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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:parthenolide
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Accession:CHEBI:7939 term browser browse the term
Definition:A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Synonyms:exact_synonym: (1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
 related_synonym: 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone;   Formula=C15H20O3;   InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1;   InChIKey=KTEXNACQROZXEV-PVLRGYAZSA-N;   SMILES=[H][C@@]12CC\\C(C)=C\\CC[C@@]3(C)O[C@]3([H])[C@@]1([H])OC(=O)C2=C
 xref: CAS:20554-84-1;   KEGG:C07609;   KNApSAcK:C00003345;   LIPID_MAPS_instance:LMPR0103090002
 xref_mesh: MESH:C002669
 xref: PMID:11410248;   PMID:11837788;   PMID:11961112;   PMID:12417429;   PMID:12628675;   PMID:14501955;   PMID:15501437;   PMID:15616293;   PMID:15987517;   PMID:16778086;   PMID:17051330;   PMID:17200339;   PMID:17986299;   PMID:19201992;   PMID:19555300;   PMID:19949351;   PMID:22688575;   PMID:23065294;   PMID:23192276;   PMID:23264600;   PMID:23688583;   PMID:23746953;   PMID:23792430;   PMID:23797801;   PMID:23876538;   PMID:23898080;   PMID:23933184;   Reaxys:3550011;   Wikipedia:Parthenolide



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parthenolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO parthenolide results in decreased expression of ABCB1 protein CTD PMID:37683593 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions ISO parthenolide binds to and results in increased activity of ADIPOR2 protein CTD PMID:23691032 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of AMH mRNA] CTD PMID:37949423 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO parthenolide results in decreased expression of ATF4 protein CTD PMID:36477977 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of ATG7 protein] CTD PMID:37858773 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO parthenolide results in increased expression of BAK1 protein CTD PMID:16024633 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO parthenolide results in increased expression of BAX protein CTD PMID:16024633 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of BCL2 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of BCL2 protein]
parthenolide results in decreased expression of BCL2 mRNA; parthenolide results in decreased expression of BCL2 protein
CTD PMID:20154269 PMID:21928377 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance ISO BCL2L1 protein results in decreased susceptibility to parthenolide CTD PMID:16024633 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO parthenolide results in increased cleavage of BID protein CTD PMID:16024633 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G C5 complement C5 multiple interactions ISO parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein] CTD PMID:19284563 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Casp3 caspase 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA] CTD PMID:30259999 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein CTD PMID:20154269 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of CAT mRNA] CTD PMID:37949423 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
parthenolide inhibits the reaction [Phenylephrine results in increased expression of CCL2 mRNA]
CTD PMID:15728586 PMID:22748497 PMID:23958496 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA] CTD PMID:23958496 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]
parthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 protein
CTD PMID:21928377 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]] CTD PMID:20089671 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cfb complement factor B decreases expression ISO parthenolide results in decreased expression of CFB mRNA CTD PMID:16921510 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein] CTD PMID:18463201 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO parthenolide results in increased expression of CTNNB1 protein CTD PMID:37683593 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA]; parthenolide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein] CTD PMID:21507677 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO parthenolide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL1 mRNA]
parthenolide results in increased expression of CXCL1 mRNA
CTD PMID:17320037 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Dazl deleted in azoospermia-like multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of DAZL mRNA] CTD PMID:37949423 NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO parthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA]
parthenolide results in increased expression of DDIT3 mRNA; parthenolide results in increased expression of DDIT3 protein
CTD PMID:11360202 PMID:36477977 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO parthenolide results in decreased expression of EIF2AK2 protein CTD PMID:36477977 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression ISO parthenolide results in decreased expression of EIF2AK3 protein CTD PMID:36477977 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO parthenolide results in decreased expression of ERO1A protein CTD PMID:36477977 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO parthenolide results in decreased expression of FAS mRNA CTD PMID:16024633 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand decreases expression ISO parthenolide results in decreased expression of FASLG mRNA CTD PMID:16024633 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA] CTD PMID:16921510 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 multiple interactions ISO parthenolide promotes the reaction [SC-203048 results in decreased expression of FLT3 mRNA] CTD PMID:21928377 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GPX2 mRNA] CTD PMID:37949423 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression ISO parthenolide affects the expression of GPX4 protein CTD PMID:36591540 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased activity of GSR protein]; parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSR mRNA] CTD PMID:37949423 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of GSTA5 mRNA] CTD PMID:37949423 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in increased expression of HPGDS protein CTD PMID:21669866 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO parthenolide results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO parthenolide inhibits the reaction [resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [resveratrol results in increased expression of ICAM1 mRNA] CTD PMID:22748497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifna1 interferon, alpha 1 decreases expression ISO parthenolide results in decreased expression of IFNA1 mRNA CTD PMID:16921510 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein] CTD PMID:18463201 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il12b interleukin 12B decreases expression ISO parthenolide results in decreased expression of IL12B mRNA CTD PMID:16921510 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO parthenolide results in decreased expression of IL1A mRNA CTD PMID:16921510 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein] CTD PMID:24444433 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
parthenolide inhibits the reaction [Methotrexate results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL6 protein]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol results in decreased expression of IL6 mRNA]
parthenolide inhibits the reaction [Cyclosporine results in increased expression of IL6 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]
CTD PMID:22748497 PMID:23958496 PMID:24444433 PMID:30259999 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO parthenolide promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions ISO parthenolide inhibits the reaction [Lipopolysaccharides results in decreased expression of LTC4S mRNA] CTD PMID:12574384 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Lyz2 lysozyme 2 multiple interactions ISO [parthenolide co-treated with artemisinin co-treated with Quercetin] inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein]; parthenolide inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of MAP1LC3B protein] CTD PMID:37858773 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression
