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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elesclomol
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Accession:CHEBI:79369 term browser browse the term
Definition:A carbohydrazide obtained by formal condensation of the carboxy groups of malonic acid with the hydrino groups of two molar equivalents of N-methylbenzenecarbothiohydrazide
Synonyms:exact_synonym: N'(1),N'(3)-dimethyl-N'(1),N'(3)-bis(phenylcarbonothioyl)malonohydrazide
 related_synonym: 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide;   Formula=C19H20N4O2S2;   InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25);   InChIKey=BKJIXTWSNXCKJH-UHFFFAOYSA-N;   SMILES=CN(NC(=O)CC(=O)NN(C)C(=S)c1ccccc1)C(=S)c1ccccc1;   elesclomolum
 alt_id: MESH:C512195
 xref: CAS:488832-69-5;   KEGG:D08909;   LINCS:LSM-4929
 xref_mesh: MESH:C512195
 xref: PMID:18389103;   PMID:18723479;   PMID:19609669;   PMID:19826135;   PMID:20933353;   PMID:22253786;   PMID:22425348;   PMID:22542443;   PMID:22865452;   PMID:23401447;   PMID:23707906;   PMID:23937981;   PMID:24161908;   PMID:24176921;   PMID:24798374;   Patent:WO2011133673;   Reaxys:11332608;   Wikipedia:Elesclomol


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elesclomol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 increases expression
multiple interactions		 ISO elesclomol results in increased expression of BAG3 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]		 CTD PMID:18723479 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 increases expression ISO elesclomol results in increased expression of CHORDC1 mRNA CTD PMID:18723479 NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162 		JBrowse link
G Clk1 CDC-like kinase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of CLK1 mRNA] CTD PMID:18723479 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO elesclomol results in increased expression of CRYAB mRNA CTD PMID:18723479 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA] CTD PMID:18723479 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB4 mRNA] CTD PMID:18723479 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO elesclomol results in increased expression of DNAJB9 mRNA CTD PMID:18723479 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO elesclomol results in increased expression of FTL mRNA CTD PMID:18723479 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA] CTD PMID:18723479 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gla galactosidase, alpha increases expression ISO elesclomol results in increased expression of GLA mRNA CTD PMID:18723479 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of HERPUD1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HERPUD1 mRNA]		 CTD PMID:18723479 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HMOX1 mRNA] CTD PMID:18723479 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO elesclomol results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1A mRNA] CTD PMID:18723479 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1B mRNA] CTD PMID:18723479 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO elesclomol results in increased expression of HSPA6 mRNA CTD PMID:18723479 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO elesclomol results in increased expression of HSPH1 mRNA CTD PMID:18723479 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Ier5 immediate early response 5 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IER5 mRNA] CTD PMID:18723479 NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IFRD1 mRNA] CTD PMID:18723479 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1E mRNA] CTD PMID:18723479 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135 		JBrowse link
G Oser1 oxidative stress responsive serine-rich 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of OSER1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of OSER1 mRNA]		 CTD PMID:18723479 NCBI chr 3:152,066,975...152,085,180
Ensembl chr 3:152,066,975...152,085,149 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PMAIP1 mRNA] CTD PMID:18723479 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO elesclomol results in increased expression of PPP1R15A mRNA CTD PMID:18723479 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 increases expression ISO elesclomol results in increased expression of PSMC1 mRNA CTD PMID:18723479 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO elesclomol results in increased expression of PSMC4 mRNA CTD PMID:18723479 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression ISO elesclomol results in increased expression of PSMC6 mRNA CTD PMID:18723479 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 increases expression ISO elesclomol results in increased expression of PSMD1 mRNA CTD PMID:18723479 NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211 		JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO elesclomol results in increased expression of PSMD12 mRNA CTD PMID:18723479 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO elesclomol results in increased expression of PSMD2 mRNA CTD PMID:18723479 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Psme4 proteasome activator subunit 4 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PSME4 mRNA] CTD PMID:18723479 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408 		JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 increases expression ISO elesclomol results in increased expression of RB1CC1 mRNA CTD PMID:18723479 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SAT1 mRNA] CTD PMID:18723479 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog increases expression ISO elesclomol results in increased expression of SDE2 mRNA CTD PMID:18723479 NCBI chr13:92,578,843...92,595,142
Ensembl chr13:92,578,874...92,595,140 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC19A2 mRNA] CTD PMID:18723479 NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC30A1 mRNA] CTD PMID:18723479 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA] CTD PMID:18723479 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA] CTD PMID:18723479 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO elesclomol results in increased expression of TXNRD1 mRNA CTD PMID:18723479 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ufm1 ubiquitin-fold modifier 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA] CTD PMID:18723479 NCBI chr 2:137,969,476...137,977,620
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089 		JBrowse link
G Uspl1 ubiquitin specific peptidase like 1 increases expression
multiple interactions		 ISO elesclomol results in increased expression of USPL1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of USPL1 mRNA]		 CTD PMID:18723479 NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366 		JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression ISO elesclomol results in increased expression of YRDC mRNA CTD PMID:18723479 NCBI chr 5:137,110,244...137,115,127
Ensembl chr 5:137,110,279...137,115,120 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 increases expression ISO elesclomol results in increased expression of ZC3HAV1 mRNA CTD PMID:18723479 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZFAND2A mRNA] CTD PMID:18723479 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
G Zfp394 zinc finger protein 394 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZNF394 mRNA] CTD PMID:18723479 NCBI chr12:9,409,047...9,417,228
Ensembl chr12:9,409,078...9,417,246 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          apoptosis inducer 13659
            elesclomol 44
              elesclomol-Cu(II) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    dicarboxylic acids and O-substituted derivatives 11129
                                      dicarboxylic acid 11123
                                        alpha,omega-dicarboxylic acid 3173
                                          malonic acid 62
                                            elesclomol 44
                                              elesclomol-Cu(II) 0
paths to the root