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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:irinotecan
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Accession:CHEBI:80630 term browser browse the term
Definition:A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Synonyms:exact_synonym: (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
 related_synonym: Formula=C33H38N4O6;   HSDB 7607;   InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1;   InChIKey=UWKQSNNFCGGAFS-XIFFEERXSA-N;   Irinophore C;   Irinotecan lactone;   Irinotecan mylan;   SMILES=C1(=CC=C2C(=C1)C(=C3C(=N2)C=4N(C3)C(C5=C(C4)[C@](C(OC5)=O)(CC)O)=O)CC)OC(=O)N6CCC(CC6)N7CCCCC7;   irinotecanum
 xref: CAS:97682-44-5;   DrugBank:DB00762;   Drug_Central:1482;   HMDB:HMDB0014900;   KEGG:C16641;   KEGG:D08086;   LINCS:LSM-2167
 xref_mesh: MESH:D000077146
 xref: PDBeChem:CP0;   PMID:26081596;   PMID:26352218;   PMID:26381420;   PMID:26487578;   PMID:26503200;   PMID:26526067;   PMID:26541586;   PMID:26574999;   PMID:26580826;   PMID:26739304;   Reaxys:4839096;   Wikipedia:Irinotecan
 cyclic_relationship: is_conjugate_base_of CHEBI:90895


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irinotecan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Irinotecan results in increased expression of A2M mRNA CTD PMID:20097248 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
affects expression
affects response to substance
affects export
affects metabolic processing		 ISO
EXP		 ABCB1 exon SNP affects the susceptibility to and affects the metabolism of Irinotecan
ABCB1 protein results in decreased susceptibility to Irinotecan
Irinotecan affects the expression of ABCB1A mRNA
ABCB1 gene polymorphism affects the susceptibility to Irinotecan
ABCB1 protein affects the export of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of Irinotecan]
ABCB1A gene mutant form results in decreased susceptibility to Irinotecan		 CTD PMID:12960109 PMID:15655543 PMID:15801936 PMID:16815871 PMID:20097248 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects metabolic processing
multiple interactions		 ISO ABCB1B protein affects the metabolism of Irinotecan
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of Irinotecan]		 CTD PMID:24727322 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases response to substance ISO ABCB6 protein results in decreased susceptibility to Irinotecan CTD PMID:25202056 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
multiple interactions
decreases expression		 ISO ABCC1 protein results in decreased susceptibility to Irinotecan
[selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of ABCC1
Irinotecan analog results in decreased expression of ABCC1 mRNA		 CTD PMID:15897249 PMID:16815871 PMID:18927307 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance
decreases response to substance		 ISO ABCC2 gene polymorphism affects the susceptibility to Irinotecan; ABCC2 gene polymorphism affects the susceptibility to Irinotecan metabolite
ABCC2 protein results in decreased susceptibility to Irinotecan
ABCC2 gene mutant form results in decreased susceptibility to Irinotecan		 CTD PMID:16815871 PMID:18981587 PMID:32387182 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export ISO ABCC4 protein affects the export of Irinotecan CTD PMID:15827327 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
affects export
decreases response to substance
affects metabolic processing
affects response to substance
increases response to substance
increases transport		 ISO bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of Irinotecan]
ABCG2 protein affects the export of Irinotecan
ABCG2 protein results in decreased susceptibility to Irinotecan; ABCG2 results in decreased susceptibility to Irinotecan
ABCG2 gene polymorphism affects the susceptibility to and affects the metabolism of Irinotecan; Porphyrins inhibits the reaction [ABCG2 protein results in decreased susceptibility to Irinotecan]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of Irinotecan]
ABCG2 affects the susceptibility to Irinotecan
ABCG2 mRNA results in increased susceptibility to Irinotecan; ABCG2 protein results in increased susceptibility to Irinotecan
ABCG2 gene mutant form results in increased susceptibility to Irinotecan		 CTD PMID:10606239 PMID:12869632 PMID:15239142 PMID:15655543 PMID:15695404 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abhd13 abhydrolase domain containing 13 decreases expression ISO Irinotecan analog results in decreased expression of ABHD13 mRNA CTD PMID:18927307 NCBI chr16:79,501,879...79,516,712
Ensembl chr16:79,501,727...79,516,748 		JBrowse link
G Abi2 abl-interactor 2 decreases expression ISO Irinotecan results in decreased expression of ABI2 mRNA CTD PMID:20185912 NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO Irinotecan analog results in decreased expression of ACACA mRNA CTD PMID:18927307 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases response to substance ISO ACAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Ache acetylcholinesterase decreases activity EXP Irinotecan results in decreased activity of ACHE protein CTD PMID:11740913 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO Irinotecan results in increased expression of ACTA2 protein
Silymarin affects the reaction [Irinotecan results in increased expression of ACTA2 protein]		 CTD PMID:28454924 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ada adenosine deaminase affects expression EXP Irinotecan affects the expression of ADA mRNA CTD PMID:20097248 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Irinotecan analog results in increased expression of ADAM19 mRNA CTD PMID:18927307 NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Irinotecan results in increased expression of ADAMTS1 mRNA CTD PMID:20097248 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Add3 adducin 3 decreases expression ISO Irinotecan metabolite results in decreased expression of ADD3 mRNA; Irinotecan results in decreased expression of ADD3 mRNA CTD PMID:15956246 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression EXP Irinotecan affects the expression of ADH1 mRNA CTD PMID:20097248 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Irinotecan analog results in decreased expression of ADI1 mRNA CTD PMID:18927307 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
G Adk adenosine kinase affects expression EXP Irinotecan affects the expression of ADK mRNA CTD PMID:20097248 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 affects expression EXP Irinotecan affects the expression of AGPAT4 mRNA CTD PMID:20097248 NCBI chr 1:48,525,131...48,633,798
Ensembl chr 1:48,527,323...48,633,345 		JBrowse link
G Agt angiotensinogen decreases expression ISO Irinotecan analog results in decreased expression of AGT mRNA CTD PMID:18927307 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects expression EXP Irinotecan affects the expression of AHCYL1 mRNA CTD PMID:20097248 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815 		JBrowse link
G Ak2 adenylate kinase 2 increases response to substance ISO AK2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Akap10 A-kinase anchoring protein 10 decreases expression ISO Irinotecan metabolite results in decreased expression of AKAP10 mRNA; Irinotecan results in decreased expression of AKAP10 mRNA CTD PMID:15956246 NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression ISO Irinotecan metabolite results in increased expression of ALAS2 mRNA; Irinotecan results in increased expression of ALAS2 mRNA CTD PMID:15956246 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Alb albumin decreases expression ISO Irinotecan analog results in decreased expression of ALB mRNA CTD PMID:18927307 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression EXP Irinotecan results in decreased expression of ALDH18A1 mRNA CTD PMID:30012503 NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Irinotecan metabolite results in decreased expression of ALDH1A1 mRNA; Irinotecan results in decreased expression of ALDH1A1 mRNA CTD PMID:15956246 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 increases expression ISO Irinotecan analog results in increased expression of AMIGO2 mRNA CTD PMID:18927307 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695 		JBrowse link
G Amy2a3 amylase 2a3 affects expression EXP Irinotecan affects the expression of AMY1A mRNA CTD PMID:20097248 NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532 		JBrowse link
G Angptl2 angiopoietin-like 2 multiple interactions ISO ANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178 		JBrowse link
G Ankh ANKH inorganic pyrophosphate transport regulator affects expression EXP Irinotecan affects the expression of ANKH mRNA CTD PMID:20097248 NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187 		JBrowse link
G Ankrd17 ankyrin repeat domain 17 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD17 mRNA CTD PMID:18927307 NCBI chr14:17,723,239...17,861,841
Ensembl chr14:17,721,932...17,862,617 		JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression ISO Irinotecan analog results in decreased expression of ANKRD28 mRNA CTD PMID:18927307 NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249 		JBrowse link
G Anxa13 annexin A13 decreases expression ISO Irinotecan analog results in decreased expression of ANXA13 mRNA CTD PMID:18927307 NCBI chr 7:89,884,356...89,936,907
Ensembl chr 7:89,884,356...89,936,907 		JBrowse link
G Anxa2 annexin A2 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of ANXA2 mRNA
[PHY 906 co-treated with Irinotecan] affects the expression of ANXA2 mRNA		 CTD PMID:15152939 PMID:32812032 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa6 annexin A6 increases expression ISO Irinotecan metabolite results in increased expression of ANXA6 mRNA; Irinotecan results in increased expression of ANXA6 mRNA CTD PMID:15956246 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 decreases expression ISO Irinotecan analog results in decreased expression of AP2B1 mRNA CTD PMID:18927307 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013 		JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of AP2S1 mRNA CTD PMID:16391804 NCBI chr 1:77,417,496...77,428,903
Ensembl chr 1:77,417,477...77,428,905 		JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression ISO Irinotecan metabolite results in decreased expression of APC mRNA; Irinotecan results in decreased expression of APC mRNA CTD PMID:15956246 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Irinotecan metabolite results in increased expression of ARAF mRNA; Irinotecan results in increased expression of ARAF mRNA CTD PMID:15956246 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Areg amphiregulin multiple interactions
increases expression		 ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of AREG mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of AREG mRNA]
Irinotecan metabolite results in increased expression of AREG mRNA; Irinotecan results in increased expression of AREG mRNA		 CTD PMID:15723263 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arf1 ARF GTPase 1 multiple interactions
decreases expression		 ISO ARF1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of ARF1 mRNA		 CTD PMID:18927307 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G Arg2 arginase 2 affects expression EXP Irinotecan affects the expression of ARG2 mRNA CTD PMID:20097248 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression
increases expression		 ISO Irinotecan metabolite results in decreased expression of ARHGAP5 mRNA; Irinotecan results in decreased expression of ARHGAP5 mRNA
Irinotecan metabolite results in increased expression of ARHGAP5 mRNA; Irinotecan results in increased expression of ARHGAP5 mRNA		 CTD PMID:15956246 NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660 		JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF12 mRNA CTD PMID:18927307 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366 		JBrowse link
G Arhgef39 Rho guanine nucleotide exchange factor 39 decreases expression ISO Irinotecan analog results in decreased expression of ARHGEF39 mRNA CTD PMID:18927307 NCBI chr 5:57,752,509...57,756,079
Ensembl chr 5:57,752,509...57,756,109 		JBrowse link
G Arid2 AT-rich interaction domain 2 decreases expression ISO Irinotecan analog results in decreased expression of ARID2 mRNA CTD PMID:18927307 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512 		JBrowse link
G Arid4a AT-rich interaction domain 4A decreases expression ISO Irinotecan metabolite results in decreased expression of ARID4A mRNA; Irinotecan results in decreased expression of ARID4A mRNA CTD PMID:15956246 NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510 		JBrowse link
G Arl4c ARF like GTPase 4C increases expression ISO Irinotecan analog results in increased expression of ARL4C mRNA CTD PMID:18927307 NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513 		JBrowse link
G Armc8 armadillo repeat containing 8 decreases expression ISO Irinotecan analog results in decreased expression of ARMC8 mRNA CTD PMID:18927307 NCBI chr 8:100,036,946...100,131,544
Ensembl chr 8:100,036,946...100,131,520 		JBrowse link
G Arsb arylsulfatase B decreases expression ISO Irinotecan analog results in decreased expression of ARSB mRNA CTD PMID:18927307 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671 		JBrowse link
G As3mt arsenite methyltransferase affects expression EXP Irinotecan affects the expression of AS3MT mRNA CTD PMID:20097248 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Asb2 ankyrin repeat and SOCS box-containing 2 affects expression EXP Irinotecan affects the expression of ASB2 mRNA CTD PMID:20097248 NCBI chr 6:122,474,754...122,511,014
Ensembl chr 6:122,474,756...122,510,854 		JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of ASS1 mRNA CTD PMID:16391804 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Irinotecan metabolite results in increased expression of ATF3 mRNA; Irinotecan results in increased expression of ATF3 mRNA CTD PMID:15956246 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atg10 autophagy related 10 decreases expression ISO Irinotecan metabolite results in decreased expression of ATG10 mRNA; Irinotecan results in decreased expression of ATG10 mRNA CTD PMID:15956246 NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233 		JBrowse link
G Atl2 atlastin GTPase 2 increases expression ISO Irinotecan analog results in increased expression of ATL2 mRNA CTD PMID:18927307 NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421 		JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Irinotecan results in increased phosphorylation of ATM protein CTD PMID:22898888 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 affects expression EXP Irinotecan affects the expression of ATP2B1 mRNA CTD PMID:20097248 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 decreases response to substance ISO ATP2B4 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions ISO ATP5PO mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592 		JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases response to substance ISO ATP6V0B protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401 		JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance
increases export		 ISO ATP7A protein results in decreased susceptibility to Irinotecan
ATP7A protein results in increased export of Irinotecan		 CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 affects expression EXP Irinotecan affects the expression of ATP8B1 mRNA CTD PMID:20097248 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396 		JBrowse link
G Atrx ATRX, chromatin remodeler decreases expression ISO Irinotecan analog results in decreased expression of ATRX mRNA CTD PMID:18927307 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Irinotecan metabolite results in decreased expression of AURKB mRNA; Irinotecan results in decreased expression of AURKB mRNA CTD PMID:15956246 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G B2m beta-2 microglobulin increases expression EXP Irinotecan results in increased expression of B2M mRNA CTD PMID:20097248 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO Irinotecan analog results in increased expression of BAMBI mRNA CTD PMID:18927307 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of BAX protein CTD PMID:15754201 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects response to substance		 ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in decreased expression of BCL2 protein; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 mRNA; [Fluorouracil co-treated with Irinotecan] results in decreased expression of BCL2 protein
BCL2 protein affects the susceptibility to Irinotecan		 CTD PMID:15754201 PMID:16391804 PMID:18949393 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 ISO Irinotecan results in decreased expression of BCL2L1 mRNA
Irinotecan promotes the reaction [AS602868 results in decreased expression of BCL2L1 mRNA]		 CTD PMID:16432164 PMID:18182997 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl7a BAF chromatin remodeling complex subunit BCL7A increases expression ISO Irinotecan metabolite results in increased expression of BCL7A mRNA; Irinotecan results in increased expression of BCL7A mRNA CTD PMID:15956246 NCBI chr12:33,211,978...33,243,903
Ensembl chr12:33,223,931...33,243,886 		JBrowse link
G Bcl9 BCL9, transcription coactivator increases expression ISO Irinotecan metabolite results in increased expression of BCL9 mRNA; Irinotecan results in increased expression of BCL9 mRNA CTD PMID:15956246 NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO Irinotecan analog results in decreased expression of BCR mRNA CTD PMID:18927307 NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of BID protein
Irinotecan results in decreased expression of BID protein		 CTD PMID:15754201 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression EXP Irinotecan affects the expression of BIRC3 mRNA CTD PMID:20097248 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO Irinotecan metabolite results in decreased expression of BIRC5 mRNA; Irinotecan results in decreased expression of BIRC5 mRNA
[Irinotecan co-treated with Bortezomib] results in decreased expression of BIRC5 protein; Irinotecan promotes the reaction [AS602868 results in decreased expression of BIRC5 mRNA]		 CTD PMID:15956246 PMID:16373703 PMID:18182997 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp8a bone morphogenetic protein 8a increases expression ISO Irinotecan metabolite results in increased expression of BMP8A mRNA; Irinotecan results in increased expression of BMP8A mRNA CTD PMID:15956246 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785 		JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 decreases expression ISO Irinotecan analog results in decreased expression of BOD1L1 mRNA CTD PMID:18927307 NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490 		JBrowse link
