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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perindopril
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Accession:CHEBI:8024 term browser browse the term
Definition:An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline
Synonyms:exact_synonym: ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate
 related_synonym: (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid;   Formula=C19H32N2O5;   InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1;   InChIKey=IPVQLZZIHOAWMC-QXKUPLGCSA-N;   SMILES=[H][C@@]12CCCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC;   perindoprilum
 xref: CAS:82834-16-0;   DrugBank:DB00790;   Drug_Central:2108;   HMDB:HMDB0014928;   KEGG:C07706;   KEGG:D03753;   LINCS:LSM-4080
 xref_mesh: MESH:D020913
 xref: PMID:24291100;   PMID:24324048;   PMID:24357222;   PMID:24511479;   PMID:24515310;   PMID:24554346;   PMID:24590580;   PMID:24602481;   PMID:24664905;   Reaxys:4300272;   Wikipedia:Perindopril
 cyclic_relationship: is_conjugate_acid_of CHEBI:78000


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perindopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Perindopril CTD PMID:11007831 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions EXP Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA]; Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein] CTD PMID:19793108 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP Perindopril results in decreased expression of ACTA2 protein
[Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of ACTA2 mRNA]		 CTD PMID:12076858 PMID:16596278 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agt angiotensinogen decreases expression
increases expression
multiple interactions		 ISO
EXP		 Perindopril results in decreased expression of AGT protein alternative form
Perindopril results in increased expression of AGT protein alternative form
[Perindopril co-treated with racecadotril] results in increased expression of AGT protein alternative form; Perindopril inhibits the reaction [Methotrexate results in decreased expression of AGT protein alternative form]; Perindopril inhibits the reaction [Methotrexate results in increased expression of AGT protein]
Perindopril results in decreased expression of AGT protein; Perindopril results in decreased expression of AGT protein alternative form		 CTD PMID:2549899 PMID:2605800 PMID:9808682 PMID:34737150 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance
multiple interactions		 ISO
EXP		 AGTR1 gene SNP affects the susceptibility to Perindopril
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]
[Perindopril co-treated with AM6545] inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]		 CTD PMID:8952600 PMID:12930639 PMID:16097048 PMID:30184259 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alb albumin multiple interactions EXP
ISO		 Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein]		 CTD PMID:16872305 PMID:30184259 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Arg1 arginase 1 multiple interactions ISO Perindopril inhibits the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of ARG1 mRNA]] CTD PMID:30184259 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Perindopril inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 mRNA alternative form] CTD PMID:16116328 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdkrb1 bradykinin receptor B1 affects expression EXP Perindopril affects the expression of BDKRB1 protein CTD PMID:18806609 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects expression EXP Perindopril affects the expression of BDKRB2 protein CTD PMID:18806609 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Cat catalase increases activity EXP Perindopril results in increased activity of CAT protein CTD PMID:26878793 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO Perindopril results in decreased expression of CCL2 protein
[AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]		 CTD PMID:19840533 PMID:30184259 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CCL3 mRNA]] CTD PMID:30184259 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CCR2 mRNA] CTD PMID:30184259 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd163 CD163 molecule multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of CD163 mRNA]] CTD PMID:30184259 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of CD68 mRNA]] CTD PMID:30184259 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP [Imatinib Mesylate co-treated with Perindopril] inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of COL1A2 mRNA] CTD PMID:16596278 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Perindopril results in decreased expression of COL3A1 mRNA CTD PMID:12076858 PMID:14871039 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [AM6545 co-treated with Perindopril] inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of FN1 protein] CTD PMID:30184259 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 EXP Perindopril results in decreased expression of FOS protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of FOS protein]		 CTD PMID:34737150 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] CTD PMID:29859236 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]] CTD PMID:30184259 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 ISO
EXP		 Perindopril results in increased expression of IL10 protein
Perindopril inhibits the reaction [Methotrexate results in decreased expression of IL10 protein]		 CTD PMID:19840533 PMID:34737150 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO
EXP		 Perindopril results in decreased expression of IL1B protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL1B protein]		 CTD PMID:19840533 PMID:34737150 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO
EXP		 Perindopril results in decreased expression of IL6 protein
Perindopril inhibits the reaction [Methotrexate results in increased expression of IL6 protein]		 CTD PMID:19840533 PMID:34737150 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Perindopril inhibits the reaction [Methotrexate results in increased expression of JUN protein] CTD PMID:34737150 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kng1 kininogen 1 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Perindopril results in decreased expression of KNG1 protein modified form
