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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pinostrobin
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Accession:CHEBI:80491 term browser browse the term
Definition:A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.
Synonyms:related_synonym: (2S)-5-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one;   (2S)-5-hydroxy-7-methoxyflavanone;   Pinocembrin-7-methylether;   dihydrotectochrysin
 xref: CAS:480-37-5;   KNApSAcK:C00008144
 xref_mesh: MESH:C411294
 xref: Reaxys:90359;   kegg.compound:C16419;   lipidmaps:LMPK12140216;   pubmed:24680612;   pubmed:25138354;   pubmed:25519455
 chemrof_formula: C16H14O4
 chemrof_smiles: COc1cc(O)c2c(c1)O[C@H](c1ccccc1)CC2=O
 chemrof_inchi: InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1
 chemrof_inchikey: ORJDDOBAOGKRJV-AWEZNQCLSA-N
 cyclic_relationship: has_functional_parent CHEBI:15606


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pinostrobin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of AARS1 mRNA CTD PMID:37777166 NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
decreases activity 		ISO [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to pinostrobin 		CTD PMID:37259354 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acvr1 activin A receptor type 1 increases expression ISO pinostrobin results in increased expression of ACVR1 mRNA CTD PMID:37777166 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:63,387,381...63,477,884 		JBrowse link
G Ahctf1 AT hook containing transcription factor 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of AHCTF1 protein CTD PMID:37164308 NCBI chr13:94,013,894...94,068,348
Ensembl chr13:94,014,469...94,068,058 		JBrowse link
G Aifm3 AIF family member 3 increases expression ISO pinostrobin results in increased expression of AIFM3 mRNA CTD PMID:37777166 NCBI chr11:97,009,100...97,030,601
Ensembl chr11:97,008,426...97,023,334 		JBrowse link
G Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 increases expression ISO pinostrobin results in increased expression of AREL1 mRNA CTD PMID:37777166 NCBI chr 6:110,296,072...110,348,751
Ensembl chr 6:110,296,072...110,320,832 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO pinostrobin results in increased expression of ASNS mRNA CTD PMID:37777166 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein CTD PMID:37208425 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression ISO pinostrobin results in increased expression of ATP5F1A mRNA CTD PMID:37777166 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO pinostrobin results in increased expression of AXL mRNA CTD PMID:37777166 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pinostrobin results in increased expression of BAD mRNA CTD PMID:37777166 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pinostrobin results in increased expression of BAK1 mRNA CTD PMID:37164308 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA] 		CTD PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO pinostrobin results in increased expression of BBC3 mRNA CTD PMID:37777166 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		pinostrobin results in decreased expression of BCL2 protein
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA] 		CTD PMID:37342552 PMID:37777166 PMID:38078205 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO pinostrobin results in increased expression of BCL2L11 mRNA CTD PMID:37777166 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl2l2 Bcl2-like 2 decreases expression ISO pinostrobin results in decreased expression of BCL2L2 mRNA CTD PMID:37164308 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379 		JBrowse link
G Bmf Bcl2 modifying factor increases expression ISO pinostrobin results in increased expression of BMF mRNA CTD PMID:37777166 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 increases expression ISO pinostrobin results in increased expression of CALHM2 mRNA CTD PMID:37777166 NCBI chr 1:255,963,661...255,969,387
Ensembl chr 1:255,963,663...255,969,387 		JBrowse link
G Capn3 calpain 3 increases expression ISO pinostrobin results in increased expression of CAPN3 mRNA CTD PMID:37777166 NCBI chr 3:127,860,002...127,913,677
Ensembl chr 3:127,861,589...127,911,638 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO
EXP 		pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein
pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein 		CTD PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases expression ISO pinostrobin results in increased expression of CASP8 mRNA CTD PMID:37208425 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases expression ISO pinostrobin results in increased expression of CASP9 mRNA CTD PMID:37208425 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbs cystathionine beta synthase increases expression ISO pinostrobin results in increased expression of CBS mRNA CTD PMID:37777166 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO pinostrobin results in decreased expression of CCNE1 protein CTD PMID:37777166 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cd14 CD14 molecule increases expression ISO pinostrobin results in increased expression of CD14 mRNA CTD PMID:37777166 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd70 Cd70 molecule increases expression ISO pinostrobin results in increased expression of CD70 mRNA CTD PMID:37777166 NCBI chr 9:2,093,540...2,096,692