G Boll boule homolog, RNA binding protein multiple interactions ISO BOLL mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:56,734,890...56,859,917
Ensembl chr 9:56,733,584...56,859,916 		JBrowse link
G Btbd3 BTB domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of BTBD3 mRNA CTD PMID:18927307 NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression
affects expression		 ISO
EXP		 Irinotecan metabolite results in decreased expression of BUB1 mRNA; Irinotecan results in decreased expression of BUB1 mRNA
Irinotecan affects the expression of BUB1 mRNA		 CTD PMID:15956246 PMID:20097248 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650 		JBrowse link
G C19h16orf87 similar to human chromosome 16 open reading frame 87 decreases expression ISO Irinotecan analog results in decreased expression of C16ORF87 mRNA CTD PMID:18927307 NCBI chr19:21,626,390...21,653,869
Ensembl chr19:21,626,914...21,654,255 		JBrowse link
G C1qc complement C1q C chain multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of C1QC mRNA CTD PMID:32812032 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C2 complement C2 affects expression EXP Irinotecan affects the expression of C2 mRNA CTD PMID:20097248 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3ar1 complement C3a receptor 1 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of C3AR1 mRNA CTD PMID:32812032 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G C7 complement C7 increases expression EXP Irinotecan results in increased expression of C7 mRNA CTD PMID:20097248 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G Cabin1 calcineurin binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of CABIN1 mRNA CTD PMID:18927307 NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression ISO Irinotecan analog results in decreased expression of CACNA1I mRNA CTD PMID:18927307 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions
affects expression		 ISO
EXP		 Irinotecan results in increased cleavage of CASP1 protein
[Irinotecan co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein
Irinotecan affects the expression of CASP1 mRNA
[Irinotecan co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein; EVP 4593 inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased cleavage of CASP1 protein]		 CTD PMID:20097248 PMID:26431797 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO [Irinotecan co-treated with alvocidib] results in increased activity of CASP3 protein; [Irinotecan co-treated with rucaparib] results in increased expression of CASP3 protein; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP3 protein]; RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP3 protein]
Irinotecan results in increased expression of CASP3 protein		 CTD PMID:11751522 PMID:16080519 PMID:16432164 PMID:18182997 PMID:22898888 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 decreases expression ISO Irinotecan metabolite results in decreased expression of CASP4 mRNA; Irinotecan results in decreased expression of CASP4 mRNA CTD PMID:15956246 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP8 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP8 protein; Ursodeoxycholic Acid promotes the reaction [Irinotecan results in increased activity of CASP8 protein] CTD PMID:16432164 PMID:18182997 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Irinotecan results in increased activity of CASP9 protein]; Irinotecan promotes the reaction [AS602868 results in increased cleavage of and results in increased activity of CASP9 protein]; Irinotecan results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18182997 PMID:22898888 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cblc Cbl proto-oncogene C affects expression EXP Irinotecan affects the expression of CBLC mRNA CTD PMID:20097248 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Cck cholecystokinin affects expression EXP Irinotecan affects the expression of CCK mRNA CTD PMID:20097248 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Irinotecan results in increased expression of CCN2 mRNA CTD PMID:20185912 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Irinotecan metabolite results in decreased expression of CCNA2 mRNA; Irinotecan results in decreased expression of CCNA2 mRNA CTD PMID:15956246 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP Irinotecan results in decreased expression of CCNB1 mRNA CTD PMID:20097248 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb1ip1 cyclin B1 interacting protein 1 increases response to substance ISO CCNB1IP1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475 		JBrowse link
G Ccnb2 cyclin B2 increases response to substance
decreases expression		 ISO
EXP		 CCNB2 protein results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of CCNB2 mRNA; Irinotecan results in decreased expression of CCNB2 mRNA		 CTD PMID:15956246 PMID:16734730 PMID:20097248 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnf cyclin F decreases expression ISO Irinotecan metabolite results in decreased expression of CCNF mRNA; Irinotecan results in decreased expression of CCNF mRNA CTD PMID:15956246 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Ccng2 cyclin G2 increases expression ISO Irinotecan analog results in increased expression of CCNG2 mRNA CTD PMID:18927307 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Irinotecan metabolite results in increased expression of CCR1 mRNA; Irinotecan results in increased expression of CCR1 mRNA CTD PMID:15956246 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of CCR6 mRNA; Irinotecan results in decreased expression of CCR6 mRNA CTD PMID:15956246 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Irinotecan analog results in decreased expression of CCT6A mRNA CTD PMID:18927307 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cd163 CD163 molecule increases expression EXP Irinotecan results in increased expression of CD163 mRNA CTD PMID:20097248 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd36 CD36 molecule affects expression EXP Irinotecan affects the expression of CD36 mRNA CTD PMID:20097248 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd47 Cd47 molecule increases expression ISO Irinotecan analog results in increased expression of CD47 mRNA CTD PMID:18927307 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD70 mRNA; Irinotecan results in increased expression of CD70 mRNA CTD PMID:15956246 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715 		JBrowse link
G Cd80 Cd80 molecule increases expression ISO Irinotecan metabolite results in increased expression of CD80 mRNA; Irinotecan results in increased expression of CD80 mRNA CTD PMID:15956246 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cdc20 cell division cycle 20 affects expression
increases response to substance		 EXP
ISO		 Irinotecan affects the expression of CDC20 mRNA
CDC20 protein results in increased susceptibility to Irinotecan		 CTD PMID:16734730 PMID:20097248 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Irinotecan metabolite results in decreased expression of CDC25B mRNA; Irinotecan results in decreased expression of CDC25B mRNA CTD PMID:15956246 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc42bpa CDC42 binding protein kinase alpha decreases expression ISO Irinotecan analog results in decreased expression of CDC42BPA mRNA CTD PMID:18927307 NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732 		JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression EXP Irinotecan results in decreased expression of CDCA3 mRNA CTD PMID:20097248 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799 		JBrowse link
G Cdh1 cadherin 1 affects response to substance ISO CDH1 protein affects the susceptibility to Irinotecan CTD PMID:34075792 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh4 cadherin 4 decreases expression ISO Irinotecan analog results in decreased expression of CDH4 mRNA CTD PMID:18927307 NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP
ISO		 Irinotecan results in decreased expression of CDK1 mRNA
Irinotecan metabolite results in decreased expression of CDK1 mRNA; Irinotecan results in decreased expression of CDK1 mRNA		 CTD PMID:15956246 PMID:20097248 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Irinotecan metabolite results in decreased expression of CDK13 mRNA; Irinotecan results in decreased expression of CDK13 mRNA CTD PMID:15956246 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721 		JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 increases expression ISO Irinotecan metabolite results in increased expression of CDK5R2 mRNA; Irinotecan results in increased expression of CDK5R2 mRNA CTD PMID:15956246 NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Irinotecan analog affects the expression of CDK6 mRNA CTD PMID:18927307 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
affects expression
multiple interactions		 ISO Irinotecan results in increased expression of CDKN1A mRNA; Irinotecan results in increased expression of CDKN1A protein
Irinotecan affects the expression of CDKN1A protein
[Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased expression of CDKN1A protein		 CTD PMID:15132777 PMID:15754201 PMID:22510560 PMID:22898888 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression
decreases expression
increases response to substance		 ISO Irinotecan affects the expression of CDKN2A protein
Irinotecan results in decreased expression of CDKN2A mRNA
CDKN2A results in increased susceptibility to Irinotecan		 CTD PMID:16432164 PMID:22898888 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO
EXP		 Irinotecan metabolite results in decreased expression of CDKN3 mRNA; Irinotecan results in decreased expression of CDKN3 mRNA CTD PMID:15956246 PMID:20097248 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Cdon cell adhesion associated, oncogene regulated decreases expression ISO Irinotecan analog results in decreased expression of CDON mRNA CTD PMID:18927307 NCBI chr 8:33,775,123...33,861,635
Ensembl chr 8:33,806,183...33,859,033 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Irinotecan results in increased expression of CEBPD mRNA CTD PMID:20097248 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Cel carboxyl ester lipase increases response to substance ISO CEL protein results in increased susceptibility to Irinotecan CTD PMID:9766666 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Cela3b chymotrypsin like elastase 3B affects expression EXP Irinotecan affects the expression of CELA3B mRNA CTD PMID:20097248 NCBI chr 5:149,628,773...149,636,937
Ensembl chr 5:149,628,773...149,636,937 		JBrowse link
G Cenpe centromere protein E decreases expression ISO Irinotecan analog results in decreased expression of CENPE mRNA; Irinotecan metabolite results in decreased expression of CENPE mRNA; Irinotecan results in decreased expression of CENPE mRNA CTD PMID:15956246 PMID:18927307 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Cenpf centromere protein F decreases expression ISO Irinotecan metabolite results in decreased expression of CENPF mRNA; Irinotecan results in decreased expression of CENPF mRNA CTD PMID:15956246 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669 		JBrowse link
G Cep192 centrosomal protein 192 decreases expression ISO Irinotecan analog results in decreased expression of CEP192 mRNA CTD PMID:18927307 NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379 		JBrowse link
G Cep290 centrosomal protein 290 decreases expression ISO Irinotecan analog results in decreased expression of CEP290 mRNA CTD PMID:18927307 NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392 		JBrowse link
G Cep295 centrosomal protein 295 decreases expression ISO Irinotecan analog results in decreased expression of CEP295 mRNA CTD PMID:18927307 NCBI chr 8:12,156,568...12,194,542
Ensembl chr 8:12,156,554...12,194,552 		JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis
increases response to substance		 ISO CES1 protein results in increased hydrolysis of Irinotecan
CES1 mRNA results in increased susceptibility to Irinotecan		 CTD PMID:15100172 PMID:15239142 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H increases expression
increases hydrolysis
affects response to substance
increases metabolic processing
increases chemical synthesis
increases response to substance
multiple interactions		 ISO Irinotecan results in increased expression of CES2 mRNA
CES2 protein results in increased hydrolysis of Irinotecan
CES2 protein affects the susceptibility to Irinotecan
CES2 protein results in increased metabolism of Irinotecan
CES2 protein results in increased chemical synthesis of Irinotecan
CES2 protein results in increased susceptibility to Irinotecan
CES2 mRNA results in increased chemical synthesis of and results in increased abundance of Irinotecan; CES2 mRNA results in increased metabolism of and results in increased activity of Irinotecan; CES2 protein affects the metabolism of and results in increased activity of Irinotecan; CES2 protein results in increased hydrolysis of and results in increased activity of Irinotecan; CES2 protein results in increased metabolism of and results in increased activity of Irinotecan		 CTD PMID:10728672 PMID:11716702 PMID:12171891 PMID:12171903 PMID:14581373 More... NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Ces3a carboxylesterase 3a increases hydrolysis ISO CES3 protein results in increased hydrolysis of Irinotecan CTD PMID:15100172 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions
affects response to substance		 ISO Irinotecan results in decreased expression of CFLAR protein
CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein]
CFLAR protein affects the susceptibility to Irinotecan		 CTD PMID:16373718 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cftr CF transmembrane conductance regulator affects expression EXP Irinotecan affects the expression of CFTR mRNA CTD PMID:20097248 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chd1 chromodomain helicase DNA binding protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of CHD1 mRNA; Irinotecan results in decreased expression of CHD1 mRNA CTD PMID:15956246 NCBI chr 1:56,661,743...56,729,119
Ensembl chr 1:56,664,054...56,728,125 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions		 ISO Irinotecan results in increased phosphorylation of CHEK1 protein
Irinotecan results in increased phosphorylation of and results in increased activity of CHEK1 protein; SAR 020106 inhibits the reaction [Irinotecan results in increased phosphorylation of CHEK1 protein]		 CTD PMID:22111927 PMID:22510560 PMID:22898888 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO Irinotecan results in increased phosphorylation of CHEK2 protein CTD PMID:22898888 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Irinotecan results in decreased expression of CKS2 mRNA CTD PMID:20097248 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression		 ISO GSK484 inhibits the reaction [Irinotecan results in decreased expression of CLDN1 protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of CLDN1 protein] CTD PMID:38341106 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn2 claudin 2 affects expression EXP Irinotecan affects the expression of CLDN2 mRNA CTD PMID:20097248 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Clec10a C-type lectin domain containing 10A increases expression EXP Irinotecan results in increased expression of CLEC10A mRNA CTD PMID:20097248 NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435 		JBrowse link
G Clgn calmegin increases expression ISO Irinotecan analog results in increased expression of CLGN mRNA CTD PMID:18927307 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758 		JBrowse link
G Clps colipase affects expression EXP Irinotecan affects the expression of CLPS mRNA CTD PMID:20097248 NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689 		JBrowse link
G Cltc clathrin heavy chain decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of CLTC mRNA
CLTC protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:18927307 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Cnnm2 cyclin and CBS domain divalent metal cation transport mediator 2 increases expression ISO Irinotecan analog results in increased expression of CNNM2 mRNA CTD PMID:18927307 NCBI chr 1:245,643,682...245,769,542
Ensembl chr 1:245,643,768...245,763,286 		JBrowse link
G Col13a1 collagen type XIII alpha 1 chain increases expression ISO Irinotecan analog results in increased expression of COL13A1 mRNA CTD PMID:18927307 NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032 		JBrowse link
G Col4a4 collagen type IV alpha 4 chain decreases expression ISO Irinotecan analog results in decreased expression of COL4A4 mRNA CTD PMID:18927307 NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain increases expression ISO Irinotecan metabolite results in increased expression of COL6A1 mRNA; Irinotecan results in increased expression of COL6A1 mRNA CTD PMID:15956246 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases response to substance ISO COL7A1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252 		JBrowse link
G Commd6 COMM domain containing 6 increases expression ISO Irinotecan metabolite results in increased expression of COMMD6 mRNA; Irinotecan results in increased expression of COMMD6 mRNA CTD PMID:15956246 NCBI chr15:78,467,333...78,474,382
Ensembl chr15:78,467,804...78,474,382 		JBrowse link
G Copa COPI coat complex subunit alpha increases expression ISO Irinotecan analog results in increased expression of COPA mRNA CTD PMID:18927307 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874 		JBrowse link
G Coq9 coenzyme Q9 decreases expression ISO Irinotecan results in decreased expression of COQ9 mRNA CTD PMID:20185912 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO Irinotecan analog results in increased expression of CPE mRNA CTD PMID:18927307 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Crebbp CREB binding protein decreases expression ISO Irinotecan analog results in decreased expression of CREBBP mRNA; Irinotecan metabolite results in decreased expression of CREBBP mRNA; Irinotecan results in decreased expression of CREBBP mRNA CTD PMID:15956246 PMID:18927307 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of CRIM1 mRNA CTD PMID:18927307 NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259 		JBrowse link
G Ctbp2 C-terminal binding protein 2 decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of CTBP2 mRNA
[Fluorouracil co-treated with Irinotecan] results in decreased expression of CTBP2 mRNA; CTBP2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:16391804 PMID:18927307 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO Irinotecan analog results in increased expression of CTH mRNA CTD PMID:18927307 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cul4a cullin 4A decreases expression ISO Irinotecan analog results in decreased expression of CUL4A mRNA CTD PMID:18927307 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 affects expression EXP Irinotecan affects the expression of CXCL11 mRNA CTD PMID:20097248 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Irinotecan analog results in decreased expression of CXCL12 mRNA CTD PMID:18927307 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of CXCL1 protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of CXCL1 protein]		 CTD PMID:27838229 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP27A1 mRNA CTD PMID:20097248 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases oxidation