Perindopril results in increased expression of KNG1 protein alternative form
Perindopril promotes the reaction [racecadotril affects the metabolism of KNG1 protein alternative form]		 CTD PMID:9808682 PMID:11855668 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lep leptin decreases expression EXP Perindopril results in decreased expression of LEP protein CTD PMID:18083506 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of MAS1 mRNA] CTD PMID:19793108 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mfn2 mitofusin 2 increases expression EXP Perindopril results in increased expression of MFN2 mRNA; Perindopril results in increased expression of MFN2 protein CTD PMID:25464244 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]		 CTD PMID:12930639 PMID:14761280 PMID:16097048 PMID:29859236 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein] CTD PMID:16097048 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of MRC1 mRNA]] CTD PMID:30184259 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] CTD PMID:29859236 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]]; Perindopril inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA]] CTD PMID:30184259 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS1 protein]] CTD PMID:30184259 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]; Perindopril inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in decreased expression of NPHS2 protein]] CTD PMID:30184259 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:14761280 PMID:16097048 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 EXP Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]
Perindopril results in increased expression of PPARG mRNA; Perindopril results in increased expression of PPARG protein		 CTD PMID:34737150 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression EXP Perindopril results in decreased expression of PPP3CA protein CTD PMID:18344631 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Perindopril results in decreased expression of PPP3R1 mRNA CTD PMID:18344631 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 Perindopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
Perindopril inhibits the reaction [Methotrexate results in increased expression of RELA protein]		 CTD PMID:29859236 PMID:34737150 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases expression
increases activity		 EXP
ISO		 Perindopril results in increased expression of REN protein
Perindopril results in increased activity of REN protein		 CTD PMID:2549899 PMID:2605800 PMID:9383173 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression		 EXP carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein] CTD PMID:19620082 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 affects binding ISO Perindopril binds to SFRP4 protein CTD PMID:25019556 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression		 EXP Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 mRNA]; Perindopril inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein]
Perindopril results in increased expression of SIRT1 mRNA; Perindopril results in increased expression of SIRT1 protein		 CTD PMID:34737150 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Perindopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression		 EXP Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Perindopril results in decreased expression of SMAD3 protein		 CTD PMID:15619341 PMID:16872305 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 increases expression
multiple interactions		 EXP Perindopril results in increased expression of SMAD7 protein
Perindopril inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]		 CTD PMID:15619341 PMID:16872305 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP
ISO		 Perindopril inhibits the reaction [Carbon Tetrachloride affects the expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Perindopril results in decreased expression of TGFB1 mRNA; Perindopril results in decreased expression of TGFB1 protein
Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]		 CTD PMID:12930639 PMID:14761280 PMID:14871039 PMID:15619341 PMID:16097048 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression
multiple interactions		 EXP Perindopril results in decreased expression of TGFBR2 mRNA
Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]		 CTD PMID:15619341 PMID:16872305 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 mRNA]; Perindopril inhibits the reaction [Methotrexate results in increased expression of TLR4 protein] CTD PMID:34737150 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
multiple interactions		 ISO
EXP		 Perindopril results in decreased expression of TNF protein
Perindopril results in increased expression of TNF protein
AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; AM6545 promotes the reaction [Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Perindopril inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]]; Perindopril promotes the reaction [AM6545 inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
Perindopril inhibits the reaction [Methotrexate results in increased expression of TNF protein]		 CTD PMID:19840533 PMID:26878793 PMID:29859236 PMID:30184259 PMID:34737150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] CTD PMID:29859236 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vwf von Willebrand factor decreases expression ISO Perindopril results in decreased expression of VWF protein CTD PMID:12224817 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        antimicrobial agent 18251
          disinfectant 14874
            ethanol 8920
              ethyl ester 4380
                perindopril 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      s-block molecular entity 19638
                        hydrogen molecular entity 19620
                          hydrides 19141
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17868
                                    ammonia 17867
                                      organic amino compound 17867
                                        amino acid 16057
                                          alpha-amino acid 13929
                                            alpha-amino acid ester 287
                                              perindopril 57
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