multiple interactions
ISO
EXP
parthenolide results in increased expression of MAPK8 mRNA
parthenolide results in increased phosphorylation of and results in increased activity of MAPK8 protein
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]
CTD PMID:16921510 PMID:30259999 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO parthenolide results in increased expression of MAPK9 mRNA CTD PMID:16921510 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter] CTD PMID:20093109 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 affects localization
multiple interactions
ISO parthenolide affects the localization of NCOR2 protein
SC-203048 promotes the reaction [parthenolide affects the localization of NCOR2 protein]
CTD PMID:21928377 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
CTD PMID:16921510 PMID:18463201 PMID:30259999 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide inhibits the reaction [bisphenol A results in increased expression of NFKBIA mRNA]
CTD PMID:18413660 PMID:18463201 PMID:19303104 PMID:38701888 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA] CTD PMID:30259999 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in increased expression of NOS2 protein]; parthenolide inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] CTD PMID:30259999 PMID:37949423 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO parthenolide results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions EXP parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA] CTD PMID:15728586 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases phosphorylation ISO parthenolide results in increased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of PTGES protein CTD PMID:21669866 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
parthenolide inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
CTD PMID:19095747 PMID:19303104 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
decreases activity
ISO
EXP
parthenolide affects the localization of RELA protein
[[parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein] which results in increased susceptibility to Tamoxifen; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [parthenolide results in decreased activity of RELA protein] which results in decreased expression of BCL2 protein; [parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [C5 protein results in increased activity of RELA protein]; parthenolide inhibits the reaction [FGF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [lauric acid results in increased activity of RELA protein]; parthenolide inhibits the reaction [RELA protein binds to MMP9 promoter]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of RELA protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; SC-203048 promotes the reaction [parthenolide affects the localization of RELA protein]
parthenolide inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of RELA mRNA]; parthenolide inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]
parthenolide inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein modified form]
CTD PMID:16921510 PMID:18413660 PMID:18463201 PMID:19095747 PMID:19284563 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rtkn rhotekin multiple interactions ISO parthenolide inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates] CTD PMID:15480428 NCBI chr 4:115,640,813...115,657,952
Ensembl chr 4:115,640,774...115,657,952
JBrowse link
G Sele selectin E decreases expression ISO parthenolide results in decreased expression of SELE mRNA CTD PMID:16921510 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selp selectin P decreases expression ISO parthenolide results in decreased expression of SELP mRNA CTD PMID:16921510 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO parthenolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP parthenolide inhibits the reaction [Paclitaxel results in decreased expression of SOD1 mRNA] CTD PMID:37949423 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sts steroid sulfatase multiple interactions ISO parthenolide inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions ISO [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 mRNA; [Selenium deficiency co-treated with parthenolide co-treated with Lipopolysaccharides] results in decreased expression of TBXAS1 protein CTD PMID:21669866 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tjp1 tight junction protein 1 increases expression ISO parthenolide results in increased expression of TJP1 protein CTD PMID:37683593 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr5 toll-like receptor 5 decreases expression ISO parthenolide results in decreased expression of TLR5 mRNA CTD PMID:16921510 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO parthenolide results in decreased expression of TLR6 mRNA CTD PMID:16921510 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; parthenolide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; parthenolide inhibits the reaction [Resveratrol promotes the reaction [TNF protein results in increased expression of TNF mRNA]]; parthenolide inhibits the reaction [Resveratrol results in increased expression of TNF mRNA]; parthenolide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; parthenolide inhibits the reaction [TNF protein results in increased localization of and results in increased phosphorylation of RELA protein]; parthenolide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
parthenolide results in decreased activity of TNF protein
parthenolide inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]
parthenolide inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]
CTD PMID:19303104 PMID:20093109 PMID:22748497 PMID:30259999 PMID:38701888 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO parthenolide results in increased expression of TP53 protein CTD PMID:16024633 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO parthenolide results in increased expression of TRADD mRNA CTD PMID:16921510 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF1 mRNA]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA]
parthenolide results in decreased expression of TRAF1 mRNA; parthenolide results in decreased expression of TRAF1 protein
CTD PMID:16921510 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 multiple interactions
decreases expression
ISO parthenolide inhibits the reaction [FGF2 protein results in increased expression of TRAF2 mRNA]
parthenolide results in decreased expression of TRAF2 mRNA; parthenolide results in decreased expression of TRAF2 protein
CTD PMID:16921510 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO parthenolide inhibits the reaction [Glupearl 19S results in increased expression of TSLP mRNA] CTD PMID:32493875 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression
multiple interactions
ISO parthenolide results in decreased expression of VCAM1 mRNA
parthenolide inhibits the reaction [bisphenol A results in increased expression of VCAM1 mRNA]
CTD PMID:16921510 PMID:38701888 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO parthenolide inhibits the reaction [VEGFA protein results in increased activity of [NFKB1 protein binds to RELA protein]]; parthenolide inhibits the reaction [VEGFA protein results in increased expression of TRAF1 mRNA] CTD PMID:16921510 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        inhibitor 18942
          parthenolide 82
            3beta-hydroxyparthenolide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  ester 17474
                                    carboxylic ester 16758
                                      lactone 13308
                                        terpene lactone 2188
                                          sesquiterpene lactone 2048
                                            parthenolide 82
                                              3beta-hydroxyparthenolide 0
paths to the root