increases response to substance
affects metabolic processing		 ISO Irinotecan metabolite results in decreased activity of CYP3A4 protein; Irinotecan results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased oxidation of Irinotecan
CYP3A4 mRNA results in increased susceptibility to Irinotecan
CYP3A4 protein affects the metabolism of Irinotecan		 CTD PMID:11901092 PMID:15100172 PMID:15239142 PMID:15523087 PMID:15655543 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of CYP3A5 CTD PMID:15897249 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4B1 mRNA CTD PMID:20097248 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 affects expression EXP Irinotecan affects the expression of CYP4F1 mRNA CTD PMID:20097248 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046 		JBrowse link
G Daglb diacylglycerol lipase, beta decreases expression ISO Irinotecan analog results in decreased expression of DAGLB mRNA CTD PMID:18927307 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154 		JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit increases response to substance ISO DBF4 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 decreases expression ISO Irinotecan analog results in decreased expression of DCAF8 mRNA CTD PMID:18927307 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726 		JBrowse link
G Dclre1a DNA cross-link repair 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DCLRE1A mRNA; Irinotecan results in decreased expression of DCLRE1A mRNA CTD PMID:15956246 NCBI chr 1:255,569,911...255,589,815
Ensembl chr 1:255,569,919...255,589,678 		JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Irinotecan analog results in increased expression of DCTN2 mRNA CTD PMID:18927307 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO Irinotecan metabolite results in increased expression of DDB2 mRNA; Irinotecan results in increased expression of DDB2 mRNA CTD PMID:15956246 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631 		JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of DDHD1 mRNA CTD PMID:18927307 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Irinotecan results in increased expression of DDIT3 mRNA CTD PMID:20097248 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Irinotecan results in increased expression of DDIT4 mRNA CTD PMID:20097248 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Irinotecan results in decreased expression of DDX17 mRNA CTD PMID:20185912 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked affects expression EXP Irinotecan affects the expression of DDX3X mRNA CTD PMID:20097248 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of DDX5 mRNA CTD PMID:32812032 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G Dedd death effector domain-containing decreases expression ISO Irinotecan analog results in decreased expression of DEDD mRNA CTD PMID:18927307 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332 		JBrowse link
G Dennd4a DENN domain containing 4A decreases expression ISO Irinotecan metabolite results in decreased expression of DENND4A mRNA; Irinotecan results in decreased expression of DENND4A mRNA CTD PMID:15956246 NCBI chr 8:65,322,920...65,436,331
Ensembl chr 8:65,322,941...65,436,330 		JBrowse link
G Denr density regulated reinitiation and release factor decreases expression ISO Irinotecan analog results in decreased expression of DENR mRNA CTD PMID:18927307 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843 		JBrowse link
G Depdc1b DEP domain containing 1B decreases expression ISO Irinotecan analog results in decreased expression of DEPDC1B mRNA CTD PMID:18927307 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779 		JBrowse link
G Desi2 desumoylating isopeptidase 2 decreases expression ISO Irinotecan analog results in decreased expression of DESI2 mRNA CTD PMID:18927307 NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416 		JBrowse link
G Dffb DNA fragmentation factor subunit beta increases response to substance ISO DFFB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit decreases expression ISO Irinotecan analog results in decreased expression of DGCR8 mRNA CTD PMID:18927307 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242 		JBrowse link
G Dip2a disco-interacting protein 2 homolog A decreases expression ISO Irinotecan analog results in decreased expression of DIP2A mRNA CTD PMID:18927307 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression ISO Irinotecan analog results in decreased expression of DLC1 mRNA CTD PMID:18927307 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Dld dihydrolipoamide dehydrogenase affects expression EXP Irinotecan affects the expression of DLD mRNA CTD PMID:20097248 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of DLG1 mRNA
DLG1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:18927307 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO Irinotecan analog results in increased expression of DLX4 mRNA CTD PMID:18927307 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456 		JBrowse link
G Dmac2l distal membrane arm assembly component 2 like decreases expression ISO Irinotecan analog results in decreased expression of DMAC2L mRNA CTD PMID:18927307 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933 		JBrowse link
G Dmwd DM1 locus, WD repeat containing increases expression ISO Irinotecan metabolite results in increased expression of DMWD mRNA; Irinotecan results in increased expression of DMWD mRNA CTD PMID:15956246 NCBI chr 1:78,722,436...78,729,224
Ensembl chr 1:78,722,330...78,740,593 		JBrowse link
G Dok6 docking protein 6 decreases expression ISO Irinotecan results in decreased expression of DOK6 mRNA CTD PMID:20185912 NCBI chr18:82,572,762...83,015,951
Ensembl chr18:82,572,762...83,015,951 		JBrowse link
G Dph2 diphthamide biosynthesis 2 decreases expression ISO Irinotecan analog results in decreased expression of DPH2 mRNA CTD PMID:18927307 NCBI chr 5:131,428,434...131,431,394
Ensembl chr 5:131,428,268...131,431,395 		JBrowse link
G Dph6 diphthamine biosynthesis 6 decreases expression ISO Irinotecan analog results in decreased expression of DPH6 mRNA CTD PMID:18927307 NCBI chr 3:101,307,229...101,437,463
Ensembl chr 3:101,307,231...101,534,603 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases response to substance
decreases expression		 ISO DPYD protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of DPYD mRNA; Irinotecan results in decreased expression of DPYD mRNA		 CTD PMID:15956246 PMID:16734730 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Drd5 dopamine receptor D5 multiple interactions ISO DRD5 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 multiple interactions ISO [selenomethylselenocysteine co-treated with Irinotecan] results in decreased expression of DRG1 CTD PMID:15897249 NCBI chr14:78,103,876...78,119,976
Ensembl chr14:78,103,876...78,119,953 		JBrowse link
G Dst dystonin decreases expression ISO Irinotecan analog results in decreased expression of DST mRNA CTD PMID:18927307 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615 		JBrowse link
G Duox2 dual oxidase 2 affects expression EXP Irinotecan affects the expression of DUOX2 mRNA CTD PMID:20097248 NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Irinotecan results in increased expression of DUSP1 mRNA CTD PMID:20097248 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp2 dual specificity phosphatase 2 increases expression ISO Irinotecan metabolite results in increased expression of DUSP2 mRNA; Irinotecan results in increased expression of DUSP2 mRNA CTD PMID:15956246 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499 		JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Irinotecan affects the expression of DUSP6 mRNA CTD PMID:20097248 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression ISO Irinotecan metabolite results in decreased expression of DYRK1A mRNA; Irinotecan results in decreased expression of DYRK1A mRNA CTD PMID:15956246 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression
affects expression		 ISO
EXP		 Irinotecan metabolite results in decreased expression of DYRK2 mRNA; Irinotecan results in decreased expression of DYRK2 mRNA
Irinotecan affects the expression of DYRK2 mRNA		 CTD PMID:15956246 PMID:20097248 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO bisindolylmaleimide I inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; bisindolylmaleimide I inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein]; Gefitinib inhibits the reaction [Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; Go 6976 inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein]; Irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein; Irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein; rottlerin inhibits the reaction [Irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [Irinotecan results in increased phosphorylation of EGFR protein] CTD PMID:15723263 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression ISO
EXP		 Irinotecan metabolite results in increased expression of EGR1 mRNA; Irinotecan results in increased expression of EGR1 mRNA CTD PMID:15956246 PMID:16280599 PMID:20097248 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Irinotecan analog affects the expression of EIF2AK4 mRNA CTD PMID:18927307 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of EIF4E mRNA CTD PMID:32812032 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Elane elastase, neutrophil expressed multiple interactions
increases expression		 ISO GSK484 inhibits the reaction [Irinotecan results in increased expression of ELANE mRNA]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of ELANE mRNA] CTD PMID:38341106 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Eml2 EMAP like 2 multiple interactions ISO EML2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341 		JBrowse link
G Eml4 EMAP like 4 affects expression EXP Irinotecan affects the expression of EML4 mRNA CTD PMID:20097248 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879 		JBrowse link
G Eno1 enolase 1 decreases expression ISO Irinotecan analog results in decreased expression of ENO1 mRNA CTD PMID:18927307 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Irinotecan metabolite results in decreased expression of EP300 mRNA; Irinotecan results in decreased expression of EP300 mRNA CTD PMID:15956246 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eppk1 epiplakin 1 increases expression ISO Irinotecan analog results in increased expression of EPPK1 mRNA CTD PMID:18927307 NCBI chr 7:107,816,919...107,842,946
Ensembl chr 7:107,817,693...107,831,159 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects expression EXP Irinotecan affects the expression of ERBB2 mRNA CTD PMID:20097248 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Irinotecan metabolite results in increased expression of ERBB4 mRNA; Irinotecan results in increased expression of ERBB4 mRNA CTD PMID:15956246 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 decreases expression ISO Irinotecan analog results in decreased expression of ERC1 mRNA CTD PMID:18927307 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO Irinotecan results in decreased expression of ERCC1 protein CTD PMID:11593056 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ereg epiregulin decreases expression ISO Irinotecan analog results in decreased expression of EREG mRNA CTD PMID:18927307 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO Irinotecan metabolite results in increased expression of ETS2 mRNA; Irinotecan results in increased expression of ETS2 mRNA CTD PMID:15956246 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319 		JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO Irinotecan metabolite results in decreased expression of ETV6 mRNA; Irinotecan results in decreased expression of ETV6 mRNA CTD PMID:15956246 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992 		JBrowse link
G Exoc4 exocyst complex component 4 decreases expression ISO Irinotecan analog results in decreased expression of EXOC4 mRNA CTD PMID:18927307 NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723 		JBrowse link
G F8 coagulation factor VIII multiple interactions ISO F8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857 		JBrowse link
G Fabp1 fatty acid binding protein 1 affects expression EXP Irinotecan affects the expression of FABP1 mRNA CTD PMID:20097248 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Irinotecan analog results in increased expression of FABP6 mRNA CTD PMID:18927307 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fam219a family with sequence similarity 219, member A decreases expression ISO Irinotecan analog results in decreased expression of FAM219A mRNA CTD PMID:18927307 NCBI chr 5:56,679,272...56,729,959
Ensembl chr 5:56,680,613...56,729,924 		JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C decreases expression ISO Irinotecan analog results in decreased expression of FAM3C mRNA CTD PMID:18927307 NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078 		JBrowse link
G Fancg FA complementation group G increases expression ISO Irinotecan metabolite results in increased expression of FANCG mRNA; Irinotecan results in increased expression of FANCG mRNA CTD PMID:15956246 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Farsb phenylalanyl-tRNA synthetase subunit beta decreases expression ISO Irinotecan analog results in decreased expression of FARSB mRNA CTD PMID:18927307 NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Irinotecan results in increased expression of and results in increased localization of FAS protein; STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]
Irinotecan results in increased expression of FAS mRNA		 CTD PMID:16204068 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO [selenomethylselenocysteine co-treated with Irinotecan] results in increased expression of FASLG
Irinotecan results in increased expression of FASL protein		 CTD PMID:15897249 PMID:21475811 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 increases expression ISO Irinotecan results in increased expression of FBXW5 mRNA CTD PMID:20185912 NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092 		JBrowse link
G Fcf1 Fcf1 rRNA-processing protein affects expression ISO Irinotecan analog affects the expression of FCF1 mRNA CTD PMID:18927307 NCBI chr 6:104,617,780...104,629,643
Ensembl chr 6:104,617,770...104,629,643 		JBrowse link
G Fcgr2b Fc gamma receptor 2B increases expression EXP Irinotecan results in increased expression of FCGR2B mRNA CTD PMID:20097248 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Irinotecan metabolite results in increased expression of FGF2 mRNA; Irinotecan results in increased expression of FGF2 mRNA CTD PMID:15956246 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf9 fibroblast growth factor 9 decreases expression ISO Irinotecan analog results in decreased expression of FGF9 mRNA CTD PMID:18927307 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Fgl2 fibrinogen-like 2 increases expression EXP Irinotecan results in increased expression of FGL2 mRNA CTD PMID:20097248 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Fh fumarate hydratase affects expression EXP Irinotecan affects the expression of FH mRNA CTD PMID:20097248 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Irinotecan results in increased expression of FKBP5 mRNA CTD PMID:20097248 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 affects expression EXP Irinotecan affects the expression of FMO5 mRNA CTD PMID:20097248 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Irinotecan analog results in increased expression of FN1 mRNA; Irinotecan metabolite results in increased expression of FN1 mRNA; Irinotecan results in increased expression of FN1 mRNA CTD PMID:15956246 PMID:18927307 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression		 ISO Irinotecan metabolite results in increased expression of FOS mRNA; Irinotecan results in increased expression of FOS mRNA
Irinotecan results in decreased expression of FOS mRNA		 CTD PMID:15956246 PMID:16432164 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Irinotecan metabolite results in increased expression of FOSB mRNA; Irinotecan results in increased expression of FOSB mRNA CTD PMID:15956246 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Foxa1 forkhead box A1 affects expression EXP Irinotecan affects the expression of FOXA1 mRNA CTD PMID:20097248 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Frk fyn-related Src family tyrosine kinase affects expression EXP Irinotecan affects the expression of FRK mRNA CTD PMID:20097248 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114 		JBrowse link
G Frmd5 FERM domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of FRMD5 mRNA CTD PMID:18927307 NCBI chr 3:108,492,099...108,763,715
Ensembl chr 3:108,474,562...108,763,498 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase decreases expression ISO Irinotecan analog results in decreased expression of FTO mRNA CTD PMID:18927307 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO Irinotecan results in increased expression of FXYD3 mRNA CTD PMID:15152939 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of FYB1 mRNA CTD PMID:18927307 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629 		JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Irinotecan results in increased expression of G0S2 mRNA CTD PMID:20097248 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451 		JBrowse link
G G2e3 G2/M-phase specific E3 ubiquitin protein ligase decreases expression ISO Irinotecan analog results in decreased expression of G2E3 mRNA CTD PMID:18927307 NCBI chr 6:68,763,847...68,795,305
Ensembl chr 6:68,764,185...68,793,924 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Irinotecan results in increased expression of GADD45A mRNA CTD PMID:20097248 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Irinotecan results in increased expression of GADD45G mRNA CTD PMID:20097248 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase affects expression EXP Irinotecan affects the expression of GAMT mRNA CTD PMID:20097248 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Irinotecan metabolite results in decreased expression of GATA3 mRNA; Irinotecan results in decreased expression of GATA3 mRNA CTD PMID:15956246 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gata4 GATA binding protein 4 affects expression EXP Irinotecan affects the expression of GATA4 mRNA CTD PMID:20097248 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gcg glucagon affects expression EXP Irinotecan affects the expression of GCG mRNA CTD PMID:20097248 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Irinotecan metabolite results in increased expression of GDF15 mRNA; Irinotecan results in increased expression of GDF15 mRNA CTD PMID:15956246 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression EXP Irinotecan results in increased expression of GEM mRNA CTD PMID:20097248 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of GGT1 mRNA CTD PMID:18927307 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gja1 gap junction protein, alpha 1 affects expression
