protein CTD PMID:27287415 NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          afzelin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  oxacycle 18300
                                    benzopyran 12186
                                      1-benzopyran 11917
                                        flavonoid 7550
                                          anthoxanthin 4621
                                            flavones 4621
                                              hydroxyflavone 4598
                                                flavonols 4464
                                                  7-hydroxyflavonol 4430
                                                    kaempferol 210
                                                      afzelin 3
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