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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isosilybin
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Accession:CHEBI:80744 term browser browse the term
Definition:A flavonolignan isolated from Silybum marianum.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-1-benzopyran-4-one
 related_synonym: Formula=C25H22O10;   InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1;   InChIKey=FDQAOULAVFHKBX-DBMPWETRSA-N;   SMILES=COc1cc(ccc1O)C1Oc2ccc(cc2OC1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
 xref: CAS:72581-71-6;   HMDB:HMDB0033322;   KEGG:C16808;   KNApSAcK:C00008662
 xref_mesh: MESH:C075820
 xref: PMID:24456525;   PMID:25708739;   PMID:25970128;   Reaxys:8952975


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isosilybin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 ISO isosilybin inhibits the reaction [T0901317 results in increased expression of ACACA mRNA]
isosilybin results in decreased expression of ACACA mRNA		 CTD PMID:36347319 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO isosilybin results in increased expression of ACOX1 mRNA CTD PMID:36347319 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CD36 mRNA] CTD PMID:36347319 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO isosilybin promotes the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A mRNA] CTD PMID:36347319 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of FAS mRNA
isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS protein]		 CTD PMID:36347319 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of MTTP mRNA]; isosilybin inhibits the reaction [T0901317 results in decreased expression of MTTP mRNA] CTD PMID:36347319 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of PNPLA3 mRNA
isosilybin inhibits the reaction [T0901317 results in increased expression of PNPLA3 mRNA]		 CTD PMID:36347319 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein] CTD PMID:36347319 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 ISO isosilybin results in decreased expression of SREBF1 mRNA
isosilybin inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 protein]; isosilybin inhibits the reaction [T0901317 results in increased expression of SREBF1 mRNA]; isosilybin inhibits the reaction [T0901317 results in increased expression of SREBF1 protein]		 CTD PMID:36347319 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            eukaryotic metabolite 19368
              plant metabolite 17985
                isosilybin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      methoxybenzenes 2062
                                        monomethoxybenzene 1864
                                          guaiacols 1396
                                            isosilybin 9
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