increases expression		 ISO
EXP		 Irinotecan analog affects the expression of GJA1 mRNA
Irinotecan results in increased expression of GJA1 mRNA		 CTD PMID:18927307 PMID:20097248 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gk glycerol kinase decreases expression ISO Irinotecan analog results in decreased expression of GK mRNA CTD PMID:18927307 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Gkn1 gastrokine 1 affects expression EXP Irinotecan affects the expression of GKN1 mRNA CTD PMID:20097248 NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389 		JBrowse link
G Glrx3 glutaredoxin 3 affects expression ISO Irinotecan analog affects the expression of GLRX3 mRNA CTD PMID:18927307 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Gna13 G protein subunit alpha 13 increases expression ISO Irinotecan analog results in increased expression of GNA13 mRNA CTD PMID:18927307 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gng11 G protein subunit gamma 11 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of GNG11 mRNA CTD PMID:32812032 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442 		JBrowse link
G Gpatch2l G patch domain containing 2-like decreases expression ISO Irinotecan analog results in decreased expression of GPATCH2L mRNA CTD PMID:18927307 NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888 		JBrowse link
G Gpatch4 G patch domain containing 4 decreases expression ISO Irinotecan analog results in decreased expression of GPATCH4 mRNA CTD PMID:18927307 NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684 		JBrowse link
G Gphn gephyrin decreases expression EXP Irinotecan results in decreased expression of GPHN mRNA CTD PMID:20097248 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612 		JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO Irinotecan metabolite results in increased expression of GPR183 mRNA; Irinotecan results in increased expression of GPR183 mRNA CTD PMID:15956246 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO Irinotecan results in increased expression of GPT protein
phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of GPT protein]		 CTD PMID:38341106 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Irinotecan metabolite results in increased expression of GPX3 mRNA; Irinotecan results in increased expression of GPX3 mRNA CTD PMID:15956246 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression EXP Irinotecan results in increased expression of GREM1 mRNA CTD PMID:20097248 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 affects expression EXP Irinotecan affects the expression of GSTA3 mRNA CTD PMID:20097248 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects expression EXP Irinotecan affects the expression of GSTA4 mRNA CTD PMID:20097248 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gzmb granzyme B affects expression EXP Irinotecan affects the expression of GZMB mRNA CTD PMID:20097248 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO Irinotecan metabolite results in increased expression of H2AX mRNA; Irinotecan results in increased expression of H2AX mRNA; Irinotecan results in increased expression of H2AX protein
[Irinotecan co-treated with rucaparib] results in increased expression of H2AX protein		 CTD PMID:15956246 PMID:30612311 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression
multiple interactions		 ISO Irinotecan metabolite results in increased expression of HBEGF mRNA; Irinotecan results in increased expression of HBEGF mRNA
Gefitinib inhibits the reaction [Irinotecan metabolite results in increased expression of HBEGF mRNA]; Gefitinib inhibits the reaction [Irinotecan results in increased expression of HBEGF mRNA]		 CTD PMID:15723263 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of HBG1 mRNA CTD PMID:18927307 NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425 		JBrowse link
G Hcfc1 host cell factor C1 decreases expression ISO Irinotecan analog results in decreased expression of HCFC1 mRNA CTD PMID:18927307 NCBI chr  X:151,687,779...151,712,688
Ensembl chr  X:151,687,779...151,712,638 		JBrowse link
G Hectd2 HECT domain E3 ubiquitin protein ligase 2 decreases expression ISO Irinotecan analog results in decreased expression of HECTD2 mRNA CTD PMID:18927307 NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487 		JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO Irinotecan analog results in decreased expression of HELLS mRNA CTD PMID:18927307 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases activity ISO Irinotecan results in increased activity of HES1 protein CTD PMID:19147571 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hgfac HGF activator affects expression EXP Irinotecan affects the expression of HGFAC mRNA CTD PMID:20097248 NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278 		JBrowse link
G Hist1h2al1 histone cluster 1 H2A family like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of H2AC6 mRNA; Irinotecan results in decreased expression of H2AC6 mRNA CTD PMID:15956246 NCBI chr17:42,707,954...42,708,420 JBrowse link
G Hk2 hexokinase 2 affects expression EXP Irinotecan affects the expression of HK2 mRNA CTD PMID:20097248 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Irinotecan metabolite results in decreased expression of HMMR mRNA; Irinotecan results in decreased expression of HMMR mRNA CTD PMID:15956246 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Luteolin promotes the reaction [Irinotecan results in increased expression of HMOX1 mRNA] CTD PMID:34699766 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmx1 H6 family homeobox 1 increases expression ISO Irinotecan results in increased expression of HMX1 mRNA CTD PMID:20185912 NCBI chr14:75,361,207...75,364,993
Ensembl chr14:75,361,225...75,364,993 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Irinotecan analog results in decreased expression of HNRNPA1 mRNA CTD PMID:18927307 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of HNRNPA3 mRNA CTD PMID:32812032 NCBI chr 3:60,578,574...60,588,755
Ensembl chr 3:60,578,673...60,588,306 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D decreases expression ISO Irinotecan analog results in decreased expression of HNRNPD mRNA CTD PMID:18927307 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Irinotecan analog results in decreased expression of HNRNPDL mRNA CTD PMID:18927307 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hrg histidine-rich glycoprotein increases expression ISO Irinotecan metabolite results in increased expression of HRG mRNA; Irinotecan results in increased expression of HRG mRNA CTD PMID:15956246 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389 		JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 increases expression ISO Irinotecan analog results in increased expression of HS3ST3B1 mRNA CTD PMID:18927307 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970 		JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like decreases expression ISO Irinotecan metabolite results in decreased expression of HSPA4L mRNA; Irinotecan results in decreased expression of HSPA4L mRNA CTD PMID:15956246 NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of HTATIP2 mRNA CTD PMID:16391804 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629 		JBrowse link
G Hypk Huntingtin interacting protein K affects expression ISO Irinotecan analog affects the expression of HYPK mRNA CTD PMID:18927307 NCBI chr 3:108,434,997...108,436,370
Ensembl chr 3:108,432,539...108,436,370 		JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase decreases expression ISO Irinotecan results in decreased expression of IBTK mRNA CTD PMID:20185912 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260 		JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Irinotecan metabolite results in decreased expression of ID2 mRNA; Irinotecan results in decreased expression of ID2 mRNA CTD PMID:15956246 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Ier3 immediate early response 3 increases expression ISO Irinotecan results in increased expression of IER3 mRNA CTD PMID:20185912 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ifi27l2a interferon, alpha-inducible protein 27 like 2A multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of IFI27L2 mRNA CTD PMID:16391804 NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 increases expression EXP
ISO		 Irinotecan results in increased expression of IFITM1 mRNA
Irinotecan analog results in increased expression of IFITM1 mRNA		 CTD PMID:18927307 PMID:20097248 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression EXP Irinotecan results in increased expression of IFITM3 mRNA CTD PMID:20097248 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 EXP Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IFNG protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IFNG protein] CTD PMID:16815871 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO Irinotecan metabolite results in increased expression of IGF1 mRNA; Irinotecan results in increased expression of IGF1 mRNA CTD PMID:15956246 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Irinotecan results in increased expression of IGFBP5 mRNA CTD PMID:20097248 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 decreases expression ISO Irinotecan analog results in decreased expression of IGHG1 mRNA CTD PMID:18927307 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il10 interleukin 10 multiple interactions
decreases secretion		 ISO
EXP		 Deoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]; Taurodeoxycholic Acid promotes the reaction [Irinotecan results in decreased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]		 CTD PMID:19401694 PMID:26706406 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 affects expression EXP Irinotecan affects the expression of IL13RA1 mRNA CTD PMID:20097248 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il15 interleukin 15 affects expression EXP Irinotecan affects the expression of IL15 mRNA CTD PMID:20097248 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il17a interleukin 17A increases expression ISO Irinotecan results in increased expression of IL17A mRNA; Irinotecan results in increased expression of IL17A protein CTD PMID:26431797 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of IL18 mRNA; Irinotecan results in increased expression of IL18 protein
[Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [Irinotecan results in increased expression of and results in increased secretion of IL18 protein]
[Fluorouracil co-treated with Irinotecan] results in decreased expression of IL18 mRNA; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL18 protein]		 CTD PMID:16391804 PMID:26431797 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
affects expression
increases secretion		 ISO
EXP		 [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]; Luteolin inhibits the reaction [Irinotecan results in increased expression of IL1B mRNA]; Luteolin inhibits the reaction [Irinotecan results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with Irinotecan] results in increased expression of and results in increased secretion of IL1B protein]
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IL1B protein]
Irinotecan results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]]; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL1B protein; [Irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; carvacrol inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Irinotecan results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein; MYD88 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; TLR2 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]
Irinotecan metabolite results in increased expression of IL1B mRNA; Irinotecan results in increased expression of IL1B mRNA
Irinotecan affects the expression of IL1B protein		 CTD PMID:15956246 PMID:16815871 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 EXP Irinotecan results in decreased expression of IL2 protein
Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL2 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]; Thalidomide inhibits the reaction [Irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [Irinotecan results in decreased expression of IL2 protein]		 CTD PMID:16815871 PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il33 interleukin 33 increases expression
increases secretion
multiple interactions		 ISO Irinotecan results in increased expression of IL33 mRNA
Irinotecan results in increased secretion of IL33 protein
Luteolin inhibits the reaction [Irinotecan results in increased expression of IL33 mRNA]; Luteolin inhibits the reaction [Irinotecan results in increased secretion of IL33 protein]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of IL33 mRNA]; Rosiglitazone inhibits the reaction [Irinotecan results in increased secretion of IL33 protein]		 CTD PMID:34699766 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases response to substance		 ISO
EXP		 Irinotecan results in increased expression of IL6 mRNA; Irinotecan results in increased expression of IL6 protein
Ciprofloxacin inhibits the reaction [Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL6 protein]
IL6 protein results in decreased susceptibility to Irinotecan
MYD88 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]; Silymarin inhibits the reaction [Irinotecan results in increased expression of IL6 protein]; TLR2 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]; TLR4 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]		 CTD PMID:16815871 PMID:17537833 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Immp2l inner mitochondrial membrane peptidase subunit 2 decreases expression ISO Irinotecan analog results in decreased expression of IMMP2L mRNA CTD PMID:18927307 NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840 		JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Irinotecan analog affects the expression of IMMT mRNA CTD PMID:18927307 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109 		JBrowse link
G Ing3 inhibitor of growth family, member 3 decreases expression ISO Irinotecan analog results in decreased expression of ING3 mRNA CTD PMID:18927307 NCBI chr 4:50,477,954...50,505,168
Ensembl chr 4:50,477,962...50,503,715 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Irinotecan analog results in decreased expression of INSIG1 mRNA CTD PMID:18927307 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Irinotecan analog results in increased expression of ITGA2 mRNA CTD PMID:18927307 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgae integrin subunit alpha E increases response to substance ISO ITGAE protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Irinotecan metabolite results in decreased expression of ITGAV mRNA; Irinotecan results in decreased expression of ITGAV mRNA CTD PMID:15956246 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgax integrin subunit alpha X increases expression ISO Irinotecan metabolite results in increased expression of ITGAX mRNA; Irinotecan results in increased expression of ITGAX mRNA CTD PMID:15956246 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein decreases expression ISO Irinotecan metabolite results in decreased expression of ITGB3BP mRNA; Irinotecan results in decreased expression of ITGB3BP mRNA CTD PMID:15956246 NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM affects expression EXP Irinotecan affects the expression of JCHAIN mRNA CTD PMID:20097248 NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298 		JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 decreases expression ISO Irinotecan analog results in decreased expression of JPT1 mRNA CTD PMID:18927307 NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO		 Irinotecan results in increased expression of JUN mRNA
Irinotecan metabolite results in increased expression of JUN mRNA; Irinotecan results in increased expression of JUN mRNA		 CTD PMID:15956246 PMID:20097248 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kansl1 KAT8 regulatory NSL complex subunit 1 multiple interactions ISO KANSL1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 NCBI chr10:89,237,667...89,368,735
Ensembl chr10:89,237,667...89,366,951 		JBrowse link
G Kat2b lysine acetyltransferase 2B increases expression ISO Irinotecan analog results in increased expression of KAT2B mRNA CTD PMID:18927307 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 increases expression EXP Irinotecan results in increased expression of KCNJ8 mRNA CTD PMID:20097248 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 decreases expression ISO Irinotecan analog results in decreased expression of KHDRBS1 mRNA CTD PMID:18927307 NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180 		JBrowse link
G Kiaa0040 KIAA0040 ortholog increases expression ISO Irinotecan analog results in increased expression of KIAA0040 mRNA CTD PMID:18927307 NCBI chr13:72,274,519...72,312,103
Ensembl chr13:72,274,552...72,312,103 		JBrowse link
G Kif14 kinesin family member 14 decreases expression ISO Irinotecan analog results in decreased expression of KIF14 mRNA CTD PMID:18927307 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
G Klf4 KLF transcription factor 4 increases expression ISO Irinotecan analog results in increased expression of KLF4 mRNA CTD PMID:18927307 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klf9 KLF transcription factor 9 increases expression ISO Irinotecan metabolite results in increased expression of KLF9 mRNA; Irinotecan results in increased expression of KLF9 mRNA CTD PMID:15956246 NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Irinotecan analog results in increased expression of KLHL24 mRNA CTD PMID:18927307 NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636 		JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of KNG1 mRNA CTD PMID:16391804 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein decreases expression EXP Irinotecan results in decreased expression of KNSTRN mRNA CTD PMID:20097248 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing decreases expression ISO Irinotecan analog results in decreased expression of KRIT1 mRNA CTD PMID:18927307 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Fluorouracil co-treated with Irinotecan co-treated with Vorinostat] results in increased cleavage of KRT18 protein CTD PMID:15754201 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Krt5 keratin 5 decreases expression ISO Irinotecan metabolite results in decreased expression of KRT5 mRNA; Irinotecan results in decreased expression of KRT5 mRNA CTD PMID:15956246 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Lbh LBH regulator of WNT signaling pathway decreases expression ISO Irinotecan analog results in decreased expression of LBH mRNA CTD PMID:18927307 NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079 		JBrowse link
