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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Asiaticoside
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Accession:CHEBI:79928 term browser browse the term
Definition:A triterpenoid saponin that has formula C48H78O19.
Synonyms:related_synonym: Formula=C48H78O19;   InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22+,24-,25-,26-,27-,28-,29+,30+,31-,32-,33+,34-,35-,36-,37-,38-,39+,40-,41+,42+,44+,45+,46-,47-,48+/m1/s1;   InChIKey=WYQVAPGDARQUBT-FGWHUCSPSA-N;   Madecassol;   SMILES=C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
 xref: CAS:16830-15-2;   KEGG:C15428;   KEGG:D07576
 xref_mesh: MESH:C004446


show annotations for term's descendants           Sort by:
Asiaticoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]
asiaticoside results in increased expression of BDNF mRNA		 CTD PMID:28238857 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased activity of CAT protein] CTD PMID:28238857 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO asiaticoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO asiaticoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of MAPK14 protein] CTD PMID:28238857 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of MTOR protein CTD PMID:28238857 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions		 EXP asiaticoside results in increased expression of NGF protein
asiaticoside inhibits the reaction [Rotenone results in decreased expression of NGF protein]		 CTD PMID:28238857 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 mRNA]; asiaticoside inhibits the reaction [Rotenone results in decreased expression of PDPK1 protein] CTD PMID:28238857 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in increased expression of PEBP1 mRNA] CTD PMID:28238857 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of PIK3R6 mRNA] CTD PMID:28238857 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP asiaticoside inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28238857 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Stx1a syntaxin 1A multiple interactions EXP [Rotenone co-treated with asiaticoside] results in decreased expression of STX1A mRNA CTD PMID:28238857 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930 		JBrowse link
G Synj1 synaptojanin 1 multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of SYNJ1 mRNA CTD PMID:28238857 NCBI chr11:30,192,629...30,269,447
Ensembl chr11:30,192,629...30,269,220 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [asiaticoside co-treated with Rotenone] results in decreased expression of TH protein CTD PMID:28238857 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biochemical role 19571
          metabolite 19558
            saponin 497
              triterpenoid saponin 424
                Asiaticoside 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbohydrates and carbohydrate derivatives 15297
                                    carbohydrate 15297
                                      carbohydrate derivative 14310
                                        glycosyl compound 13075
                                          glycoside 11844
                                            saponin 497
                                              triterpenoid saponin 424
                                                Asiaticoside 14
paths to the root