Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Phenoxybenzamine
go back to main search page
Accession:CHEBI:8077 term browser browse the term
Definition:An aromatic amine that has formula C18H22ClNO.
Synonyms:related_synonym: Formula=C18H22ClNO;   InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3;   InChIKey=QZVCTJOXCFMACW-UHFFFAOYSA-N;   SMILES=CC(COc1ccccc1)N(CCCl)Cc1ccccc1;   dibenylin;   dibenyline;   dibenzyline;   phenoxybenzamine HCl;   phenoxybenzamine hydrochloride
 xref: CAS:59-96-1;   Drug_Central:2136;   HMDB:HMDB0015061;   KEGG:C07435;   KEGG:D08358;   LINCS:LSM-1729
 xref_mesh: MESH:D010643


show annotations for term's descendants           Sort by:
Phenoxybenzamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Phenoxybenzamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions EXP [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein] CTD PMID:10416824 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions EXP Phenoxybenzamine binds to and results in decreased activity of ADRB1 protein CTD PMID:11886792 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Phenoxybenzamine results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity EXP Phenoxybenzamine affects the activity of CALCA protein CTD PMID:7906887 PMID:8058111 PMID:10075105 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ereg epiregulin decreases expression ISO Phenoxybenzamine results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Phenoxybenzamine results in increased expression of FOS protein CTD PMID:22236039 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions
decreases expression		 EXP Phenoxybenzamine inhibits the reaction [[Estrogens co-treated with Progesterone] results in increased expression of GAL mRNA]
Phenoxybenzamine results in decreased expression of GAL mRNA		 CTD PMID:7512492 PMID:7537244 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Phenoxybenzamine results in increased expression of GFAP protein CTD PMID:17845906 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 decreases secretion EXP Phenoxybenzamine results in decreased secretion of GNRH1 protein CTD PMID:17845906 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Phenoxybenzamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Phenoxybenzamine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein] CTD PMID:8627522 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Phenoxybenzamine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Phenoxybenzamine results in decreased secretion of and results in decreased expression of LHB protein CTD PMID:3953791 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Phenoxybenzamine results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 affects localization
decreases expression		 EXP Phenoxybenzamine affects the localization of NCAM1 protein modified form
Phenoxybenzamine results in decreased expression of NCAM1 protein modified form		 CTD PMID:17845906 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Phenoxybenzamine results in increased activity of NR1I2 protein
[Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:31312845 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Phenoxybenzamine binds to and results in increased activity of NR1I3 protein alternative form; Phenoxybenzamine inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein] CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Phenoxybenzamine results in decreased activity of NR3C1 protein CTD PMID:7887964 PMID:8838141 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Phenoxybenzamine inhibits the reaction [Ethanol results in increased secretion of POMC protein] CTD PMID:22236039 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity		 ISO Phenoxybenzamine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A1 protein		 CTD PMID:12110607 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
Phenoxybenzamine results in decreased activity of SLC22A2 protein		 CTD PMID:12110607 PMID:18728938 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions		 ISO Phenoxybenzamine results in decreased activity of SLC22A3 protein
Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:12110607 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 decreases expression EXP Phenoxybenzamine results in decreased expression of ST8SIA4 mRNA CTD PMID:17845906 NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          ammonia 17865
            organic amino compound 17865
              aromatic amine 15478
                Phenoxybenzamine 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          Phenoxybenzamine 28
paths to the root