G Lgals8 galectin 8 multiple interactions ISO LGALS8 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764 		JBrowse link
G Lmf1 lipase maturation factor 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of LMF1 mRNA CTD PMID:16391804 NCBI chr10:14,597,726...14,684,071
Ensembl chr10:14,597,594...14,684,119 		JBrowse link
G Lmo7 LIM domain 7 affects expression EXP Irinotecan affects the expression of LMO7 mRNA CTD PMID:20097248 NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783 		JBrowse link
G Loxl3 lysyl oxidase-like 3 decreases expression ISO Irinotecan analog results in decreased expression of LOXL3 mRNA CTD PMID:18927307 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 decreases expression ISO Irinotecan analog results in decreased expression of LPCAT1 mRNA CTD PMID:18927307 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401 		JBrowse link
G Lrch3 leucine rich repeats and calponin homology domain containing 3 decreases expression ISO Irinotecan analog results in decreased expression of LRCH3 mRNA CTD PMID:18927307 NCBI chr11:67,772,499...67,872,269
Ensembl chr11:67,772,506...67,872,264 		JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated increases response to substance ISO LSM7 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119 		JBrowse link
G Ltf lactotransferrin decreases expression ISO Irinotecan metabolite results in decreased expression of LTF mRNA; Irinotecan results in decreased expression of LTF mRNA CTD PMID:15956246 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Ltv1 LTV1 ribosome biogenesis factor decreases expression ISO Irinotecan analog results in decreased expression of LTV1 mRNA CTD PMID:18927307 NCBI chr 1:7,565,673...7,578,398
Ensembl chr 1:7,565,669...7,578,563 		JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of LYZ2 mRNA CTD PMID:32812032 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of MAD2L1 mRNA; Irinotecan results in decreased expression of MAD2L1 mRNA CTD PMID:15956246 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Maf MAF bZIP transcription factor affects expression EXP Irinotecan affects the expression of MAF mRNA CTD PMID:20097248 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 decreases expression EXP Irinotecan results in decreased expression of MAGI1 mRNA CTD PMID:20097248 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Irinotecan metabolite results in increased expression of MAL mRNA; Irinotecan results in increased expression of MAL mRNA CTD PMID:15956246 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mall mal, T-cell differentiation protein-like increases expression ISO Irinotecan metabolite results in increased expression of MALL mRNA; Irinotecan results in increased expression of MALL mRNA CTD PMID:15956246 NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Irinotecan metabolite results in decreased expression of MAP3K5 mRNA; Irinotecan results in decreased expression of MAP3K5 mRNA CTD PMID:15956246 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 increases expression EXP Irinotecan results in increased expression of MAP3K6 mRNA CTD PMID:20097248 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 decreases expression ISO Irinotecan analog results in decreased expression of MAP4K3 mRNA CTD PMID:18927307 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression		 ISO
EXP		 Irinotecan results in increased phosphorylation of and results in increased activity of MAPK1 protein
Irinotecan results in increased expression of MAPK1 mRNA		 CTD PMID:16432164 PMID:20097248 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 affects expression EXP Irinotecan affects the expression of MAPK13 mRNA CTD PMID:20097248 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Irinotecan results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16432164 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases expression ISO Irinotecan analog results in increased expression of MARCHF6 mRNA CTD PMID:18927307 NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910 		JBrowse link
G Matn2 matrilin 2 increases expression ISO Irinotecan analog results in increased expression of MATN2 mRNA CTD PMID:18927307 NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113 		JBrowse link
G Matr3 matrin 3 decreases expression ISO Irinotecan analog results in decreased expression of MATR3 mRNA CTD PMID:18927307 NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166 		JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 decreases expression ISO Irinotecan analog results in decreased expression of MBNL1 mRNA CTD PMID:18927307 NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368 		JBrowse link
G Mbp myelin basic protein decreases expression ISO Irinotecan analog results in decreased expression of MBP mRNA CTD PMID:18927307 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of MCCC2 mRNA
MCCC2 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:18927307 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972 		JBrowse link
G Mcf2l MCF.2 cell line derived transforming sequence-like decreases expression ISO Irinotecan metabolite results in decreased expression of MCF2L mRNA; Irinotecan results in decreased expression of MCF2L mRNA CTD PMID:15956246 NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases response to substance ISO MCL1 protein results in decreased susceptibility to Irinotecan CTD PMID:21507240 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Irinotecan metabolite results in decreased expression of MCM4 mRNA; Irinotecan results in decreased expression of MCM4 mRNA CTD PMID:15956246 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Irinotecan metabolite results in increased expression of MDM2 mRNA; Irinotecan results in increased expression of MDM2 mRNA CTD PMID:15956246 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdn1 midasin AAA ATPase 1 affects expression ISO Irinotecan analog affects the expression of MDN1 mRNA CTD PMID:18927307 NCBI chr 5:47,055,435...47,190,426
Ensembl chr 5:47,055,447...47,186,332 		JBrowse link
G Med13 mediator complex subunit 13 decreases expression ISO Irinotecan analog results in decreased expression of MED13 mRNA CTD PMID:18927307 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242 		JBrowse link
G Mef2b myocyte enhancer factor 2B increases expression ISO Irinotecan metabolite results in increased expression of MEF2B mRNA; Irinotecan results in increased expression of MEF2B mRNA CTD PMID:15956246 NCBI chr16:19,253,008...19,269,514
Ensembl chr16:19,253,010...19,268,967 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression
increases response to substance		 ISO Irinotecan metabolite results in decreased expression of MGMT mRNA
MGMT mRNA results in increased susceptibility to Irinotecan		 CTD PMID:15239142 PMID:18492797 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Minpp1 multiple inositol-polyphosphate phosphatase 1 affects expression EXP Irinotecan affects the expression of MINPP1 mRNA CTD PMID:20097248 NCBI chr 1:230,354,483...230,379,730
Ensembl chr 1:230,354,438...230,379,730 		JBrowse link
G Mip major intrinsic protein of lens fiber decreases expression ISO Irinotecan analog results in decreased expression of MIP mRNA CTD PMID:18927307 NCBI chr 7:643,502...653,121
Ensembl chr 7:647,315...654,400 		JBrowse link
G Mir128-1 microRNA 128-1 increases expression ISO Irinotecan results in increased expression of MIR128-1 mRNA CTD PMID:22898888 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530 		JBrowse link
G Mir34a microRNA 34a increases expression ISO Irinotecan results in increased expression of MIR34A mRNA CTD PMID:22898888 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mir449a microRNA 449a increases expression ISO Irinotecan results in increased expression of MIR449A mRNA CTD PMID:22898888 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of MKI67 protein CTD PMID:30612311 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mkx mohawk homeobox decreases expression ISO Irinotecan analog results in decreased expression of MKX mRNA CTD PMID:18927307 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Mlh1 mutL homolog 1 affects response to substance ISO MLH1 protein affects the susceptibility to Irinotecan CTD PMID:18949393 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mlxipl MLX interacting protein-like affects expression EXP Irinotecan affects the expression of MLXIPL mRNA CTD PMID:20097248 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Irinotecan results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein CTD PMID:36191607 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO Irinotecan metabolite results in increased expression of MMP9 mRNA; Irinotecan results in increased expression of MMP9 mRNA
[Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; Irinotecan results in decreased secretion of and results in decreased activity of and affects the expression of MMP9 protein		 CTD PMID:15956246 PMID:36191607 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
increases activity
increases expression		 ISO 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]]; carvacrol inhibits the reaction [Irinotecan results in increased activity of MPO protein]; GSK484 inhibits the reaction [Irinotecan results in increased activity of MPO protein]; GSK484 inhibits the reaction [Irinotecan results in increased expression of MPO mRNA]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased activity of MPO protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of MPO mRNA]
Irinotecan metabolite results in decreased expression of MPO mRNA; Irinotecan results in decreased expression of MPO mRNA
[Irinotecan co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein; Irinotecan promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]		 CTD PMID:15956246 PMID:27838229 PMID:38341106 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mpp7 MAGUK p55 scaffold protein 7 increases expression ISO Irinotecan analog results in increased expression of MPP7 mRNA CTD PMID:18927307 NCBI chr17:55,439,939...55,706,810
Ensembl chr17:55,442,696...55,706,748 		JBrowse link
G Mpst mercaptopyruvate sulfurtransferase decreases expression ISO Irinotecan results in decreased expression of MPST mRNA CTD PMID:20185912 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141 		JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 decreases expression ISO Irinotecan analog results in decreased expression of MRPS30 mRNA CTD PMID:18927307 NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105 		JBrowse link
G Msh2 mutS homolog 2 decreases expression
affects response to substance		 ISO Irinotecan metabolite results in decreased expression of MSH2 mRNA; Irinotecan results in decreased expression of MSH2 mRNA
MSH2 protein affects the susceptibility to Irinotecan		 CTD PMID:15956246 PMID:18949393 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msr1 macrophage scavenger receptor 1 increases expression EXP Irinotecan results in increased expression of MSR1 mRNA CTD PMID:20097248 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of ATP6 mRNA CTD PMID:16391804 NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Irinotecan results in increased expression of MT1A mRNA CTD PMID:20097248 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Irinotecan analog results in decreased expression of MTHFD1L mRNA CTD PMID:18927307 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase decreases expression ISO Irinotecan metabolite results in decreased expression of MTHFS mRNA; Irinotecan results in decreased expression of MTHFS mRNA CTD PMID:15956246 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtmr4 myotubularin related protein 4 affects expression EXP Irinotecan affects the expression of MTMR4 mRNA CTD PMID:20097248 NCBI chr10:72,393,411...72,416,342
Ensembl chr10:72,392,551...72,416,342 		JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Irinotecan metabolite results in decreased expression of MX2 mRNA; Irinotecan results in decreased expression of MX2 mRNA CTD PMID:15956246 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions
affects response to substance		 ISO MYD88 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; MYD88 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; MYD88 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; MYD88 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; MYD88 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; MYD88 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]
MYD88 protein affects the susceptibility to Irinotecan		 CTD PMID:35728726 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Myh10 myosin heavy chain 10 decreases expression ISO Irinotecan analog results in decreased expression of MYH10 mRNA CTD PMID:18927307 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165 		JBrowse link
G Mysm1 myb-like, SWIRM and MPN domains 1 decreases expression ISO Irinotecan analog results in decreased expression of MYSM1 mRNA CTD PMID:18927307 NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967 		JBrowse link
G N4bp1 Nedd4 binding protein 1 decreases expression ISO Irinotecan analog results in decreased expression of N4BP1 mRNA CTD PMID:18927307 NCBI chr19:20,222,811...20,273,570
Ensembl chr19:20,222,776...20,273,570 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of NCF1 mRNA CTD PMID:32812032 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nck1 NCK adaptor protein 1 decreases expression ISO Irinotecan metabolite results in decreased expression of NCK1 mRNA; Irinotecan results in decreased expression of NCK1 mRNA CTD PMID:15956246 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 increases expression ISO Irinotecan metabolite results in increased expression of NCOA1 mRNA; Irinotecan results in increased expression of NCOA1 mRNA CTD PMID:15956246 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions
decreases expression		 ISO NCOR1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of NCOR1 mRNA		 CTD PMID:18927307 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncstn nicastrin affects response to substance ISO NCSTN protein affects the susceptibility to Irinotecan CTD PMID:19147571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases response to substance ISO NDRG1 protein results in decreased susceptibility to Irinotecan CTD PMID:15867226 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO Irinotecan metabolite results in decreased expression of NEK2 mRNA; Irinotecan results in decreased expression of NEK2 mRNA CTD PMID:15956246 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of NFE2L2 mRNA
Luteolin inhibits the reaction [Irinotecan results in increased expression of NFE2L2 mRNA]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NFE2L2 mRNA]]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NFE2L2 mRNA]		 CTD PMID:34699766 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
increases activity
multiple interactions		 EXP
ISO		 Irinotecan results in increased expression of NFKB1 mRNA
Irinotecan results in increased activity of NFKB1 protein
Irinotecan results in increased expression of NFKB1 protein
carvacrol inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]; Silymarin inhibits the reaction [Irinotecan results in increased expression of NFKB1 protein]		 CTD PMID:18182997 PMID:20097248 PMID:27838229 PMID:28454924 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
increases response to substance		 EXP
ISO		 Irinotecan results in increased expression of NFKBIA mRNA
AS602868 inhibits the reaction [Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Irinotecan results in increased phosphorylation of and results in decreased expression of NFKBIA protein
NFKBIA gene mutant form results in increased susceptibility to Irinotecan		 CTD PMID:12675310 PMID:18182997 PMID:20097248 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 increases expression ISO Irinotecan metabolite results in increased expression of NHERF2 mRNA; Irinotecan results in increased expression of NHERF2 mRNA CTD PMID:15956246 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Nid1 nidogen 1 increases expression ISO Irinotecan metabolite results in increased expression of NID1 mRNA; Irinotecan results in increased expression of NID1 mRNA CTD PMID:15956246 NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267 		JBrowse link
G Nmu neuromedin U affects expression EXP Irinotecan affects the expression of NMU mRNA CTD PMID:20097248 NCBI chr14:31,844,564...31,872,196
Ensembl chr14:31,844,728...31,872,192 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of NOS2 mRNA
Luteolin inhibits the reaction [Irinotecan results in increased expression of NOS2 mRNA]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NOS2 mRNA]
GSK484 inhibits the reaction [Irinotecan results in increased expression of NOS2 mRNA]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of NOS2 mRNA]		 CTD PMID:34699766 PMID:38341106 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
increases expression		 ISO Irinotecan analog results in decreased expression of NQO1 mRNA
Luteolin inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]; PPARG protein affects the reaction [Luteolin inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]		 CTD PMID:18927307 PMID:34699766 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects expression		 ISO MYD88 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA] CTD PMID:35728726 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
multiple interactions		 ISO Irinotecan affects the expression of NR1I3 mRNA
MYD88 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]		 CTD PMID:35728726 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases response to substance ISO NR3C1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects expression EXP Irinotecan affects the expression of NR3C2 mRNA CTD PMID:20097248 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of NRIP1 mRNA CTD PMID:16391804 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Ns5atp4 NS5A transactivated protein 4 decreases expression ISO Irinotecan analog results in decreased expression of C1ORF43 mRNA CTD PMID:18927307 NCBI chr 2:175,494,406...175,507,281
Ensembl chr 2:175,494,304...175,510,663 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression ISO Irinotecan analog results in decreased expression of NSF mRNA CTD PMID:18927307 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor decreases expression ISO Irinotecan results in decreased expression of NSMAF mRNA CTD PMID:20185912 NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627 		JBrowse link