Ensembl chr 9:2,086,848...2,096,692 		JBrowse link
G Cdc40 cell division cycle 40 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDC40 protein CTD PMID:37164308 NCBI chr20:45,855,739...45,908,239
Ensembl chr20:45,855,739...45,907,978 		JBrowse link
G Cdh1 cadherin 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of CDH1 protein CTD PMID:37164308 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein CTD PMID:37777166 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pinostrobin results in increased expression of CDKN1B protein CTD PMID:37777166 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO pinostrobin results in increased expression of CEBPB mRNA CTD PMID:37777166 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO pinostrobin results in increased expression of CHAC1 mRNA CTD PMID:37777166 NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b increases expression ISO pinostrobin results in increased expression of CIDEB mRNA CTD PMID:37777166 NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688 		JBrowse link
G Cldn7 claudin 7 increases expression ISO pinostrobin results in increased expression of CLDN7 mRNA CTD PMID:37777166 NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression ISO pinostrobin results in decreased expression of CRELD2 protein CTD PMID:37164308 NCBI chr 7:121,788,754...121,796,230
Ensembl chr 7:121,788,745...121,796,228 		JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO pinostrobin results in increased expression of CTH mRNA CTD PMID:37777166 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein 		CTD PMID:37164308 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO pinostrobin results in increased expression of CXCR4 mRNA CTD PMID:37777166 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Dcps decapping enzyme, scavenger increases expression ISO pinostrobin results in increased expression of DCPS mRNA CTD PMID:37777166 NCBI chr 8:41,729,507...41,782,222
Ensembl chr 8:41,724,563...41,782,222 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO pinostrobin results in increased expression of DDIT3 mRNA CTD PMID:37777166 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO pinostrobin results in increased expression of DDIT4 mRNA CTD PMID:37777166 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Dnase1 deoxyribonuclease 1 increases expression ISO pinostrobin results in increased expression of DNASE1 mRNA CTD PMID:37777166 NCBI chr10:12,005,305...12,030,615
Ensembl chr10:12,005,306...12,010,497 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO pinostrobin results in increased expression of DNASE2 mRNA CTD PMID:37777166 NCBI chr19:40,149,505...40,152,225
Ensembl chr19:40,149,505...40,152,225 		JBrowse link
G Doc2b double C2 domain beta increases phosphorylation ISO pinostrobin results in increased phosphorylation of DOC2B protein CTD PMID:37164308 NCBI chr10:61,126,295...61,151,533
Ensembl chr10:61,126,295...61,151,533 		JBrowse link
G Elmo1 engulfment and cell motility 1 increases expression ISO pinostrobin results in increased expression of ELMO1 mRNA CTD PMID:37777166 NCBI chr17:48,982,188...49,518,525
Ensembl chr17:48,982,188...49,518,159 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression ISO pinostrobin results in increased expression of ERC1 mRNA CTD PMID:37777166 NCBI chr 4:154,435,936...154,727,987
Ensembl chr 4:154,435,944...154,727,987 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit increases expression ISO pinostrobin results in increased expression of ERCC2 mRNA CTD PMID:37777166 NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102 		JBrowse link
G Etv6 ETS variant transcription factor 6 increases expression ISO pinostrobin results in increased expression of ETV6 mRNA CTD PMID:37777166 NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802 		JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression ISO pinostrobin results in increased expression of FANK1 mRNA CTD PMID:37777166 NCBI chr 1:198,007,496...198,114,790
Ensembl chr 1:198,007,547...198,115,561 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pinostrobin results in increased expression of FAS mRNA CTD PMID:37208425 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Fbh1 F-box DNA helicase 1 increases expression ISO pinostrobin results in increased expression of FBH1 mRNA CTD PMID:37777166 NCBI chr17:71,659,351...71,697,431
Ensembl chr17:71,659,249...71,697,432 		JBrowse link
G Fcmr Fc mu receptor increases expression ISO pinostrobin results in increased expression of FCMR mRNA CTD PMID:37777166 NCBI chr13:44,889,628...44,903,926
