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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:paricalcitol
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Accession:CHEBI:7931 term browser browse the term
Definition:A seco-cholestane that has formula C27H44O3.
Synonyms:exact_synonym: (1R,3R,7E)-17beta-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-9,10-secoestra-5,7-diene-1,3-diol
 related_synonym: 19-Nor-1alpha,25-dihydroxyvitamin D2;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1;   InChIKey=BPKAHTKRCLCHEA-UBFJEZKGSA-N;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1C[C@@H](O)C[C@H](O)C1)[C@H](C)\\C=C\\[C@H](C)C(C)(C)O;   Zemplar
 xref: CAS:131918-61-1;   DrugBank:DB00910;   Drug_Central:2066;   KEGG:C08127;   KEGG:D00930
 xref_mesh: MESH:C084656
 xref: Patent:EP387077;   Patent:US5587497;   Wikipedia:Paricalcitol


show annotations for term's descendants           Sort by:
paricalcitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of AADAC mRNA CTD PMID:17715259 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO paricalcitol results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor1 adiponectin receptor 1 increases expression ISO paricalcitol results in increased expression of ADIPOR1 protein CTD PMID:25037058 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA CTD PMID:17715259 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO paricalcitol inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
[Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA		 CTD PMID:17715259 PMID:25037058 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of B4GALT1 mRNA CTD PMID:17715259 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2 CTD PMID:15781666 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2L1 CTD PMID:15781666 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of BMP4 mRNA CTD PMID:17715259 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO paricalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; paricalcitol promotes the reaction [resveratrol results in increased expression of CAMP mRNA] CTD PMID:24039193 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
paricalcitol results in decreased expression of CCL2 protein
paricalcitol results in increased expression of CCL2 mRNA		 CTD PMID:17513326 PMID:20720404 PMID:25037058 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO paricalcitol results in increased expression of CCR2 mRNA CTD PMID:25037058 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions		 ISO paricalcitol results in increased expression of CD14 protein
[Phosphorus co-treated with paricalcitol] results in increased expression of CD14 mRNA		 CTD PMID:12618899 PMID:17715259 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA CTD PMID:17715259 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of COL15A1 mRNA CTD PMID:17715259 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of COL1A1 mRNA CTD PMID:17715259 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO paricalcitol results in increased expression of COL3A1 mRNA CTD PMID:25037058 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CP mRNA CTD PMID:17715259 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpn2 carboxypeptidase N subunit 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CPN2 mRNA CTD PMID:17715259 NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of CPT1A mRNA CTD PMID:17715259 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crip1 cysteine rich protein 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CRIP1 mRNA CTD PMID:17715259 NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620 		JBrowse link
G Ctdspl CTD small phosphatase like multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 NCBI chr 8:118,642,729...118,767,238
Ensembl chr 8:118,642,672...118,767,117 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
paricalcitol results in decreased expression of CYBA protein		 CTD PMID:20720404 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP1B1 mRNA CTD PMID:17715259 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO [arsenic trioxide results in decreased expression of CYP24A1] which results in increased activity of paricalcitol; [Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA CTD PMID:15781666 PMID:17715259 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP2B6 mRNA CTD PMID:17715259 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO paricalcitol results in increased expression of CYP3A4 mRNA CTD PMID:11723248 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form] CTD PMID:21565836 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of EDNRB mRNA CTD PMID:17715259 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fbln2 fibulin 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of FBLN2 mRNA CTD PMID:17715259 NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA CTD PMID:25037058 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id3 inhibitor of DNA binding 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA CTD PMID:17715259 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of IL11 mRNA CTD PMID:17715259 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1B mRNA CTD PMID:17715259 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1RN mRNA CTD PMID:17715259 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il24 interleukin 24 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL24 mRNA CTD PMID:17715259 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL36RN mRNA CTD PMID:17715259 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of IL6 mRNA CTD PMID:17715259 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO paricalcitol results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO paricalcitol results in increased expression of ITGAM protein CTD PMID:12618899 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Mapk13 mitogen activated protein kinase 13 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MAPK13 mRNA CTD PMID:17715259 NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222 		JBrowse link