G Nup153 nucleoporin 153 decreases expression ISO Irinotecan analog results in decreased expression of NUP153 mRNA CTD PMID:18927307 NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO
EXP		 Irinotecan analog results in decreased expression of NUSAP1 mRNA
Irinotecan results in decreased expression of NUSAP1 mRNA		 CTD PMID:18927307 PMID:20097248 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624 		JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Irinotecan results in decreased expression of OAT mRNA CTD PMID:30012503 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Ocln occludin decreases expression
multiple interactions		 ISO Irinotecan results in decreased expression of OCLN protein
GSK484 inhibits the reaction [Irinotecan results in decreased expression of OCLN protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of OCLN protein]		 CTD PMID:38341106 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Ophn1 oligophrenin 1 increases expression ISO Irinotecan analog results in increased expression of OPHN1 mRNA CTD PMID:18927307 NCBI chr  X:63,599,746...63,976,678
Ensembl chr  X:63,603,042...63,976,633 		JBrowse link
G Orc1 origin recognition complex, subunit 1 increases response to substance ISO ORC1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Osmr oncostatin M receptor decreases response to substance
increases expression		 ISO OSMR protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in increased expression of OSMR mRNA; Irinotecan results in increased expression of OSMR mRNA		 CTD PMID:15956246 PMID:16734730 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 increases expression ISO Irinotecan analog results in increased expression of PAG1 mRNA CTD PMID:18927307 NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression ISO Irinotecan analog results in decreased expression of PAM mRNA CTD PMID:18927307 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pan3 poly(A) specific ribonuclease subunit PAN3 decreases expression ISO Irinotecan analog results in decreased expression of PAN3 mRNA CTD PMID:18927307 NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of PARP1 protein
rucaparib inhibits the reaction [Irinotecan results in increased expression of PARP1 protein]		 CTD PMID:30612311 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression ISO Irinotecan results in decreased expression of PAWR mRNA CTD PMID:20185912 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pax5 paired box 5 decreases expression ISO Irinotecan analog results in decreased expression of PAX5 mRNA CTD PMID:18927307 NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326 		JBrowse link
G Pax7 paired box 7 decreases expression ISO Irinotecan analog results in decreased expression of PAX7 mRNA CTD PMID:18927307 NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979 		JBrowse link
G Pbxip1 PBX homeobox interacting protein 1 decreases response to substance ISO PBXIP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:174,856,339...174,868,922
Ensembl chr 2:174,856,397...174,868,919 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 decreases expression ISO Irinotecan analog results in decreased expression of PCBD2 mRNA CTD PMID:18927307 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO Irinotecan metabolite results in increased expression of PCDHGC3 mRNA; Irinotecan results in increased expression of PCDHGC3 mRNA CTD PMID:15956246 NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression EXP Irinotecan affects the expression of PCK1 mRNA CTD PMID:20097248 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pclaf PCNA clamp associated factor multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of PCLAF mRNA CTD PMID:16391804 NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Irinotecan inhibits the reaction [nitrosobenzylmethylamine results in increased expression of PCNA protein] CTD PMID:15547733 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde4b phosphodiesterase 4B decreases expression
affects expression		 ISO
EXP		 Irinotecan metabolite results in decreased expression of PDE4B mRNA; Irinotecan results in decreased expression of PDE4B mRNA
Irinotecan affects the expression of PDE4B mRNA		 CTD PMID:15956246 PMID:20097248 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pdlim5 PDZ and LIM domain 5 decreases expression ISO Irinotecan analog results in decreased expression of PDLIM5 mRNA CTD PMID:18927307 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275 		JBrowse link
G Pfdn2 prefoldin subunit 2 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PFDN2 mRNA CTD PMID:32812032 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504 		JBrowse link
G Pgm2l1 phosphoglucomutase 2-like 1 increases expression ISO Irinotecan analog results in increased expression of PGM2L1 mRNA CTD PMID:18927307 NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Irinotecan analog results in decreased expression of PHLDA1 mRNA CTD PMID:18927307 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases expression ISO Irinotecan results in increased expression of PHLDA2 mRNA CTD PMID:20185912 NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836 		JBrowse link
G Pigw phosphatidylinositol glycan anchor biosynthesis, class W decreases expression ISO Irinotecan analog results in decreased expression of PIGW mRNA CTD PMID:18927307 NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475 		JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta affects expression EXP Irinotecan affects the expression of PIP5K1B mRNA CTD PMID:20097248 NCBI chr 1:221,907,220...222,183,672
Ensembl chr 1:221,914,159...222,183,672 		JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic decreases expression ISO Irinotecan results in decreased expression of PKDCC mRNA CTD PMID:20185912 NCBI chr 6:11,455,686...11,465,002
Ensembl chr 6:11,455,686...11,465,556 		JBrowse link
G Pla2g1b phospholipase A2 group IB affects expression EXP Irinotecan affects the expression of PLA2G1B mRNA CTD PMID:20097248 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g2d phospholipase A2, group IID affects expression EXP Irinotecan affects the expression of PLA2G2D mRNA CTD PMID:20097248 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525 		JBrowse link
G Plat plasminogen activator, tissue type increases expression
decreases expression		 EXP
ISO		 Irinotecan results in increased expression of PLAT mRNA
Irinotecan analog results in decreased expression of PLAT mRNA		 CTD PMID:18927307 PMID:20097248 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases secretion		 ISO [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein
Irinotecan results in decreased secretion of PLAU protein		 CTD PMID:36191607 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; Irinotecan results in increased secretion of and results in decreased expression of PLAUR protein CTD PMID:36191607 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Irinotecan results in decreased expression of PLCB1 mRNA CTD PMID:20097248 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 increases expression ISO Irinotecan analog results in increased expression of PLCXD2 mRNA CTD PMID:18927307 NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344 		JBrowse link
G Pld1 phospholipase D1 affects expression EXP Irinotecan affects the expression of PLD1 mRNA CTD PMID:20097248 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Plekha5 pleckstrin homology domain containing A5 decreases expression ISO Irinotecan analog results in decreased expression of PLEKHA5 mRNA CTD PMID:18927307 NCBI chr 4:173,333,891...173,503,546
Ensembl chr 4:173,334,055...173,503,546 		JBrowse link
G Plekhh3 pleckstrin homology, MyTH4 and FERM domain containing H3 increases expression ISO Irinotecan metabolite results in increased expression of PLEKHH3 mRNA; Irinotecan results in increased expression of PLEKHH3 mRNA CTD PMID:15956246 NCBI chr10:86,098,461...86,106,931
Ensembl chr10:86,098,469...86,106,880 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PLK1 mRNA; Irinotecan results in decreased expression of PLK1 mRNA CTD PMID:15956246 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Irinotecan metabolite results in increased expression of PLK2 mRNA; Irinotecan results in increased expression of PLK2 mRNA CTD PMID:15956246 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Irinotecan metabolite results in increased expression of PLK3 mRNA; Irinotecan results in increased expression of PLK3 mRNA CTD PMID:15956246 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Plpp1 phospholipid phosphatase 1 decreases response to substance ISO PLPP1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plrg1 pleiotropic regulator 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PLRG1 mRNA CTD PMID:16391804 NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Irinotecan metabolite results in increased expression of PMAIP1 mRNA; Irinotecan results in increased expression of PMAIP1 mRNA CTD PMID:15956246 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pmp22 peripheral myelin protein 22 affects expression EXP Irinotecan affects the expression of PMP22 mRNA CTD PMID:20097248 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 increases expression ISO Irinotecan analog results in increased expression of PNRC1 mRNA CTD PMID:18927307 NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161 		JBrowse link
G Pogz pogo transposable element derived with ZNF domain decreases expression ISO Irinotecan analog results in decreased expression of POGZ mRNA CTD PMID:18927307 NCBI chr 2:182,394,269...182,440,711
Ensembl chr 2:182,380,768...182,440,707 		JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases response to substance
affects expression		 ISO
EXP		 POLA1 protein results in increased susceptibility to Irinotecan
Irinotecan affects the expression of POLA1 mRNA		 CTD PMID:16734730 PMID:20097248 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit increases response to substance ISO POLE2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305 		JBrowse link
G Polk DNA polymerase kappa decreases expression ISO Irinotecan analog results in decreased expression of POLK mRNA CTD PMID:18927307 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313 		JBrowse link
G Polr3g RNA polymerase III subunit G increases response to substance ISO POLR3G protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:11,945,215...11,986,125
Ensembl chr 2:11,945,217...11,986,125 		JBrowse link
G Pon3 paraoxonase 3 affects expression EXP Irinotecan affects the expression of PON3 mRNA CTD PMID:20097248 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
G Por cytochrome p450 oxidoreductase increases response to substance ISO POR mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions		 ISO Irinotecan results in decreased expression of PPARG mRNA
Luteolin inhibits the reaction [Irinotecan results in decreased expression of PPARG mRNA]; PPARG protein affects the reaction [Luteolin inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]]; PPARG protein affects the reaction [Luteolin inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NFE2L2 mRNA]]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of NQO1 mRNA]]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]]		 CTD PMID:34699766 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Irinotecan analog results in increased expression of PPM1D mRNA CTD PMID:18927307 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of PPP3CA mRNA
[Fluorouracil co-treated with Irinotecan] results in increased expression of PPP3CA mRNA; PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:16391804 PMID:18927307 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta decreases expression ISO Irinotecan metabolite results in decreased expression of PPP3CB mRNA; Irinotecan results in decreased expression of PPP3CB mRNA CTD PMID:15956246 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B decreases expression ISO Irinotecan analog results in decreased expression of PPP4R3B mRNA CTD PMID:18927307 NCBI chr14:102,917,043...102,965,210
Ensembl chr14:102,917,443...103,068,192 		JBrowse link
G Prap1 proline-rich acidic protein 1 affects expression EXP Irinotecan affects the expression of PRAP1 mRNA CTD PMID:20097248 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases expression ISO Irinotecan analog results in decreased expression of PRKAA1 mRNA CTD PMID:18927307 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCA protein; Irinotecan results in increased phosphorylation of PRKCA protein CTD PMID:15723263 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCB protein; Irinotecan results in increased phosphorylation of PRKCB protein CTD PMID:15723263 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCD protein; Irinotecan results in increased phosphorylation of PRKCD protein CTD PMID:15723263 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkci protein kinase C, iota increases phosphorylation ISO Irinotecan metabolite results in increased phosphorylation of PRKCI protein; Irinotecan results in increased phosphorylation of PRKCI protein CTD PMID:15723263 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions
increases phosphorylation		 ISO IC486241 inhibits the reaction [Irinotecan results in increased phosphorylation of PRKDC protein] CTD PMID:17441964 PMID:21221710 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prlr prolactin receptor affects expression EXP Irinotecan affects the expression of PRLR mRNA CTD PMID:20097248 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Irinotecan metabolite results in decreased expression of PROM1 mRNA; Irinotecan results in decreased expression of PROM1 mRNA CTD PMID:15956246 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Prr13 proline rich 13 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PRR13 mRNA CTD PMID:16391804 NCBI chr 7:133,592,511...133,595,817
Ensembl chr 7:133,592,490...133,601,005 		JBrowse link
G Prr15 proline rich 15 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PRR15 mRNA CTD PMID:32812032 NCBI chr 4:83,432,002...83,435,582
Ensembl chr 4:83,431,758...83,437,436 		JBrowse link
G Prss12 serine protease 12 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of PRSS12 mRNA CTD PMID:32812032 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases response to substance ISO PSAT1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Ptch1 patched 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of PTCH1 mRNA CTD PMID:16391804 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Irinotecan metabolite results in increased expression of PTGES mRNA; Irinotecan results in increased expression of PTGES mRNA CTD PMID:15956246 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Irinotecan results in increased expression of PTGS2 protein
carvacrol inhibits the reaction [Irinotecan results in increased expression of PTGS2 protein]		 CTD PMID:27838229 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Irinotecan analog results in decreased expression of PTK2 mRNA CTD PMID:18927307 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO Irinotecan analog results in decreased expression of PTP4A1 mRNA CTD PMID:18927307 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases expression ISO Irinotecan metabolite results in decreased expression of PTPN13 mRNA; Irinotecan results in decreased expression of PTPN13 mRNA CTD PMID:15956246 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 increases expression ISO Irinotecan metabolite results in increased expression of PTPN22 mRNA; Irinotecan results in increased expression of PTPN22 mRNA CTD PMID:15956246 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D increases expression ISO Irinotecan metabolite results in increased expression of PTPRD mRNA; Irinotecan results in increased expression of PTPRD mRNA CTD PMID:15956246 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G decreases expression ISO Irinotecan analog results in decreased expression of PTPRG mRNA CTD PMID:18927307 NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094 		JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N increases expression ISO Irinotecan metabolite results in increased expression of PTPRN mRNA; Irinotecan results in increased expression of PTPRN mRNA CTD PMID:15956246 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin affects expression EXP Irinotecan affects the expression of PTTG1 mRNA CTD PMID:20097248 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family affects expression EXP Irinotecan affects the expression of RAB27A mRNA CTD PMID:20097248 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829 		JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases response to substance ISO RAB31 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253 		JBrowse link
G Rac3 Rac family small GTPase 3 increases expression ISO Irinotecan metabolite results in increased expression of RAC3 mRNA; Irinotecan results in increased expression of RAC3 mRNA CTD PMID:15956246 NCBI chr10:106,002,808...106,005,243
Ensembl chr10:105,993,087...106,005,260 		JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein decreases expression ISO Irinotecan metabolite results in decreased expression of RAD23B mRNA; Irinotecan results in decreased expression of RAD23B mRNA CTD PMID:15956246 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319 		JBrowse link
G Rad51 RAD51 recombinase increases expression
multiple interactions		 ISO Irinotecan results in increased expression of RAD51 protein
[Irinotecan co-treated with 2-(morpholin-4-yl)benzo(h)chromen-4-one] results in increased expression of RAD51 protein; [Irinotecan co-treated with IC486241] results in increased expression of RAD51 protein		 CTD PMID:21221710 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Ramp1 receptor activity modifying protein 1 affects expression EXP Irinotecan affects the expression of RAMP1 mRNA CTD PMID:20097248 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151 		JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression EXP Irinotecan results in increased expression of RARRES1 mRNA CTD PMID:20097248 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978 		JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression ISO Irinotecan analog results in decreased expression of RASA1 mRNA CTD PMID:18927307 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression ISO Irinotecan affects the expression of RB1 protein CTD PMID:15132777 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression
increases expression		 ISO Irinotecan metabolite results in decreased expression of RBBP5 mRNA; Irinotecan results in decreased expression of RBBP5 mRNA