Ensembl chr13:44,889,697...44,906,314 		JBrowse link
G Fer1l4 fer-1-like family member 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of FER1L4 protein CTD PMID:37164308 NCBI chr 3:164,996,183...165,031,719
Ensembl chr 3:164,996,183...165,031,719 		JBrowse link
G Flcn folliculin increases expression ISO pinostrobin results in increased expression of FLCN mRNA CTD PMID:37777166 NCBI chr10:45,088,164...45,107,581
Ensembl chr10:45,088,167...45,107,309 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases phosphorylation ISO pinostrobin results in decreased phosphorylation of FMO5 protein CTD PMID:37164308 NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464 		JBrowse link
G Foxa1 forkhead box A1 increases expression ISO pinostrobin results in increased expression of FOXA1 mRNA CTD PMID:37777166 NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression 		ISO pinostrobin results in increased expression of and affects the localization of FOXO3 protein
pinostrobin results in increased expression of FOXO3 mRNA 		CTD PMID:37777166 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein] CTD PMID:37866152 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO pinostrobin results in increased expression of FYN mRNA CTD PMID:37777166 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO pinostrobin results in increased expression of GADD45A mRNA CTD PMID:37777166 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Glb1 galactosidase, beta 1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of GLB1 protein CTD PMID:37164308 NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO pinostrobin results in increased expression of GRINA mRNA CTD PMID:37777166 NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042 		JBrowse link
G Grn granulin precursor increases expression ISO pinostrobin results in increased expression of GRN mRNA CTD PMID:37777166 NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:37342552 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein] CTD PMID:37342552 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hip1 huntingtin interacting protein 1 increases expression ISO pinostrobin results in increased expression of HIP1 mRNA CTD PMID:37777166 NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO pinostrobin results in increased expression of HMOX1 mRNA CTD PMID:37777166 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing increases expression ISO pinostrobin results in increased expression of HSH2D mRNA CTD PMID:37777166 NCBI chr16:17,664,548...17,686,976
Ensembl chr16:17,669,345...17,682,013 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO pinostrobin results in increased expression of ID3 mRNA CTD PMID:37777166 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein] CTD PMID:38078205 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein] CTD PMID:37342552 PMID:37866152 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ing4 inhibitor of growth family, member 4 increases expression ISO pinostrobin results in increased expression of ING4 mRNA CTD PMID:37777166 NCBI chr 4:159,528,183...159,536,762
Ensembl chr 4:159,528,189...159,536,761 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pinostrobin results in increased expression of INHBA mRNA CTD PMID:37777166 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508 		JBrowse link
G Ino80 INO80 complex ATPase subunit increases phosphorylation ISO pinostrobin results in increased phosphorylation of INO80 protein CTD PMID:37164308 NCBI chr 3:126,822,280...126,919,532
Ensembl chr 3:126,822,280...126,919,532 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression ISO pinostrobin results in increased expression of IRF7 mRNA CTD PMID:37777166 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO pinostrobin results in increased expression of ITGAM mRNA CTD PMID:37777166 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase increases expression ISO pinostrobin results in increased expression of ITPK1 mRNA CTD PMID:37777166 NCBI chr 6:127,475,589...127,609,320
Ensembl chr 6:127,476,808...127,609,062 		JBrowse link
G Kdm2b lysine demethylase 2B increases expression ISO pinostrobin results in increased expression of KDM2B mRNA CTD PMID:37777166 NCBI chr12:39,224,422...39,362,126
Ensembl chr12:39,235,301...39,362,127 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein] CTD PMID:37342552 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lgals2 galectin 2 increases expression ISO pinostrobin results in increased expression of LGALS2 mRNA CTD PMID:37777166 NCBI chr 7:112,283,630...112,290,228
