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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenindione
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Accession:CHEBI:8066 term browser browse the term
Definition:A beta-diketone that has formula C15H10O2.
Synonyms:exact_synonym: 2-phenyl-1H-indene-1,3(2H)-dione
 related_synonym: 2-Phenyl-1,3-indandione;   2-phenyl-1,3(2H)-Indenedione;   2-phenyl-1,3-diketohydrindene;   Formula=C15H10O2;   InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H;   InChIKey=NFBAXHOPROOJAW-UHFFFAOYSA-N;   PID;   SMILES=O=C1C(C(=O)c2ccccc12)c1ccccc1;   fenindiona;   phenindionum
 xref: Beilstein:1911699;   CAS:83-12-5;   DrugBank:DB00498;   Drug_Central:2130;   KEGG:C07584;   KEGG:D08354;   LINCS:LSM-5784
 xref_mesh: MESH:D010630
 xref: Wikipedia:Phenindione


show annotations for term's descendants           Sort by:
phenindione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I; [Phenindione results in decreased activity of NQO1 protein] which results in increased abundance of aristolochic acid I metabolite CTD PMID:21613233 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Tp53 tumor protein p53 increases degradation ISO Phenindione results in increased degradation of TP53 protein CTD PMID:14634213 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases activity
multiple interactions		 ISO Phenindione results in decreased activity of VKORC1 protein
Phenindione inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]		 CTD PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 multiple interactions
decreases activity		 ISO Phenindione inhibits the reaction [VKORC1L1 protein results in increased reduction of Vitamin K 1]
Phenindione results in decreased activity of VKORC1L1 protein		 CTD PMID:29581108 NCBI chr12:26,717,959...26,768,193
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            hematologic agent 4995
              anticoagulant 4451
                phenindione 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                carbocyclic compound 18608
                                  carbopolycyclic compound 17197
                                    carbobicyclic compound 5899
                                      ortho-fused bicyclic hydrocarbon 2448
                                        indane 6
                                          phenindione 4
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