Irinotecan metabolite results in increased expression of RBBP5 mRNA; Irinotecan results in increased expression of RBBP5 mRNA		 CTD PMID:15956246 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RBL1 mRNA; Irinotecan results in decreased expression of RBL1 mRNA CTD PMID:15956246 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbm24 RNA binding motif protein 24 increases expression ISO Irinotecan analog results in increased expression of RBM24 mRNA CTD PMID:18927307 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102 		JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 decreases response to substance ISO RBMS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376 		JBrowse link
G Rbp2 retinol binding protein 2 affects expression EXP Irinotecan affects the expression of RBP2 mRNA CTD PMID:20097248 NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions
decreases expression		 ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of RBPJ mRNA
Irinotecan analog results in decreased expression of RBPJ mRNA		 CTD PMID:16391804 PMID:18927307 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO Irinotecan analog results in increased expression of RECK mRNA CTD PMID:18927307 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Reg1a regenerating family member 1 alpha affects expression EXP Irinotecan affects the expression of REG1A mRNA CTD PMID:20097248 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Reg3b regenerating family member 3 beta affects expression EXP Irinotecan affects the expression of REG3B mRNA CTD PMID:20097248 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Reg3g regenerating family member 3 gamma affects expression EXP Irinotecan affects the expression of REG3G mRNA CTD PMID:20097248 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
decreases response to substance
increases activity		 EXP
ISO		 Irinotecan results in increased expression of RELA protein
[Irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [Irinotecan co-treated with Thalidomide] results in increased expression of RELA protein
RELA protein results in decreased susceptibility to Irinotecan
Irinotecan results in increased activity of RELA protein		 CTD PMID:15161687 PMID:16685529 PMID:18182997 PMID:18535404 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Reps1 RALBP1 associated Eps domain containing 1 multiple interactions
decreases expression		 ISO REPS1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of REPS1 mRNA		 CTD PMID:18927307 NCBI chr 1:12,697,742...12,775,562
Ensembl chr 1:12,697,747...12,775,561 		JBrowse link
G Rfc3 replication factor C subunit 3 increases response to substance
decreases expression		 ISO RFC3 protein results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of RFC3 mRNA; Irinotecan results in decreased expression of RFC3 mRNA		 CTD PMID:15956246 PMID:16734730 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Irinotecan metabolite results in increased expression of RGS1 mRNA; Irinotecan results in increased expression of RGS1 mRNA CTD PMID:15956246 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Rgs10 regulator of G-protein signaling 10 multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of RGS10 mRNA CTD PMID:32812032 NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697 		JBrowse link
G Rgs22 regulator of G-protein signaling 22 decreases expression ISO Irinotecan analog results in decreased expression of RGS22 mRNA CTD PMID:18927307 NCBI chr 7:67,188,531...67,308,805
Ensembl chr 7:67,188,519...67,308,875 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 increases expression EXP Irinotecan results in increased expression of RGS4 mRNA CTD PMID:20097248 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rhob ras homolog family member B increases expression ISO Irinotecan results in increased expression of RHOB mRNA CTD PMID:20185912 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rhou ras homolog family member U increases expression ISO Irinotecan analog results in increased expression of RHOU mRNA CTD PMID:18927307 NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552 		JBrowse link
G Rlim ring finger protein, LIM domain interacting decreases expression ISO Irinotecan analog results in decreased expression of RLIM mRNA CTD PMID:18927307 NCBI chr  X:68,983,259...69,004,368
Ensembl chr  X:68,988,375...69,004,271 		JBrowse link
G Rnf34 ring finger protein 34 multiple interactions
decreases response to substance		 ISO RNF34 protein inhibits the reaction [Irinotecan results in increased activity of CASP3 protein]
RNF34 protein results in decreased susceptibility to Irinotecan		 CTD PMID:16080519 NCBI chr12:33,703,655...33,724,606
Ensembl chr12:33,703,673...33,724,586 		JBrowse link
G Rpl4 ribosomal protein L4 decreases expression ISO Irinotecan analog results in decreased expression of RPL4 mRNA CTD PMID:18927307 NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [Irinotecan co-treated with rucaparib] results in decreased expression of RPS6KB1 protein CTD PMID:30612311 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO Irinotecan analog results in increased expression of HLA-DRB1 mRNA CTD PMID:18927307 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 affects expression EXP Irinotecan affects the expression of RTP4 mRNA CTD PMID:20097248 NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437 		JBrowse link
G Runx1 RUNX family transcription factor 1 decreases expression ISO Irinotecan metabolite results in decreased expression of RUNX1 mRNA; Irinotecan results in decreased expression of RUNX1 mRNA CTD PMID:15956246 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
G S100g S100 calcium binding protein G affects expression EXP Irinotecan affects the expression of S100G mRNA CTD PMID:20097248 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Samd9 sterile alpha motif domain containing 9 increases expression ISO Irinotecan analog results in increased expression of SAMD9 mRNA CTD PMID:18927307 NCBI chr 4:31,164,639...31,184,278
Ensembl chr 4:31,164,510...31,184,322 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 affects expression ISO Irinotecan analog affects the expression of SAMHD1 mRNA CTD PMID:18927307 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 decreases response to substance
increases expression		 ISO SAT1 mRNA results in decreased susceptibility to Irinotecan
Irinotecan results in increased expression of SAT1 mRNA		 CTD PMID:15152939 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Scaf4 SR-related CTD-associated factor 4 decreases expression ISO Irinotecan analog results in decreased expression of SCAF4 mRNA CTD PMID:18927307 NCBI chr11:29,460,479...29,521,153
Ensembl chr11:29,465,106...29,521,153 		JBrowse link
G Scai suppressor of cancer cell invasion decreases expression ISO Irinotecan analog results in decreased expression of SCAI mRNA CTD PMID:18927307 NCBI chr 3:22,813,283...22,925,337
Ensembl chr 3:22,819,574...22,925,363 		JBrowse link
G Scamp3 secretory carrier membrane protein 3 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SCAMP3 mRNA CTD PMID:16391804 NCBI chr 2:174,583,124...174,588,984
Ensembl chr 2:174,570,653...174,588,985 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Irinotecan analog results in increased expression of SCD4 mRNA CTD PMID:18927307 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scin scinderin affects expression EXP Irinotecan affects the expression of SCIN mRNA CTD PMID:20097248 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Sdc4 syndecan 4 increases expression ISO Irinotecan metabolite results in increased expression of SDC4 mRNA; Irinotecan results in increased expression of SDC4 mRNA CTD PMID:15956246 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component decreases expression ISO Irinotecan analog results in decreased expression of SEC31A mRNA CTD PMID:18927307 NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273 		JBrowse link
G Sema3c semaphorin 3C increases expression ISO Irinotecan analog results in increased expression of SEMA3C mRNA CTD PMID:18927307 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534 		JBrowse link
G Senp6 SUMO specific peptidase 6 decreases expression ISO Irinotecan analog results in decreased expression of SENP6 mRNA CTD PMID:18927307 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170 		JBrowse link
G Serpinb5 serpin family B member 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SERPINB5 mRNA CTD PMID:16391804 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO SERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with Irinotecan] CTD PMID:17327601 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Irinotecan results in increased expression of SERTAD1 mRNA CTD PMID:20185912 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Irinotecan metabolite results in increased expression of SESN2 mRNA; Irinotecan results in increased expression of SESN2 mRNA CTD PMID:15956246 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase decreases expression ISO Irinotecan analog results in decreased expression of SETD1B mRNA CTD PMID:18927307 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934 		JBrowse link
G Setd5 SET domain containing 5 decreases expression ISO Irinotecan analog results in decreased expression of SETD5 mRNA CTD PMID:18927307 NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894 		JBrowse link
G Sfn stratifin multiple interactions ISO [Irinotecan co-treated with Bortezomib] results in decreased expression of SFN protein CTD PMID:16373703 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Irinotecan analog results in increased expression of SGK1 mRNA; Irinotecan metabolite results in increased expression of SGK1 mRNA; Irinotecan results in increased expression of SGK1 mRNA CTD PMID:15956246 PMID:18927307 PMID:20185912 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sgo2 shugoshin 2 decreases expression ISO Irinotecan analog results in decreased expression of SGO2 mRNA CTD PMID:18927307 NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229 		JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of SIGLEC1 mRNA CTD PMID:16391804 NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850 		JBrowse link
G Skp2 S-phase kinase associated protein 2 increases response to substance ISO SKP2 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc13a2 solute carrier family 13 member 2 affects expression EXP Irinotecan affects the expression of SLC13A2 mRNA CTD PMID:20097248 NCBI chr10:63,291,813...63,319,127
Ensembl chr10:63,291,815...63,319,127 		JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression ISO Irinotecan metabolite results in decreased expression of SLC16A4 mRNA; Irinotecan results in decreased expression of SLC16A4 mRNA CTD PMID:15956246 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC19A1 mRNA CTD PMID:18927307 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc25a21 solute carrier family 25 member 21 decreases expression ISO Irinotecan analog results in decreased expression of SLC25A21 mRNA CTD PMID:18927307 NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680 		JBrowse link
G Slc25a36 solute carrier family 25 member 36 affects expression EXP Irinotecan affects the expression of SLC25A36 mRNA CTD PMID:20097248 NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Irinotecan analog results in decreased expression of SLC30A1 mRNA CTD PMID:18927307 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 affects expression EXP Irinotecan affects the expression of SLC31A1 mRNA CTD PMID:20097248 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc39a4 solute carrier family 39 member 4 affects expression EXP Irinotecan affects the expression of SLC39A4 mRNA CTD PMID:20097248 NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553 		JBrowse link
G Slc44a1 solute carrier family 44 member 1 affects expression EXP Irinotecan affects the expression of SLC44A1 mRNA CTD PMID:20097248 NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor affects expression EXP Irinotecan affects the expression of SLPI mRNA CTD PMID:20097248 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Smad3 SMAD family member 3 decreases expression ISO Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 decreases expression ISO Irinotecan analog results in decreased expression of SMCHD1 mRNA CTD PMID:18927307 NCBI chr 9:111,243,445...111,387,272
Ensembl chr 9:111,247,702...111,349,665 		JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression ISO Irinotecan analog results in decreased expression of SMU1 mRNA CTD PMID:18927307 NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 affects expression ISO Irinotecan analog affects the expression of SMURF1 mRNA CTD PMID:18927307 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Snrpa1 small nuclear ribonucleoprotein polypeptide A' multiple interactions
decreases expression		 ISO SNRPA1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan analog results in decreased expression of SNRPA1 mRNA		 CTD PMID:18927307 NCBI chr 1:119,641,402...119,654,653
Ensembl chr 1:119,638,481...119,654,653 		JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F increases response to substance ISO SNRPF protein results in increased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129 		JBrowse link
G Snx18 sorting nexin 18 decreases expression ISO Irinotecan metabolite results in decreased expression of SNX18 mRNA; Irinotecan results in decreased expression of SNX18 mRNA CTD PMID:15956246 NCBI chr 2:45,232,325...45,258,345
Ensembl chr 2:45,232,325...45,258,345 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
increases expression
multiple interactions		 ISO Irinotecan results in decreased expression of SOD1 protein
Irinotecan results in increased expression of SOD1 mRNA
Luteolin inhibits the reaction [Irinotecan results in decreased expression of SOD1 protein]; Luteolin inhibits the reaction [Irinotecan results in increased expression of SOD1 mRNA]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of SOD1 mRNA]		 CTD PMID:34699766 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Irinotecan co-treated with Fluorouracil] results in increased activity of SOD2 protein CTD PMID:15886469 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor decreases expression
multiple interactions
increases phosphorylation		 ISO Irinotecan analog results in decreased expression of SP1 mRNA
SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]
Irinotecan results in increased phosphorylation of SP1 protein		 CTD PMID:17441964 PMID:18927307 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sphk1 sphingosine kinase 1 affects expression EXP Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spib Spi-B transcription factor increases expression ISO Irinotecan metabolite results in increased expression of SPIB mRNA; Irinotecan results in increased expression of SPIB mRNA CTD PMID:15956246 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780 		JBrowse link
G Srp19 signal recognition particle 19 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of SRP19 mRNA CTD PMID:16391804 NCBI chr18:25,931,734...25,937,974
Ensembl chr18:25,931,589...25,938,017 		JBrowse link
G Srpx sushi-repeat-containing protein, X-linked increases expression EXP Irinotecan results in increased expression of SRPX mRNA CTD PMID:20097248 NCBI chr  X:12,676,984...12,751,296
Ensembl chr  X:12,566,645...12,747,882 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases phosphorylation
multiple interactions		 ISO Irinotecan results in increased phosphorylation of STAT1 protein
STAT1 protein promotes the reaction [Irinotecan results in increased localization of FAS protein]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]		 CTD PMID:16204068 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stk25 serine/threonine kinase 25 affects expression EXP Irinotecan affects the expression of STK25 mRNA CTD PMID:20097248 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244 		JBrowse link
G Stk38 serine/threonine kinase 38 increases expression ISO Irinotecan metabolite results in increased expression of STK38 mRNA; Irinotecan results in increased expression of STK38 mRNA CTD PMID:15956246 NCBI chr20:7,034,245...7,067,803
Ensembl chr20:7,034,242...7,068,198 		JBrowse link
G Stk4 serine/threonine kinase 4 decreases expression
multiple interactions		 ISO Irinotecan analog results in decreased expression of STK4 mRNA; Irinotecan metabolite results in decreased expression of STK4 mRNA; Irinotecan results in decreased expression of STK4 mRNA
STK4 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:15956246 PMID:18927307 NCBI chr 3:152,745,958...152,827,747
Ensembl chr 3:152,745,681...152,827,744 		JBrowse link
G Stx5 syntaxin 5 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of STX5 mRNA CTD PMID:16391804 NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563 		JBrowse link
G Syde2 synapse defective Rho GTPase homolog 2 increases expression ISO Irinotecan analog results in increased expression of SYDE2 mRNA CTD PMID:18927307 NCBI chr 2:234,897,975...234,930,994
Ensembl chr 2:234,897,717...234,930,994 		JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Irinotecan analog results in decreased expression of SYT1 mRNA CTD PMID:18927307 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
G Taf2 TATA-box binding protein associated factor 2 decreases expression ISO Irinotecan metabolite results in decreased expression of TAF2 mRNA; Irinotecan results in decreased expression of TAF2 mRNA CTD PMID:15956246 NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616 		JBrowse link
G Taf5l1 TATA-box binding protein associated factor 5 like 1 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TAF5L mRNA CTD PMID:16391804 NCBI chr19:51,991,704...52,011,001
Ensembl chr19:51,991,708...52,011,295 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TARDBP mRNA CTD PMID:32812032 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tbcc tubulin folding cofactor C increases expression ISO Irinotecan metabolite results in increased expression of TBCC mRNA; Irinotecan results in increased expression of TBCC mRNA CTD PMID:15956246 PMID:20185912 NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042 		JBrowse link
G Tcf12 transcription factor 12 decreases expression ISO Irinotecan analog results in decreased expression of TCF12 mRNA CTD PMID:18927307 NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 decreases expression ISO Irinotecan analog results in decreased expression of TCF7L2 mRNA CTD PMID:18927307 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tesk2 testis associated actin remodelling kinase 2 affects expression EXP Irinotecan affects the expression of TESK2 mRNA CTD PMID:20097248 NCBI chr 5:130,178,715...130,270,594
Ensembl chr 5:130,185,033...130,271,292 		JBrowse link
G Tfcp2 transcription factor CP2 decreases expression ISO Irinotecan analog results in decreased expression of TFCP2 mRNA CTD PMID:18927307 NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939 		JBrowse link