Ensembl chr 7:112,282,822...112,285,392 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein] CTD PMID:37866152 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Madd MAP-kinase activating death domain increases expression ISO pinostrobin results in increased expression of MADD mRNA CTD PMID:37777166 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:97,570,787...97,613,509 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO pinostrobin results in decreased expression of MCL1 mRNA CTD PMID:37164308 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO pinostrobin results in increased expression of MEF2A mRNA CTD PMID:37777166 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162 		JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO pinostrobin results in increased expression of MEF2D mRNA CTD PMID:37777166 NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760 		JBrowse link
G Mir410 microRNA 410 decreases expression
multiple interactions 		ISO pinostrobin results in decreased expression of MIR410 mRNA
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein] 		CTD PMID:37164308 NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839 		JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 increases phosphorylation ISO pinostrobin results in increased phosphorylation of MRPL1 protein CTD PMID:37164308 NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,604,499...13,663,602 		JBrowse link
G Mt3 metallothionein 3 increases expression ISO pinostrobin results in increased expression of MT3 mRNA CTD PMID:37777166 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO pinostrobin results in increased expression of MUTYH mRNA CTD PMID:37777166 NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:135,517,695...135,522,776 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression ISO pinostrobin results in increased expression of NAIP mRNA CTD PMID:37777166 NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:33,241,521...33,276,859 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO pinostrobin results in increased expression of NINJ1 mRNA CTD PMID:37777166 NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063 		JBrowse link
G Nisch nischarin increases expression ISO pinostrobin results in increased expression of NISCH mRNA CTD PMID:37777166 NCBI chr16:6,370,809...6,407,104
Ensembl chr16:6,370,809...6,407,387 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A increases expression ISO pinostrobin results in increased expression of NLRP1 mRNA CTD PMID:37777166 NCBI chr10:56,277,134...56,332,229
Ensembl chr10:56,277,134...56,323,880 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein] CTD PMID:37342552 PMID:37866152 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pinostrobin results in increased expression of NOS3 mRNA CTD PMID:37777166 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO pinostrobin results in increased expression of NR4A1 mRNA CTD PMID:37777166 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041 		JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO pinostrobin results in increased expression of NTSR1 mRNA CTD PMID:37777166 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:187,983,778...188,033,934 		JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression ISO pinostrobin results in increased expression of P2RX1 mRNA CTD PMID:37777166 NCBI chr10:58,117,107...58,132,167
Ensembl chr10:58,117,088...58,132,164 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO pinostrobin results in increased expression of P2RX7 mRNA CTD PMID:37777166 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Pde1b phosphodiesterase 1B increases expression ISO pinostrobin results in increased expression of PDE1B mRNA CTD PMID:37777166 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 increases expression ISO pinostrobin results in increased expression of PELI3 mRNA CTD PMID:37777166 NCBI chr 1:211,659,416...211,672,280
Ensembl chr 1:211,661,610...211,672,239 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO pinostrobin results in increased expression of PHLDA3 mRNA CTD PMID:37777166 NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase increases expression ISO pinostrobin results in increased expression of PIM2 mRNA CTD PMID:37777166 NCBI chr  X:17,289,509...17,294,778
Ensembl chr  X:17,289,509...17,294,778 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO pinostrobin results in increased expression of PLAUR mRNA CTD PMID:37777166 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Pld1 phospholipase D1 increases expression ISO pinostrobin results in increased expression of PLD1 protein CTD PMID:37164308 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245 		JBrowse link
G Plec plectin decreases expression ISO pinostrobin results in decreased expression of PLEC protein CTD PMID:37164308 NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089 		JBrowse link
G Plxnd1 plexin D1 increases expression ISO pinostrobin results in increased expression of PLXND1 mRNA CTD PMID:37777166 NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:150,675,377...150,715,566 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO pinostrobin results in increased expression of PMP22 mRNA CTD PMID:37777166 NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940 		JBrowse link
