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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GW 3965
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Accession:CHEBI:79995 term browser browse the term
Definition:A diarylmethane that has formula C33H31ClF3NO3.
Synonyms:related_synonym: Formula=C33H31ClF3NO3;   InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);   InChIKey=NAXSRXHZFIBFMI-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
 xref: CAS:405911-09-3;   KEGG:C15631;   LINCS:LSM-2738
 xref_mesh: MESH:C473027


show annotations for term's descendants           Sort by:
GW 3965 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
multiple interactions
increases degradation		 ISO
EXP		 GW 3965 results in increased expression of ABCA1 mRNA
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA]
GW 3965 results in increased expression of ABCA1 mRNA; GW 3965 results in increased expression of ABCA1 protein
NR1H2 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]
GW3965 increases degradation of cell surface resident ABCA1 protein in HepG2 cells		 CTD
RGD		 PMID:15633131 PMID:16107141 PMID:17449538 PMID:18841091 PMID:19426978 More... RGD:18936994 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression
multiple interactions		 ISO GW 3965 results in increased expression of ABCG1 mRNA
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]		 CTD PMID:15633131 PMID:17449538 PMID:30036686 PMID:31011801 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO GW 3965 results in increased expression of ABCG5 mRNA CTD PMID:15633131 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO GW 3965 results in increased expression of ABCG8 mRNA CTD PMID:15633131 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of ACLY mRNA] CTD PMID:31421115 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b affects expression EXP GW 3965 affects the expression of AGTR1B mRNA CTD PMID:17420776 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects expression EXP GW 3965 affects the expression of AGTR2 mRNA CTD PMID:17420776 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions		 ISO
EXP		 GW 3965 results in increased expression of APOE mRNA
NR1H2 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA]
GW 3965 results in increased expression of and results in increased secretion of APOE protein
GW 3965 promotes the reaction [Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of APOE mRNA]]		 CTD PMID:17449538 PMID:27598782 PMID:30185694 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO GW 3965 results in decreased expression of BUB1B mRNA CTD PMID:31437187 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP GW 3965 inhibits the reaction [Palmitates results in increased cleavage of CASP3 protein] CTD PMID:21209018 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO GW 3965 results in decreased expression of CCNE1 mRNA CTD PMID:31437187 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO GW 3965 results in decreased expression of CCNE2 mRNA CTD PMID:31437187 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdc14a cell division cycle 14A increases expression ISO GW 3965 results in increased expression of CDC14A mRNA CTD PMID:31437187 NCBI chr 2:204,225,540...204,380,927
Ensembl chr 2:204,225,540...204,380,927 		JBrowse link
G Cdc14b cell division cycle 14B decreases expression ISO GW 3965 results in decreased expression of CDC14B mRNA CTD PMID:31437187 NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO GW 3965 results in decreased expression of CDC25A mRNA CTD PMID:31437187 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO GW 3965 results in decreased expression of CDC25C mRNA CTD PMID:31437187 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO GW 3965 results in decreased expression of CDC45 mRNA CTD PMID:31437187 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO GW 3965 results in decreased expression of CDK2 mRNA CTD PMID:31437187 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO GW 3965 results in increased expression of CDKN2A mRNA CTD PMID:31437187 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO GW 3965 results in increased expression of CDKN2B mRNA CTD PMID:31437187 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO GW 3965 results in decreased expression of CYP11A1 mRNA CTD PMID:17449538 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO GW 3965 results in increased expression of CYP1A1 mRNA CTD PMID:23041609 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO GW 3965 results in increased expression of CYP1A2 mRNA CTD PMID:23041609 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO GW 3965 inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA] CTD PMID:23732298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO GW 3965 results in increased expression of CYP3A4 mRNA
[GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA; GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]		 CTD PMID:23732298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP GW 3965 results in increased expression of CYP7A1 mRNA CTD PMID:17420776 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO GW 3965 results in decreased expression of E2F1 mRNA CTD PMID:31437187 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO GW 3965 results in decreased expression of E2F2 mRNA CTD PMID:31437187 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G E2f3 E2F transcription factor 3 decreases expression ISO GW 3965 results in decreased expression of E2F3 mRNA CTD PMID:31437187 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein] CTD PMID:27052460 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO GW 3965 results in increased expression of FABP4 mRNA CTD PMID:31437187 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA]
[Bexarotene co-treated with GW 3965] results in increased expression of FASN mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of FASN mRNA
GW 3965 results in increased expression of FASN mRNA		 CTD PMID:31421115 PMID:31437187 PMID:32123961 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
GW 3965 results in increased expression of ICAM1 mRNA		 CTD PMID:19426978 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 GW 3965 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
GW 3965 inhibits the reaction [IL6 protein results in increased expression of SOCS3 protein]; GW 3965 inhibits the reaction [IL6 protein results in increased expression of STAT3 protein modified form]		 CTD PMID:16107141 PMID:27052460 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO GW 3965 results in increased expression of INSIG1 mRNA CTD PMID:31437187 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Krt19 keratin 19 multiple interactions ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein] CTD PMID:27052460 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO GW 3965 results in decreased expression of LDLR protein CTD PMID:27598782 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO GW 3965 results in increased expression of LPL mRNA CTD PMID:31437187 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO GW 3965 results in decreased expression of MCM2 mRNA CTD PMID:31437187 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO GW 3965 results in decreased expression of MCM3 mRNA CTD PMID:31437187 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO GW 3965 results in decreased expression of MCM4 mRNA CTD PMID:31437187 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO GW 3965 results in decreased expression of MCM5 mRNA CTD PMID:31437187 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO GW 3965 results in decreased expression of MCM6 mRNA CTD PMID:31437187 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mlxipl MLX interacting protein-like decreases expression