G Tff1 trefoil factor 1 affects expression EXP Irinotecan affects the expression of TFF1 mRNA CTD PMID:20097248 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tff3 trefoil factor 3 affects expression EXP Irinotecan affects the expression of TFF3 mRNA CTD PMID:20097248 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Irinotecan analog results in decreased expression of TFPI mRNA CTD PMID:18927307 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Irinotecan analog results in increased expression of TFRC mRNA CTD PMID:18927307 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
decreases response to substance
increases secretion		 ISO Gefitinib inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; Gefitinib inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [Irinotecan results in increased secretion of TGFA protein]
TGFA protein results in decreased susceptibility to Irinotecan
Irinotecan metabolite results in increased secretion of TGFA protein; Irinotecan results in increased secretion of TGFA protein		 CTD PMID:15723263 PMID:16734730 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression ISO Irinotecan analog results in decreased expression of TGFBI mRNA CTD PMID:18927307 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to Irinotecan CTD PMID:16734730 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 increases expression EXP Irinotecan results in increased expression of THBS2 mRNA CTD PMID:20097248 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Them4 thioesterase superfamily member 4 decreases expression ISO Irinotecan analog results in decreased expression of THEM4 mRNA CTD PMID:18927307 NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708 		JBrowse link
G Thnsl1 threonine synthase-like 1 decreases expression ISO Irinotecan analog results in decreased expression of THNSL1 mRNA CTD PMID:18927307 NCBI chr17:83,714,794...83,722,190
Ensembl chr17:83,714,738...83,723,805 		JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 decreases expression ISO Irinotecan analog results in decreased expression of THRAP3 mRNA CTD PMID:18927307 NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477 		JBrowse link
G Thy1 Thy-1 cell surface antigen increases expression ISO Irinotecan metabolite results in increased expression of THY1 mRNA; Irinotecan results in increased expression of THY1 mRNA CTD PMID:15956246 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO Irinotecan results in decreased expression of TJP1 protein
GSK484 inhibits the reaction [Irinotecan results in decreased expression of TJP1 protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of TJP1 protein]		 CTD PMID:38341106 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr2 toll-like receptor 2 affects response to substance
multiple interactions		 ISO TLR2 protein affects the susceptibility to Irinotecan
TLR2 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; TLR2 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; TLR2 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]		 CTD PMID:35728726 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
affects response to substance		 ISO Irinotecan results in increased expression of TLR4 protein
Silymarin inhibits the reaction [Irinotecan results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [Irinotecan affects the expression of IL1B mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I2 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of NR1I3 mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; TLR4 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; TLR4 protein affects the reaction [Irinotecan results in increased expression of IL6 mRNA]
TLR4 protein affects the susceptibility to Irinotecan		 CTD PMID:28454924 PMID:35728726 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem123 transmembrane protein 123 decreases expression ISO Irinotecan analog results in decreased expression of TMEM123 mRNA CTD PMID:18927307 NCBI chr 8:4,922,077...4,952,228
Ensembl chr 8:4,922,098...4,952,224 		JBrowse link
G Tmem267 transmembrane protein 267 decreases expression ISO Irinotecan analog results in decreased expression of TMEM267 mRNA CTD PMID:18927307 NCBI chr 2:51,580,210...51,588,937
Ensembl chr 2:51,581,252...51,587,636 		JBrowse link
G Tmem37 transmembrane protein 37 affects expression EXP Irinotecan affects the expression of TMEM37 mRNA CTD PMID:20097248 NCBI chr13:31,184,322...31,191,477
Ensembl chr13:31,171,355...31,191,077 		JBrowse link
G Tmem41b transmembrane protein 41B decreases expression ISO Irinotecan metabolite results in decreased expression of TMEM41B mRNA; Irinotecan results in decreased expression of TMEM41B mRNA CTD PMID:15956246 NCBI chr 1:164,012,585...164,026,967
Ensembl chr 1:164,012,592...164,026,933 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TMSB4X mRNA CTD PMID:32812032 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tmt1b thiol methyltransferase 1B affects expression EXP Irinotecan affects the expression of TMT1B mRNA CTD PMID:20097248 NCBI chr 7:1,388,876...1,391,526
Ensembl chr 7:1,388,879...1,391,526 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
affects expression		 EXP
ISO		 [Irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]; Irinotecan inhibits the reaction [Mitogens results in increased expression of TNF protein]; Irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Irinotecan results in increased expression of TNF protein]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]]; carvacrol inhibits the reaction [Irinotecan results in increased expression of TNF protein]; GSK484 inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; MYD88 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; TLR2 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]; TLR4 protein affects the reaction [Irinotecan affects the expression of TNF mRNA]
Irinotecan results in increased expression of TNF mRNA; Irinotecan results in increased expression of TNF protein
Luteolin inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; PPARG protein affects the reaction [Luteolin inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]]; PPARG protein affects the reaction [Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]]; Rosiglitazone inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]
Irinotecan results in increased secretion of TNF protein		 CTD PMID:16815871 PMID:18182997 PMID:18535404 PMID:19401694 PMID:26431797 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Irinotecan metabolite results in decreased expression of TNFAIP6 mRNA; Irinotecan results in decreased expression of TNFAIP6 mRNA CTD PMID:15956246 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Irinotecan results in increased expression of TNFRSF12A mRNA CTD PMID:20097248 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045 		JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 affects expression EXP Irinotecan affects the expression of TNFRSF14 mRNA CTD PMID:20097248 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Irinotecan results in increased expression of TNFRSF1A mRNA CTD PMID:20097248 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases activity		 ISO CFLAR protein alternative form inhibits the reaction [Irinotecan results in increased activity of TNFSF10 protein] CTD PMID:16373718 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tob1 transducer of ErbB-2.1 increases expression ISO Irinotecan metabolite results in increased expression of TOB1 mRNA; Irinotecan results in increased expression of TOB1 mRNA CTD PMID:15956246 NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215 		JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression ISO Irinotecan metabolite results in increased expression of TOB2 mRNA; Irinotecan results in increased expression of TOB2 mRNA CTD PMID:15956246 NCBI chr 7:113,362,703...113,371,423
Ensembl chr 7:113,361,148...113,372,688 		JBrowse link
G Top1 DNA topoisomerase I decreases activity
affects binding
affects response to substance		 ISO Irinotecan results in decreased activity of TOP1 protein
Irinotecan binds to TOP1 protein
TOP1 protein affects the susceptibility to Irinotecan		 CTD PMID:11914913 PMID:15041737 PMID:15655543 PMID:18509181 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top2a DNA topoisomerase II alpha increases response to substance
decreases expression		 ISO TOP2A mRNA results in increased susceptibility to Irinotecan
Irinotecan metabolite results in decreased expression of TOP2A mRNA; Irinotecan results in decreased expression of TOP2A mRNA		 CTD PMID:15239142 PMID:15956246 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top6bl TOP6B like initiator of meiotic double strand breaks increases expression ISO Irinotecan analog results in increased expression of TOP6BL mRNA CTD PMID:18927307 NCBI chr 1:201,902,564...201,989,945 JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase decreases expression ISO Irinotecan metabolite results in decreased expression of TOPORS mRNA; Irinotecan results in decreased expression of TOPORS mRNA CTD PMID:15956246 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
multiple interactions
increases phosphorylation
affects response to substance
affects activity		 ISO Irinotecan results in increased expression of TP53 mRNA; Irinotecan results in increased expression of TP53 protein
TP53 results in increased susceptibility to Irinotecan
[Irinotecan co-treated with Bortezomib] results in increased ubiquitination of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased activity of TP53 protein; Irinotecan results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 protein affects the susceptibility to [Irinotecan co-treated with Bortezomib]; TP53 protein inhibits the reaction [Irinotecan results in increased phosphorylation of STAT1 protein]
Irinotecan results in increased phosphorylation of TP53 protein
TP53 protein affects the susceptibility to Irinotecan
Irinotecan affects the activity of TP53 protein; Irinotecan metabolite affects the activity of TP53 protein		 CTD PMID:16204068 PMID:16373703 PMID:16963839 PMID:22510560 PMID:22898888 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Irinotecan analog results in increased expression of TP53INP1 mRNA CTD PMID:18927307 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression
multiple interactions		 ISO Irinotecan analog results in increased expression of TPMT mRNA
TPMT protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog]		 CTD PMID:18927307 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
G Tppp tubulin polymerization promoting protein increases expression ISO Irinotecan analog results in increased expression of TPPP mRNA CTD PMID:18927307 NCBI chr 1:29,257,111...29,281,134
Ensembl chr 1:29,261,255...29,281,134 		JBrowse link
G Tpx2 TPX2, microtubule nucleation factor decreases expression ISO Irinotecan metabolite results in decreased expression of TPX2 mRNA; Irinotecan results in decreased expression of TPX2 mRNA CTD PMID:15956246 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Irinotecan metabolite results in increased expression of TRADD mRNA; Irinotecan results in increased expression of TRADD mRNA CTD PMID:15956246 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 decreases expression
increases expression		 ISO Irinotecan metabolite results in decreased expression of TRAF1 mRNA; Irinotecan results in decreased expression of TRAF1 mRNA
Irinotecan metabolite results in increased expression of TRAF1 mRNA; Irinotecan results in increased expression of TRAF1 mRNA		 CTD PMID:15956246 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression ISO Irinotecan metabolite results in decreased expression of TRDMT1 mRNA; Irinotecan results in decreased expression of TRDMT1 mRNA CTD PMID:15956246 NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439 		JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO Irinotecan analog results in increased expression of TRIB1 mRNA CTD PMID:18927307 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
G Trib2 tribbles pseudokinase 2 affects expression ISO Irinotecan analog affects the expression of TRIB2 mRNA CTD PMID:18927307 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370 		JBrowse link
G Trim9 tripartite motif-containing 9 increases expression ISO Irinotecan analog results in increased expression of TRIM9 mRNA CTD PMID:18927307 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:88,757,303...88,856,542 		JBrowse link
G Trmt13 tRNA methyltransferase 13 homolog decreases expression ISO Irinotecan analog results in decreased expression of TRMT13 mRNA CTD PMID:18927307 NCBI chr 2:204,533,630...204,547,711
Ensembl chr 2:204,533,632...204,546,843 		JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 decreases expression ISO Irinotecan results in decreased expression of TSEN2 mRNA CTD PMID:20185912 NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215 		JBrowse link
G Tspan4 tetraspanin 4 increases expression EXP Irinotecan results in increased expression of TSPAN4 mRNA CTD PMID:20097248 NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448 		JBrowse link
G Tspan8 tetraspanin 8 multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in decreased expression of TSPAN8 mRNA CTD PMID:16391804 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
G Ttk Ttk protein kinase decreases expression ISO Irinotecan metabolite results in decreased expression of TTK mRNA; Irinotecan results in decreased expression of TTK mRNA CTD PMID:15956246 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Irinotecan results in increased expression of TXNIP mRNA CTD PMID:20185912 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 affects expression EXP Irinotecan affects the expression of TXNRD1 mRNA CTD PMID:20097248 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO TYMP mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO TYMS mRNA affects the susceptibility to [Irinotecan co-treated with Fluorouracil co-treated with Leucovorin] CTD PMID:17454858 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp multiple interactions ISO [PHY 906 co-treated with Irinotecan] affects the expression of TYROBP mRNA CTD PMID:32812032 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Ubd ubiquitin D affects expression EXP Irinotecan affects the expression of UBD mRNA CTD PMID:20097248 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO
EXP		 Irinotecan metabolite results in decreased expression of UBE2C mRNA; Irinotecan results in decreased expression of UBE2C mRNA CTD PMID:15956246 PMID:20097248 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression ISO Irinotecan analog results in decreased expression of UBE2E3 mRNA CTD PMID:18927307 NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237 		JBrowse link
G Ube2j2 ubiquitin-conjugating enzyme E2, J2 decreases expression ISO Irinotecan analog results in decreased expression of UBE2J2 mRNA CTD PMID:18927307 NCBI chr 5:166,533,374...166,547,811
Ensembl chr 5:166,533,418...166,547,804 		JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 affects expression EXP Irinotecan affects the expression of UBE2L6 mRNA CTD PMID:20097248 NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048 		JBrowse link
G Uchl5 ubiquitin C-terminal hydrolase L5 decreases expression ISO Irinotecan metabolite results in decreased expression of UCHL5 mRNA; Irinotecan results in decreased expression of UCHL5 mRNA CTD PMID:15956246 NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502 		JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 decreases expression ISO Irinotecan analog results in decreased expression of UGGT2 mRNA CTD PMID:18927307 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects response to substance
multiple interactions
increases glucuronidation
affects metabolic processing
increases metabolic processing
decreases glucuronidation
decreases activity
decreases expression
affects glucuronidation		 ISO
EXP		 UGT1A1 gene polymorphism affects the susceptibility to Irinotecan; UGT1A1 promoter polymorphism affects the susceptibility to Irinotecan; UGT1A1 protein affects the susceptibility to Irinotecan
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Irinotecan; [UGT1A1 protein mutant form affects the glucuronidation of Irinotecan] which results in decreased abundance of 7-ethyl-10-hydroxycamptothecin beta-glucuronide; [UGT1A1 protein results in increased glucuronidation of Irinotecan] which results in increased abundance of 7-ethyl-10-hydroxycamptothecin beta-glucuronide; UGT1A1 gene polymorphism affects the susceptibility to [Fluorouracil co-treated with Irinotecan]; UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Irinotecan
UGT1A1 protein affects the metabolism of Irinotecan
UGT1A1 protein results in increased metabolism of Irinotecan
UGT1A1 gene mutant form results in decreased glucuronidation of Irinotecan; UGT1A1 protein polymorphism results in decreased glucuronidation of Irinotecan
Irinotecan results in decreased activity of UGT1A1 protein
MYD88 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; TLR2 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]; TLR4 protein affects the reaction [Irinotecan results in decreased expression of UGT1A1 mRNA]		 CTD PMID:12960109 PMID:15517893 PMID:15523087 PMID:15655543 PMID:15716465 More... NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Irinotecan CTD PMID:15716465 PMID:35930428 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Irinotecan; UGT1A8 protein results in increased glucuronidation of Irinotecan CTD PMID:15833930 NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions
affects glucuronidation		 ISO
EXP		 UGT1A9 protein results in increased glucuronidation of Irinotecan
[UGT1A9 protein mutant form affects the glucuronidation of Irinotecan] which results in decreased abundance of 7-ethyl-10-hydroxycamptothecin beta-glucuronide		 CTD PMID:15833930 PMID:17898154 PMID:35930428 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ulk4 unc-51 like kinase 4 decreases expression ISO Irinotecan analog results in decreased expression of ULK4 mRNA CTD PMID:18927307 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924 		JBrowse link
G Uso1 USO1 vesicle transport factor decreases expression ISO Irinotecan analog results in decreased expression of USO1 mRNA CTD PMID:18927307 NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171 		JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO Irinotecan analog results in decreased expression of USP24 mRNA CTD PMID:18927307 NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311 		JBrowse link
G Utp3 UTP3, small subunit processome component multiple interactions ISO [Fluorouracil co-treated with Irinotecan] results in increased expression of UTP3 mRNA CTD PMID:16391804 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Vldlr very low density lipoprotein receptor affects expression EXP Irinotecan affects the expression of VLDLR mRNA CTD PMID:20097248 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression EXP Irinotecan results in decreased expression of VPS13B mRNA CTD PMID:20097248 NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429 		JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A decreases expression