G Pou3f3 POU class 3 homeobox 3 increases expression ISO pinostrobin results in increased expression of POU3F3 mRNA CTD PMID:37777166 NCBI chr 9:52,438,026...52,441,152
Ensembl chr 9:52,435,625...52,454,705 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO pinostrobin results in increased expression of PPARA mRNA CTD PMID:37777166 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein] CTD PMID:37342552 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression ISO pinostrobin results in increased expression of PTK2B mRNA CTD PMID:37777166 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression ISO pinostrobin results in increased expression of QARS1 mRNA CTD PMID:37777166 NCBI chr 8:118,086,243...118,094,274
Ensembl chr 8:118,086,228...118,094,274 		JBrowse link
G Ret ret proto-oncogene increases expression ISO pinostrobin results in increased expression of RET mRNA CTD PMID:37777166 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G Rnf130 ring finger protein 130 increases expression ISO pinostrobin results in increased expression of RNF130 mRNA CTD PMID:37777166 NCBI chr10:34,843,920...34,957,130
Ensembl chr10:34,843,915...34,960,408 		JBrowse link
G Rnf216 ring finger protein 216 increases expression ISO pinostrobin results in increased expression of RNF216 mRNA CTD PMID:37777166 NCBI chr12:16,568,327...16,689,868
Ensembl chr12:16,568,347...16,690,989 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 increases expression ISO pinostrobin results in increased expression of HLA-F mRNA CTD PMID:37777166 NCBI chr20:3,407,880...3,484,130 JBrowse link
G Rtkn rhotekin increases expression ISO pinostrobin results in increased expression of RTKN mRNA CTD PMID:37777166 NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660 		JBrowse link
G Scfd2 sec1 family domain containing 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCFD2 protein CTD PMID:37164308 NCBI chr14:34,037,392...34,369,423
Ensembl chr14:34,037,430...34,363,436 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SCN2A protein CTD PMID:37164308 NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:70,710,954...70,845,279 		JBrowse link
G Scx scleraxis bHLH transcription factor increases expression ISO pinostrobin results in increased expression of SCX mRNA CTD PMID:37777166 NCBI chr 7:110,056,897...110,059,283
Ensembl chr 7:110,054,601...110,061,438 		JBrowse link
G Selenos selenoprotein S increases expression ISO pinostrobin results in increased expression of SELENOS mRNA CTD PMID:37777166 NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:129,070,230...129,077,991 		JBrowse link
G Serpinf1 serpin family F member 1 increases expression ISO pinostrobin results in increased expression of SERPINF1 mRNA CTD PMID:37777166 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 multiple interactions
increases expression
increases phosphorylation 		ISO pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]
pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein
pinostrobin results in increased phosphorylation of SFRP5 protein 		CTD PMID:37164308 NCBI chr 1:250,956,050...250,960,512
Ensembl chr 1:250,956,050...250,960,512 		JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression ISO pinostrobin results in increased expression of SHARPIN mRNA CTD PMID:37777166 NCBI chr 7:109,951,336...109,955,552
Ensembl chr 7:109,950,345...109,955,552 		JBrowse link
G Shisa5 shisa family member 5 increases expression ISO pinostrobin results in increased expression of SHISA5 mRNA CTD PMID:37777166 NCBI chr 8:118,569,975...118,584,880
Ensembl chr 8:118,569,975...118,584,880 		JBrowse link
G Slc10a5 solute carrier family 10, member 5 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SLC10A5 protein CTD PMID:37164308 NCBI chr 2:93,364,959...93,366,263
Ensembl chr 2:93,360,766...93,368,978 		JBrowse link
G Slc25a5-ps11 solute carrier family 25 member 5, pseudogene 11 increases expression ISO pinostrobin results in increased expression of SLC25A6 mRNA CTD PMID:37777166 NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 increases expression ISO pinostrobin results in increased expression of SLC46A2 mRNA CTD PMID:37777166 NCBI chr 5:79,594,003...79,603,074
Ensembl chr 5:79,595,150...79,603,114 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO pinostrobin results in increased expression of SLC7A11 mRNA CTD PMID:37777166 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Slco5a1 solute carrier organic anion transporter family, member 5A1 increases expression ISO pinostrobin results in increased expression of SLCO5A1 protein CTD PMID:37164308 NCBI chr 5:11,012,001...11,141,180
Ensembl chr 5:11,012,075...11,141,177 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO pinostrobin results in increased expression of SMAD3 mRNA CTD PMID:37777166 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smim7 small integral membrane protein 7 increases phosphorylation ISO pinostrobin results in increased phosphorylation of SMIM7 protein CTD PMID:37164308 NCBI chr16:17,308,466...17,312,384