multiple interactions		 ISO GW 3965 results in decreased expression of MLXIPL mRNA
[Bexarotene co-treated with GW 3965] results in decreased expression of MLXIPL mRNA		 CTD PMID:32123961 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mylip myosin regulatory light chain interacting protein increases expression ISO GW 3965 results in increased expression of MYLIP mRNA CTD PMID:27598782 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO GW 3965 results in decreased expression of NPC1L1 mRNA CTD PMID:15633131 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
multiple interactions		 ISO GW 3965 results in increased expression of NR0B2 mRNA
[Bexarotene co-treated with GW 3965] results in increased expression of NR0B2 mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of NR0B2 mRNA		 CTD PMID:32123961 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H2 protein]; NR1H2 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]; NR1H2 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA]
[GW 3965 co-treated with NR1H3 protein] results in decreased expression of NR1H2 mRNA; GW 3965 inhibits the reaction [NR1H2 protein results in increased expression of NR1H3 mRNA]; GW 3965 inhibits the reaction [NR1H2 protein results in increased expression of POU5F1 mRNA]		 CTD PMID:27598782 PMID:31421115 PMID:31932555 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 [Bexarotene co-treated with GW 3965] results in increased expression of NR1H3 mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of NR1H3 mRNA; [GW 3965 co-treated with NR1H3 protein] results in decreased expression of NR1H2 mRNA; [GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA; GW 3965 binds to and results in increased activity of NR1H3 protein; GW 3965 inhibits the reaction [NR1H2 protein results in increased expression of NR1H3 mRNA]; NR1H3 mutant form inhibits the reaction [GW 3965 results in increased expression of ABCA1 mRNA]
GW 3965 results in increased expression of NR1H3 mRNA
GW 3965 binds to and results in increased activity of NR1H3 protein; GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H3 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H3 protein]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of ABCA1 mRNA]; NR1H3 protein affects the reaction [GW 3965 results in increased expression of APOE mRNA]
GW 3965 results in increased activity of NR1H3 protein
GW 3965 promotes the reaction [decitabine inhibits the reaction [Cadmium results in decreased expression of NR1H3 mRNA]]		 CTD PMID:12932788 PMID:15633131 PMID:17420776 PMID:17449538 PMID:23732298 More... NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H4 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in decreased expression of NR1H4 protein] CTD PMID:31421115 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Bexarotene co-treated with GW 3965] results in increased expression of NRIP1 mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of NRIP1 mRNA CTD PMID:32123961 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO GW 3965 results in decreased expression of ORC1 mRNA CTD PMID:31437187 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375 		JBrowse link
G Orc6 origin recognition complex, subunit 6 decreases expression ISO GW 3965 results in decreased expression of ORC6 mRNA CTD PMID:31437187 NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP GW 3965 inhibits the reaction [Palmitates results in increased cleavage of PARP1 protein] CTD PMID:21209018 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein] CTD PMID:27052460 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pltp phospholipid transfer protein increases expression ISO GW 3965 results in increased expression of PLTP mRNA CTD PMID:17449538 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression		 ISO GW 3965 inhibits the reaction [NR1H2 protein results in increased expression of POU5F1 mRNA]
GW 3965 results in decreased expression of POU5F1 protein		 CTD PMID:31932555 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO GW 3965 results in decreased expression of RBL1 mRNA CTD PMID:31437187 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SCD1 mRNA]
[Bexarotene co-treated with GW 3965] results in increased expression of SCD mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of SCD mRNA
GW 3965 results in increased expression of SCD mRNA		 CTD PMID:31421115 PMID:31437187 PMID:32123961 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]
GW 3965 results in increased expression of SELE mRNA		 CTD PMID:19426978 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO GW 3965 results in decreased expression of SKP2 mRNA CTD PMID:31437187 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Snca synuclein alpha increases expression ISO GW 3965 results in increased expression of SNCA mRNA; GW 3965 results in increased expression of SNCA protein CTD PMID:18841091 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP GW 3965 inhibits the reaction [IL6 protein results in increased expression of SOCS3 protein] CTD PMID:27052460 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO
EXP		 GW 3965 results in increased expression of SREBF1 mRNA; GW 3965 results in increased expression of SREBF1 protein
[Bexarotene co-treated with GW 3965] results in increased expression of SREBF1 mRNA; [CD 3254 co-treated with GW 3965] results in increased expression of SREBF1 mRNA; puag-haad inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]; Resveratrol inhibits the reaction [GW 3965 results in increased expression of SREBF1 protein]
GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]; GW 3965 inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]		 CTD PMID:16107141 PMID:23651738 PMID:27598782 PMID:28315714 PMID:29702089 More... NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO GW 3965 results in decreased expression of STAR mRNA CTD PMID:17449538 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP GW 3965 inhibits the reaction [IL6 protein results in increased expression of STAT3 protein modified form] CTD PMID:27052460 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO GW 3965 results in decreased expression of TFDP1 mRNA CTD PMID:31437187 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817 		JBrowse link
G Tnfsf15 TNF superfamily member 15 increases expression ISO GW 3965 results in increased expression of TNFSF15 mRNA CTD PMID:19426978 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
GW 3965 results in increased expression of VCAM1 mRNA		 CTD PMID:19426978 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      group 19863
        polyatomic entity 19862
          molecule 19752
            cyclic compound 19523
              organic cyclic compound 19526
                organic aromatic compound 19390
                  diarylmethane 9440
                    GW 3965 70
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      p-block molecular entity 19826
                        carbon group molecular entity 19766
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  diarylmethane 9440
                                    GW 3965 70
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