Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Pargyline
go back to main search page
Accession:CHEBI:7930 term browser browse the term
Definition:An aromatic amine that has formula C11H13N.
Synonyms:related_synonym: Formula=C11H13N;   InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3;   InChIKey=DPWPWRLQFGFJFI-UHFFFAOYSA-N;   N-Methyl-N-benzylpropynylamine;   SMILES=CN(CC#C)Cc1ccccc1;   eutonyl;   pargylamine;   pargylin;   pargyline HCl;   pargyline hydrochloride;   supirdyl
 xref: CAS:555-57-7;   Drug_Central:2065;   HMDB:HMDB0015563;   KEGG:C07414;   KEGG:D08453;   LINCS:LSM-3878
 xref_mesh: MESH:D010293


show annotations for term's descendants           Sort by:
Pargyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO Pargyline inhibits the reaction [COL6A1 protein affects the abundance of Reactive Oxygen Species] CTD PMID:20716577 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO Pargyline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Pargyline results in decreased activity of CYP2B6 protein		 CTD PMID:25656918 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Pargyline CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Maoa monoamine oxidase A decreases activity
multiple interactions		 ISO Pargyline results in decreased activity of MAOA protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]		 CTD PMID:20716577 PMID:23499958 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B decreases activity
multiple interactions		 ISO Pargyline results in decreased activity of MAOB protein
[[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [Resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]		 CTD PMID:20716577 PMID:23499958 PMID:27270453 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] inhibits the reaction [Resveratrol promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]]; [[Clorgyline results in decreased activity of MAOA protein] co-treated with [Pargyline results in decreased activity of MAOB protein]] promotes the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein] CTD PMID:23499958 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          ammonia 17865
            organic amino compound 17865
              aromatic amine 15478
                Pargyline 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          Pargyline 6
paths to the root