Ensembl chr16:17,308,395...17,312,371 		JBrowse link
G Stap2 signal transducing adaptor family member 2 increases phosphorylation ISO pinostrobin results in increased phosphorylation of STAP2 protein CTD PMID:37164308 NCBI chr 9:915,546...924,604
Ensembl chr 9:915,550...924,380 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO pinostrobin results in increased expression of STAR mRNA CTD PMID:37777166 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Stxbp1 syntaxin binding protein 1 increases expression ISO pinostrobin results in increased expression of STXBP1 mRNA CTD PMID:37777166 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058 		JBrowse link
G Sycp2l synaptonemal complex protein 2-like increases expression ISO pinostrobin results in increased expression of SYCP2L mRNA CTD PMID:37777166 NCBI chr17:23,798,424...23,851,017
Ensembl chr17:23,798,649...23,854,050 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression ISO pinostrobin results in increased expression of TAF10 mRNA CTD PMID:37777166 NCBI chr 1:169,506,940...169,508,234
Ensembl chr 1:169,506,940...169,508,208 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 increases expression ISO pinostrobin results in increased expression of TCIRG1 mRNA CTD PMID:37777166 NCBI chr 1:210,556,270...210,568,021
Ensembl chr 1:210,556,270...210,568,033 		JBrowse link
G Tmem109 transmembrane protein 109 increases expression ISO pinostrobin results in increased expression of TMEM109 mRNA CTD PMID:37777166 NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138 		JBrowse link
G Tmem39a transmembrane protein 39a increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMEM39A protein CTD PMID:37164308 NCBI chr11:75,666,154...75,695,486
Ensembl chr11:75,666,154...75,695,486 		JBrowse link
G Tmem79 transmembrane protein 79 increases expression ISO pinostrobin results in increased expression of TMEM79 mRNA CTD PMID:37777166 NCBI chr 2:176,096,092...176,100,996
Ensembl chr 2:176,096,092...176,100,870 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases phosphorylation ISO pinostrobin results in increased phosphorylation of TMPRSS4 protein CTD PMID:37164308 NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:54,372,805...54,405,157 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein] CTD PMID:37342552 PMID:37866152 PMID:38078205 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A multiple interactions EXP pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein] CTD PMID:37866152 NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257 		JBrowse link
G Tnfsf14 TNF superfamily member 14 increases expression ISO pinostrobin results in increased expression of TNFSF14 mRNA CTD PMID:37777166 NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,155,270...2,160,191 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO pinostrobin results in increased expression of TNFSF9 mRNA CTD PMID:37777166 NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO pinostrobin results in increased expression of TP53 mRNA CTD PMID:37208425 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO pinostrobin results in increased expression of TRAP1 mRNA CTD PMID:37777166 NCBI chr10:11,971,259...12,005,306
Ensembl chr10:11,970,995...12,005,355 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO pinostrobin results in increased expression of TRIB3 mRNA CTD PMID:37777166 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 increases expression ISO pinostrobin results in increased expression of TRPM2 mRNA CTD PMID:37777166 NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,704,482...10,752,802 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression ISO pinostrobin results in increased expression of TRPV1 mRNA CTD PMID:37777166 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO pinostrobin results in increased expression of VEGFA mRNA CTD PMID:37777166 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO pinostrobin results in increased expression of XBP1 mRNA CTD PMID:37777166 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Zfp746 zinc finger protein 746 increases expression ISO pinostrobin results in increased expression of ZNF746 mRNA CTD PMID:37777166 NCBI chr 4:78,385,945...78,410,240
Ensembl chr 4:78,385,945...78,409,832 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            protective agent 18433
              antidote 10106
                pinostrobin 158
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  oxacycle 18273
                                    benzopyran 10790
                                      1-benzopyran 10376
                                        flavans 3662
                                          flavanones 597
                                            methoxyflavanone 328
                                              monomethoxyflavanone 328
                                                pinostrobin 158
paths to the root