G Meltf melanotransferrin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MELTF mRNA CTD PMID:17715259 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300 		JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MGP mRNA CTD PMID:17715259 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mrpl33 mitochondrial ribosomal protein L33 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MRPL33 mRNA CTD PMID:17715259 NCBI chr 6:24,825,800...24,833,994
Ensembl chr 6:24,825,827...24,833,834 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the localization of NCOR1 protein; [Phosphorus co-treated with paricalcitol] results in decreased expression of NCOR1 protein CTD PMID:17715259 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
paricalcitol results in decreased expression of NOS2 protein		 CTD PMID:20720404 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression		 ISO [paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein
paricalcitol results in increased expression of NOS3 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:21565836 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y increases expression ISO paricalcitol results in increased expression of NPY mRNA CTD PMID:25037058 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of NR4A1 mRNA CTD PMID:17715259 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNA CTD PMID:17715259 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of PEX11A mRNA CTD PMID:17715259 NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172 		JBrowse link
G Postn periostin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of POSTN mRNA CTD PMID:17715259 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased localization of PPARG protein CTD PMID:17715259 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO paricalcitol results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression		 EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]
paricalcitol results in decreased expression of PRKCA protein modified form		 CTD PMID:21565836 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNA CTD PMID:17715259 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS2 mRNA
paricalcitol results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein		 CTD PMID:17715259 PMID:20720404 PMID:25037058 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone decreases secretion
decreases expression		 ISO paricalcitol results in decreased secretion of PTH protein
paricalcitol results in decreased expression of PTH protein		 CTD PMID:12631365 PMID:15898824 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rarres1 retinoic acid receptor responder 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of RARRES1 mRNA CTD PMID:17715259 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased localization of RELA protein CTD PMID:17715259 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of SERPINE1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of SERPINE1 protein CTD PMID:17715259 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation
multiple interactions		 EXP paricalcitol results in decreased phosphorylation of SMAD2 protein
Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]		 CTD PMID:17513326 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO paricalcitol results in increased expression of SOD1 protein
[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions		 ISO paricalcitol results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of SOD3 mRNA CTD PMID:17715259 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 ISO [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
paricalcitol results in increased expression of SPP1 mRNA		 CTD PMID:17715259 PMID:25037058 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 EXP Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
paricalcitol results in decreased expression of TGFB1 mRNA; paricalcitol results in decreased expression of TGFB1 protein		 CTD PMID:17513326 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TGFB3 mRNA CTD PMID:17715259 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of THBD mRNA; [Phosphorus co-treated with paricalcitol] results in increased expression of THBD protein CTD PMID:17715259 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 protein CTD PMID:17715259 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 paricalcitol results in decreased expression of TNF protein
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein
paricalcitol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]		 CTD PMID:20720404 PMID:25037058 PMID:32812453 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of TNFRSF11B mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of TNFRSF11B protein CTD PMID:17715259 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression EXP paricalcitol results in increased expression of TNFSF11 mRNA; paricalcitol results in increased expression of TNFSF11 protein CTD PMID:17352647 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnxb tenascin XB multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TNXB mRNA CTD PMID:17715259
G Trem1 triggering receptor expressed on myeloid cells 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TREM1 mRNA CTD PMID:17715259 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203 		JBrowse link
G Vdr vitamin D receptor multiple interactions
affects binding		 ISO [Phosphorus co-treated with paricalcitol] results in increased expression of VDR protein; [Phosphorus co-treated with paricalcitol] results in increased localization of VDR protein; paricalcitol binds to and affects the activity of VDR protein
paricalcitol binds to VDR protein		 CTD PMID:15898824 PMID:16076355 PMID:17715259 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vwf von Willebrand factor decreases expression ISO paricalcitol results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pesticide 18067
          rodenticide 12369
            vitamin D2 82
              paricalcitol 82
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic polycyclic compound 17291
                                  steroid 14716
                                    hydroxy steroid 14466
                                      hydroxy seco-steroid 2705
                                        vitamin D 2700
                                          vitamin D2 82
                                            paricalcitol 82
paths to the root